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Asymmetric alkylation-, Michael- and aldol reactions of Cα-nitrogen- or bromo-substituted N-acylsultams

Zhou, Changyou Von Oppolzer, Wolfgang

1993

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2
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Heparin attenuates HMGB1 expression in arterial tissue subjected to limb ischemia/reperfusion

Liu, Yang ; He, Yuxiang ; Wu, Xuejun ; Zhang, Shiyi ; Chong, Zhenyue ; Jiang, Yue ; Zhou, Changyou ; Jin, Xing

International Journal of Cardiology, 20 September 2014, Vol.176(2), pp.543-546 [Peer Reviewed Journal]

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3
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Blockade of HMGB1 preserves vascular homeostasis and improves blood perfusion in rats of acute limb ischemia/reperfusion

Liu, Yang ; Zhou, Changyou ; Jiang, Jianjun ; Su, Qingbo ; Ding, Xiangjiu

Microvascular Research, July 2017, Vol.112, pp.37-40 [Peer Reviewed Journal]

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4
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The enantioselective synthesis of alpha-amino acid derivatives via organoboranes

O'Donnell, Martin J ; Drew, Mark D ; Cooper, Jeremy T ; Delgado, Francisca ; Zhou, Changyou

Journal of the American Chemical Society, 14 August 2002, Vol.124(32), pp.9348-9 [Peer Reviewed Journal]

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5
Solid-Phase Unnatural Peptide Synthesis (UPS)
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Solid-Phase Unnatural Peptide Synthesis (UPS)

O'Donnell, Martin J. ; Zhou, Changyou ; Scott, William L.

Journal of the American Chemical Society, 01/1996, Vol.118(25), pp.6070-6071 [Peer Reviewed Journal]

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6
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Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity

Zhou, Changyou ; Garcia-Calvo, Margareta ; Pinto, Shirly ; Lombardo, Matthew ; Feng, Zhe ; Bender, Kate ; Pryor, Kellyann D ; Bhatt, Urmi R ; Chabin, Renee M ; Geissler, Wayne M ; Shen, Zhu ; Tong, Xinchun ; Zhang, Zhoupeng ; Wong, Kenny K ; Roy, Ranabir Sinha ; Chapman, Kevin T ; Yang, Lihu ; Xiong, Yusheng

Journal of medicinal chemistry, 14 October 2010, Vol.53(19), pp.7251-63 [Peer Reviewed Journal]

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7
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The solid phase synthesis of α,α-disubstituted unnatural amino acids and peptides (di-UPS)

Scott, William L ; Zhou, Changyou ; Fang, Zhiqiang ; O'Donnell, Martin J

Tetrahedron Letters, 1997, Vol.38(21), pp.3695-3698 [Peer Reviewed Journal]

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8
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Discovery of novel dihydrobenzofuran cyclopropane carboxylic acid based calcium sensing receptor antagonists for the treatment of osteoporosis

Liang, Gui-Bai ; Zhou, Changyou ; Huo, Xianghong ; Wang, Hank ; Yang, Xuelin ; Huang, Shaoqiang ; Wang, Haisheng ; Wilkinson, Hilary ; Luo, Lusong ; Tang, Wei ; Sutton, David ; Li, Hong ; Zaller, Dennis ; Meinke, Peter T

Bioorganic & Medicinal Chemistry Letters, 15 August 2016, Vol.26(16), pp.4077-4080 [Peer Reviewed Journal]

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9
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3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists

Walsh, Shawn P ; Severino, Alexandra ; Zhou, Changyou ; He, Jiafang ; Liang, Gui-Bai ; Tan, Carina P ; Cao, Jin ; Eiermann, George J ; Xu, Ling ; Salituro, Gino ; Howard, Andrew D ; Mills, Sander G ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(11), pp.3390-3394 [Peer Reviewed Journal]

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10
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Solid-phase synthesis of unnatural α-amino acid derivatives using a resin-bound glycine cation equivalent

O'Donnell, Martin J ; Delgado, Francisca ; Drew, Mark D ; Pottorf, Richard S ; Zhou, Changyou ; Scott, William L

Tetrahedron Letters, 1999, Vol.40(32), pp.5831-5835 [Peer Reviewed Journal]

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11
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Solid-phase synthesis of unnatural amino acids using unactivated alkyl halides

O'Donnell, Martin J ; Lugar, Charles W ; Pottorf, Richard S ; Zhou, Changyou ; Scott, William L ; Cwi, Cynthia L

Tetrahedron Letters, 1997, Vol.38(41), pp.7163-7166 [Peer Reviewed Journal]

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12
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Palladium-catalyzed reaction of a malonate anion with a glycine cation equivalent: Bis-phosphine ligands and in situ catalyst formation

O'Donnell, Martin J ; Zhou, Changyou ; Mi, Aiqiao ; Chen, Ning ; Kyle, Jeffrey A ; Andersson, Pher G

Tetrahedron Letters, 1995, Vol.36(24), pp.4205-4208 [Peer Reviewed Journal]

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13
Efficient Catalytic Enantioselective Reaction of a Glycine Cation Equivalent with Malonate Anions via Palladium Catalysis
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Efficient Catalytic Enantioselective Reaction of a Glycine Cation Equivalent with Malonate Anions via Palladium Catalysis

O'Donnell, Martin J. ; Chen, Ning ; Zhou, Changyou ; Murray, Angela ; Kubiak, Clifford P. ; Yang, Fan ; Stanley, George G.

The Journal of Organic Chemistry, 06/1997, Vol.62(12), pp.3962-3975 [Peer Reviewed Journal]

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14
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Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors

Shen, Hong C ; Ding, Fa-Xiang ; Zhou, Changyou ; Xiong, Yusheng ; Verras, Andreas ; Chabin, Renee M ; Xu, Suoyu ; Tong, Xinchun ; Xie, Dan ; Lassman, Michael E ; Bhatt, Urmi R ; Garcia-Calvo, Margarita M ; Geissler, Wayne ; Shen, Zhu ; Chen, Dunlu ; Sinharoy, Ranabir ; Hale, Jeffery J ; Tata, James R ; Pinto, Shirly ; Shen, Dong-Ming ; Colletti, Steven L

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(5), pp.1299-1305 [Peer Reviewed Journal]

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15
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Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists

Yang, Lihu ; Butora, Gabor ; Jiao, Richard X ; Pasternak, Alex ; Zhou, Changyou ; Parsons, William H ; Mills, Sander G ; Vicario, Pasquale P ; Ayala, Julia M ; Cascieri, Margaret A ; Maccoss, Malcolm

Journal of medicinal chemistry, 31 May 2007, Vol.50(11), pp.2609-11 [Peer Reviewed Journal]

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16
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BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers

Tang, Zhiyu ; Yuan, Xi ; Du, Rong ; Cheung, Shing-Hu ; Zhang, Guoliang ; Wei, Jing ; Zhao, Yuan ; Feng, Yingcai ; Peng, Hao ; Zhang, Yi ; Du, Yunguang ; Hu, Xiaoxia ; Gong, Wenfeng ; Liu, Yong ; Gao, Yajuan ; Liu, Ye ; Hao, Rui ; Li, Shengjian ; Wang, Shaohui ; Ji, Jiafu ; Zhang, Lianhai ; Li, Shuangxi ; Sutton, David ; Wei, Min ; Zhou, Changyou ; Wang, Lai ; Luo, Lusong

Molecular cancer therapeutics, October 2015, Vol.14(10), pp.2187-97 [Peer Reviewed Journal]

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17
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Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists

Zhou, Changyou ; Tang, Cheng ; Chang, Eric ; Ge, Min ; Lin, Songnian ; Cline, Eric ; Tan, Carina P ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George J ; Petrov, Aleksandr ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro E ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel ; Howard, Andrew D ; Thornberry, Nancy ; Mills, Sander G ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(3), pp.1298-1301 [Peer Reviewed Journal]

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18
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Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice

Tan, Carina P ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George J ; Petrov, Aleksandr ; Zhou, Changyou ; Lin, Songnian ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro E ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel P ; Mills, Sander G ; Thornberry, Nancy A ; Yang, Lihu ; Howard, Andrew D

Diabetes, August 2008, Vol.57(8), pp.2211-9 [Peer Reviewed Journal]

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19
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Alpha-aminothiazole-gamma-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists

Zhou, Changyou ; Guo, Liangqin ; Parsons, William H ; Mills, Sander G ; Maccoss, Malcolm ; Vicario, Pasquale P ; Zweerink, Hans ; Cascieri, Margaret A ; Springer, Martin S ; Yang, Lihu

Bioorganic & medicinal chemistry letters, 15 January 2007, Vol.17(2), pp.309-14 [Peer Reviewed Journal]

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20
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α-Aminothiazole-γ-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists

Zhou, Changyou ; Guo, Liangqin ; Parsons, William H ; Mills, Sander G ; Maccoss, Malcolm ; Vicario, Pasquale P ; Zweerink, Hans ; Cascieri, Margaret A ; Springer, Martin S ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(2), pp.309-314 [Peer Reviewed Journal]

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21
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Design, synthesis, and structure–activity relationship of novel CCR2 antagonists

Kothandaraman, Shankaran ; Donnely, Karla L ; Butora, Gabor ; Jiao, Richard ; Pasternak, Alexander ; Morriello, Gregori J ; Goble, Stephen D ; Zhou, Changyou ; Mills, Sander G ; Maccoss, Malcolm ; Vicario, Pasquale P ; Ayala, Julia M ; Demartino, Julie A ; Struthers, Mary ; Cascieri, Margaret A ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(6), pp.1830-1834 [Peer Reviewed Journal]

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22
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Discovery of 3,5-bis(trifluoromethyl)benzyl l-arylglycinamide based potent CCR2 antagonists

Yang, Lihu ; Zhou, Changyou ; Guo, Liangqin ; Morriello, Gregori ; Butora, Gabor ; Pasternak, Alexander ; Parsons, William H ; Mills, Sander G ; Maccoss, Malcolm ; Vicario, Pasquale P ; Zweerink, Hans ; Ayala, Julia M ; Goyal, Shefali ; Hanlon, William A ; Cascieri, Margaret A ; Springer, Marty S

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(14), pp.3735-3739 [Peer Reviewed Journal]

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23
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Design and syntheses of melanocortin subtype-4 receptor agonists: evolution of the pyridazinone archetype

Ujjainwalla, Feroze ; Warner, Daniel ; Walsh, Thomas F ; Wyvratt, Matthew J ; Zhou, Changyou ; Yang, Lihu ; Kalyani, Rubana N ; Macneil, Tanya ; Van Der Ploeg, Lex H.T ; Rosenblum, Charles I ; Tang, Rui ; Vongs, Aurawan ; Weinberg, David H ; Goulet, Mark T

Bioorganic & Medicinal Chemistry Letters, 15 December 2003, Vol.13(24), pp.4431-4435 [Peer Reviewed Journal]

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24
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Nipecotic and iso-nipecotic amides as potent and selective somatostatin subtype-2 receptor agonists

Zhou, Changyou ; Guo, Liangqin ; Morriello, Greg ; Pasternak, Alex ; Pan, Yanping ; Rohrer, Susan P ; Birzin, Elizebeth T ; Huskey, Su-Er Wu ; Jacks, Tom ; Schleim, Klaus D ; Cheng, Kang ; Schaeffer, James M ; Patchett, Arthur A ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 02 February 2001, Vol.11(3), pp.415-417 [Peer Reviewed Journal]

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25
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Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase

Guo, Yunhang ; Liu, Ye ; Hu, Nan ; Yu, Desheng ; Zhou, Changyou ; Shi, Gongyin ; Zhang, Bo ; Wei, Min ; Liu, Junhua ; Luo, Lusong ; Tang, Zhiyu ; Song, Huipeng ; Guo, Yin ; Liu, Xuesong ; Su, Dan ; Zhang, Shuo ; Song, Xiaomin ; Zhou, Xing ; Hong, Yuan ; Chen, Shuaishuai ; Cheng, Zhenzhen ; Young, Steve ; Wei, Qiang ; Wang, Haisheng ; Wang, Qiuwen ; Lv, Lei ; Wang, Fan ; Xu, Haipeng ; Sun, Hanzi ; Xing, Haimei ; Li, Na ; Zhang, Wei ; Wang, Zhongbo ; Liu, Guodong ; Sun, Zhijian ; Zhou, Dongping ; Li, Wei ; Liu, Libin ; Wang, Lai ; Wang, Zhiwei

Journal of medicinal chemistry, 12 September 2019, Vol.62(17), pp.7923-7940 [Peer Reviewed Journal]

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