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Total synthesis of (+)-irciniastatin A (a.k.a. psymberin) and (-)-irciniastatin B

An, Chihui ; Jurica, Jon A ; Walsh, Shawn P ; Hoye, Adam T ; Smith, Amos B

The Journal of organic chemistry, 03 May 2013, Vol.78(9), pp.4278-96 [Peer Reviewed Journal]

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A novel domino reaction for the preparation of substituted non-racemic β-proline derivatives

Gilbert, Eric J ; Brunskill, Andrew ; Cai, Jiaqiang ; Cai, Yaxian ; Chu, Xin-Jie ; Dai, Xing ; Hao, Jinsong ; Kuethe, Jeffrey T ; Lai, Zhong ; Liu, Hong ; Mu, Cuizhi ; Qi, Yan ; Scott, Jack D ; Taoka, Brandon ; Truong, Quang ; Walsh, Shawn P ; Wu, Wen-Lian ; Cumming, Jared N

Tetrahedron, 06 October 2016, Vol.72(40), pp.6011-6020 [Peer Reviewed Journal]

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Total syntheses of the assigned structures of lituarines B and C

Smith, Amos B ; Duffey, Matthew O ; Basu, Kallol ; Walsh, Shawn P ; Suennemann, Hans W ; Frohn, Michael

Journal of the American Chemical Society, 16 January 2008, Vol.130(2), pp.422-3 [Peer Reviewed Journal]

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Total synthesis of (+)-psymberin (irciniastatin A): catalytic reagent control as the strategic cornerstone

Smith, Amos B ; Jurica, Jon A ; Walsh, Shawn P

Organic letters, 18 December 2008, Vol.10(24), pp.5625-8 [Peer Reviewed Journal]

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Diversity-oriented synthesis of polyketide natural products via iterative chemo- and stereoselective functionalization of polyenoates: development of a unified approach for the C(1-19) segments of lituarines A-C

Smith, Amos B ; Walsh, Shawn P ; Frohn, Michael ; Duffey, Matthew O

Organic letters, 06 January 2005, Vol.7(1), pp.139-42 [Peer Reviewed Journal]

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3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists

Walsh, Shawn P ; Severino, Alexandra ; Zhou, Changyou ; He, Jiafang ; Liang, Gui-Bai ; Tan, Carina P ; Cao, Jin ; Eiermann, George J ; Xu, Ling ; Salituro, Gino ; Howard, Andrew D ; Mills, Sander G ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(11), pp.3390-3394 [Peer Reviewed Journal]

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Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one

Tang, Haifeng ; de Jesus, Reynald K ; Walsh, Shawn P ; Zhu, Yuping ; Yan, Yan ; Priest, Birgit T ; Swensen, Andrew M ; Alonso-Galicia, Magdalena ; Felix, John P ; Brochu, Richard M ; Bailey, Timothy ; Thomas-Fowlkes, Brande ; Zhou, Xiaoyan ; Pai, Lee-Yuh ; Hampton, Caryn ; Hernandez, Melba ; Owens, Karen ; Roy, Sophie ; Kaczorowski, Gregory J ; Yang, Lihu ; Garcia, Maria L ; Pasternak, Alexander

Bioorganic & Medicinal Chemistry Letters, 01 November 2013, Vol.23(21), pp.5829-5832 [Peer Reviewed Journal]

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Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure

Tang, Haifeng ; Zhu, Yuping ; Teumelsan, Nardos ; Walsh, Shawn P ; Shahripour, Aurash ; Priest, Birgit T ; Swensen, Andrew M ; Felix, John P ; Brochu, Richard M ; Bailey, Timothy ; Thomas-Fowlkes, Brande ; Pai, Lee-Yuh ; Hampton, Caryn ; Corona, Aaron ; Hernandez, Melba ; Metzger, Joseph ; Forrest, Michael ; Zhou, Xiaoyan ; Owens, Karen ; Tong, Vincent ; Parmee, Emma ; Roy, Sophie ; Kaczorowski, Gregory J ; Yang, Lihu ; Alonso-Galicia, Magdalena ; Garcia, Maria L ; Pasternak, Alexander

ACS medicinal chemistry letters, 14 July 2016, Vol.7(7), pp.697-701 [Peer Reviewed Journal]

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Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics

Tang, Haifeng ; Walsh, Shawn P ; Yan, Yan ; De Jesus, Reynalda K ; Shahripour, Aurash ; Teumelsan, Nardos ; Zhu, Yuping ; Ha, Sookhee ; Owens, Karen A ; Thomas-Fowlkes, Brande S ; Felix, John P ; Liu, Jessica ; Kohler, Martin ; Priest, Birgit T ; Bailey, Timothy ; Brochu, Richard ; Alonso-Galicia, Magdalena ; Kaczorowski, Gregory J ; Roy, Sophie ; Yang, Lihu ; Mills, Sander G ; Garcia, Maria L ; Pasternak, Alexander

ACS medicinal chemistry letters, 10 May 2012, Vol.3(5), pp.367-72 [Peer Reviewed Journal]

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Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold

Zhu, Yuping ; de Jesus, Reynalda K ; Tang, Haifeng ; Walsh, Shawn P ; Jiang, Jinlong ; Gu, Xin ; Teumelsan, Nardos ; Shahripour, Aurash ; Pio, Barbara ; Ding, Fa-Xiang ; Ha, Sookhee ; Priest, Birgit T ; Swensen, Andrew M ; Alonso-Galicia, Magdalena ; Felix, John P ; Brochu, Richard M ; Bailey, Timothy ; Thomas-Fowlkes, Brande ; Zhou, Xiaoyan ; Pai, Lee-Yuh ; Hampton, Caryn ; Hernandez, Melba ; Owens, Karen ; Ehrhart, Juliann ; Roy, Sophie ; Kaczorowski, Gregory J ; Yang, Lihu ; Parmee, Emma R ; Sullivan, Kathleen ; Garcia, Maria L ; Pasternak, Alexander

Bioorganic & Medicinal Chemistry Letters, 01 December 2016, Vol.26(23), pp.5695-5702 [Peer Reviewed Journal]

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Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation

Walsh, Shawn P ; Shahripour, Aurash ; Tang, Haifeng ; de Jesus, Reynalda K ; Teumelsan, Nardos ; Zhu, Yuping ; Frie, Jessica ; Priest, Birgit T ; Swensen, Andrew M ; Alonso-Galicia, Magdalena ; Felix, John P ; Brochu, Richard M ; Bailey, Timothy ; Thomas-Fowlkes, Brande ; Zhou, Xiaoyan ; Pai, Lee-Yuh ; Hampton, Caryn ; Hernandez, Melba ; Owens, Karen ; Ehrhart, Juliann ; Roy, Sophie ; Kaczorowski, Gregory J ; Yang, Lihu ; Garcia, Maria L ; Pasternak, Alexander

Bioorganic & Medicinal Chemistry Letters, 01 May 2016, Vol.26(9), pp.2339-2343 [Peer Reviewed Journal]

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12
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Furoyl and benzofuroyl pyrroloquinolones as potent and selective PDE5 inhibitors for treatment of erectile dysfunction

Jiang, Weiqin ; Sui, Zhihua ; Macielag, Mark J ; Walsh, Shawn P ; Fiordeliso, James J ; Lanter, James C ; Guan, Jihua ; Qiu, Yuhong ; Kraft, Patricia ; Bhattacharjee, Sheela ; Craig, Elizabeth ; Haynes-Johnson, Donna ; John, T Matthew ; Clancy, Joanna

Journal of medicinal chemistry, 30 January 2003, Vol.46(3), pp.441-4 [Peer Reviewed Journal]

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13
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Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation

Walsh, Shawn P ; Shahripour, Aurash ; Tang, Haifeng ; Teumelsan, Nardos ; Frie, Jessica ; Zhu, Yuping ; Priest, Birgit T ; Swensen, Andrew M ; Liu, Jessica ; Margulis, Michael ; Visconti, Richard ; Weinglass, Adam ; Felix, John P ; Brochu, Richard M ; Bailey, Timothy ; Thomas-Fowlkes, Brande ; Alonso-Galicia, Magdalena ; Zhou, Xiaoyan ; Pai, Lee-Yuh ; Corona, Aaron ; Hampton, Caryn ; Hernandez, Melba ; Bentley, Ross ; Chen, Jing ; Shah, Kashmira ; Metzger, Joseph ; Forrest, Michael ; Owens, Karen ; Tong, Vincent ; Ha, Sookhee ; Roy, Sophie ; Kaczorowski, Gregory J ; Yang, Lihu ; Parmee, Emma ; Garcia, Maria L ; Sullivan, Kathleen ; Pasternak, Alexander

ACS medicinal chemistry letters, 09 July 2015, Vol.6(7), pp.747-52 [Peer Reviewed Journal]

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Material Type:
Research Dataset
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CCDC 1488930: Experimental Crystal Structure Determination

Gilbert, Eric J. ; Brunskill, Andrew ; Cai, Jiaqiang ; Cai, Yaxian ; Chu, Xin-Jie ; Dai, Xing ; Hao, Jinsong ; Kuethe, Jeffrey T. ; Lai, Zhong ; Liu, Hong ; Mu, Cuizhi ; Qi, Yan ; Scott, Jack D. ; Taoka, Brandon ; Truong, Quang ; Walsh, Shawn P. ; Wu, Wen-Lian ; Cumming, Jared N.

2016

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Oil Vulnerabilities and United States Strategy
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Technical Report
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Oil Vulnerabilities and United States Strategy

Walsh, Shawn P Army War Coll Carlisle Barracks PA (Corporate Author)

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