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Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

Liesz, Arthur ; Zhou, Wei ; MracskÓ, ÉVa ; Karcher, Simone ; Bauer, Henrike ; Schwarting, SÖNke ; Sun, Li ; Bruder, Dunja ; Stegemann, Sabine ; Cerwenka, Adelheid ; Sommer, Clemens ; Dalpke, Alexander H ; Veltkamp, Roland

Brain, 2011, Vol. 134(3), pp.704-720 [Peer Reviewed Journal]

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Vascular cell adhesion molecule‐1 (VCAM‐1)—An increasing insight into its role in tumorigenicity and metastasis

Schlesinger, Martin ; Bendas, Gerd

International Journal of Cancer, 01 June 2015, Vol.136(11), pp.2504-2514 [Peer Reviewed Journal]

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Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist

Setoguchi, Masaki ; Iimura, Shin ; Sugimoto, Yuuichi ; Yoneda, Yoshiyuki ; Chiba, Jun ; Watanabe, Toshiyuki ; Muro, Fumihito ; Iigo, Yutaka ; Takayama, Gensuke ; Yokoyama, Mika ; Taira, Tomoe ; Aonuma, Misato ; Takashi, Tohru ; Nakayama, Atsushi ; Machinaga, Nobuo

Bioorganic & Medicinal Chemistry, 01 February 2012, Vol.20(3), pp.1201-1212 [Peer Reviewed Journal]

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A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid

Setoguchi, Masaki ; Iimura, Shin ; Sugimoto, Yuuichi ; Yoneda, Yoshiyuki ; Chiba, Jun ; Watanabe, Toshiyuki ; Muro, Fumihito ; Iigo, Yutaka ; Takayama, Gensuke ; Yokoyama, Mika ; Taira, Tomoe ; Aonuma, Misato ; Takashi, Tohru ; Nakayama, Atsushi ; Machinaga, Nobuo

Bioorganic & Medicinal Chemistry, 01 January 2013, Vol.21(1), pp.42-61 [Peer Reviewed Journal]

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Impaired Transmigration of Myeloid-Derived Suppressor Cells across Human Sinusoidal Endothelium Is Associated with Decreased Expression of CD13

Resheq, Yazid ; Tickle, Joseph ; Ka-Kit, Li ; Wilhelm, Annika ; Hepburn, Elizabeth ; Ward, Stephen ; Curbishley, Stuart ; Zimmermann, Henning ; Bruns, Tony ; Gilbert, Daniel ; Mackensen, Andreas ; Adams, David ; Weston, Chris

The Journal of Immunology, Sep 1, 2017, Vol.199(5), pp.1672-1681 [Peer Reviewed Journal]

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Ligation of the CD44 Glycoform HCELL on Culture-Expanded Human Monocyte-Derived Dendritic Cells Programs Transendothelial Migration

Videira, Paula ; Silva, Mariana ; Martin, Kyle ; Sackstein, Robert

The Journal of Immunology, Aug 1, 2018, Vol.201(3), pp.1030-1043 [Peer Reviewed Journal]

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Positron Emission Tomography Imaging of Macaques with Tuberculosis Identifies Temporal Changes in Granuloma Glucose Metabolism and Integrin α4β1–Expressing Immune Cells

Mattila, Joshua ; Teresa, Coleman ; White, Alexander ; Scanga, Charles ; Flynn, Joanne ; Anderson, Carolyn

The Journal of Immunology, Jul 15, 2017, Vol.199(2), pp.806-815 [Peer Reviewed Journal]

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The pathogenic relevance of the prognostic markers CD38 and CD49d in chronic lymphocytic leukemia

Brachtl, Gabriele ; Piñón Hofbauer, Josefina ; Greil, Richard ; Hartmann, Tanja

Annals of Hematology, 2014, Vol.93(3), pp.361-374 [Peer Reviewed Journal]

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G9a Correlates with VLA-4 Integrin and Influences the Migration of Childhood Acute Lymphoblastic Leukemia Cells

Madrazo, Elena ; Ruano, David ; Abad, Lorea ; Alonso-Gómez, Estefanía ; Sánchez-Valdepeñas, Carmen ; González-Murillo, África ; Ramírez, Manuel ; Redondo-Muñoz, Javier

Cancers, Sep 2018, Vol.10(9) [Peer Reviewed Journal]

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The inhibition of the integrin VLA-4 in MV3 melanoma cell binding by non-anticoagulant heparin derivatives

Schlesinger, Martin ; Schmitz, Patrick ; Zeisig, Reiner ; Naggi, Annamaria ; Torri, Giangiacomo ; Casu, Benito ; Bendas, Gerd

Thrombosis Research, May 2012, Vol.129(5), pp.603-610 [Peer Reviewed Journal]

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Membrane microvesicles as mediators for melanoma-fibroblasts communication: Roles of the VCAM-1/VLA-4 axis and the ERK1/2 signal pathway

Zhao, Xiao-Ping ; Wang, Meng ; Song, Yong ; Song, Kai ; Yan, Ting-Lin ; Wang, Lin ; Liu, Ke ; Shang, Zheng-Jun

Cancer Letters, 01 May 2015, Vol.360(2), pp.125-133 [Peer Reviewed Journal]

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Comparison of two cross-bridged macrocyclic chelators for the evaluation of 64Cu-labeled-LLP2A, a peptidomimetic ligand targeting VLA-4-positive tumors

Jiang, Majiong ; Ferdani, Riccardo ; Shokeen, Monica ; Anderson, Carolyn J

Nuclear Medicine and Biology, February 2013, Vol.40(2), pp.245-251 [Peer Reviewed Journal]

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Discovery of a potent, orally bioavailable pyrimidine VLA-4 antagonist effective in a sheep asthma model

Semko, Christopher M ; Chen, Linda ; Dressen, Darren B ; Dreyer, Mark L ; Dunn, Whitney ; Farouz, Francine S ; Freedman, Stephen B ; Holsztynska, Elizabeth J ; Jefferies, Michael ; Konradi, Andrei W ; Liao, Anna ; Lugar, Judevin ; Mutter, Linda ; Pleiss, Michael A ; Quinn, Kevin P ; Thompson, Thomas ; Thorsett, Eugene D ; Vandevert, Christopher ; Xu, Ying-Zi ; Yednock, Ted A

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(6), pp.1741-1743 [Peer Reviewed Journal]

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Synthesis and evaluation of 4,5-dihydro-5-methylisoxazolin-5-carboxamide derivatives as VLA-4 antagonists

Soni, Ajay ; Rehman, Abdul ; Naik, Keshav ; Dastidar, Sunanda ; Alam, M.S ; Ray, Abhijit ; Chaira, Tridib ; Shah, Vanya ; Palle, Venkata P ; Cliffe, Ian A ; Sattigeri, Viswajanani J

Bioorganic & Medicinal Chemistry Letters, 01 March 2013, Vol.23(5), pp.1482-1485 [Peer Reviewed Journal]

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CCN1 is a novel target to reduce the metastasis of melanoma

Hutchenreuther, James

Journal of Cell Communication and Signaling, 2014, Vol.8(1), pp.65-66 [Peer Reviewed Journal]

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16
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Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke

Neumann, Jens ; Riek-Burchardt, Monika ; Herz, Josephine ; Doeppner, Thorsten ; König, Rebecca ; Hütten, Heiko ; Etemire, Eloho ; Männ, Linda ; Klingberg, Anika ; Fischer, Thomas ; Görtler, Michael ; Heinze, Hans-Jochen ; Reichardt, Peter ; Schraven, Burkhart ; Hermann, Dirk ; Reymann, Klaus ; Gunzer, Matthias

Acta Neuropathologica, 2015, Vol.129(2), pp.259-277 [Peer Reviewed Journal]

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Gastric cancer increases transmigratory potential of peripheral blood monocytes by upregulation of β1- and β2-integrins

Eljaszewicz, Andrzej ; Jankowski, Michal ; Wiese-Szadkowska, Malgorzata ; Gackowska, Lidia ; Michalkiewicz, Jacek ; Zegarski, Wojciech ; Moniuszko, Marcin

Contemporary Oncology, 2018, Vol.22(1A), p.33-37 [Peer Reviewed Journal]

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18
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Simultaneous Inhibition of CXCR4 and VLA-4 Exhibits Combinatorial Effect in Overcoming Stroma-Mediated Chemotherapy Resistance in Mantle Cell Lymphoma Cells

Kim, Yu-Ri ; Eom, Ki-Seong

Immune network, December 2014, Vol.14(6), pp.296-306 [Peer Reviewed Journal]

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19
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Neutralize the neutrophils! Neutrophil β^sub 1^/β^sub 2^ integrin activation contributes to JAK2-V617F-driven thrombosis

Oh, Stephen

Journal of Clinical Investigation, Oct 2018, Vol.128(10), pp.4248-4250 [Peer Reviewed Journal]

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20
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mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell–derived hematopoietic progenitors

Lee, Jungmin ; Dykstra, Brad ; Spencer, Joel ; Kenney, Laurie ; Greiner, Dale ; Shultz, Leonard ; Brehm, Michael ; Lin, Charles ; Sackstein, Robert ; Rossi, Derrick

Journal of Clinical Investigation, Jun 2017, Vol.127(6), pp.2433-2437 [Peer Reviewed Journal]

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21
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The evaluation of thioridazine as a hematopoietic progenitor cell mobilizing agent in healthy human subjects

Chigaev, Alexandre ; Sklar, Larry A. ; Schrader, Ronald ; Stephens, Nicole ; Raissy, Hengameh ; Winter, Stuart S.

Journal of Clinical Pharmacology, May 2015, Vol.55(5), pp.512-516 [Peer Reviewed Journal]

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22
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Osteopontin binding to the alpha 4 integrin requires highest affinity integrin conformation, but is independent of post-translational modifications of osteopontin

Hui, Tommy ; Sørensen, Esben S ; Rittling, Susan R

Matrix Biology, January 2015, Vol.41, pp.19-25 [Peer Reviewed Journal]

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23
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Integrin Antagonists Prevent Costimulatory Blockade‐Resistant Transplant Rejection by CD8+ Memory T Cells

Kitchens, W. H. ; Haridas, D. ; Wagener, M. E. ; Song, M. ; Kirk, A. D. ; Larsen, C. P. ; Ford, M. L.

American Journal of Transplantation, January 2012, Vol.12(1), pp.69-80 [Peer Reviewed Journal]

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24
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Optimisation and Use of Humanised RBL NF-AT-GFP and NF-AT-DsRed Reporter Cell Lines Suitable for High-Throughput Scale Detection of Allergic Sensitisation in Array Format and Identification of the ECM–Integrin Interaction as Critical Factor

Wang, Xiaowei ; Cato, Paul ; Lin, Hsiu-Chen ; Li, Tongen ; Wan, Daniel ; Alcocer, Marcos ; Falcone, Franco

Molecular Biotechnology, 2014, Vol.56(2), pp.136-146 [Peer Reviewed Journal]

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25
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The role of VLA-4 binding for experimental melanoma metastasis and its inhibition by heparin

Schlesinger, Martin ; Roblek, Marko ; Ortmann, Katrin ; Naggi, Annamaria ; Torri, Giangiacomo ; Borsig, Lubor ; Bendas, Gerd

Thrombosis Research, May 2014, Vol.133(5), pp.855-862 [Peer Reviewed Journal]

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26
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PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier

Rom, Slava ; Zuluaga-Ramirez, Viviana ; Reichenbach, Nancy ; Dykstra, Holly ; Gajghate, Sachin ; Pacher, Pal ; Persidsky, Yuri ; Rom, Slava ; Zuluaga-Ramirez, Viviana ; Reichenbach, Nancy ; Dykstra, Holly ; Gajghate, Sachin ; Pacher, Pal ; Persidsky, Yuri

Journal of Neuroinflammation, 2016, Vol.13 [Peer Reviewed Journal]

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27
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In vitro VLA-4 blockade results in an impaired NK cell-mediated immune surveillance against melanoma

Gandoglia, Ilaria ; Ivaldi, Federico ; Carrega, Paolo ; Armentani, Eric ; Ferlazzo, Guido ; Mancardi, Gianluigi ; Kerlero de Rosbo, Nicole ; Uccelli, Antonio ; Laroni, Alice

Immunology Letters, January 2017, Vol.181, pp.109-115 [Peer Reviewed Journal]

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28
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High CXCR4 and low VLA-4 expression predicts poor survival in adults with acute lymphoblastic leukemia

Ko, Sun-Young ; Park, Chan-Jeoung ; Park, Sang-Hyuk ; Cho, Young-Uk ; Jang, Seongsoo ; Seo, Eul-Ju ; Kim, Nayoung ; Kim, Dae-Young ; Koh, Kyung Nam ; Im, Ho Joon ; Seo, Jong-Jin ; Chi, Hyun-Sook

Leukemia Research, January 2014, Vol.38(1), pp.65-70 [Peer Reviewed Journal]

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29
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Aspects of VLA-4 and LFA-1 regulation that may contribute to rolling and firm adhesion

Chigaev, Alexandre ; Sklar, Larry A

Frontiers in immunology, 2012, Vol.3, pp.242 [Peer Reviewed Journal]

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30
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The role of CD44 in the pathophysiology of chronic lymphocytic leukemia

Julia Christine Gutjahr ; Julia Christine Gutjahr ; Richard Egreil ; Richard Egreil ; Tanja Nicole Hartmann ; Tanja Nicole Hartmann

Frontiers in Immunology, 01 April 2015, Vol.6 [Peer Reviewed Journal]

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31
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Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus

Breuer, Johanna ; Korpos, Eva ; Hannocks, Melanie-Jane ; Schneider-Hohendorf, Tilman ; Song, Jian ; Zondler, Lisa ; Herich, Sebastian ; Flanagan, Ken ; Korn, Thomas ; Zarbock, Alexander ; Kuhlmann, Tanja ; Sorokin, Lydia ; Wiendl, Heinz ; Schwab, Nicholas

Journal of neuroinflammation, 22 August 2018, Vol.15(1), pp.236 [Peer Reviewed Journal]

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32
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Arylsulfonamide pyrimidines as VLA-4 antagonists

Xu, Ying-Zi ; Konradi, Andrei W ; Bard, Frederique ; Dappen, Michael ; Dofiles, Lilibeth ; Dreyer, Mark ; Gallager, Ian ; Garrido, Caroline ; Krimm, Mike ; Liao, Zhenmei ; Messersmith, Elizabeth ; Mutter, Linda ; Pleiss, Michael A ; Samant, Bhushan ; Semko, Christopher M ; Smith, Jennifer ; Stappenbeck, Frank ; Stupi, Brian ; Vandervert, Chris ; Welch, Brent ; Wipke, Brian ; Yednock, Ted

Bioorganic & Medicinal Chemistry Letters, 15 May 2013, Vol.23(10), pp.3070-3074 [Peer Reviewed Journal]

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33
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Leukocyte adhesion molecule dynamics after Natalizumab withdrawal in Multiple Sclerosis

Cobo-Calvo, Álvaro ; Figueras, Agnes ; Bau, Laura ; Matas, Elisabet ; Mañé Martínez, María Alba ; León, Isabel ; Majòs, Carles ; Romero-Pinel, Lucia ; Martínez-Yélamos, Sergio

Clinical Immunology, October 2016, Vol.171, pp.18-24 [Peer Reviewed Journal]

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34
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Antibody to α4 integrin suppresses natural killer cells infiltration in central nervous system in experimental autoimmune encephalomyelitis

Gan, Yan ; Liu, Ruolan ; Wu, Wei ; Bomprezzi, Roberto ; Shi, Fu-Dong

Journal of Neuroimmunology, 15 June 2012, Vol.247(1-2), pp.9-15 [Peer Reviewed Journal]

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35
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Solid-phase synthesis of 2,3-diphenylpropionic acid library as VLA-4 antagonists

Hoshina, Yoichiro ; Ikegami, Satoru ; Fujimoto, Kyoko ; Okuyama, Akihiko ; Harada, Tatsuhiro ; James, Susan ; Griffiths, Peter G ; Wu, Zemin ; Lilly, Michael ; Bray, Andrew M

Tetrahedron Letters, 2005, Vol.46(52), pp.9035-9038 [Peer Reviewed Journal]

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Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists

Chiba, Jun ; Takayama, Gensuke ; Takashi, Tohru ; Yokoyama, Mika ; Nakayama, Atsushi ; Baldwin, John J ; Mcdonald, Edward ; Moriarty, Kevin J ; Sarko, Christopher R ; Saionz, Kurt W ; Swanson, Robert ; Hussain, Zahid ; Wong, Angela ; Machinaga, Nobuo

Bioorganic & Medicinal Chemistry, 2006, Vol.14(8), pp.2725-2746 [Peer Reviewed Journal]

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37