skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Index

29 Results  for Everything (Includes Articles)

Show only
Result Number Material Type Add to My Shelf Action Record Details and Options
1
Material Type:
Article
Add to e-Shelf

Chemoselective Peptide Modification via Photocatalytic Tryptophan β-Position Conjugation

Yu, Younong ; Zhang, Li-Kang ; Buevich, Alexei V ; Li, Guoqing ; Tang, Haiqun ; Vachal, Petr ; Colletti, Steven L ; Shi, Zhi-Cai

Journal of the American Chemical Society, 06 June 2018, Vol.140(22), pp.6797-6800 [Peer Reviewed Journal]

Full text available

View all versions
2
Material Type:
Article
Add to e-Shelf

Organic chemistry. Nanomole-scale high-throughput chemistry for the synthesis of complex molecules

Buitrago Santanilla, Alexander ; Regalado, Erik L ; Pereira, Tony ; Shevlin, Michael ; Bateman, Kevin ; Campeau, Louis-Charles ; Schneeweis, Jonathan ; Berritt, Simon ; Shi, Zhi-Cai ; Nantermet, Philippe ; Liu, Yong ; Helmy, Roy ; Welch, Christopher J ; Vachal, Petr ; Davies, Ian W ; Cernak, Tim ; Dreher, Spencer D

Science (New York, N.Y.), 02 January 2015, Vol.347(6217), pp.49-53 [Peer Reviewed Journal]

Full text available

View all versions
3
Material Type:
Article
Add to e-Shelf

Late-Stage Functionalization of Biologically Active Heterocycles Through Photoredox Catalysis

Dirocco, Daniel A ; Dykstra, Kevin ; Krska, Shane ; Vachal, Petr ; Conway, Donald V ; Tudge, Matthew

Angewandte Chemie, May 5, 2014, Vol.53(19), pp.4802-4806 [Peer Reviewed Journal]

Full text available

View all versions
4
Material Type:
Article
Add to e-Shelf

Late‐Stage Functionalization of Biologically Active Heterocycles Through Photoredox Catalysis

Dirocco, Daniel A. ; Dykstra, Kevin ; Krska, Shane ; Vachal, Petr ; Conway, Donald V. ; Tudge, Matthew

Angewandte Chemie International Edition, 05 May 2014, Vol.53(19), pp.4802-4806 [Peer Reviewed Journal]

Full text available

View all versions
5
Material Type:
Article
Add to e-Shelf

Structure-based analysis and optimization of a highly enantioselective catalyst for the strecker reaction

Vachal, Petr ; Jacobsen, Eric N

Journal of the American Chemical Society, 28 August 2002, Vol.124(34), pp.10012-4 [Peer Reviewed Journal]

Full text available

View all versions
6
Material Type:
Article
Add to e-Shelf

General facile synthesis of 2,5-diarylheteropentalenes

Vachal, Petr ; Toth, Leslie M

Tetrahedron Letters, 2004, Vol.45(38), pp.7157-7161 [Peer Reviewed Journal]

Full text available

View all versions
7
Material Type:
Article
Add to e-Shelf

Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench‐Stable Organozinc Reagents

Greshock, Thomas J. ; Moore, Keith P. ; Mcclain, Ray T. ; Bellomo, Ana ; Chung, Cheol K. ; Dreher, Spencer D. ; Kutchukian, Peter S. ; Peng, Zhengwei ; Davies, Ian W. ; Vachal, Petr ; Ellwart, Mario ; Manolikakes, Sophia M. ; Knochel, Paul ; Nantermet, Philippe G.

Angewandte Chemie International Edition, 24 October 2016, Vol.55(44), pp.13714-13718 [Peer Reviewed Journal]

Full text available

View all versions
8
Material Type:
Article
Add to e-Shelf

Effects of anacetrapib on plasma lipids, apolipoproteins and PCSK9 in healthy, lean rhesus macaques

Roddy, Thomas P ; Mclaren, David G ; Chen, Ying ; Xie, Dan ; Dunn, Keiana ; Kulick, Alison ; Szeto, Daphne ; Forrest, Gail ; Albanese, Kelly ; Donnelly, Marcie ; Gai, Cesaire ; Gewain, Andrew ; Lederman, Harmony ; Jensen, Kristian K ; Ai, Xi ; Vachal, Petr ; Akinsanya, Karen O ; Cleary, Michele A ; Previs, Stephen F ; Dansky, Hayes M ; Johns, Douglas G

European Journal of Pharmacology, 05 October 2014, Vol.740, pp.410-416 [Peer Reviewed Journal]

Full text available

View all versions
9
Material Type:
Article
Add to e-Shelf

A direct functionalization of tertiary alkyl bromides with O-, N-, and C-nucleophiles

Vachal, Petr ; Fletcher, Joan M ; Hagmann, William K

Tetrahedron Letters, 13 August 2007, Vol.48(33), pp.5761-5765 [Peer Reviewed Journal]

Full text available

View all versions
10
Material Type:
Article
Add to e-Shelf

Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors

Cernak, Tim ; Gesmundo, Nathan J ; Dykstra, Kevin ; Yu, Yang ; Wu, Zhicai ; Shi, Zhi-Cai ; Vachal, Petr ; Sperbeck, Donald ; He, Shuwen ; Murphy, Beth Ann ; Sonatore, Lisa ; Williams, Steven ; Madeira, Maria ; Verras, Andreas ; Reiter, Maud ; Lee, Claire Heechoon ; Cuff, James ; Sherer, Edward C ; Kuethe, Jeffrey ; Goble, Stephen ; Perrotto, Nicholas ; Pinto, Shirly ; Shen, Dong-Ming ; Nargund, Ravi ; Balkovec, James ; Devita, Robert J ; Dreher, Spencer D

Journal of medicinal chemistry, 11 May 2017, Vol.60(9), pp.3594-3605 [Peer Reviewed Journal]

Full text available

View all versions
11
Material Type:
Article
Add to e-Shelf

Late‐Stage Functionalization of Biologically Active Heterocycles Through Photoredox Catalysis

Dirocco, Daniel A. ; Dykstra, Kevin ; Krska, Shane ; Vachal, Petr ; Conway, Donald V. ; Tudge, Matthew

Angewandte Chemie, 05 May 2014, Vol.126(19), pp.4902-4906 [Peer Reviewed Journal]

Full text available

View all versions
12
Material Type:
Article
Add to e-Shelf

Profiling and Application of Photoredox C(sp)-C(sp) Cross-Coupling in Medicinal Chemistry

Zhang, Rui ; Li, Guoqing ; Wismer, Michael ; Vachal, Petr ; Colletti, Steven L ; Shi, Zhi-Cai

ACS medicinal chemistry letters, 12 July 2018, Vol.9(7), pp.773-777 [Peer Reviewed Journal]

Full text available

View all versions
13
Enantioselective Catalytic Addition of HCN to Ketoimines. Catalytic Synthesis of Quaternary Amino Acids
Material Type:
Article
Add to e-Shelf

Enantioselective Catalytic Addition of HCN to Ketoimines. Catalytic Synthesis of Quaternary Amino Acids

Vachal, Petr ; Jacobsen, Eric N.

Organic Letters, 03/2000, Vol.2(6), pp.867-870 [Peer Reviewed Journal]

Full text available

View all versions
14
Material Type:
Article
Add to e-Shelf

1,3,8-Triazaspiro4.5decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia

Vachal, Petr ; Miao, Shouwu ; Pierce, Joan M ; Guiadeen, Deodial ; Colandrea, Vincent J ; Wyvratt, Matthew J ; Salowe, Scott P ; Sonatore, Lisa M ; Milligan, James A ; Hajdu, Richard ; Gollapudi, Anantha ; Keohane, Carol A ; Lingham, Russell B ; Mandala, Suzanne M ; Demartino, Julie A ; Tong, Xinchun ; Wolff, Michael ; Steinhuebel, Dietrich ; Kieczykowski, Gerard R ; Fleitz, Fred J ; Chapman, Kevin ; Athanasopoulos, John ; Adam, Gregory ; Akyuz, Can D ; Jena, Dhirendra K ; Lusen, Jeffrey W ; Meng, Juncai ; Stein, Benjamin D ; Xia, Lei ; Sherer, Edward C ; Hale, Jeffrey J

Journal of medicinal chemistry, 12 April 2012, Vol.55(7), pp.2945-59 [Peer Reviewed Journal]

Full text available

View all versions
15
Material Type:
Article
Add to e-Shelf

Fluorescence Properties and Dipole Moments of Novel Fused Thienobenzofurans. Solvent and Structural Effects

Aaron, Jean-Jacques ; Parkanyi, Cyril ; Adenier, Alain ; Potin, Caroline ; Zajickova, Zuzana ; Martinez, Omar R ; Svoboda, Jiri ; Pihera, Pavel ; Vachal, Petr Lge, Admin (Editor)

Journal of Fluorescence, 2011, Vol.21(6), pp.2133--2141 [Peer Reviewed Journal]

Full text available

16
Material Type:
Article
Add to e-Shelf

A General Catalyst for the Asymmetric Strecker Reaction

Sigman, Matthew S. ; Vachal, Petr ; Jacobsen, Eric N.

Angewandte Chemie International Edition, 03 April 2000, Vol.39(7), pp.1279-1281 [Peer Reviewed Journal]

Full text available

View all versions
17
Material Type:
Article
Add to e-Shelf

A General Small-Scale Reactor To Enable Standardization and Acceleration of Photocatalytic Reactions

Le, Chi Chip ; Wismer, Michael K ; Shi, Zhi-Cai ; Zhang, Rui ; Conway, Donald V ; Li, Guoqing ; Vachal, Petr ; Davies, Ian W ; Macmillan, David W C

ACS central science, 28 June 2017, Vol.3(6), pp.647-653

Full text available

View all versions
18
Material Type:
Article
Add to e-Shelf

Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods

Kutchukian, Peter S ; Dropinski, James F ; Dykstra, Kevin D ; Li, Bing ; Dirocco, Daniel A ; Streckfuss, Eric C ; Campeau, Louis-Charles ; Cernak, Tim ; Vachal, Petr ; Davies, Ian W ; Krska, Shane W ; Dreher, Spencer D

Chemical science, 21 April 2016, Vol.7(4), pp.2604-2613 [Peer Reviewed Journal]

Full text available

View all versions
19
Material Type:
Article
Add to e-Shelf

Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench‐Stable Organozinc Reagents

Greshock, Thomas J. ; Moore, Keith P. ; Mcclain, Ray T. ; Bellomo, Ana ; Chung, Cheol K. ; Dreher, Spencer D. ; Kutchukian, Peter S. ; Peng, Zhengwei ; Davies, Ian W. ; Vachal, Petr ; Ellwart, Mario ; Manolikakes, Sophia M. ; Knochel, Paul ; Nantermet, Philippe G.

Angewandte Chemie, 24 October 2016, Vol.128(44), pp.13918-13922 [Peer Reviewed Journal]

Full text available

View all versions
20
Material Type:
Article
Add to e-Shelf

High-throughput purification platform in support of drug discovery

Liu, Min ; Chen, Kuanchang ; Christian, Denny ; Fatima, Tazeen ; Pissarnitski, Natalya ; Streckfuss, Eric ; Zhang, Chaowei ; Xia, Lei ; Borges, Scott ; Shi, Zhicai ; Vachal, Petr ; Tata, James ; Athanasopoulos, John

ACS combinatorial science, 09 January 2012, Vol.14(1), pp.51-9 [Peer Reviewed Journal]

Full text available

View all versions
21
Material Type:
Article
Add to e-Shelf

Discovery of Novel Indoline Cholesterol Ester Transfer Protein Inhibitors (CETP) through a Structure-Guided Approach

Wilson, Jonathan E ; Kurukulasuriya, Ravi ; Reibarkh, Mikhail ; Reiter, Maud ; Zwicker, Aaron ; Zhao, Kake ; Zhang, Fengqi ; Anand, Rajan ; Colandrea, Vincent J ; Cumiskey, Anne-Marie ; Crespo, Alejandro ; Duffy, Ruth A ; Murphy, Beth Ann ; Mitra, Kaushik ; Johns, Douglas G ; Duffy, Joseph L ; Vachal, Petr

ACS medicinal chemistry letters, 10 March 2016, Vol.7(3), pp.261-5 [Peer Reviewed Journal]

Full text available

View all versions
22
Material Type:
Article
Add to e-Shelf

Synthesis and study of alendronate derivatives as potential prodrugs of alendronate sodium for the treatment of low bone density and osteoporosis

Vachal, Petr ; Hale, Jeffrey J ; Lu, Zhe ; Streckfuss, Eric C ; Mills, Sander G ; Maccoss, Malcolm ; Yin, Daniel H ; Algayer, Kimberly ; Manser, Kimberly ; Kesisoglou, Filippos ; Ghosh, Soumojeet ; Alani, Laman L

Journal of medicinal chemistry, 01 June 2006, Vol.49(11), pp.3060-3 [Peer Reviewed Journal]

Full text available

View all versions
23
Material Type:
Article
Add to e-Shelf

Practical Synthesis of a Soluble Schiff Base Catalyst for the Asymmetric Strecker Reaction

Su, Julius T. ; Vachal, Petr ; Jacobsen, Eric N.

Advanced Synthesis & Catalysis, 26 February 2001, Vol.343(2), pp.197-200 [Peer Reviewed Journal]

Full text available

View all versions
24
Material Type:
Article
Add to e-Shelf

A new approach to the synthesis of benzofuro[3,2‐ b ]quinolines, benzothieno[3,2‐ b ]quinolines and indolo[3,2‐ b ]quinolines

Rádl, Stanislav ; Konvička, Petr ; Váchal, Petr

Journal of Heterocyclic Chemistry, July 2000, Vol.37(4), pp.855-862 [Peer Reviewed Journal]

Full text available

View all versions
25
Material Type:
Article
Add to e-Shelf

1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity

Vachal, Petr ; Fletcher, Joan M ; Fong, Tung M ; Huang, Cathy C R-R ; Lao, Julie ; Xiao, Jing C ; Shen, Chun-Pyn ; Strack, Alison M ; Shearman, Lauren ; Stribling, Sloan ; Chen, Richard Z ; Frassetto, Andrea ; Tong, Xinchun ; Wang, Junying ; Ball, Richard G ; Tsou, Nancy N ; Hickey, Gerard J ; Thompson, Donald F ; Faidley, Terry D ; Nicolich, Susan ; Achanfuo-Yeboah, Joana ; Hora, Donald F ; Hale, Jeffrey J ; Hagmann, William K

Journal of medicinal chemistry, 23 April 2009, Vol.52(8), pp.2550-8 [Peer Reviewed Journal]

Full text available

View all versions
26
Material Type:
Article
Add to e-Shelf

Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P 1) receptor

Vachal, Petr ; Toth, Leslie M ; Hale, Jeffrey J ; Yan, Lin ; Mills, Sander G ; Chrebet, Gary L ; Koehane, Carol A ; Hajdu, Richard ; Milligan, James A ; Rosenbach, Mark J ; Mandala, Suzanne

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(14), pp.3684-3687 [Peer Reviewed Journal]

Full text available

View all versions
27
Material Type:
Article
Add to e-Shelf

Development of indazole mineralocorticoid receptor antagonists and investigation into their selective late-stage functionalization

Liu, Kun ; Kurukulasuriya, Ravi ; Dykstra, Kevin ; Dimichelle, Lisa ; Liu, Jinchu ; Vachal, Petr ; Ogawa, Anthony ; Devita, Robert J ; Shen, Dong-Ming ; Tan, Qiang ; Chen, Yili ; Gauthier, Don ; Verras, Andreas ; Crespo, Alejandro ; Zamlynny, Beata ; Madwed, Jeffrey ; Hoek, Maarten ; Bateman, Thomas ; Yang, Yun-Fang ; Houk, K.N ; Krska, Shane ; Cernak, Tim

Bioorganic & Medicinal Chemistry Letters, 15 July 2019, Vol.29(14), pp.1854-1858 [Peer Reviewed Journal]

Full text available

View all versions
28
Material Type:
Dissertation
Add to e-Shelf
29
Material Type:
Article
Add to e-Shelf

Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)

Yu, Yang ; Wu, Zhicai ; Shi, Zhi-Cai ; He, Shuwen ; Lai, Zhong ; Cernak, Timothy A ; Vachal, Petr ; Liu, Min ; Liu, Jian ; Hong, Qingmei ; Jian, Tianying ; Guiadeen, Deodial ; Krikorian, Arto ; Sperbeck, Donald M ; Verras, Andreas ; Sonatore, Lisa M ; Murphy, Beth A ; Wiltsie, Judyann ; Chung, Christine C ; Gorski, Judith N ; Liu, Jinqi ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; De Vita, Robert J ; Pinto, Shirly ; Nargund, Ravi P

Bioorganic & Medicinal Chemistry Letters, 01 June 2019, Vol.29(11), pp.1380-1385 [Peer Reviewed Journal]

Full text available

View all versions

29 Results  for Everything (Includes Articles)

Refine Search Results

Expand My Results

  1.   

Show only

  1. Peer-reviewed Journals (27)

Refine My Results

Material Type 

  1. Articles  (28)
  2. Dissertations  (1)
  3. More options open sub menu

Publication Date 

From To
  1. Before 2004  (5)
  2. 2004 To 2008  (4)
  3. 2009 To 2013  (4)
  4. 2014 To 2017  (11)
  5. After 2017  (4)
  6. More options open sub menu

Language 

  1. English  (28)
  2. German  (2)
  3. Czech  (1)
  4. More options open sub menu

Suggested New Searches

Ignore my query and look for everything

by this author/creator:

  1. Vachal, Petr
  2. Vachal, P.
  3. Dykstra, Kevin
  4. Shi, Zhi-Cai
  5. Krska, Shane

Searching Remote Databases, Please Wait