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Evidence that elevated plasma corticosterone levels are the cause of reduced hypothalamic corticotrophin-releasing hormone gene expression in diabetes

Schwartz, Michael W ; Strack, Alison M ; Dallman, Mary F

Regulatory Peptides, 1997, Vol.72(2), pp.105-112 [Peer Reviewed Journal]

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The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization

Chobanian, Harry R ; Guo, Yan ; Liu, Ping ; Lanza, Thomas J ; Chioda, Marc ; Chang, Linda ; Kelly, Theresa M ; Kan, Yanqing ; Palyha, Oksana ; Guan, Xiao-Ming ; Marsh, Donald J ; Metzger, Joseph M ; Raustad, Katie ; Wang, Sheng-Ping ; Strack, Alison M ; Gorski, Judith N ; Miller, Randy ; Pang, Jianmei ; Lyons, Kathy ; Dragovic, Jasminka

Bioorganic & Medicinal Chemistry, 01 May 2012, Vol.20(9), pp.2845-2849 [Peer Reviewed Journal]

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Melanocortin-4 receptor (MC4R) agonists for the treatment of obesity

Nargund, Ravi P ; Strack, Alison M ; Fong, Tung M

Journal of medicinal chemistry, 13 July 2006, Vol.49(14), pp.4035-43 [Peer Reviewed Journal]

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Utilizing HaloTag Technology to Track the Fate of PCSK9 from Intracellular vs. Extracellular Sources

Ai, Xi ; Fischer, Paul ; Palyha, Oksana C ; Wisniewski, Douglas ; Hubbard, Brian ; Akinsanya, Karen ; Strack, Alison M ; Ehrhardt, Anka G

Current chemical genomics, 2012, Vol.6, pp.38-47 [Peer Reviewed Journal]

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Discovery of N-(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano2,3-bpyridin-4-yl-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity

Yan, Lin ; Huo, Pei ; Debenham, John S ; Madsen-Duggan, Christina B ; Lao, Julie ; Chen, Richard Z ; Xiao, Jing Chen ; Shen, Chun-Pyn ; Stribling, D Sloan ; Shearman, Lauren P ; Strack, Alison M ; Tsou, Nancy ; Ball, Richard G ; Wang, Junying ; Tong, Xinchun ; Bateman, Thomas J ; Reddy, Vijay B G ; Fong, Tung M ; Hale, Jeffrey J

Journal of medicinal chemistry, 27 May 2010, Vol.53(10), pp.4028-37 [Peer Reviewed Journal]

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Cannabinoid-1 receptor inhibition prevents the reduction of 24-hour energy expenditure with weight loss

Strack, Alison M ; Nicolich, Susan ; Faidley, Terry ; Achanfuo-Yeboah, Joana ; Cunningham, Paul K ; Hora, Donald ; Thompson, Donald ; Hickey, Gerry ; Johnson-Levonas, Amy O ; Fong, Tung M ; Heymsfield, Steven B

Metabolism, April 2012, Vol.61(4), pp.546-553 [Peer Reviewed Journal]

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Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists

Wang, Liping ; Hubert, James A ; Lee, Susan J ; Pan, Jie ; Qian, Su ; Reitman, Marc L ; Strack, Alison M ; Weingarth, Drew T ; Macneil, Douglas J ; Weber, Ann E ; Edmondson, Scott D

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(10), pp.2911-2915 [Peer Reviewed Journal]

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The Neural Network that Regulates Energy Balance Is Responsive to Glucocorticoids and Insulin and Also Regulates HPA Axis Responsivity at a Site Proximal to CRF Neuronsa

Dallman, Mary F. ; Akana, Susan F. ; Strack, Alison M. ; Hanson, E. Simon ; Sebastian, Raynard J.

Annals of the New York Academy of Sciences, December 1995, Vol.771(1), pp.730-742 [Peer Reviewed Journal]

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Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality

Liu, Ping ; Lanza, Thomas J ; Chioda, Marc ; Jones, Carrie ; Chobanian, Harry R ; Guo, Yan ; Chang, Linda ; Kelly, Theresa M ; Kan, Yanqing ; Palyha, Oksana ; Guan, Xiao-Ming ; Marsh, Donald J ; Metzger, Joseph M ; Ramsay, Katie ; Wang, Sheng-Ping ; Strack, Alison M ; Miller, Randy ; Pang, Jianmei ; Lyons, Kathy ; Dragovic

ACS medicinal chemistry letters, 08 December 2011, Vol.2(12), pp.933-7 [Peer Reviewed Journal]

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Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

Chobanian, Harry R ; Guo, Yan ; Liu, Ping ; Chioda, Marc ; Lanza, Thomas J ; Chang, Linda ; Kelly, Theresa M ; Kan, Yanqing ; Palyha, Oksana ; Guan, Xiao-Ming ; Marsh, Donald J ; Metzger, Joseph M ; Gorski, Judith N ; Raustad, Kate ; Wang, Sheng-Ping ; Strack, Alison M ; Miller, Randy ; Pang, Jianmei ; Madeira, Maria ; Lyons

ACS medicinal chemistry letters, 08 March 2012, Vol.3(3), pp.252-6 [Peer Reviewed Journal]

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Reconstituted HDL Elicits Marked Changes in Plasma Lipids Following Single-Dose Injection in C57Bl/6 Mice

Chen, Zhu ; O'Neill, Edward A ; Meurer, Roger D ; Gagen, Karen ; Luell, Silvi ; Wang, Sheng-Ping ; Ichetovkin, Marina ; Frantz-Wattley, Betsy ; Eveland, Suzanne ; Strack, Alison M ; Fisher, Timothy S ; Johns, Douglas G ; Sparrow, Carl P ; Wright, Samuel D ; Hubbard, Brian K ; Carballo-Jane, Ester

Journal of Cardiovascular Pharmacology and Therapeutics, September 2012, Vol.17(3), pp.315-323 [Peer Reviewed Journal]

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Body temperature as a mouse pharmacodynamic response to bombesin receptor subtype-3 agonists and other potential obesity treatments

Metzger, Joseph M ; Gagen, Karen ; Raustad, Kate A ; Yang, Liming ; White, Amanda ; Wang, Sheng-Ping ; Craw, Stephanie ; Liu, Ping ; Lanza, Thomas ; Lin, Linus S ; Nargund, Ravi P ; Guan, Xiao-Ming ; Strack, Alison M ; Reitman, Marc L

American journal of physiology. Endocrinology and metabolism, November 2010, Vol.299(5), pp.E816-24 [Peer Reviewed Journal]

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13
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Peripheral and central pathways regulating the kidney: a study using pseudorabies virus

Schramm, Lawrence P ; Strack, Alison M ; Platt, Kenneth B ; Loewy, Arthur D

Brain Research, 1993, Vol.616(1), pp.251-262 [Peer Reviewed Journal]

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14
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Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism

Marsh, Donald J ; Weingarth, Drew T ; Novi, Dawn E ; Chen, Howard Y ; Trumbauer, Myrna E ; Chen, Airu S ; Guan, Xiao-Ming ; Jiang, Michael M ; Feng, Yue ; Camacho, Ramon E ; Shen, Zhu ; Frazier, Easter G ; Yu, Hong ; Metzger, Joseph M ; Kuca, Stephanie J ; Shearman, Lauren P ; Gopal-Truter, Shobhna ; Macneil, Douglas J ; Strack, Alison M ; Macintyre

Proceedings of the National Academy of Sciences of the United States of America, 05 March 2002, Vol.99(5), pp.3240-5 [Peer Reviewed Journal]

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15
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Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis

Strack, Alison M ; Carballo-Jane, Ester ; Wang, Sheng-Ping ; Xue, Jiyan ; Ping, Xiaoli ; Mcnamara, Lesley Ann ; Thankappan, Anil ; Price, Olga ; Wolff, Michael ; Wu, T J ; Kawka, Douglas ; Mariano, Michele ; Burton, Charlotte ; Chang, Ching H ; Chen, Jing ; Menke, John ; Luell, Silvi ; Zycband, Emanuel I ; Tong, Xinchun ; Raubertas

Journal of lipid research, January 2013, Vol.54(1), pp.177-88 [Peer Reviewed Journal]

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16
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Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

Hong, Qingmei ; Bakshi, Raman K ; Palucki, Brenda L ; Park, Min K ; Ye, Zhixiong ; He, Shuwen ; Pollard, Patrick G ; Sebhat, Iyassu K ; Liu, Jian ; Guo, Liangqin ; Cashen, Doreen E ; Martin, William J ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Tamvakopoulos, Constantin ; Peng, Qianping ; Miller, Randy R ; Stearns, Ralph A ; Chen

Bioorganic & medicinal chemistry letters, 15 April 2011, Vol.21(8), pp.2330-4 [Peer Reviewed Journal]

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17
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Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist

Guan, Xiao-Ming ; Metzger, Joseph M ; Yang, Liming ; Raustad, Kate A ; Wang, Sheng-Ping ; Spann, Stephanie K ; Kosinski, Jennifer A ; Yu, Hong ; Shearman, Lauren P ; Faidley, Terry D ; Palyha, Oksana ; Kan, Yanqing ; Kelly, Theresa M ; Sebhat, Iyassu ; Lin, Linus S ; Dragovic, Jasminka ; Lyons, Kathy A ; Craw, Stephanie ; Nargund, Ravi P ; Marsh

The Journal of pharmacology and experimental therapeutics, February 2011, Vol.336(2), pp.356-64 [Peer Reviewed Journal]

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18
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The mu-opioid receptor subtype is required for the anorectic effect of an opioid receptor antagonist

Zhang, Jiaping ; Frassetto, Andrea ; Huang, Ruey-Ruey C ; Lao, Julie Z ; Pasternak, Alexander ; Wang, Sheng-Ping ; Metzger, Joseph M ; Strack, Alison M ; Fong, Tung M ; Chen, Richard Z

European journal of pharmacology, 18 September 2006, Vol.545(2-3), pp.147-52 [Peer Reviewed Journal]

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The μ-opioid receptor subtype is required for the anorectic effect of an opioid receptor antagonist

Zhang, Jiaping ; Frassetto, Andrea ; Huang, Ruey-Ruey C ; Lao, Julie Z ; Pasternak, Alexander ; Wang, Sheng-Ping ; Metzger, Joseph M ; Strack, Alison M ; Fong, Tung M ; Chen, Richard Z

European Journal of Pharmacology, 2006, Vol.545(2), pp.147-152 [Peer Reviewed Journal]

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20
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Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice

Bradbury, Margaret J ; Campbell, Una ; Giracello, Darlene ; Chapman, Deborah ; King, Chris ; Tehrani, Lida ; Cosford, Nicholas D P ; Anderson, Jeff ; Varney, Mark A ; Strack, Alison M

The Journal of pharmacology and experimental therapeutics, April 2005, Vol.313(1), pp.395-402 [Peer Reviewed Journal]

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21
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Furo[2,3- b]pyridine-based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation. Part 1

Debenham, John S ; Madsen-Duggan, Christina B ; Toupence, Richard B ; Walsh, Thomas F ; Wang, Junying ; Tong, Xinchun ; Kumar, Sanjeev ; Lao, Julie ; Fong, Tung M ; Xiao, Jing Chen ; Huang, Cathy R.-R.C ; Shen, Chun-Pyn ; Feng, Yue ; Marsh, Donald J ; Stribling, D. Sloan ; Shearman, Lauren P ; Strack, Alison M ; Goulet, Mark T

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(4), pp.1448-1452 [Peer Reviewed Journal]

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Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: Synthesis, SAR and biological evaluation

Madsen-Duggan, Christina B ; Debenham, John S ; Walsh, Thomas F ; Yan, Lin ; Huo, Pei ; Wang, Junying ; Tong, Xinchun ; Lao, Julie ; Fong, Tung M ; Xiao, Jing Chen ; Huang, Cathy R.-R.C ; Shen, Chun-Pyn ; Stribling, D.Sloan ; Shearman, Lauren P ; Strack, Alison M ; Goulet, Mark T ; Hale, Jeffrey J

Bioorganic & Medicinal Chemistry Letters, 15 June 2010, Vol.20(12), pp.3750-3754 [Peer Reviewed Journal]

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23
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1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity

Vachal, Petr ; Fletcher, Joan M ; Fong, Tung M ; Huang, Cathy C R-R ; Lao, Julie ; Xiao, Jing C ; Shen, Chun-Pyn ; Strack, Alison M ; Shearman, Lauren ; Stribling, Sloan ; Chen, Richard Z ; Frassetto, Andrea ; Tong, Xinchun ; Wang, Junying ; Ball, Richard G ; Tsou, Nancy N ; Hickey, Gerard J ; Thompson, Donald F ; Faidley, Terry D ; Nicolich

Journal of medicinal chemistry, 23 April 2009, Vol.52(8), pp.2550-8 [Peer Reviewed Journal]

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24
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An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes

Zhang, Liwen ; Mccabe, Timothy ; Condra, Jon H ; Ni, Yan G ; Peterson, Laurence B ; Wang, Weirong ; Strack, Alison M ; Wang, Fubao ; Pandit, Shilpa ; Hammond, Holly ; Wood, Dana ; Lewis, Dale ; Rosa, Ray ; Mendoza, Vivienne ; Cumiskey, Anne Marie ; Johns, Douglas G ; Hansen, Barbara C ; Shen, Xun ; Geoghagen, Neil ; Jensen

International journal of biological sciences, 2012, Vol.8(3), pp.310-27 [Peer Reviewed Journal]

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25
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Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats

Shearman, Lauren P ; Camacho, Ramon E ; Sloan Stribling, D ; Zhou, Dan ; Bednarek, Maria A ; Hreniuk, Donna L ; Feighner, Scott D ; Tan, Carina P ; Howard, Andrew D ; Van Der Ploeg, Lex H.T ; Macintyre, D.Euan ; Hickey, Gerard J ; Strack, Alison M

European Journal of Pharmacology, 2003, Vol.475(1), pp.37-47 [Peer Reviewed Journal]

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26
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Discovery of potent, selective, and orally bioavailable 3H-spiroisobenzofuran-1,4'-piperidine based melanocortin subtype-4 receptor agonists

Guo, Liangqin ; Ye, Zhixiong ; Liu, Jian ; He, Shuwen ; Bakshi, Raman K ; Sebhat, Iyassu K ; Dobbelaar, Peter H ; Hong, Qingmei ; Jian, Tianying ; Dellureficio, James P ; Tsou, Nancy N ; Ball, Richard G ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Tamvakopoulos, Constantin ; Peng, Qianping ; Chen, Howard Y ; Chen, Airu S ; Martin, William J ; Macintyre, D Euan ; Strack, Alison M ; Fong, Tung M ; Wyvratt, Matthew J ; Nargund, Ravi P

Bioorganic & medicinal chemistry letters, 15 August 2010, Vol.20(16), pp.4895-900 [Peer Reviewed Journal]

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27
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Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity

He, Shuwen ; Ye, Zhixiong ; Dobbelaar, Peter H ; Sebhat, Iyassu K ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Lai, Yingjie ; Franklin, Christopher L ; Bakshi, Raman K ; Dellureficio, James P ; Hong, Qingmei ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Strack, Alison M ; Tamvakopoulos, Constantin ; Peng, Qianping ; Miller, Randy R ; Stearns, Ralph A

Bioorganic & Medicinal Chemistry Letters, 01 August 2010, Vol.20(15), pp.4399-4405 [Peer Reviewed Journal]

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Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist

He, Shuwen ; Ye, Zhixiong ; Dobbelaar, Peter H ; Sebhat, Iyassu K ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Lai, Yingjie ; Franklin, Christopher L ; Bakshi, Raman K ; Dellureficio, James P ; Hong, Qingmei ; Tsou, Nancy N ; Ball, Richard G ; Cashen, Doreen E ; Martin, William J ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Tamvakopoulos

Bioorganic & medicinal chemistry letters, 01 April 2010, Vol.20(7), pp.2106-10 [Peer Reviewed Journal]

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29
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Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity

He, Shuwen ; Ye, Zhixiong ; Dobbelaar, Peter H ; Bakshi, Raman K ; Hong, Qingmei ; Dellureficio, James P ; Sebhat, Iyassu K ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Lai, Yingjie ; Franklin, Christopher L ; Reibarkh, Mikhail ; Holmes, Mark A ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Tamvakopoulos, Constantin ; Peng, Qianping ; Miller

Bioorganic & medicinal chemistry letters, 15 November 2010, Vol.20(22), pp.6524-32 [Peer Reviewed Journal]

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Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists

He, Shuwen ; Dobbelaar, Peter H ; Liu, Jian ; Jian, Tianying ; Sebhat, Iyassu K ; Lin, Linus S ; Goodman, Allan ; Guo, Cheng ; Guzzo, Peter R ; Hadden, Mark ; Henderson, Alan J ; Ruenz, Megan ; Sargent, Bruce J ; Yet, Larry ; Kelly, Theresa M ; Palyha, Oksana ; Kan, Yanqing ; Pan, Jie ; Chen, Howard ; Marsh

Bioorganic & medicinal chemistry letters, 15 March 2010, Vol.20(6), pp.1913-7 [Peer Reviewed Journal]

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31
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Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents

Shearman, Lauren P ; Stribling, D Sloan ; Camacho, Ramon E ; Rosko, Kimberly M ; Wang, Junying ; Tong, Sharon ; Feng, Yue ; Marsh, Donald J ; Yu, Hong ; Guan, Xiaoming ; Spann, Stephanie K ; Macneil, Douglas J ; Fong, Tung M ; Metzger, Joseph M ; Goulet, Mark T ; Hagmann, William K ; Plummer, Christopher W ; Finke, Paul E ; Mills, Sander G ; Shah

European journal of pharmacology, 28 January 2008, Vol.579(1-3), pp.215-24 [Peer Reviewed Journal]

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32
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Design and pharmacology of N-(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl-(1R)-1-(4-chlorobenzyl)- 2-4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist

Sebhat, Iyassu K ; Martin, William J ; Ye, Zhixiong ; Barakat, Khaled ; Mosley, Ralph T ; Johnston, David B R ; Bakshi, Raman ; Palucki, Brenda ; Weinberg, David H ; Macneil, Tanya ; Kalyani, Rubana N ; Tang, Rui ; Stearns, Ralph A ; Miller, Randy R ; Tamvakopoulos, Constantin ; Strack, Alison M ; Mcgowan, Erin ; Cashen, Doreen E ; Drisko, Jennifer E ; Hom

Journal of medicinal chemistry, 10 October 2002, Vol.45(21), pp.4589-93 [Peer Reviewed Journal]

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Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia

Yin, Wu ; Carballo-Jane, Ester ; Mclaren, David G ; Mendoza, Vivienne H ; Gagen, Karen ; Geoghagen, Neil S ; Mcnamara, Lesley Ann ; Gorski, Judith N ; Eiermann, George J ; Petrov, Aleksandr ; Wolff, Michael ; Tong, Xinchun ; Wilsie, Larissa C ; Akiyama, Taro E ; Chen, Jing ; Thankappan, Anil ; Xue, Jiyan ; Ping, Xiaoli ; Andrews, Genevieve ; Wickham

Journal of lipid research, January 2012, Vol.53(1), pp.51-65 [Peer Reviewed Journal]

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Enhanced running wheel activity of both Mch1r- and Pmch-deficient mice

Zhou, Dan ; Shen, Zhu ; Strack, Alison M ; Marsh, Donald J ; Shearman, Lauren P

Regulatory Peptides, 2005, Vol.124(1), pp.53-63 [Peer Reviewed Journal]

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The role of melanocortins in body weight regulation: opportunities for the treatment of obesity

Macneil, Douglas J ; Howard, Andrew D ; Guan, Xiaoming ; Fong, Tung M ; Nargund, Ravi P ; Bednarek, Maria A ; Goulet, Mark T ; Weinberg, David H ; Strack, Alison M ; Marsh, Donald J ; Chen, Howard Y ; Shen, Chun-Pyn ; Chen, Airu S ; Rosenblum, Charles I ; Macneil, Tanya ; Tota, Michael ; Macintyre, Euan D ; Van Der Ploeg, Lex H T

European journal of pharmacology, 16 August 2002, Vol.450(1), pp.93-109 [Peer Reviewed Journal]

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The role of melanocortins in body weight regulation: opportunities for the treatment of obesity

Macneil, Douglas J ; Howard, Andrew D ; Guan, Xiaoming ; Fong, Tung M ; Nargund, Ravi P ; Bednarek, Maria A ; Goulet, Mark T ; Weinberg, David H ; Strack, Alison M ; Marsh, Donald J ; Chen, Howard Y ; Shen, Chun-Pyn ; Chen, Airu S ; Rosenblum, Charles I ; Macneil, Tanya ; Tota, Michael ; Macintyre, Euan D ; Van Der Ploeg, Lex H.T

European Journal of Pharmacology, 2002, Vol.440(2), pp.141-157 [Peer Reviewed Journal]

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