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15 Results  for Everything (Includes Articles)

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Discovery of the development candidate N-tert-butyl nodulisporamide: a safe and efficacious once monthly oral agent for the control of fleas and ticks on companion animals

Meinke, Peter T ; Colletti, Steven L ; Fisher, Michael H ; Wyvratt, Matthew J ; Shih, Thomas L ; Ayer, Michelle B ; Li, Chunshi ; Lim, Julie ; Ok, Dong ; Salva, Steve ; Warmke, Lynn M ; Zakson, Michelle ; Michael, Bruce F ; Demontigny, Pierre ; Ostlind, Dan A ; Fink, David ; Drag, Marlene ; Schmatz, Dennis M ; Shoop, Wesley L

Journal of medicinal chemistry, 11 June 2009, Vol.52(11), pp.3505-15 [Peer Reviewed Journal]

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Synthesis of side chain truncated 3"-aldehyde, 3"-carboxylic acid, and 1"-aldehyde from nodulisporic acid A

Chakravarty, Prasun K ; Tyagarajan, Sriram ; Shih, Thomas L ; Salva, Steve ; Snedden, Christine ; Wyvratt, Matthew J ; Fisher, Michael H ; Meinke, Peter T

Organic letters, 18 April 2002, Vol.4(8), pp.1291-4 [Peer Reviewed Journal]

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The total synthesis of argiopine (argiotoxin-636)

Shih, Thomas L ; Ruiz-Sanchez, Jose ; Mrozik, Helmut

Tetrahedron Letters, 1987, Vol.28(48), pp.6015-6018 [Peer Reviewed Journal]

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Reactivity of an epoxy-spiroketal within avermectin B 2a

Newbold, Ronald C ; Shih, Thomas L ; Mrozik, Helmut ; Fisher, Michael H

Tetrahedron Letters, 1993, Vol.34(24), pp.3825-3828 [Peer Reviewed Journal]

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Cleavage of the spiroketal portion of avermectin B 2a

Shih, Thomas L ; Mrozik, Helmut ; Holmes, Mark A ; Fisher, Michael H

Tetrahedron Letters, 1990, Vol.31(25), pp.3525-3528 [Peer Reviewed Journal]

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A wittig approach to novel C 24 and C 25-substituted avermectins

Shih, Thomas L ; Mrozik, Helmut ; Holmes, Mark A ; Fisher, Michael H

Tetrahedron Letters, 1990, Vol.31(25), pp.3529-3532 [Peer Reviewed Journal]

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7
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Synthesis of an avermectin-nemadectin hybrid

Shih, Thomas L ; Holmes, Mark A ; Mrozik, Helmut ; Fisher, Michael H

Tetrahedron Letters, 1991, Vol.32(30), pp.3663-3666 [Peer Reviewed Journal]

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An unusual twist in the synthesis and hydrolysis of the 23,24-epoxide of 22,23-dihydroavermectin B 1a

Shih, Thomas L ; Mrozik, Helmut ; Holmes, Mark A ; Arison, Bryon H ; Doss, George A ; Waksmunski, Frank ; Fisher, Michael H

Tetrahedron Letters, 1992, Vol.33(13), pp.1709-1712 [Peer Reviewed Journal]

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9
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Rapid pharmacokinetic screening for the selection of new drug discovery candidates using a generic isocratic liquid chromatography–atmospheric pressure ionization tandem mass spectrometry method

Colwell, Lawrence F ; Tamvakopoulos, Constantin S ; Wang, Pei Ran ; Pivnichny, James V ; Shih, Thomas L

Journal of Chromatography B, 2002, Vol.772(1), pp.89-98 [Peer Reviewed Journal]

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10
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Argiopine differentiates between vertebrate and invertebrate glutamate binding sites

Schaeffer, James M ; Ruiz-Sanchez, Jose ; Shih, Thomas L ; Mrozik, Helmut

Pesticide Biochemistry and Physiology, 1989, Vol.35(1), pp.26-32 [Peer Reviewed Journal]

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Side-chain homologation of nodulisporic acid: synthesis of potent new dienyl derivatives

Ok, Dong ; Li, Chunshi ; Shih, Thomas L ; Salva, Steve ; Ayer, Michelle B ; Colletti, Steven L ; Chakravarty, Prasun K ; Wyvratt, Matthew J ; Fisher, Michael H ; Gregory, Lynn ; Zakson-Aiken, Michelle ; Shoop, Wesley L ; Schmatz, Dennis M ; Meinke, Peter T

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(13), pp.1751-1754 [Peer Reviewed Journal]

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Nodulisporic acid side-Chain modifications: access to the 2″, 3″, 4″, and 6″ registers

Chakravarty, Prasun K ; Shih, Thomas L ; Colletti, Steven L ; Ayer, Michelle B ; Snedden, Christine ; Kuo, Howard ; Tyagarajan, Sriram ; Gregory, Lynn ; Zakson-Aiken, Michelle ; Shoop, Wesley L ; Schmatz, Dennis M ; Wyvratt, Matthewj ; Fisher, Michael H ; Meinke, Peter T

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(1), pp.147-150 [Peer Reviewed Journal]

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Chemical modification of nodulisporic acid A: preliminary structure–activity relationships

Meinke, Peter T ; Ayer, Michelle B ; Colletti, Steven L ; Li, Chunshi ; Lim, Julie ; Ok, Dong ; Salva, Steve ; Schmatz, Dennis M ; Shih, Thomas L ; Shoop, Wesley L ; Warmke, Lynn M ; Wyvratt, Matthew J ; Zakson-Aiken, Michelle ; Fisher, Michael H

Bioorganic & Medicinal Chemistry Letters, 2000, Vol.10(20), pp.2371-2374 [Peer Reviewed Journal]

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4″-Deoxy-4″-aminoavermectins with potent broad spectrum antiparasitic activities

Mrozik, Helmut ; Eskola, Philip ; Arison, Byron H ; Linn, Bruce O ; Lusi, Aino ; Matzuk, Alexander ; Shih, Thomas L ; Tischler, Maureen ; Waksmunski, Frank S ; Wyvratt, Matthew J ; Blizzard, Timothy A ; Margiatto, Gaye M ; Fisher, Michael H ; Shoop, Wesley L ; Egerton, John R

Bioorganic & Medicinal Chemistry Letters, 1995, Vol.5(20), pp.2435-2440 [Peer Reviewed Journal]

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L-770,644: A potent and selective human β3 adrenergic receptor agonist with improved oral bioavailability

Shih, Thomas L ; Candelore, Mari R ; Cascieri, Margaret A ; Chiu, Shuet-Hing L ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Miller, Randall R ; Stearns, Ralph A ; Strader, Catherine D ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 1999, Vol.9(9), pp.1251-1254 [Peer Reviewed Journal]

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