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1
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Accelerating effect of triazolyl and related heteroaryl substituents on SNAr reactions: evidence of hydrogen-bond stabilized transition states

Qian, Wenyuan ; Wang, Hao ; Bartberger, Michael D

Journal of the American Chemical Society, 30 September 2015, Vol.137(38), pp.12261-8 [Peer Reviewed Journal]

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2
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A "click and activate" approach in one-pot synthesis of a triazolyl-pyridazinone library

Qian, Wenyuan ; Winternheimer, David ; Allen, Jennifer

Organic letters, 01 April 2011, Vol.13(7), pp.1682-5 [Peer Reviewed Journal]

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3
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One-pot synthesis of [1,2,3]triazole-fused pyrazinopyridazindione tricycles by a ‘click and activate’ approach

Qian, Wenyuan ; Winternheimer, David ; Amegadzie, Albert ; Allen, Jennifer

Tetrahedron Letters, 2012, Vol.53(3), pp.271-274 [Peer Reviewed Journal]

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4
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Regioselective synthesis of multiply halogenated azaxanthones

Qian, Wenyuan ; Brown, James ; Chen, Jian Jeffrey ; Cheng, Yuan

Tetrahedron Letters, 24 December 2014, Vol.55(52), pp.7229-7232 [Peer Reviewed Journal]

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5
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Copper‐Catalyzed Domino Cycloaddition/CN Coupling/Cyclization/(CH Arylation): An Efficient Three‐Component Synthesis of Nitrogen Polyheterocycles

Qian, Wenyuan ; Wang, Hao ; Allen, Jennifer

Angewandte Chemie International Edition, 11 October 2013, Vol.52(42), pp.10992-10996 [Peer Reviewed Journal]

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6
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One-pot synthesis of 3-triazolyl-2-iminochromenes via a catalytic three component cascade reaction

Qian, Wenyuan ; Amegadzie, Albert ; Winternheimer, David ; Allen, Jennifer

Organic letters, 21 June 2013, Vol.15(12), pp.2986-9 [Peer Reviewed Journal]

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7
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One-pot synthesis of 3-triazolyl-quinolin-2-(1H)-ones via sequential Ugi-“click”-Knoevenagel condensations

Qian, Wenyuan ; Wang, Dahai ; Wang, Honglin ; Yu, Peng ; Liu, Shilan ; Chen, Shuhui

Tetrahedron Letters, 30 May 2018, Vol.59(22), pp.2167-2169 [Peer Reviewed Journal]

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8
Complete Control over Addend Permutation at All Six Pseudooctahedral Positions of Fullerene C 60
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Complete Control over Addend Permutation at All Six Pseudooctahedral Positions of Fullerene C 60

Qian, Wenyuan ; Rubin, Yves

Journal of the American Chemical Society, 10/2000, Vol.122(39), pp.9564-9565 [Peer Reviewed Journal]

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9
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Article
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Convergent, regioselective synthesis of tetrakisfulleroids from C(60)

Qian, Wenyuan ; Rubin, Yves

The Journal of organic chemistry, 01 November 2002, Vol.67(22), pp.7683-7 [Peer Reviewed Journal]

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10
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Article
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Copper‐Catalyzed Domino Cycloaddition/CN Coupling/Cyclization/(CH Arylation): An Efficient Three‐Component Synthesis of Nitrogen Polyheterocycles

Qian, Wenyuan ; Wang, Hao ; Allen, Jennifer

Angewandte Chemie, 11 October 2013, Vol.125(42), pp.11198-11202 [Peer Reviewed Journal]

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11
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Towards Sixfold Functionalization of Buckminsterfullerene (C 60 ) at Fully Addressable Octahedral Sites

Qian, Wenyuan ; Rubin, Yves

Angewandte Chemie International Edition, 16 August 1999, Vol.38(16), pp.2356-2360 [Peer Reviewed Journal]

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12
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A Parallel Library of all Seven A 2 +B 2 +C 2 T h Regioisomeric Hexakisadducts of Fullerene C 60 : Inspiration from Werner's Octahedral Stereoisomerism

Qian, Wenyuan ; Rubin, Yves

Angewandte Chemie International Edition, 01 September 2000, Vol.39(17), pp.3133-3137 [Peer Reviewed Journal]

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13
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Synthesis of stable derivatives of c(62): the first nonclassical fullerene incorporating a four-membered ring

Qian, Wenyuan ; Chuang, Shih-Ching ; Amador, Roberto B ; Jarrosson, Thibaut ; Sander, Michael ; Pieniazek, Susan ; Khan, Saeed I ; Rubin, Yves

Journal of the American Chemical Society, 26 February 2003, Vol.125(8), pp.2066-7 [Peer Reviewed Journal]

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14
C 62 , a Non-Classical Fullerene Incorporating a Four-Membered Ring
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C 62 , a Non-Classical Fullerene Incorporating a Four-Membered Ring

Qian, Wenyuan ; Bartberger, Michael D. ; Pastor, Salvador J. ; Houk, Kendall N. ; Wilkins, Charles L. ; Rubin, Yves

Journal of the American Chemical Society, 08/2000, Vol.122(34), pp.8333-8334 [Peer Reviewed Journal]

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15
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Total synthesis and structural elucidation of azaspiracid-1. Construction of key building blocks for originally proposed structure

Nicolaou, K C ; Pihko, Petri M ; Bernal, Federico ; Frederick, Michael O ; Qian, Wenyuan ; Uesaka, Noriaki ; Diedrichs, Nicole ; Hinrichs, Jürgen ; Koftis, Theocharis V ; Loizidou, Eriketi ; Petrovic, Goran ; Rodriquez, Manuela ; Sarlah, David ; Zou, Ning

Journal of the American Chemical Society, 22 February 2006, Vol.128(7), pp.2244-57 [Peer Reviewed Journal]

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16
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Discovery of dehydro-oxopiperazine acetamides as novel bradykinin B1 receptor antagonists with enhanced in vitro potency

Qian, Wenyuan ; Chen, Jian Jeffrey ; Human, Jason ; Aya, Toshihiro ; Zhu, Jiawang ; Biswas, Kaustav ; Peterkin, Tanya ; Hungate, Randall W ; Arik, Leyla ; Johnson, Eileen ; Kumar, Gondi ; Joseph, Smriti ; Jona, Janan ; Guo, Hong-Xun ; Wu, Zufan

Bioorganic & Medicinal Chemistry Letters, 15 January 2012, Vol.22(2), pp.1061-1067 [Peer Reviewed Journal]

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17
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Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer’s disease

Chen, Jian Jeffrey ; Qian, Wenyuan ; Biswas, Kaustav ; Yuan, Chester ; Amegadzie, Albert ; Liu, Qingyian ; Nixey, Thomas ; Zhu, Joe ; Ncube, Mqhele ; Rzasa, Robert M ; Chavez, Frank ; Chen, Ning ; Demorin, Frenel ; Rumfelt, Shannon ; Tegley, Christopher M ; Allen, Jennifer R ; Hitchcock, Stephen ; Hungate, Randy ; Bartberger, Michael D ; Zalameda, Leeanne

Bioorganic & Medicinal Chemistry Letters, 01 December 2013, Vol.23(23), pp.6447-6454 [Peer Reviewed Journal]

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18
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Synthesis of the ABCD Ring System of Azaspiracid

Nicolaou, K. C. ; Qian, Wenyuan ; Bernal, Federico ; Uesaka, Noriaki ; Pihko, Petri M. ; Hinrichs, Jürgen

Angewandte Chemie International Edition, 05 November 2001, Vol.40(21), pp.4068-4071 [Peer Reviewed Journal]

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19
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Tandem Nucleophilic Addition/Diels–Alder Reaction of N ‐Butadienyl N , O ‐Ketene Silyl Acetals with C 60 : Stereoselective Formation of Bicyclic Octahydroquinolino‐1,2,3,4‐Tetrahydrobuckminsterfullerenes and Combined NMR Spectroscopic and Computational Evaluation of the Functionalization Reactions

Rubin, Yves ; Ganapathi, Padma S. ; Franz, Andreas ; An, Yi‐Zhong ; Qian, Wenyuan ; Neier, Reinhard

Chemistry – A European Journal, 05 November 1999, Vol.5(11), pp.3162-3184 [Peer Reviewed Journal]

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20
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3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation

Chen, Jian Jeffrey ; Nguyen, Thomas ; D’amico, Derin C ; Qian, Wenyuan ; Human, Jason ; Aya, Toshihiro ; Biswas, Kaustav ; Fotsch, Christopher ; Han, Nianhe ; Liu, Qingyian ; Nishimura, Nobuko ; Peterkin, Tanya A.N ; Yang, Kevin ; Zhu, Jiawang ; Riahi, Babak Bobby ; Hungate, Randall W ; Andersen, Neil G ; Colyer, John T ; Faul, Margaret M

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(11), pp.3384-3389 [Peer Reviewed Journal]

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21
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Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer’s disease

Chen, Jian Jeffrey ; Liu, Qingyian ; Yuan, Chester ; Gore, Vijay ; Lopez, Patricia ; Ma, Vu ; Amegadzie, Albert ; Qian, Wenyuan ; Judd, Ted C ; Minatti, Ana E ; Brown, James ; Cheng, Yuan ; Xue, May ; Zhong, Wenge ; Dineen, Thomas A ; Epstein, Oleg ; Human, Jason ; Kreiman, Charles ; Marx, Isaac ; Weiss, Matthew M

Bioorganic & Medicinal Chemistry Letters, 15 February 2015, Vol.25(4), pp.767-774 [Peer Reviewed Journal]

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22
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Aryl sulfonamides containing tetralin allylic amines as potent and selective bradykinin B1 receptor antagonists

Liu, Qingyian ; Qian, Wenyuan ; Li, Aiwen ; Biswas, Kaustav ; Chen, Jian Jeffrey ; Fotsch, Christopher ; Han, Nianhe ; Yuan, Chester ; Arik, Leyla ; Biddlecome, Gloria ; Johnson, Eileen ; Kumar, Gondi ; Lester-Zeiner, Dianna ; Ng, Gordon Y ; Hungate, Randall W ; Askew, Benny C

Bioorganic & Medicinal Chemistry Letters, 01 August 2010, Vol.20(15), pp.4593-4597 [Peer Reviewed Journal]

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23
Triplet-State Properties and Singlet Oxygen Generation in a Homologous Series of Functionalized Fullerene Derivatives
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Triplet-State Properties and Singlet Oxygen Generation in a Homologous Series of Functionalized Fullerene Derivatives

Prat, Ferran ; Stackow, Robert ; Bernstein, Robert ; Qian, Wenyuan ; Rubin, Yves ; Foote, Christopher S.

The Journal of Physical Chemistry A, 09/1999, Vol.103(36), pp.7230-7235 [Peer Reviewed Journal]

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24
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Total Synthesis of the Proposed Azaspiracid‐1 Structure, Part 1: Construction of the Enantiomerically Pure C1–C20, C21–C27, and C28–C40 Fragments

Nicolaou, K. C. ; Li, Yiwei ; Uesaka, Noriaki ; Koftis, Theocharis V. ; Vyskocil, Stepan ; Ling, Taotao ; Govindasamy, Mugesh ; Qian, Wenyuan ; Bernal, Federico ; Chen, David Y. ‐K.

Angewandte Chemie International Edition, 11 August 2003, Vol.42(31), pp.3643-3648 [Peer Reviewed Journal]

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25
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A Parallel Library of all Seven A 2 +B 2 +C 2 T h Regioisomeric Hexakisadducts of Fullerene C 60 : Inspiration from Werner's Octahedral Stereoisomerism

Qian, Wenyuan ; Rubin, Yves

Angewandte Chemie, 01 September 2000, Vol.112(17), pp.3263-3267 [Peer Reviewed Journal]

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26
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Auf dem Weg zur vollständigen Kontrolle der sechsfachen Funktionalisierung von Buckminsterfulleren (C 60 ) an oktaedrischen Positionen

Qian, Wenyuan ; Rubin, Yves

Angewandte Chemie, 16 August 1999, Vol.111(16), pp.2504-2508 [Peer Reviewed Journal]

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27
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An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities

Cheng, Yuan ; Brown, James ; Judd, Ted C ; Lopez, Patricia ; Qian, Wenyuan ; Powers, Timothy S ; Chen, Jian Jeffrey ; Bartberger, Michael D ; Chen, Kui ; Dunn, Robert T ; Epstein, Oleg ; Fremeau, Robert T ; Harried, Scott ; Hickman, Dean ; Hitchcock, Stephen A ; Luo, Yi ; Minatti, Ana Elena ; Patel, Vinod F ; Vargas, Hugo M ; Wahl

ACS medicinal chemistry letters, 12 February 2015, Vol.6(2), pp.210-5 [Peer Reviewed Journal]

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28
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Total Synthesis of the Proposed Azaspiracid‐1 Structure, Part 2: Coupling of the C1–C20, C21–C27, and C28–C40 Fragments and Completion of the Synthesis

Nicolaou, K. C. ; Chen, David Y. ‐K. ; Li, Yiwei ; Qian, Wenyuan ; Ling, Taotao ; Vyskocil, Stepan ; Koftis, Theocharis V. ; Govindasamy, Mugesh ; Uesaka, Noriaki

Angewandte Chemie International Edition, 11 August 2003, Vol.42(31), pp.3649-3653 [Peer Reviewed Journal]

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29
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Synthesis of the ABCD Ring System of Azaspiracid

Nicolaou, K. C. ; Qian, Wenyuan ; Bernal, Federico ; Uesaka, Noriaki ; Pihko, Petri M. ; Hinrichs, Jürgen

Angewandte Chemie, 05 November 2001, Vol.113(21), pp.4192-4195 [Peer Reviewed Journal]

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30
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Discovery of dihydroquinoxalinone acetamides containing bicyclic amines as potent Bradykinin B1 receptor antagonists

Chen, Jian Jeffrey ; Qian, Wenyuan ; Biswas, Kaustav ; Viswanadhan, Vellarkad N ; Askew, Benny C ; Hitchcock, Stephen ; Hungate, Randall W ; Arik, Leyla ; Johnson, Eileen

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(16), pp.4477-4481 [Peer Reviewed Journal]

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31
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Pressure-tuning vibrational spectroscopic study of ( η5-C 5H 5)Co(C 64H 4) Can endohedral fullerenes be formed under pressure?

Edwards, Clare M ; Butler, Ian S ; Qian, Wenyuan ; Rubin, Yves

Journal of Molecular Structure, 1998, Vol.442(1), pp.169-174 [Peer Reviewed Journal]

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32
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Total Synthesis of the Proposed Azaspiracid‐1 Structure, Part 2: Coupling of the C1–C20, C21–C27, and C28–C40 Fragments and Completion of the Synthesis

Nicolaou, K. C. ; Chen, David Y. ‐K. ; Li, Yiwei ; Qian, Wenyuan ; Ling, Taotao ; Vyskocil, Stepan ; Koftis, Theocharis V. ; Govindasamy, Mugesh ; Uesaka, Noriaki

Angewandte Chemie, 11 August 2003, Vol.115(31), pp.3777-3781 [Peer Reviewed Journal]

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33
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Total Synthesis of the Proposed Azaspiracid‐1 Structure, Part 1: Construction of the Enantiomerically Pure C1–C20, C21–C27, and C28–C40 Fragments

Nicolaou, K. C. ; Li, Yiwei ; Uesaka, Noriaki ; Koftis, Theocharis V. ; Vyskocil, Stepan ; Ling, Taotao ; Govindasamy, Mugesh ; Qian, Wenyuan ; Bernal, Federico ; Chen, David Y. ‐K.

Angewandte Chemie, 11 August 2003, Vol.115(31), pp.3771-3776 [Peer Reviewed Journal]

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34
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Aryl sulfones as novel Bradykinin B1 receptor antagonists for treatment of chronic pain

Biswas, Kaustav ; Aya, Toshihiro ; Qian, Wenyuan ; Peterkin, Tanya A.N ; Chen, Jian Jeffrey ; Human, Jason ; Hungate, Randall W ; Kumar, Gondi ; Arik, Leyla ; Lester-Zeiner, Dianna ; Biddlecome, Gloria ; Manning, Barton H ; Sun, Hong ; Dong, Hong ; Huang, Ming ; Loeloff, Richard ; Johnson, Eileen J ; Askew, Benny C

Bioorganic & Medicinal Chemistry Letters, 01 September 2008, Vol.18(17), pp.4764-4769 [Peer Reviewed Journal]

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35
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The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement

Frohn, Michael ; Liu, Longbin ; Siegmund, Aaron C ; Qian, Wenyuan ; Amegadzie, Albert ; Chen, Ning ; Tan, Helming ; Hickman, Dean ; Wood, Stephen ; Wen, Paul H ; Bartberger, Michael D ; Whittington, Douglas A ; Allen, Jennifer R ; Bourbeau, Matthew P

Bioorganic & medicinal chemistry letters, 15 July 2020, Vol.30(14) [Peer Reviewed Journal]

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36
Material Type:
Research Dataset
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CCDC 210122: Experimental Crystal Structure Determination

Nicolaou, K.C. ; Li, Yiwei ; Uesaka, N. ; Koftis, T.V. ; Vyskocil, S. ; Ling, Taotao ; Govindasamy, M. ; Qian, Wenyuan ; Bernal, F. ; Chen, D.Y.-K.

2004

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