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Modern molecular approaches to drug design and discovery

Ojima, Iwao

Accounts of chemical research, January 2008, Vol.41(1), pp.2-3 [Peer Reviewed Journal]

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Exploration of fluorine chemistry at the multidisciplinary interface of chemistry and biology

Ojima, Iwao

The Journal of organic chemistry, 05 July 2013, Vol.78(13), pp.6358-83 [Peer Reviewed Journal]

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Pd-catalyzed asymmetric allylic amination with BOP ligands and its applications to the synthesis of fused polycyclic alkaloids

Zang, Yang ; Ojima, Iwao

Tetrahedron Letters, 03 June 2015, Vol.56(23), pp.3288-3292 [Peer Reviewed Journal]

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Pd-catalyzed asymmetric allylic etherification using chiral biphenol-based diphosphinite ligands and its application for the formal total synthesis of (-)-galanthamine

Zang, Yang ; Ojima, Iwao

The Journal of organic chemistry, 19 April 2013, Vol.78(8), pp.4013-8 [Peer Reviewed Journal]

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Advances in the chemistry of β-lactam and its medicinal applications

Kamath, Anushree ; Ojima, Iwao

Tetrahedron, 30 December 2012, Vol.68(52), pp.10640-10664 [Peer Reviewed Journal]

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Formal enantioselective total synthesis of schulzeines A-C via Pd-catalyzed intramolecular asymmetric allylic amination

Lin, Chi-Feng ; Ojima, Iwao

The Journal of organic chemistry, 05 August 2011, Vol.76(15), pp.6240-9 [Peer Reviewed Journal]

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Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ

Haranahalli, Krupanandan ; Tong, Simon ; Ojima, Iwao

Bioorganic & Medicinal Chemistry, 15 December 2016, Vol.24(24), pp.6354-6369 [Peer Reviewed Journal]

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Microwave-assisted Diels–Alder reactions between Danishefsky's diene and derivatives of ethyl α-(hydroxymethyl)acrylate. Synthetic approach toward a biotinylated anti-inflammatory monocyclic cyanoenone

Zheng, Suqing ; Chowdhury, Allison ; Ojima, Iwao ; Honda, Tadashi

Tetrahedron, 25 February 2013, Vol.69(8), pp.2052-2055 [Peer Reviewed Journal]

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Enantioselective synthesis of 1-vinyltetrahydroisoquinolines via Pd-catalyzed intramolecular asymmetric allylic amination reactions

Chien, Chih-Wei ; Shi, Ce ; Lin, Chi-Feng ; Ojima, Iwao

Tetrahedron, 2011, Vol.67(35), pp.6513-6523 [Peer Reviewed Journal]

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Synthesis of Colchicinoids and Allocolchicinoids through Rh(I)-Catalyzed 2+2+2+1 and 2+2+2 Cycloadditions of o-Phenylenetriynes with and without CO

Chien, Chih-Wei ; Teng, Yu-Han Gary ; Honda, Tadashi ; Ojima, Iwao

The Journal of organic chemistry, 05 October 2018, Vol.83(19), pp.11623-11644 [Peer Reviewed Journal]

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11
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Synthesis of a Next-Generation Taxoid by Rapid Methylation Amenable for C-Labeling

Seitz, Joshua D ; Wang, Tao ; Vineberg, Jacob G ; Honda, Tadashi ; Ojima, Iwao

The Journal of organic chemistry, 02 March 2018, Vol.83(5), pp.2847-2857 [Peer Reviewed Journal]

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12
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Design, synthesis, and biological evaluation of theranostic vitamin-linker-taxoid conjugates

Vineberg, Jacob G ; Wang, Tao ; Zuniga, Edison S ; Ojima, Iwao

Journal of medicinal chemistry, 12 March 2015, Vol.58(5), pp.2406-16 [Peer Reviewed Journal]

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Drug discovery targeting cell division proteins, microtubules and FtsZ

Ojima, Iwao ; Kumar, Kunal ; Awasthi, Divya ; Vineberg, Jacob G

Bioorganic & Medicinal Chemistry, 15 September 2014, Vol.22(18), pp.5060-5077 [Peer Reviewed Journal]

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14
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Tumor-targeting drug delivery of chemotherapeutic agents

Ojima, Iwao

Pure and Applied Chemistry. Chimie Pure et Appliquee, 2011, Vol.83(9), pp.1685-1698 [Peer Reviewed Journal]

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Strategic incorporation of fluorine into taxoid anticancer agents for medicinal chemistry and chemical biology studies

Ojima, Iwao

Journal of Fluorine Chemistry, June 2017, Vol.198, pp.10-23 [Peer Reviewed Journal]

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SAR studies on trisubstituted benzimidazoles as inhibitors of Mtb FtsZ for the development of novel antitubercular agents

Awasthi, Divya ; Kumar, Kunal ; Knudson, Susan E ; Slayden, Richard A ; Ojima, Iwao

Journal of medicinal chemistry, 12 December 2013, Vol.56(23), pp.9756-70 [Peer Reviewed Journal]

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SB-RA-2001 inhibits bacterial proliferation by targeting FtsZ assembly

Singh, Dipty ; Bhattacharya, Anusri ; Rai, Ankit ; Dhaked, Hemendra Pal Singh ; Awasthi, Divya ; Ojima, Iwao ; Panda, Dulal

Biochemistry, 13 May 2014, Vol.53(18), pp.2979-92 [Peer Reviewed Journal]

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Modern natural products chemistry and drug discovery

Ojima, Iwao

Journal of medicinal chemistry, 08 May 2008, Vol.51(9), pp.2587-8 [Peer Reviewed Journal]

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Guided molecular missiles for tumor-targeting chemotherapy--case studies using the second-generation taxoids as warheads

Ojima, Iwao

Accounts of chemical research, January 2008, Vol.41(1), pp.108-19 [Peer Reviewed Journal]

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20
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Design, synthesis, and biological evaluations of tumor-targeting dual-warhead conjugates for a taxoid-camptothecin combination chemotherapy

Vineberg, Jacob G ; Zuniga, Edison S ; Kamath, Anushree ; Chen, Ying-Jen ; Seitz, Joshua D ; Ojima, Iwao

Journal of medicinal chemistry, 10 July 2014, Vol.57(13), pp.5777-91 [Peer Reviewed Journal]

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21
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Design, synthesis and biological evaluation of a highly-potent and cancer cell selective folate–taxoid conjugate

Seitz, Joshua D ; Vineberg, Jacob G ; Herlihy, Evan ; Park, Bora ; Melief, Eduard ; Ojima, Iwao

Bioorganic & Medicinal Chemistry, 01 May 2015, Vol.23(9), pp.2187-2194 [Peer Reviewed Journal]

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22
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Inhibition of Fatty Acid Binding Proteins Elevates Brain Anandamide Levels and Produces Analgesia (FABP Inhibitors Reduce Pain and Elevate Brain Anandamide Levels)

Kaczocha, Martin ; Rebecchi, Mario J ; Ralph, Brian P ; Teng, Yu-Han Gary ; Berger, William T ; Galbavy, William ; Elmes, Matthew W ; Glaser, Sherrye T ; Wang, Liqun ; Rizzo, Robert C ; Deutsch, Dale G ; Ojima, Iwao Price, Theodore John (Editor)

2014, Vol.9(4), p.e94200 [Peer Reviewed Journal]

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23
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Targeting Fatty Acid Binding Protein (FABP) Anandamide Transporters – A Novel Strategy for Development of Anti-Inflammatory and Anti-Nociceptive Drugs (Discovery of Anandamide Transporter Inhibitors)

Berger, William T ; Ralph, Brian P ; Kaczocha, Martin ; Sun, Jing ; Balius, Trent E ; Rizzo, Robert C ; Haj-Dahmane, Samir ; Ojima, Iwao ; Deutsch, Dale G Catapano, Alberico (Editor)

2012, Vol.7(12), p.e50968 [Peer Reviewed Journal]

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24
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Design and synthesis of de novo cytotoxic alkaloids by mimicking the bioactive conformation of paclitaxel

Sun, Liang ; Veith, Jean M ; Pera, Paula ; Bernacki, Ralph J ; Ojima, Iwao

Bioorganic & Medicinal Chemistry, 2010, Vol.18(19), pp.7101-7112 [Peer Reviewed Journal]

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25
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The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites

Hsu, Hao-Chi ; Tong, Simon ; Zhou, Yuchen ; Elmes, Matthew W ; Yan, Su ; Kaczocha, Martin ; Deutsch, Dale G ; Rizzo, Robert C ; Ojima, Iwao ; Li, Huilin

Biochemistry, 11 July 2017, Vol.56(27), pp.3454-3462 [Peer Reviewed Journal]

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26
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Great Challenges in Organic Chemistry

Ojima, Iwao

Frontiers in chemistry, 2017, Vol.5, pp.52

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27
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Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents

Kumar, Kunal ; Awasthi, Divya ; Lee, Seung-Yub ; Zanardi, Ilaria ; Ruzsicska, Bela ; Knudson, Susan ; Tonge, Peter J ; Slayden, Richard A ; Ojima, Iwao

Journal of medicinal chemistry, 13 January 2011, Vol.54(1), pp.374-81 [Peer Reviewed Journal]

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28
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New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase

Li, Wei ; Zheng, Suqing ; Higgins, Maureen ; Morra, Rocco P ; Mendis, Anne T ; Chien, Chih-Wei ; Ojima, Iwao ; Mierke, Dale F ; Dinkova-Kostova, Albena T ; Honda, Tadashi

Journal of medicinal chemistry, 11 June 2015, Vol.58(11), pp.4738-48 [Peer Reviewed Journal]

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29
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Benzimidazole-based antibacterial agents against Francisella tularensis

Kumar, Kunal ; Awasthi, Divya ; Lee, Seung-Yub ; Cummings, Jason E ; Knudson, Susan E ; Slayden, Richard A ; Ojima, Iwao

Bioorganic & Medicinal Chemistry, 01 June 2013, Vol.21(11), pp.3318-3326 [Peer Reviewed Journal]

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30
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Identification of small molecule inhibitors of botulinum neurotoxin serotype E via footprint similarity

Zhou, Yuchen ; Mcgillick, Brian E ; Teng, Yu-Han Gary ; Haranahalli, Krupanandan ; Ojima, Iwao ; Swaminathan, Subramanyam ; Rizzo, Robert C

Bioorganic & Medicinal Chemistry, 15 October 2016, Vol.24(20), pp.4875-4889 [Peer Reviewed Journal]

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31
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Computer-aided identification, synthesis, and biological evaluation of novel inhibitors for botulinum neurotoxin serotype A

Teng, Yu-Han Gary ; Berger, William T ; Nesbitt, Natasha M ; Kumar, Kunal ; Balius, Trent E ; Rizzo, Robert C ; Tonge, Peter J ; Ojima, Iwao ; Swaminathan, Subramanyam

Bioorganic & Medicinal Chemistry, 01 September 2015, Vol.23(17), pp.5489-5495 [Peer Reviewed Journal]

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32
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Design, synthesis and evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents

Park, Bora ; Awasthi, Divya ; Chowdhury, Soumya R ; Melief, Eduard H ; Kumar, Kunal ; Knudson, Susan E ; Slayden, Richard A ; Ojima, Iwao

Bioorganic & Medicinal Chemistry, 01 May 2014, Vol.22(9), pp.2602-2612 [Peer Reviewed Journal]

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33
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Establishment of highly tumorigenic human colorectal cancer cell line (CR4) with properties of putative cancer stem cells

Rowehl, Rebecca A ; Burke, Stephanie ; Bialkowska, Agnieszka B ; Pettet, Donald W ; Rowehl, Leahana ; Li, Ellen ; Antoniou, Eric ; Zhang, Yuanhao ; Bergamaschi, Roberto ; Shroyer, Kenneth R ; Ojima, Iwao ; Botchkina, Galina I

PloS one, 2014, Vol.9(6), pp.e99091 [Peer Reviewed Journal]

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34
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A Trisubstituted Benzimidazole Cell Division Inhibitor with Efficacy against Mycobacterium tuberculosis

Knudson, Susan ; Awasthi, Divya ; Kumar, Kunal ; Carreau, Alexandra ; Goullieux, Laurent ; Lagrange, Sophie ; Vermet, Hélèn ; Ojima, Iwao ; Slayden, Richard

PLoS One, Apr 2014, Vol.9(4), p.e93953 [Peer Reviewed Journal]

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35
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Prostate cancer stem cell-targeted efficacy of a new-generation taxoid, SBT-1214 and novel polyenolic zinc-binding curcuminoid, CMC2.24

Botchkina, Galina I ; Zuniga, Edison S ; Rowehl, Rebecca H ; Park, Rosa ; Bhalla, Rahuldev ; Bialkowska, Agnieszka B ; Johnson, Francis ; Golub, Lorne M ; Zhang, Yu ; Ojima, Iwao ; Shroyer, Kenneth R

PloS one, 2013, Vol.8(9), pp.e69884 [Peer Reviewed Journal]

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36
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Cell division inhibitors with efficacy equivalent to isoniazid in the acute murine Mycobacterium tuberculosis infection model

Knudson, Susan E ; Awasthi, Divya ; Kumar, Kunal ; Carreau, Alexandra ; Goullieux, Laurent ; Lagrange, Sophie ; Vermet, Hélène ; Ojima, Iwao ; Slayden, Richard A

Journal of Antimicrobial Chemotherapy, 2015, Vol. 70(11), pp.3070-3073 [Peer Reviewed Journal]

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37