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10 Results  for Everything (Includes Articles)

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Metabolism of a thiazole benzenesulfonamide derivative, a potent and elective agonist of the human beta3-adrenergic receptor, in rats: identification of a novel isethionic acid conjugate

Tang, Wei ; Stearns, Ralph A ; Miller, Randall R ; Ngui, Jason S ; Mathvink, Robert J ; Weber, Ann E ; Kwei, Gloria Y ; Strauss, John R ; Keohane, Carol A ; Doss, George A ; Chiu, Shuet-Hing L ; Baillie, Thomas A

Drug metabolism and disposition: the biological fate of chemicals, July 2002, Vol.30(7), pp.778-87 [Peer Reviewed Journal]

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(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-1,2,4triazolo1,5-a-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Edmondson, Scott D ; Mastracchio, Anthony ; Mathvink, Robert J ; He, Jiafang ; Harper, Bart ; Park, You-Jung ; Beconi, Maria ; Di Salvo, Jerry ; Eiermann, George J ; He, Huaibing ; Leiting, Barbara ; Leone, Joseph F ; Levorse, Dorothy A ; Lyons, Kathryn ; Patel, Reshma A ; Patel, Sangita B ; Petrov, Aleksandr ; Scapin, Giovanna ; Shang, Jackie ; Roy

Journal of medicinal chemistry, 15 June 2006, Vol.49(12), pp.3614-27 [Peer Reviewed Journal]

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Discovery of a Potent, Orally Bioavailable β 3 Adrenergic Receptor Agonist, ( R )- N -[4-[2-[[2-Hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide
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Discovery of a Potent, Orally Bioavailable β 3 Adrenergic Receptor Agonist, ( R )- N -[4-[2-[[2-Hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide

Mathvink, Robert J. ; Tolman, J. Samuel ; Chitty, Dawn ; Candelore, Mari R. ; Cascieri, Margaret A. ; Colwell, Lawrence F. ; Deng, Liping ; Feeney, William P. ; Forrest, Michael J. ; Hom, Gary J. ; Macintyre, D. Euan ; Miller, Randall R. ; Stearns, Ralph A. ; Tota, Laurie ; Wyvratt, Matthew J. ; Fisher, Michael H. ; Weber, Ann E.

Journal of Medicinal Chemistry, 10/2000, Vol.43(21), pp.3832-3836 [Peer Reviewed Journal]

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Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes

Chen, Ping ; Caldwell, Charles G ; Mathvink, Robert J ; Leiting, Barbara ; Marsilio, Frank ; Patel, Reshma A ; Wu, Joseph K ; He, Huaibing ; Lyons, Kathryn A ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(21), pp.5853-5857 [Peer Reviewed Journal]

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Potent, selective human β3 adrenergic receptor agonists containing a substituted indoline-5-sulfonamide pharmacophore

Mathvink, Robert J ; Barritta, Anna Maria ; Candelore, Mari R ; Cascieri, Margaret A ; Liping Deng ; Tota, Laurie ; Strader, Catherine D ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 1999, Vol.9(13), pp.1869-1874 [Peer Reviewed Journal]

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Potent, selective benzenesulfonamide agonists of the human β 3 adrenergic receptor

Weber, Ann E ; Mathvink, Robert J ; Perkins, Leroy ; Hutchins, Jennifer E ; Candelore, Mari R ; Tota, Laurie ; Strader, Catherine D ; Wyvratt, Matthew J ; Fisher, Michael H

Bioorganic & Medicinal Chemistry Letters, 1998, Vol.8(9), pp.1101-1106 [Peer Reviewed Journal]

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Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors

Xu, Jinyou ; Wei, Lan ; Mathvink, Robert J ; Edmondson, Scott D ; Eiermann, George J ; He, Huaibing ; Leone, Joseph F ; Leiting, Barbara ; Lyons, Kathryn A ; Marsilio, Frank ; Patel, Reshma A ; Patel, Sangita B ; Petrov, Aleksandr ; Scapin, Giovanna ; Wu, Joseph K ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(20), pp.5373-5377 [Peer Reviewed Journal]

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The pharmacokinetics of a thiazole benzenesulfonamide beta 3-adrenergic receptor agonist and its analogs in rats, dogs, and monkeys: improving oral bioavailability

Stearns, Ralph A ; Miller, Randy R ; Tang, Wei ; Kwei, Gloria Y ; Tang, Frank S ; Mathvink, Robert J ; Naylor, Elizabeth M ; Chitty, Dawn ; Colandrea, Vincent J ; Weber, Ann E ; Colletti, Adria E ; Strauss, John R ; Keohane, Carol Ann ; Feeney, William P ; Iliff, Susan A ; Chiu, Shuet-Hing Lee

Drug metabolism and disposition: the biological fate of chemicals, July 2002, Vol.30(7), pp.771-7 [Peer Reviewed Journal]

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Potent, selective 3-pyridylethanolamine β 3 adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore

Mathvink, Robert J ; Tolman, J.Samuel ; Chitty, Dawn ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2000, Vol.10(17), pp.1971-1973 [Peer Reviewed Journal]

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3-Pyridyloxypropanolamine agonists of the β3 adrenergic receptor with improved pharmacokinetic properties

Weber, Ann E ; Ok, Hyun O ; Alvaro, Raul F ; Candelore, Mari R ; Cascieri, Margaret A ; Chiu, Shuet-Hing L ; Deng, Liping ; Forrest, Michael J ; Hom, Gary J ; Hutchins, Jennifer E ; Kao, John ; Macintyre, D.Euan ; Mathvink, Robert J ; Mcloughlin, Debra ; Miller, Randall R ; Newbold, Ronald C ; Olah, Timothy V ; Parmee, Emma R ; Perkins, Leroy ; Stearns, Ralph A

Bioorganic & Medicinal Chemistry Letters, 1998, Vol.8(16), pp.2111-2116 [Peer Reviewed Journal]

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