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MP017 PROTEIN O−GLCNACYLATION REGULATES MITOCHONDRIAL FUNCTION AND ALBUMIN REABSORPTION IN PROXIMAL TUBULAR CELLS O-GLCNACYLATION REGULATES MITOCHONDRIAL FUNCTION AND ALBUMIN REABSORPTION IN PROXIMAL TUBULAR CELLS

Sugahara, Sho ; Kume, Shinji ; Takeda, Naoko ; Chin - Kanasaki, Masami ; Araki, Hisazumi ; Yanagita, Motoko ; Araki, Shin - Ichi ; Maegawa, Hiroshi

Nephrology Dialysis Transplantation, 2017, Vol. 32(suppl3), pp.iii435-iii435 [Peer Reviewed Journal]

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Nutrient sensing, autophagy, and diabetic nephropathy

Kume, Shinji ; Thomas, Merlin C ; Koya, Daisuke

Diabetes, January 2012, Vol.61(1), pp.23-9 [Peer Reviewed Journal]

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Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway

Kitada, Munehiro ; Kume, Shinji ; Imaizumi, Noriko ; Koya, Daisuke

Diabetes, February 2011, Vol.60(2), pp.634-43 [Peer Reviewed Journal]

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Multiple osteoporotic fractures in a patient with CKD stage G3b

Uzu, Takashi ; Araki, Shin-Ichi ; Araki, Hisazumi ; Kume, Shinji ; Maegawa, Hiroshi

Kidney International, May 2015, Vol.87(5), pp.1077-1077 [Peer Reviewed Journal]

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5
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Autophagy: A Novel Therapeutic Target for Diabetic Nephropathy

Kume, Shinji ; Koya, Daisuke

Diabetes & metabolism journal, December 2015, Vol.39(6), pp.451-60 [Peer Reviewed Journal]

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GW501516, a PPARδ Agonist, Ameliorates Tubulointerstitial Inflammation in Proteinuric Kidney Disease via Inhibition of TAK1-NFκB Pathway in Mice (PPARδ Agonist in Proteinuric Kidney Disease)

Yang, Xu ; Kume, Shinji ; Tanaka, Yuki ; Isshiki, Keiji ; Araki, Shin-ichi ; Chin-Kanasaki, Masami ; Sugimoto, Toshiro ; Koya, Daisuke ; Haneda, Masakazu ; Sugaya, Takeshi ; Li, Detian ; Han, Ping ; Nishio, Yoshihiko ; Kashiwagi, Atsunori ; Maegawa, Hiroshi ; Uzu, Takashi Chatziantoniou, Christos (Editor)

PLoS ONE, 2011, Vol.6(9), p.e25271 [Peer Reviewed Journal]

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Predictive effects of urinary liver-type fatty acid-binding protein for deteriorating renal function and incidence of cardiovascular disease in type 2 diabetic patients without advanced nephropathy

Araki, Shin-Ichi ; Haneda, Masakazu ; Koya, Daisuke ; Sugaya, Takeshi ; Isshiki, Keiji ; Kume, Shinji ; Kashiwagi, Atsunori ; Uzu, Takashi ; Maegawa, Hiroshi

Diabetes care, May 2013, Vol.36(5), pp.1248-53 [Peer Reviewed Journal]

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8
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Pivotal Role of -GlcNAc Modification in Cold-Induced Thermogenesis by Brown Adipose Tissue Through Mitochondrial Biogenesis

Ohashi, Natsuko ; Morino, Katsutaro ; Ida, Shogo ; Sekine, Osamu ; Lemecha, Mengistu ; Kume, Shinji ; Park, Shi-Young ; Choi, Cheol Soo ; Ugi, Satoshi ; Maegawa, Hiroshi

Diabetes, September 2017, Vol.66(9), pp.2351-2362 [Peer Reviewed Journal]

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MicroRNA148b-3p inhibits mTORC1-dependent apoptosis in diabetes by repressing TNFR2 in proximal tubular cells

Kuwagata, Shogo ; Kume, Shinji ; Chin-Kanasaki, Masami ; Araki, Hisazumi ; Araki, Shinichi ; Nakazawa, Jun ; Sugaya, Takeshi ; Koya, Daisuke ; Haneda, Masakazu ; Maegawa, Hiroshi ; Uzu, Takashi

Kidney International, December 2016, Vol.90(6), pp.1211-1225 [Peer Reviewed Journal]

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A very-low-protein diet ameliorates advanced diabetic nephropathy through autophagy induction by suppression of the mTORC1 pathway in Wistar fatty rats, an animal model of type 2 diabetes and obesity

Kitada, Munehiro ; Ogura, Yoshio ; Suzuki, Taeko ; Sen, Shi ; Lee, Seon ; Kanasaki, Keizo ; Kume, Shinji ; Koya, Daisuke

Diabetologia, 2016, Vol.59(6), pp.1307-1317 [Peer Reviewed Journal]

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Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

Kume, Shinji ; Uzu, Takashi ; Horiike, Kihachiro ; Chin-Kanasaki, Masami ; Isshiki, Keiji ; Araki, Shin-Ichi ; Sugimoto, Toshiro ; Haneda, Masakazu ; Kashiwagi, Atsunori ; Koya, Daisuke

The Journal of clinical investigation, April 2010, Vol.120(4), pp.1043-55 [Peer Reviewed Journal]

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12
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Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy

Tagawa, Atsuko ; Yasuda, Mako ; Kume, Shinji ; Yamahara, Kosuke ; Nakazawa, Jun ; Chin-Kanasaki, Masami ; Araki, Hisazumi ; Araki, Shin-Ichi ; Koya, Daisuke ; Asanuma, Katsuhiko ; Kim, Eun-Hee ; Haneda, Masakazu ; Kajiwara, Nobuyuki ; Hayashi, Kazuyuki ; Ohashi, Hiroshi ; Ugi, Satoshi ; Maegawa, Hiroshi ; Uzu, Takashi

Diabetes, March 2016, Vol.65(3), pp.755-67 [Peer Reviewed Journal]

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Association between urinary type IV collagen level and deterioration of renal function in type 2 diabetic patients without overt proteinuria

Araki, Shin-Ichi ; Haneda, Masakazu ; Koya, Daisuke ; Isshiki, Keiji ; Kume, Shinji ; Sugimoto, Toshiro ; Kawai, Hiromichi ; Nishio, Yoshihiko ; Kashiwagi, Atsunori ; Uzu, Takashi ; Maegawa, Hiroshi

Diabetes care, August 2010, Vol.33(8), pp.1805-10 [Peer Reviewed Journal]

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14
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Role of Nutrient-Sensing Signals in the Pathogenesis of Diabetic Nephropathy

Kume, Shinji ; Koya, Daisuke ; Uzu, Takashi ; Maegawa, Hiroshi

BioMed Research International, 2014, Vol.2014 [Peer Reviewed Journal]

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15
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Emerging role of mammalian autophagy in ketogenesis to overcome starvation

Takagi, Ayano ; Kume, Shinji ; Maegawa, Hiroshi ; Uzu, Takashi

Autophagy, 02 April 2016, Vol.12(4), pp.709-710 [Peer Reviewed Journal]

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16
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Fenofibrate, a PPARα agonist, has renoprotective effects in mice by enhancing renal lipolysis

Tanaka, Yuki ; Kume, Shinji ; Araki, Shin-Ichi ; Isshiki, Keiji ; Chin-Kanasaki, Masami ; Sakaguchi, Masayoshi ; Sugimoto, Toshiro ; Koya, Daisuke ; Haneda, Masakazu ; Kashiwagi, Atsunori ; Maegawa, Hiroshi ; Uzu, Takashi

Kidney International, 02 April 2011, Vol.79(8), pp.871-882 [Peer Reviewed Journal]

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17
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Predictive Properties of Plasma Amino Acid Profile for Cardiovascular Disease in Patients with Type 2 Diabetes

Kume, Shinji ; Araki, Shin-Ichi ; Ono, Nobukazu ; Shinhara, Atsuko ; Muramatsu, Takahiko ; Araki, Hisazumi ; Isshiki, Keiji ; Nakamura, Kazuki ; Miyano, Hiroshi ; Koya, Daisuke ; Haneda, Masakazu ; Ugi, Satoshi ; Kawai, Hiromichi ; Kashiwagi, Atsunori ; Uzu, Takashi ; Maegawa, Hiroshi

PLoS One, Jun 2014, Vol.9(6), p.e101219 [Peer Reviewed Journal]

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18
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Fructose and uric acid in diabetic nephropathy

Bjornstad, Petter ; Lanaspa, Miguel ; Ishimoto, Takuji ; Kosugi, Tomoki ; Kume, Shinji ; Jalal, Diana ; Maahs, David ; Snell-Bergeon, Janet ; Johnson, Richard ; Nakagawa, Takahiko

Diabetologia, 2015, Vol.58(9), pp.1993-2002 [Peer Reviewed Journal]

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19
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Summary of the 2018 ISN Frontiers Meeting: Kidney Disease and Cardiovascular Disease

Kume, Shinji ; Nagasu, Hajime ; Nangaku, Masaomi ; Nishiyama, Akira ; Nakamoto, Hidetomo ; Kashihara, Naoki

Kidney International Reports, July 2018, Vol.3(4), pp.804-816 [Peer Reviewed Journal]

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20
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Emerging role of podocyte autophagy in the progression of diabetic nephropathy

Yasuda-Yamahara, Mako ; Kume, Shinji ; Tagawa, Atsuko ; Maegawa, Hiroshi ; Uzu, Takashi

Autophagy, 01 December 2015, Vol.11(12), pp.2385-2386 [Peer Reviewed Journal]

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21
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The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy

Yamahara, Kosuke ; Yasuda, Mako ; Kume, Shinji ; Koya, Daisuke ; Maegawa, Hiroshi ; Uzu, Takashi Kanasaki, Keizo

Journal of Diabetes Research, 2013, Vol.2013, 9 pages [Peer Reviewed Journal]

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22
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Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation

Kitada, Munehiro ; Kume, Shinji ; Takeda-Watanabe, Ai ; Tsuda, Shin-Ichi ; Kanasaki, Keizo ; Koya, Daisuke

BBA - General Subjects, October 2013, Vol.1830(10), pp.4820-4827 [Peer Reviewed Journal]

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23
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Renoprotective effect of DPP-4 inhibitors against free fatty acid-bound albumin-induced renal proximal tubular cell injury

Tanaka, Yuki ; Kume, Shinji ; Chin-Kanasaki, Masami ; Araki, Hisazumi ; Araki, Shin-Ichi ; Ugi, Satoshi ; Sugaya, Takeshi ; Uzu, Takashi ; Maegawa, Hiroshi

Biochemical and Biophysical Research Communications, 12 February 2016, Vol.470(3), pp.539-545 [Peer Reviewed Journal]

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24
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Impact of obesity on annual medical expenditures and diabetes care in Japanese patients with type 2 diabetes mellitus

Kusunoki‐Tsuji, Chisato ; Araki, Shin‐Ichi ; Kume, Shinji ; Chin‐Kanasaki, Masami ; Osawa, Norihisa ; Morino, Katsutaro ; Sekine, Osamu ; Ugi, Satoshi ; Kashiwagi, Atsunori ; Maegawa, Hiroshi

Journal of Diabetes Investigation, July 2018, Vol.9(4), pp.776-781 [Peer Reviewed Journal]

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25
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Autophagy as a Therapeutic Target in Diabetic Nephropathy

Tanaka, Yuki ; Kume, Shinji ; Kitada, Munehiro ; Kanasaki, Keizo ; Uzu, Takashi ; Maegawa, Hiroshi ; Koya, Daisuke Lee, Ki-Up

Experimental Diabetes Research, 2012, Vol.2012, 12 pages [Peer Reviewed Journal]

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26
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Oral glucose‐stimulated serum C ‐peptide predicts successful switching from insulin therapy to liraglutide monotherapy in Japanese patients with type 2 diabetes and renal impairment

Araki, Hisazumi ; Tanaka, Yuki ; Yoshida, Syohei ; Morita, Yoshikata ; Kume, Shinji ; Isshiki, Keiji ; Araki, Shin‐Ichi ; Uzu, Takashi ; Kashiwagi, Atsunori ; Maegawa, Hiroshi

Journal of Diabetes Investigation, July 2014, Vol.5(4), pp.435-441 [Peer Reviewed Journal]

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27
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The effects of blood pressure control levels on the renoprotection of type 2 diabetic patients without overt proteinuria

Uzu, Takashi ; Kida, Yasuo ; Yamauchi, Atsushi ; Kume, Shinji ; Isshiki, Keiji ; Araki, Shin-Ichi ; Koya, Daisuke ; Haneda, Masakazu ; Kashiwagi, Atsunori ; Maegawa, Hiroshi ; Kikkawa, Ryuichi

Journal of the American Society of Hypertension, March 2012, Vol.6(2), pp.124-131 [Peer Reviewed Journal]

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28
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Lack of O-GlcNAcylation enhances exercise-dependent glucose utilization potentially through AMP-activated protein kinase activation in skeletal muscle

Murata, Koichiro ; Morino, Katsutaro ; Ida, Shogo ; Ohashi, Natsuko ; Lemecha, Mengistu ; Park, Shi-Young ; Ishikado, Atsushi ; Kume, Shinji ; Choi, Cheol Soo ; Sekine, Osamu ; Ugi, Satoshi ; Maegawa, Hiroshi

Biochemical and Biophysical Research Communications, 08 January 2018, Vol.495(2), pp.2098-2104 [Peer Reviewed Journal]

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29
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Role of angiotensin II-mediated AMPK inactivation on obesity-related salt-sensitive hypertension

Deji, Naoko ; Kume, Shinji ; Araki, Shin-Ichi ; Isshiki, Keiji ; Araki, Hisazumi ; Chin-Kanasaki, Masami ; Tanaka, Yuki ; Nishiyama, Akira ; Koya, Daisuke ; Haneda, Masakazu ; Kashiwagi, Atsunori ; Maegawa, Hiroshi ; Uzu, Takashi

Biochemical and Biophysical Research Communications, 17 February 2012, Vol.418(3), pp.559-564 [Peer Reviewed Journal]

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30
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Overexpression of acetyl CoA carboxylase β exacerbates podocyte injury in the kidney of streptozotocin-induced diabetic mice

Tanaka, Yuki ; Kume, Shinji ; Maeda, Shiro ; Osawa, Norihisa ; Takeda, Naoko ; Chin-Kanasaki, Masami ; Isshiki, Keiji ; Ugi, Satoshi ; Oshima, Itsuki ; Uzu, Takashi ; Maegawa, Hiroshi ; Araki, Shin-Ichi

Biochemical and Biophysical Research Communications, 01 January 2018, Vol.495(1), pp.1115-1121 [Peer Reviewed Journal]

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31
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Diverse metabolic effects of O -GlcNAcylation in the pancreas but limited effects in insulin-sensitive organs in mice

Ida, Shogo ; Morino, Katsutaro ; Sekine, Osamu ; Ohashi, Natsuko ; Kume, Shinji ; Chano, Tokuhiro ; Iwasaki, Kanako ; Harada, Norio ; Inagaki, Nobuya ; Ugi, Satoshi ; Maegawa, Hiroshi

Diabetologia, 2017, Vol.60(9), pp.1761-1769 [Peer Reviewed Journal]

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32
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Fructose induces tubulointerstitial injury in the kidney of mice

Aoyama, Masahiro ; Isshiki, Keiji ; Kume, Shinji ; Chin-Kanasaki, Masami ; Araki, Hisazumi ; Araki, Shin-Ichi ; Koya, Daisuke ; Haneda, Masakazu ; Kashiwagi, Atsunori ; Maegawa, Hiroshi ; Uzu, Takashi

Biochemical and Biophysical Research Communications, 09 March 2012, Vol.419(2), pp.244-249 [Peer Reviewed Journal]

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33
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Lamp-2 deficiency prevents high-fat diet-induced obese diabetes via enhancing energy expenditure

Yasuda-Yamahara, Mako ; Kume, Shinji ; Yamahara, Kosuke ; Nakazawa, Jun ; Chin-Kanasaki, Masami ; Araki, Hisazumi ; Araki, Shin-Ichi ; Koya, Daisuke ; Haneda, Masakzu ; Ugi, Satoshi ; Maegawa, Hiroshi ; Uzu, Takashi

Biochemical and Biophysical Research Communications, 18 September 2015, Vol.465(2), pp.249-255 [Peer Reviewed Journal]

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34
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Ezetimibe prevents hepatic steatosis induced by a high-fat but not a high-fructose diet

Ushio, Masateru ; Nishio, Yoshihiko ; Sekine, Osamu ; Nagai, Yoshio ; Maeno, Yasuhiro ; Ugi, Satoshi ; Yoshizaki, Takeshi ; Morino, Katsutaro ; Kume, Shinji ; Kashiwagi, Atsunori ; Maegawa, Hiroshi

American journal of physiology. Endocrinology and metabolism, 15 July 2013, Vol.305(2), pp.E293-304 [Peer Reviewed Journal]

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35
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Stearoyl-CoA Desaturase-1 Protects Cells against Lipotoxicity-Mediated Apoptosis in Proximal Tubular Cells

Iwai, Tamaki ; Kume, Shinji ; Chin-Kanasaki, Masami ; Kuwagata, Shogo ; Araki, Hisazumi ; Takeda, Naoko ; Sugaya, Takeshi ; Uzu, Takashi ; Maegawa, Hiroshi ; Araki, Shin-Ichi Cai, Lu (editor) ; Wang, Yuehui (editor) ; Zhang, Zhiguo (editor)

International Journal of Molecular Sciences, 2016, Vol.17(11) [Peer Reviewed Journal]

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36
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Safety and efficacy of skin patches containing loxoprofen sodium in diabetic patients with overt nephropathy

Araki, Hisazumi ; Kuwagata, Shogo ; Soumura, Mariko ; Yamahara, Kosuke ; Morita, Yoshikata ; Kume, Shinji ; Isshiki, Keiji ; Araki, Shin-ichi ; Kashiwagi, Atsunori ; Maegawa, Hiroshi ; Uzu, Takashi

Clinical and Experimental Nephrology, 2014, Vol.18(3), pp.487-491 [Peer Reviewed Journal]

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37
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Autophagy regulates inflammation in adipocytes

Yoshizaki, Takeshi ; Kusunoki, Chisato ; Kondo, Motoyuki ; Yasuda, Mako ; Kume, Shinji ; Morino, Katsutaro ; Sekine, Osamu ; Ugi, Satoshi ; Uzu, Takashi ; Nishio, Yoshihiko ; Kashiwagi, Atsunori ; Maegawa, Hiroshi

Biochemical and Biophysical Research Communications, 06 January 2012, Vol.417(1), pp.352-357 [Peer Reviewed Journal]

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