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Pharmacodynamic consequences of administration of VLA-4 antagonist CDP323 to multiple sclerosis subjects: a randomized, double-blind phase 1/2 study

Wolf, Christian ; Sidhu, Jagdev ; Otoul, Christian ; Morris, Dexter L ; Cnops, Jennifer ; Taubel, Jorg ; Bennett, Barbara

PloS one, 2013, Vol.8(3), pp.e58438 [Peer Reviewed Journal]

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Treatment with Ibrutinib Inhibits BTK- and VLA-4-Dependent Adhesion of Chronic Lymphocytic Leukemia Cells In Vivo

Herman, Sarah E M ; Mustafa, Rashida Z ; Jones, Jade ; Wong, Deanna H ; Farooqui, Mohammed ; Wiestner, Adrian

Clinical cancer research : an official journal of the American Association for Cancer Research, 15 October 2015, Vol.21(20), pp.4642-51 [Peer Reviewed Journal]

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Substituted N-(3,5-dichlorobenzenesulfonyl)-L-prolyl-phenylalanine analogues as potent VLA-4 antagonists

Kopka, Ihor E ; Young, David N ; Lin, Linus S ; Mumford, Richard A ; Magriotis, Plato A ; Maccoss, Malcolm ; Mills, Sander G ; Van Riper, Gail ; Mccauley, Ermengilda ; Egger, Linda E ; Kidambi, Usha ; Schmidt, John A ; Lyons, Kathryn ; Stearns, Ralph ; Vincent, Stella ; Colletti, Adria ; Wang, Zhen ; Tong, Sharon ; Wang, Junying ; Zheng, Song ; Owens, Karen ; Levorse, Dorothy ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 25 February 2002, Vol.12(4), pp.637-40 [Peer Reviewed Journal]

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2,3-Diphenylpropionic acids as potent VLA-4 antagonists

Hoshina, Yoichiro ; Ikegami, Satoru ; Okuyama, Akihiko ; Fukui, Hideto ; Inoguchi, Kiyoshi ; Maruyama, Tatsuya ; Fujimoto, Kyoko ; Matsumura, Yuzuru ; Aoyama, Akinori ; Harada, Tatsuhiro ; Tanaka, Hiroshi ; Nakamura, Tsutomu

Bioorganic & medicinal chemistry letters, 03 January 2005, Vol.15(1), pp.217-20 [Peer Reviewed Journal]

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Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists

Witherington, Jason ; Blaney, Emma L ; Bordas, Vincent ; Elliott, Richard L ; Gaiba, Alessandra ; Garton, Neil ; Green, Philip M ; Naylor, Antoinette ; Smith, David G ; Spalding, David J ; Takle, Andrew K ; Ward, Robert W

Bioorganic & medicinal chemistry letters, 01 November 2006, Vol.16(21), pp.5538-41 [Peer Reviewed Journal]

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Influence of acid surrogates toward potency of VLA-4 antagonist

Venkatraman, Shankar ; Lim, Jongwon ; Cramer, Merryl ; Gardner, Michael F ; James, Joyce ; Alves, Kenneth ; Lingham, Russell B ; Mumford, Richard A ; Munoz, Benito

Bioorganic & medicinal chemistry letters, 15 September 2005, Vol.15(18), pp.4053-6 [Peer Reviewed Journal]

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Highly constrained bicyclic VLA-4 antagonists

Chang, Linda L ; Truong, Quang ; Doss, George A ; Maccoss, Malcolm ; Lyons, Kathryn ; Mccauley, Ermengilda ; Mumford, Richard ; Forrest, Gail ; Vincent, Stella ; Schmidt, John A ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 01 February 2007, Vol.17(3), pp.597-601 [Peer Reviewed Journal]

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Sulphonamide-based small molecule VLA-4 antagonists

Stasiak, Marcin ; Mehlin, Christopher ; Boni, Erica ; Vaisar, Tomas ; Little, Thomas ; Kim, Hwa-Ok ; Qabar, Maher

Bioorganic & medicinal chemistry letters, 03 November 2003, Vol.13(21), pp.3875-8 [Peer Reviewed Journal]

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Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist

Chiba, Jun ; Machinaga, Nobuo ; Takashi, Tohru ; Ejima, Akio ; Takayama, Gensuke ; Yokoyama, Mika ; Nakayama, Atsushi ; Baldwin, John J ; Mcdonald, Edward ; Moriarty, Kevin J ; Sarko, Christopher R ; Saionz, Kurt W ; Swanson, Robert ; Hussain, Zahid ; Wong, Angela

Bioorganic & medicinal chemistry letters, 03 January 2005, Vol.15(1), pp.41-5 [Peer Reviewed Journal]

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N-isonicotinoyl-(L)-4-aminophenylalanine derivatives as tight binding VLA-4 antagonists

Doherty, George A ; Yang, Ginger X ; Borges, Edite ; Tong, Sharon ; Mccauley, Ermengilda D ; Treonz, Kelly M ; Van Riper, Gail ; Pacholok, Stephen ; Si, Qian ; Koo, Gloria C ; Shah, Kashmira ; Mumford, Richard A ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 02 June 2003, Vol.13(11), pp.1891-5 [Peer Reviewed Journal]

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Amidines as amide bond replacements in VLA-4 antagonists

Kamenecka, Theodore M ; Park, You-Jung ; Lin, Linus S ; De Laszlo, Stephen ; Mccauley, Ermengilda D ; Van Riper, Gail ; Egger, Linda ; Kidambi, Usha ; Mumford, Richard A ; Tong, Sharon ; Tang, Wei ; Colletti, Adria ; Teffera, Yohannes ; Stearns, Ralph ; Maccoss, Malcolm ; Schmidt, John A ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 03 May 2004, Vol.14(9), pp.2323-6 [Peer Reviewed Journal]

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Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores

Castanedo, Georgette M ; Sailes, Fredrick C ; Dubree, Nathan J P ; Nicholas, John B ; Caris, Lisa ; Clark, Kevin ; Keating, Susan M ; Beresini, Maureen H ; Chiu, Henry ; Fong, Sherman ; Marsters, James C ; Jackson, David Y ; Sutherlin, Daniel P

Bioorganic & medicinal chemistry letters, 21 October 2002, Vol.12(20), pp.2913-7 [Peer Reviewed Journal]

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Highly potent, water soluble benzimidazole antagonist for activated alpha 4 beta 1 integrin

Carpenter, Richard D ; Andrei, Mirela ; Lau, Edmond Y ; Lightstone, Felice C ; Liu, Ruiwu ; Lam, Kit S ; Kurth, Mark J

Journal of medicinal chemistry, 15 November 2007, Vol.50(23), pp.5863-7 [Peer Reviewed Journal]

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Discovery and evaluation of N-(triazin-1,3,5-yl) phenylalanine derivatives as VLA-4 integrin antagonists

Porter, John R ; Archibald, Sarah C ; Brown, Julien A ; Childs, Kirstie ; Critchley, David ; Head, John C ; Hutchinson, Brian ; Parton, Ted A H ; Robinson, Martyn K ; Shock, Anthony ; Warrellow, Graham J ; Zomaya, Alex

Bioorganic & medicinal chemistry letters, 17 June 2002, Vol.12(12), pp.1591-4 [Peer Reviewed Journal]

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N-(arylacetyl)-biphenylalanines as potent VLA-4 antagonists

Li, Bing ; De Laszlo, Stephen E ; Kamenecka, Theodore M ; Kopka, Ihor E ; Durette, Philippe L ; Lanza, Thomas ; Maccoss, Malcolm ; Tong, Sharon ; Mumford, Richard A ; Mccauley, Ermengilda D ; Van Riper, Gail ; Schmidt, John A ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 19 August 2002, Vol.12(16), pp.2141-4 [Peer Reviewed Journal]

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Modeling the molecular basis for α4β1 integrin antagonism

Hutt, Oliver E ; Saubern, Simon ; Winkler, David A

Bioorganic & medicinal chemistry, 01 October 2011, Vol.19(19), pp.5903-11 [Peer Reviewed Journal]

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Bioisosteric replacement of anilide with benzoxazole: potent and orally bioavailable antagonists of VLA-4

Lin, Linus S ; Lanza, Thomas J ; Castonguay, Laurie A ; Kamenecka, Theodore ; Mccauley, Ermenegilda ; Van Riper, Gail ; Egger, Linda A ; Mumford, Richard A ; Tong, Xinchun ; Maccoss, Malcolm ; Schmidt, John A ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 03 May 2004, Vol.14(9), pp.2331-4 [Peer Reviewed Journal]

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18
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N-aryl-prolyl-dipeptides as potent antagonists of VLA-4

Kamenecka, Theodore M ; Lanza, Thomas ; De Laszlo, Stephen E ; Li, Bing ; Mccauley, Ermengilda D ; Van Riper, Gail ; Egger, Linda A ; Kidambi, Usha ; Mumford, Richard A ; Tong, Sharon ; Maccoss, Malcolm ; Schmidt, John A ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 19 August 2002, Vol.12(16), pp.2205-8 [Peer Reviewed Journal]

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19
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N-Tetrahydrofuroyl-(L)-phenylalanine derivatives as potent VLA-4 antagonists

Yang, Ginger X ; Chang, Linda L ; Truong, Quang ; Doherty, George A ; Magriotis, Plato A ; De Laszlo, Stephen E ; Li, Bing ; Maccoss, Malcolm ; Kidambi, Usha ; Egger, Linda A ; Mccauley, Ermengilda ; Van Riper, Gail ; Mumford, Richard A ; Schmidt, John A ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 03 June 2002, Vol.12(11), pp.1497-500 [Peer Reviewed Journal]

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20
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Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists

Kopka, Ihor E ; Lin, Linus S ; Mumford, Richard A ; Lanza, Thomas ; Magriotis, Plato A ; Young, David ; Delaszlo, Stephen E ; Maccoss, Malcolm ; Mills, Sander G ; Van Riper, Gail ; Mccauley, Ermengilda ; Lyons, Kathryn ; Vincent, Stella ; Egger, Linda A ; Kidambi, Usha ; Stearns, Ralph ; Colletti, Adria ; Teffera, Yohannes ; Tong, Sharon ; Owens, Karen ; Levorse, Dorothy ; Schmidt, John A ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 02 September 2002, Vol.12(17), pp.2415-8 [Peer Reviewed Journal]

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21
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Pyridone derivatives as potent and selective VLA-4 integrin antagonists

Witherington, Jason ; Bordas, Vincent ; Gaiba, Alessandra ; Green, Phil M ; Naylor, Antoinette ; Parr, Nigel ; Smith, David G ; Takle, Andrew K ; Ward, Robert W

Bioorganic & medicinal chemistry letters, 15 April 2006, Vol.16(8), pp.2256-9 [Peer Reviewed Journal]

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Efficient synthesis of 3-aminocyclobut-2-en-1-ones: squaramide surrogates as potent VLA-4 antagonists

Brand, Stephen ; De Candole, Benjamin C ; Brown, Julien A

Organic letters, 26 June 2003, Vol.5(13), pp.2343-6 [Peer Reviewed Journal]

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23
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Dehydrophenylalanine derivatives as VLA-4 integrin antagonists

Porter, John R ; Archibald, Sarah C ; Brown, Julien A ; Childs, Kirstie ; Critchley, David ; Head, John C ; Parton, Ted A H ; Robinson, Martyn K ; Shock, Anthony ; Taylor, Richard J ; Warrellow, Graham J

Bioorganic & medicinal chemistry letters, 10 March 2003, Vol.13(5), pp.805-8 [Peer Reviewed Journal]

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N-(3-phenylsulfonyl-3-piperidinoyl)-phenylalanine derivatives as potent, selective VLA-4 antagonists

Gutteridge, Clare E ; De Laszlo, Stephen E ; Kamenecka, Theodore M ; Mccauley, Ermengilda ; Van Riper, Gail ; Mumford, Richard A ; Kidambi, Usha ; Egger, Linda A ; Tong, Sharon ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 10 March 2003, Vol.13(5), pp.885-90 [Peer Reviewed Journal]

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25
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Synthesis, characterization and evaluation of pro-drugs of VLA-4 antagonists

Huryn, Donna M ; Ashwell, Susan ; Baudy, Reinhardt ; Dressen, Darren B ; Gallaway, William ; Grant, Francine S ; Konradi, Andrei ; Ley, Robert W ; Petusky, Susan ; Pleiss, Michael A ; Sarantakis, Dimitri ; Semko, Christopher M ; Sherman, Mary M ; Tio, Cesar ; Zhang, Lu

Bioorganic & medicinal chemistry letters, 05 April 2004, Vol.14(7), pp.1651-4 [Peer Reviewed Journal]

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26
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Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists

Chiba, Jun ; Iimura, Shin ; Yoneda, Yoshiyuki ; Watanabe, Toshiyuki ; Muro, Fumito ; Tsubokawa, Masao ; Iigou, Yutaka ; Satoh, Atsushi ; Takayama, Gensuke ; Yokoyama, Mika ; Takashi, Tohru ; Nakayama, Atsushi ; Machinaga, Nobuo

Bioorganic & medicinal chemistry, 15 February 2007, Vol.15(4), pp.1679-93 [Peer Reviewed Journal]

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27
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N-(pyrimidin-4-yl) and N-(pyridin-2-yl) phenylalanine derivatives as VLA-4 integrin antagonists

Porter, John R ; Archibald, Sarah C ; Brown, Julien A ; Childs, Kirstie ; Critchley, David ; Head, John C ; Hutchinson, Brian ; Parton, Ted A H ; Robinson, Martyn K ; Shock, Anthony ; Warrellow, Graham J ; Zomaya, Alex

Bioorganic & medicinal chemistry letters, 17 June 2002, Vol.12(12), pp.1595-8 [Peer Reviewed Journal]

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28
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2,6-Quinolinyl derivatives as potent VLA-4 antagonists

Lassoie, Marie-Agnès ; Broeders, Fabienne ; Collart, Philippe ; Defrère, Laurent ; De Laveleye-Defais, Françoise ; Demaude, Thierry ; Gassama, Abdoulaye ; Guillaumet, Gérald ; Hayez, Jean-Claude ; Kiss, Laszlo ; Knerr, Laurent ; Nicolas, Jean-Marie ; Norsikian, Stéphanie ; Quéré, Luc ; Routier, Sylvain ; Verbois, Valérie ; Provins, Laurent

Bioorganic & medicinal chemistry letters, 01 January 2007, Vol.17(1), pp.142-6 [Peer Reviewed Journal]

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29
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Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual alpha(4)beta(7)/alpha(4)beta(1) integrin antagonist

Sircar, Ila ; Gudmundsson, Kristjan S ; Martin, Richard ; Liang, Jimmy ; Nomura, Sumihiro ; Jayakumar, Honnappa ; Teegarden, Bradley R ; Nowlin, Dawn M ; Cardarelli, Pina M ; Mah, Jason R ; Connell, Samuel ; Griffith, Ronald C ; Lazarides, Elias

Bioorganic & medicinal chemistry, June 2002, Vol.10(6), pp.2051-66 [Peer Reviewed Journal]

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30
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Structural requirements of MLD-containing disintegrins for functional interaction with alpha 4 beta 1 and alpha 9 beta1 integrins

Bazan-Socha, Stanislawa ; Kisiel, Dariusz G ; Young, Brad ; Theakston, R David G ; Calvete, Juan J ; Sheppard, Dean ; Marcinkiewicz, Cezary

Biochemistry, 17 February 2004, Vol.43(6), pp.1639-47 [Peer Reviewed Journal]

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31
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Identification of unique VLA-4 antagonists from a combinatorial library

De Laszlo, Stephen E ; Li, Bing ; Mccauley, Ermengilda ; Van Riper, Gail ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 25 February 2002, Vol.12(4), pp.685-8 [Peer Reviewed Journal]

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32
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The discovery of acylated beta-amino acids as potent and orally bioavailable VLA-4 antagonists

Lin, Linus S ; Kopka, Ihor E ; Mumford, Richard A ; Magriotis, Plato A ; Lanza, Thomas ; Durette, Philippe L ; Kamenecka, Theodore ; Young, David N ; De Laszlo, Stephen E ; Mccauley, Ermenegilda ; Riper, Gail Van ; Kidambi, Usha ; Egger, Linda A ; Tong, Xinchun ; Lyons, Kathryn ; Vincent, Stella ; Stearns, Ralph ; Colletti, Adria ; Teffera, Yohannes ; Fenyk-Melody, Judy ; Schmidt, John A ; Maccoss, Malcolm ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 25 February 2002, Vol.12(4), pp.611-4 [Peer Reviewed Journal]

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Substituted tetrahydrofuroyl-1-phenylalanine derivatives as potent and specific VLA-4 antagonists

Doherty, George A ; Yang, Ginger X ; Borges, Edite ; Chang, Linda L ; Maccoss, Malcolm ; Tong, Sharon ; Kidambi, Usha ; Egger, Linda A ; Mccauley, Ermenegilda ; Van Riper, Gail ; Mumford, Richard A ; Schmidt, John A ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 03 June 2002, Vol.12(11), pp.1501-5 [Peer Reviewed Journal]

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34
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A small molecule very late antigen-4 antagonist can inhibit ovalbumin-induced lung inflammation

Koo, Gloria C ; Shah, Kashmira ; Ding, Gloria J F ; Xiao, Jianying ; Wnek, Richard ; Doherty, George ; Tong, Xin Chun ; Pepinsky, R Blake ; Lin, Ko-Chung ; Hagmann, William K ; Kawka, Douglas ; Singer, Irwin I

American journal of respiratory and critical care medicine, 15 May 2003, Vol.167(10), pp.1400-9 [Peer Reviewed Journal]

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35
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Aza-bicyclic amino acid sulfonamides as alpha(4)beta(1)/alpha(4)beta(7) integrin antagonists

Dyatkin, Alexey B ; Hoekstra, William J ; Kinney, William A ; Kontoyianni, Maria ; Santulli, Rosemary J ; Kimball, Edward S ; Fisher, M Carolyn ; Carolyn Fisher, M ; Prouty, Stephen M ; Abraham, William M ; De Garavilla, Lawrence ; Andrade-Gordon, Patricia ; Hlasta, Dennis J ; He, Wei ; Hornby, Pamela J ; Damiano, Bruce P ; Maryanoff, Bruce E

Bioorganic & medicinal chemistry letters, 09 February 2004, Vol.14(3), pp.591-6 [Peer Reviewed Journal]

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Focused library approach for identification of new N-acylphenylalanines as VCAM/VLA-4 antagonists

Chen, Li ; Trilles, Richard ; Miklowski, Dorota ; Huang, Tai-Nan ; Fry, David ; Campbell, Robert ; Rowan, Karen ; Schwinge, Virginia ; Tilley, Jefferson W

Bioorganic & medicinal chemistry letters, 17 June 2002, Vol.12(12), pp.1679-82 [Peer Reviewed Journal]

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37