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28 Results  for Everything (Includes Articles)

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1
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Inverse vaccination with islet autoantigens to halt progression of autoimmune diabetes

Hinke, Simon A. Gurwitz, David

Drug Development Research, December 2011, Vol.72(8), pp.788-804 [Peer Reviewed Journal]

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Anchored phosphatases modulate glucose homeostasis

Hinke, Simon A ; Navedo, Manuel F ; Ulman, Allison ; Whiting, Jennifer L ; Nygren, Patrick J ; Tian, Geng ; Jiménez Caliani, Antonio Javier ; Langeberg, Lorene K. ; Cirulli, Vincenzo ; Tengholm, Anders ; Dell'Acqua, Mark L ; Santana, L Fernando ; Scott, John D.

EMBO journal: European Molecular Biology Organization, 2012, Issue 20, pp.3991-4004 [Peer Reviewed Journal]

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Anchored phosphatases modulate glucose homeostasis

Hinke, Simon A ; Navedo, Manuel F ; Ulman, Allison ; Whiting, Jennifer L ; Nygren, Patrick J ; Tian, Geng ; Jimenez‐Caliani, Antonio J ; Langeberg, Lorene K ; Cirulli, Vincenzo ; Tengholm, Anders ; Dell' Acqua, Mark L ; Santana, L Fernando ; Scott, John D

EMBO Journal, 17 October 2012, Vol.31(20), pp.3991-4004 [Peer Reviewed Journal]

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Anchored phosphatases modulate glucose homeostasis

Hinke, Simon A ; Navedo, Manuel F ; Ulman, Allison ; Whiting, Jennifer L ; Nygren, Patrick J ; Tian, Geng ; Jimenez‐Caliani, Antonio J ; Langeberg, Lorene K ; Cirulli, Vincenzo ; Tengholm, Anders ; Dell' Acqua, Mark L ; Fernando Santana, L ; Scott, John D

EMBO Journal, 28 November 2012, Vol.31(23), pp.4481-4481 [Peer Reviewed Journal]

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5
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State-Dependent Allosteric Inhibition of the Human SLC13A5 Citrate Transporter by Hydroxysuccinic Acids, PF-06649298 and PF-06761281

Rives, Marie-Laure ; Shaw, Morena ; Zhu, Bin ; Hinke, Simon A ; Wickenden, Alan D

Molecular pharmacology, December 2016, Vol.90(6), pp.766-774 [Peer Reviewed Journal]

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6
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MyRIP anchors protein kinase A to the exocyst complex

Goehring, April S ; Pedroja, Benjamin S ; Hinke, Simon A ; Langeberg, Lorene K ; Scott, John D

The Journal of biological chemistry, 09 November 2007, Vol.282(45), pp.33155-67 [Peer Reviewed Journal]

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7
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Plasticity of the beta cell insulin secretory competence: preparing the pancreatic beta cell for the next meal

Hinke, Simon A ; Hellemans, Karine ; Schuit, Frans C

The Journal of physiology, 15 July 2004, Vol.558(Pt 2), pp.369-80 [Peer Reviewed Journal]

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8
Structure−Function Analysis of a Series of Novel GIP Analogues Containing Different Helical Length Linkers †
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Structure−Function Analysis of a Series of Novel GIP Analogues Containing Different Helical Length Linkers †

Manhart, Susanne ; Hinke, Simon A. ; Mcintosh, Christopher H. S. ; Pederson, Raymond A. ; Demuth, Hans-Ulrich

Biochemistry, 03/2003, Vol.42(10), pp.3081-3088 [Peer Reviewed Journal]

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9
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Structure-function analysis of a series of novel GIP analogues containing different helical length linkers

Manhart, Susanne ; Hinke, Simon A ; Mcintosh, Christopher H S ; Pederson, Raymond A ; Demuth, Hans-Ulrich

Biochemistry, 18 March 2003, Vol.42(10), pp.3081-8 [Peer Reviewed Journal]

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10
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Ser2- and SerP2 incretin analogs: comparison of dipeptidyl peptidase IV resistance and biological activities in vitro and in vivo

Hinke, Simon A ; Manhart, Susanne ; Kühn-Wache, Kerstin ; Nian, Cuilan ; Demuth, Hans-Ulrich ; Pederson, Raymond A ; Mcintosh, Christopher H S

The Journal of biological chemistry, 06 February 2004, Vol.279(6), pp.3998-4006 [Peer Reviewed Journal]

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11
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AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K+ currents in ventricular myocytes following myocardial infarction

Nieves-Cintrón, Madeline ; Hirenallur-Shanthappa, Dinesh ; Nygren, Patrick J ; Hinke, Simon A ; Dell'Acqua, Mark L ; Langeberg, Lorene K ; Navedo, Manuel ; Santana, Luis F ; Scott, John D

Cellular Signalling, July 2016, Vol.28(7), pp.733-740 [Peer Reviewed Journal]

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12
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Potent Sodium/Glucose Cotransporter SGLT1/2 Dual Inhibition Improves Glycemic Control Without Marked Gastrointestinal Adaptation or Colonic Microbiota Changes in Rodents

Du, Fuyong ; Hinke, Simon A ; Cavanaugh, Cassandre ; Polidori, David ; Wallace, Nathanial ; Kirchner, Thomas ; Jennis, Matthew ; Lang, Wensheng ; Kuo, Gee-Hong ; Gaul, Micheal D ; Lenhard, James ; Demarest, Keith ; Ajami, Nadim J ; Liang, Yin ; Hornby, Pamela J

The Journal of pharmacology and experimental therapeutics, June 2018, Vol.365(3), pp.676-687 [Peer Reviewed Journal]

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13
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In depth analysis of the N-terminal bioactive domain of gastric inhibitory polypeptide

Hinke, Simon A ; Manhart, Susanne ; Speck, Madeleine ; Pederson, Raymond A ; Demuth, Hans-Ulrich ; Mcintosh, Christopher H.S

Life Sciences, 2004, Vol.75(15), pp.1857-1870 [Peer Reviewed Journal]

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14
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On combination therapy of diabetes with metformin and dipeptidyl peptidase IV inhibitors

Hinke, Simon A ; Mcintosh, Christopher H S ; Hoffmann, Torsten ; Kühn-Wache, Kerstin ; Wagner, Leona ; Bär, Joachim ; Manhart, Susanne ; Wermann, Michael ; Pederson, Raymond A ; Demuth, Hans-Ulrich

Diabetes care, August 2002, Vol.25(8), pp.1490-1; author reply 1491-2 [Peer Reviewed Journal]

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15
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Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody

Hinke, Simon A ; Cieniewicz, Anne M ; Kirchner, Thomas ; D'Aquino, Katharine ; Nanjunda, Rupesh ; Aligo, Jason ; Perkinson, Robert ; Cooper, Philip ; Boayke, Ken ; Chiu, Mark L ; Jarantow, Steve ; Lacy, Eilyn R ; Liang, Yin ; Johnson, Dana L ; Whaley, Jean M ; Lingham, Russell B ; Kihm, Anthony J

Molecular Metabolism, April 2018, Vol.10, pp.87-99 [Peer Reviewed Journal]

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16
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Novel Monoclonal Antibody Is an Allosteric Insulin Receptor Antagonist That Induces Insulin Resistance

Cieniewicz, Anne M ; Kirchner, Thomas ; Hinke, Simon A ; Nanjunda, Rupesh ; D'Aquino, Katharine ; Boayke, Ken ; Cooper, Philip R ; Perkinson, Robert ; Chiu, Mark L ; Jarantow, Stephen ; Johnson, Dana L ; Whaley, Jean M ; Lacy, Eilyn R ; Lingham, Russell B ; Liang, Yin ; Kihm, Anthony J

Diabetes, January 2017, Vol.66(1), pp.206-217 [Peer Reviewed Journal]

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17
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AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus

Nystoriak, Matthew A ; Nieves-Cintrón, Madeline ; Nygren, Patrick J ; Hinke, Simon A ; Nichols, C Blake ; Chen, Chao-Yin ; Puglisi, Jose L ; Izu, Leighton T ; Bers, Donald M ; Dell'Acqua, Mark L ; Scott, John D ; Santana, Luis F ; Navedo, Manuel F

Circulation research, 14 February 2014, Vol.114(4), pp.607-15 [Peer Reviewed Journal]

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18
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Dipeptidyl peptidase IV-resistant D-Ala(2)glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats

Hinke, Simon A ; Gelling, Richard W ; Pederson, Raymond A ; Manhart, Susanne ; Nian, Cuilan ; Demuth, Hans-Ulrich ; Mcintosh, Christopher H S

Diabetes, March 2002, Vol.51(3), pp.652-61 [Peer Reviewed Journal]

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19
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Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors

Hansotia, Tanya ; Baggio, Laurie L ; Delmeire, Dominique ; Hinke, Simon A ; Yamada, Yuichiro ; Tsukiyama, Katsushi ; Seino, Yutaka ; Holst, Jens J ; Schuit, Frans ; Drucker, D J

Diabetes, May 2004, Vol.53(5), pp.1326-35 [Peer Reviewed Journal]

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20
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Rebuttal to Deacon and Holst: “Metformin effects on dipeptidyl peptidase IV degradation of glucagon-like peptide-1” versus “Dipeptidyl peptidase inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective”

Demuth, Hans-Ulrich ; Hinke, Simon A ; Pederson, Raymond A ; Mcintosh, Christopher H.S

Biochemical and Biophysical Research Communications, 2002, Vol.296(2), pp.229-232 [Peer Reviewed Journal]

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21
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Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation

Cai, Ying ; Martens, Geert A ; Hinke, Simon A ; Heimberg, Harry ; Pipeleers, Daniel ; Van de Casteele, Mark

Free Radical Biology and Medicine, 2007, Vol.42(1), pp.64-78 [Peer Reviewed Journal]

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22
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Prior in vitro exposure to GLP-1 with or without GIP can influence the subsequent beta cell responsiveness

Delmeire, Dominique ; Flamez, Daisy ; Moens, Karen ; Hinke, Simon A ; Van Schravendijk, Chris ; Pipeleers, Daniel ; Schuit, Frans

Biochemical Pharmacology, 2004, Vol.68(1), pp.33-39 [Peer Reviewed Journal]

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23
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Identification of a bioactive domain in the amino-terminus of glucose-dependent insulinotropic polypeptide (GIP)

Hinke, Simon A ; Manhart, Susanne ; Pamir, Nathalie ; Demuth, Hans-Ulrich ; W. Gelling, Richard ; Pederson, Raymond A ; Mcintosh, Christopher H.S

Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular Enzymology, 2001, Vol.1547(1), pp.143-155 [Peer Reviewed Journal]

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24
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Rebuttal to Deacon and Holst: "Metformin effects on dipeptidyl peptidase IV degradation of glucagon-like peptide-1" versus "Dipeptidyl peptidase inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective"

Demuth, Hans-Ulrich ; Hinke, Simon A ; Pederson, Raymond A ; Mcintosh, Christopher H S

Biochemical and biophysical research communications, 16 August 2002, Vol.296(2), pp.229-32 [Peer Reviewed Journal]

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25
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Metformin Effects on Dipeptidylpeptidase IV Degradation of Glucagon-like Peptide-1

Hinke, Simon A ; Kühn-Wache, Kerstin ; Hoffmann, Torsten ; Pederson, Raymond A ; Mcintosh, Christopher H.S ; Demuth, Hans-Ulrich

Biochemical and Biophysical Research Communications, 15 March 2002, Vol.291(5), pp.1302-1308 [Peer Reviewed Journal]

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26
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Metabolism of glucagon by dipeptidyl peptidase IV (CD26)

Pospisilik, John A ; Hinke, Simon A ; Pederson, Raymond A ; Hoffmann, Torsten ; Rosche, Fred ; Schlenzig, Dagmar ; Glund, Konrad ; Heiser, Ulrich ; Mcintosh, Christopher H.S ; Demuth, Hans-Ulrich

Regulatory Peptides, 2001, Vol.96(3), pp.133-141 [Peer Reviewed Journal]

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27
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Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis

Pamir, Nathalie ; Lynn, Francis C ; Buchan, Alison M J ; Ehses, Jan ; Hinke, Simon A ; Pospisilik, J Andrew ; Miyawaki, Kazumasa ; Yamada, Yuichiro ; Seino, Yutaka ; Mcintosh, Christopher H S ; Pederson, Raymond A

American journal of physiology. Endocrinology and metabolism, May 2003, Vol.284(5), pp.E931-9 [Peer Reviewed Journal]

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28
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Review
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Plasticity of the β cell insulin secretory competence: preparing the pancreatic β cell for the next meal

Hinke, Simon A. ; Hellemans, Karine ; Schuit, Frans C.

Journal of Physiology, July 2004, Vol.558(2), pp.369-380 [Peer Reviewed Journal]

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