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gem-Difluoroolefination of Diazo Compounds with TMSCF3 or TMSCF2Br: Transition-Metal-Free Cross-Coupling of Two Carbene Precursors

Hu, Mingyou ; Ni, Chuanfa ; Li, Lingchun ; Han, Yongxin ; Hu, Jinbo

Journal of the American Chemical Society, 18 November 2015, Vol.137(45), pp.14496-501 [Peer Reviewed Journal]

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Fast alternating projection methods for constrained tomographic reconstruction

Liu, Li ; Han, Yongxin ; Jin, Mingwu Zeng, Li (editor)

PLoS ONE, 2017, Vol.12(3) [Peer Reviewed Journal]

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Copper-mediated trifluoromethylthiolation of α-diazoesters

Hu, Mingyou ; Rong, Jian ; Miao, Wenjun ; Ni, Chuanfa ; Han, Yongxin ; Hu, Jinbo

Organic letters, 04 April 2014, Vol.16(7), pp.2030-3 [Peer Reviewed Journal]

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Novel S -Xanthenyl Protecting Groups for Cysteine and Their Applications for the N α -9-Fluorenylmethyloxycarbonyl (Fmoc) Strategy of Peptide Synthesis 1-3
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Novel S -Xanthenyl Protecting Groups for Cysteine and Their Applications for the N α -9-Fluorenylmethyloxycarbonyl (Fmoc) Strategy of Peptide Synthesis 1-3

Han, Yongxin ; Barany, George

The Journal of Organic Chemistry, 06/1997, Vol.62(12), pp.3841-3848 [Peer Reviewed Journal]

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5
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Repurposing a Histamine Detection Platform for High-Throughput Screening of Histidine Decarboxylase

Juang, Yu-Chi ; Fradera, Xavier ; Han, Yongxin ; Partridge, Anthony William

SLAS Discovery, October 2018, Vol.23(9), pp.974-981 [Peer Reviewed Journal]

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6
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A novel polymer-supported sulfur-transfer reagent for the synthesis of phosphorothioates

Zhang, Zhaoda ; Han, Yongxin ; Tang, Jimmy X ; Tang, Jin-Yan

Tetrahedron Letters, 2002, Vol.43(24), pp.4347-4349 [Peer Reviewed Journal]

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7
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One pot biaryl synthesis via in situ boronate formation

Giroux, André ; Han, Yongxin ; Prasit, Petpiboon

Tetrahedron Letters, 1997, Vol.38(22), pp.3841-3844 [Peer Reviewed Journal]

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8
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A divergent protocol for solid-phase synthesis of highly substituted Bi-aryl furan derivatives

Han, Yongxin ; Roy, Amélie ; Giroux, André

Tetrahedron Letters, 2000, Vol.41(29), pp.5447-5451 [Peer Reviewed Journal]

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9
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Synthesis of phenylacetic acids under rhodium-catalyzed carbonylation conditions

Giroux, André ; Nadeau, Christian ; Han, Yongxin

Tetrahedron Letters, 2000, Vol.41(40), pp.7601-7604 [Peer Reviewed Journal]

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10
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Occurrence and Minimization of Cysteine Racemization during Stepwise Solid-Phase Peptide Synthesis(1)(,)(2)

Han, Yongxin ; Albericio, Fernando ; Barany, George

The Journal of organic chemistry, 27 June 1997, Vol.62(13), pp.4307-4312 [Peer Reviewed Journal]

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11
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The discovery of 4-{1-({2,5-dimethyl-4-4-(trifluoromethyl)benzyl-3-thienyl}carbonyl)aminocyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist

Blouin, Marc ; Han, Yongxin ; Burch, Jason ; Farand, Julie ; Mellon, Christophe ; Gaudreault, Mireille ; Wrona, Mark ; Lévesque, Jean-François ; Denis, Danielle ; Mathieu, Marie-Claude ; Stocco, Rino ; Vigneault, Erika ; Therien, Alex ; Clark, Patsy ; Rowland, Steve ; Xu, Daigen ; O'Neill

Journal of medicinal chemistry, 11 March 2010, Vol.53(5), pp.2227-38 [Peer Reviewed Journal]

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12
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Facial selectivity in Diels-Alder reaction of 4,4-disubstituted 2,5-cyclohexadienones

Hsing-Jang, Liu ; Han, Yongxin

Tetrahedron Letters, 15 January 1993, Vol.34(3), pp.423-426 [Peer Reviewed Journal]

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13
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Silicon directed ipso-substitution of polymer bound arylsilanes: Preparation of biaryls via the Suzuki cross-coupling reaction

Han, Yongxin ; Walker, Shawn D ; Young, Robert N

Tetrahedron Letters, 1996, Vol.37(16), pp.2703-2706 [Peer Reviewed Journal]

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14
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Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis

Julien, Sofi G ; Dubé, Nadia ; Read, Michelle ; Penney, Janice ; Paquet, Marilene ; Han, Yongxin ; Kennedy, Brian P ; Muller, William J ; Tremblay, Michel L

Nature genetics, March 2007, Vol.39(3), pp.338-46 [Peer Reviewed Journal]

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15
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A caspase active site probe reveals high fractional inhibition needed to block DNA fragmentation

Méthot, Nathalie ; Vaillancourt, John P ; Huang, Jingqi ; Colucci, John ; Han, Yongxin ; Ménard, Stéphane ; Zamboni, Robert ; Toulmond, Sylvie ; Nicholson, Donald W ; Roy, Sophie

The Journal of biological chemistry, 02 July 2004, Vol.279(27), pp.27905-14 [Peer Reviewed Journal]

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16
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Correlating the fractional inhibition of caspase-3 in NT2 cells with apoptotic markers using an active-caspase-3 enzyme-linked immunosorbent assay

Tawa, Paul ; Giroux, Andre ; Grimm, Erich ; Han, Yongxin ; Nicholson, Donald W ; Xanthoudakis, Steven

Analytical Biochemistry, 2006, Vol.350(1), pp.32-40 [Peer Reviewed Journal]

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17
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Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP 4 receptor

Burch, Jason D ; Farand, Julie ; Colucci, John ; Sturino, Claudio ; Ducharme, Yves ; Friesen, Richard W ; Lévesque, Jean-François ; Gagné, Sébastien ; Wrona, Mark ; Therien, Alex G ; Mathieu, Marie-Claude ; Denis, Danielle ; Vigneault, Erika ; Xu, Daigen ; Clark, Patsy ; Rowland, Steve

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(3), pp.1041-1046 [Peer Reviewed Journal]

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18
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Applying the pro-drug approach to afford highly bioavailable antagonists of P2Y 14

Robichaud, Joël ; Fournier, Jean-François ; Gagné, Sébastien ; Gauthier, Jacques Yves ; Hamel, Martine ; Han, Yongxin ; Hénault, Martin ; Kargman, Stacia ; Levesque, Jean-François ; Mamane, Yaël ; Mancini, Joseph ; Morin, Nicolas ; Mulrooney, Erin

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(14), pp.4366-4368 [Peer Reviewed Journal]

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19
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Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of spirocyclic piperidines

Chen, Austin ; Aspiotis, Renee ; Campeau, Louis-Charles ; Cauchon, Elizabeth ; Chefson, Amadine ; Ducharme, Yves ; Falgueyret, Jean-Pierre ; Gagné, Sébastien ; Han, Yongxin ; Houle, Robert ; Laliberté, Sébastien ; Larouche, Guillaume ; Lévesque, Jean-François ; Mckay, Dan

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(24), pp.7399-7404 [Peer Reviewed Journal]

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20
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Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents

Lévesque, Jean-François ; Bleasby, Kelly ; Chefson, Amandine ; Chen, Austin ; Dubé, Daniel ; Ducharme, Yves ; Fournier, Pierre-André ; Gagné, Sébastien ; Gallant, Michel ; Grimm, Erich ; Hafey, Michael ; Han, Yongxin ; Houle, Robert ; Lacombe, Patrick

Bioorganic & Medicinal Chemistry Letters, 15 September 2011, Vol.21(18), pp.5547-5551 [Peer Reviewed Journal]

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21
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A novel series of potent and selective EP4 receptor ligands: Facile modulation of agonism and antagonism

Boyd, Michael J ; Berthelette, Carl ; Chiasson, Jean-François ; Clark, Patsy ; Colucci, John ; Denis, Danielle ; Han, Yongxin ; Lévesque, Jean-Francois ; Mathieu, Marie-Claude ; Stocco, Rino ; Therien, Alex ; Rowland, Steve ; Wrona, Mark ; Xu, Daigen

Bioorganic & Medicinal Chemistry Letters, 01 January 2011, Vol.21(1), pp.484-487 [Peer Reviewed Journal]

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22
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3,4-Diarylpiperidines as potent renin inhibitors

Lacombe, Patrick ; Arbour, Mélissa ; Aspiotis, Renée ; Cauchon, Elizabeth ; Chen, Austin ; Dubé, Daniel ; Falgueyret, Jean-Pierre ; Fournier, Pierre-André ; Gallant, Michel ; Grimm, Erich ; Han, Yongxin ; Juteau, Hélène ; Liu, Suzanna ; Mellon, Christophe

Bioorganic & Medicinal Chemistry Letters, 01 March 2012, Vol.22(5), pp.1953-1957 [Peer Reviewed Journal]

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23
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The Total Synthesis of Racemic Teucvin and 12‐ epi ‐Teucvin

Liu, Hsing‐Jang ; Zhu, Jia‐Liang ; Chen, I‐Chia ; Jankowska, Renata ; Han, Yongxin ; Shia, Kak‐Shan

Angewandte Chemie International Edition, 25 April 2003, Vol.42(16), pp.1851-1853 [Peer Reviewed Journal]

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24
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Preparation and Applications of Xanthenylamide (XAL) Handles for Solid-Phase Synthesis of C-Terminal Peptide Amides under Particularly Mild Conditions(1-3)

Han, Yongxin ; Bontems, Susan L ; Hegyes, Peter ; Munson, Mark C ; Minor, Charles A ; Kates, Steven A ; Albericio, Fernando ; Barany, George

The Journal of organic chemistry, 06 September 1996, Vol.61(18), pp.6326-6339 [Peer Reviewed Journal]

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25
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Remote electronic control in the regioselective reduction of succinimides: a practical, scalable synthesis of Ep4 antagonist MF-310

Molinaro, Carmela ; Gauvreau, Danny ; Hughes, Gregory ; Lau, Stephen ; Lauzon, Sophie ; Angelaud, Rémy ; O'Shea, Paul D ; Janey, Jacob ; Palucki, Michael ; Hoerrner, Scott R ; Raab, Conrad E ; Sidler, Rick R ; Belley, Michel ; Han, Yongxin

The Journal of organic chemistry, 04 September 2009, Vol.74(17), pp.6863-6 [Peer Reviewed Journal]

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26
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Design and synthesis of potent, isoxazole-containing renin inhibitors

Fournier, Pierre-André ; Arbour, Mélissa ; Cauchon, Elizabeth ; Chen, Austin ; Chefson, Amandine ; Ducharme, Yves ; Falgueyret, Jean-Pierre ; Gagné, Sébastien ; Grimm, Erich ; Han, Yongxin ; Houle, Robert ; Lacombe, Patrick ; Lévesque, Jean-François ; Macdonald, Dwight

Bioorganic & Medicinal Chemistry Letters, 15 April 2012, Vol.22(8), pp.2670-2674 [Peer Reviewed Journal]

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27
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Discovery of Disubstituted Imidazo4,5-bpyridines and Purines as Potent TrkA Inhibitors

Wang, Tao ; Lamb, Michelle L ; Block, Michael H ; Davies, Audrey Molina ; Han, Yongxin ; Hoffmann, Ethan ; Ioannidis, Stephanos ; Josey, John A ; Liu, Zhong-Ying ; Lyne, Paul D ; Macintyre, Terry ; Mohr, Peter J ; Omer, Charles A ; Sjögren, Tove ; Thress, Kenneth ; Wang, Bin ; Wang, Haiyun ; Yu, Dingwei ; Zhang

ACS medicinal chemistry letters, 13 September 2012, Vol.3(9), pp.705-9 [Peer Reviewed Journal]

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28
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CT-721, a Potent Bcr-Abl Inhibitor, Exhibits Excellent and Efficacy in the Treatment of Chronic Myeloid Leukemia

Sun, Yinghui ; Zhao, Na ; Wang, Huan ; Wu, Qiong ; Han, Yunqi ; Liu, Qichao ; Wu, Mangang ; Liu, Yuliang ; Kong, Fansheng ; Wang, He ; Sun, Ying ; Sun, Deguang ; Jing, Lutao ; Tang, Guojing ; Hu, Yuandong ; Xiao, Dengming ; Luo, Hong ; Han, Yongxin ; Peng, Yong

Journal of Cancer, 2017, Vol.8(14), pp.2774-2784 [Peer Reviewed Journal]

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29
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Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of pyridone-substituted piperidines

Chen, Austin ; Campeau, Louis-Charles ; Cauchon, Elizabeth ; Chefson, Amandine ; Ducharme, Yves ; Dubé, Daniel ; Falgueyret, Jean-Pierre ; Fournier, Pierre-André ; Gagné, Sébastien ; Grimm, Erich ; Han, Yongxin ; Houle, Robert ; Huang, Jing-Qi ; Lacombe, Patrick ; Laliberté, Sébastien

Bioorganic & Medicinal Chemistry Letters, 01 July 2011, Vol.21(13), pp.3970-3975 [Peer Reviewed Journal]

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30
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Discovery of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain

Colucci, John ; Boyd, Michael ; Berthelette, Carl ; Chiasson, Jean-Francois ; Wang, Zhaoyin ; Ducharme, Yves ; Friesen, Rick ; Wrona, Mark ; Levesque, Jean-Francois ; Denis, Danielle ; Mathieu, Marie-Claude ; Stocco, Rino ; Therien, Alex G ; Clarke, Patsy ; Rowland, Steve ; Xu, Daigen ; Han, Yongxin

Bioorganic & Medicinal Chemistry Letters, 15 June 2010, Vol.20(12), pp.3760-3763 [Peer Reviewed Journal]

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31
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Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury

Han, Byung Hee ; Xu, Daigen ; Choi, Junjeong ; Han, Yongxin ; Xanthoudakis, Steven ; Roy, Sophie ; Tam, John ; Vaillancourt, John ; Colucci, John ; Siman, Robert ; Giroux, Andre ; Robertson, George S ; Zamboni, Robert ; Nicholson, Donald W ; Holtzman, David M

The Journal of biological chemistry, 16 August 2002, Vol.277(33), pp.30128-36 [Peer Reviewed Journal]

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32
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Solid phase parallel synthesis of highly substituted thiophene derivatives and identification of novel phosphodiesterase-4 (PDE-4) inhibitors

Han, Yongxin ; Giroux, André ; Lépine, Carole ; Laliberté, France ; Huang, Zheng ; Perrier, Hélène ; Bayly, Christopher I ; Young, Robert N

Tetrahedron, 1999, Vol.55(39), pp.11669-11685 [Peer Reviewed Journal]

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33
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Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases

Wang, Tao ; Lamb, Michelle L ; Scott, David A ; Wang, Haixia ; Block, Michael H ; Lyne, Paul D ; Lee, John W ; Davies, Audrey M ; Zhang, Hai-Jun ; Zhu, Yanyi ; Gu, Fei ; Han, Yongxin ; Wang, Bin ; Mohr, Peter J ; Kaus, Robert J ; Josey, John A ; Hoffmann, Ethan ; Thress, Ken ; Macintyre, Terry ; Wang

Journal of medicinal chemistry, 14 August 2008, Vol.51(15), pp.4672-84 [Peer Reviewed Journal]

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34
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Prostaglandin E 2-bisphosphonate conjugates: potential agents for treatment of osteoporosis

Gil, Laurent ; Han, Yongxin ; Opas, Evan E ; Rodan, Gideon A ; Ruel, Réjean ; Seedor, J.Gregory ; Tyler, Peter C ; Young, Robert N

Bioorganic & Medicinal Chemistry, 1999, Vol.7(5), pp.901-919 [Peer Reviewed Journal]

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35
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Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis

Becker, Joseph W ; Rotonda, Jennifer ; Soisson, Stephen M ; Aspiotis, Renee ; Bayly, Christopher ; Francoeur, Sébastien ; Gallant, Michel ; Garcia-Calvo, Marga ; Giroux, Andre ; Grimm, Erich ; Han, Yongxin ; Mckay, Dan ; Nicholson, Donald W ; Peterson, Erin ; Renaud, Johanne ; Roy, Sophie ; Thornberry, Nancy ; Zamboni, Robert

Journal of medicinal chemistry, 06 May 2004, Vol.47(10), pp.2466-74 [Peer Reviewed Journal]

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36
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Novel Quinoline-Based P2-P4 Macrocyclic Derivatives As Pan-Genotypic HCV NS3/4a Protease Inhibitors

Shah, Unmesh ; Jayne, Charles ; Chackalamannil, Samuel ; Velázquez, Francisco ; Guo, Zhuyan ; Buevich, Alexei ; Howe, John A ; Chase, Robert ; Soriano, Aileen ; Agrawal, Sony ; Rudd, Michael T ; Mccauley, John A ; Liverton, Nigel J ; Romano, Joseph ; Bush, Kimberly ; Coleman, Paul J ; Grisé-Bard, Christiane ; Brochu

ACS medicinal chemistry letters, 13 March 2014, Vol.5(3), pp.264-9 [Peer Reviewed Journal]

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37