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The effect of alcohol and gemfibrozil co-administration in Wistar rats

Kolovou, Genovefa D ; Mikhailidis, Dimitri P ; Kafaltis, Nikolaos ; Adamopoulou, Evdokia N ; Yazitsoglou, Elefterios ; Hatzaki, Aggeliki ; Pilatis, Nectarios ; Margeli, Alexandra P ; Salpea, Klelia D ; Mykoniatis, Michael ; Cokkinos, Dennis V

In vivo (Athens, Greece), 2004, Vol.18(1), pp.49-53 [Peer Reviewed Journal]

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Systematic analysis of cell cycle effects of common drugs leads to the discovery of a suppressive interaction between gemfibrozil and fluoxetine

Hoose, Scott A ; Duran, Camille ; Malik, Indranil ; Eslamfam, Shabnam ; Shasserre, Samantha C ; Downing, S Sabina ; Hoover, Evelyn M ; Dowd, Katherine E ; Smith, Roger ; Polymenis, Michael

PloS one, 2012, Vol.7(5), pp.e36503 [Peer Reviewed Journal]

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The influence of gemfibrozil on malondialdehyde level and paraoxonase 1 activity in wistar and fisher rats

Macan, Marija ; Marija, Macan ; Konjevoda, Paško ; Paško, Konjevoda ; Lovric, Jasna ; Jasna, Lovrić ; Koprivanac, Marijan ; Marijan, Koprivanac ; Kelava, Marta ; Marta, Kelava ; Vrkic, Nada ; Nada, Vrkić ; Bradamante, Vlasta ; Vlasta, Bradamante

Basic & clinical pharmacology & toxicology, June 2011, Vol.108(6), pp.428-35 [Peer Reviewed Journal]

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The Role of Metformin Response in Lipid Metabolism in Patients with Recent-Onset Type 2 Diabetes: HbA1c Level as a Criterion for Designating Patients as Responders or Nonresponders to Metformin

Kashi, Zahra ; Mahrooz, Abdolkarim ; Kianmehr, Anvarsadat ; Alizadeh, Ahad

PloS one, 2016, Vol.11(3), pp.e0151543 [Peer Reviewed Journal]

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The PPAR alpha agonist gemfibrozil is an ineffective treatment for spinal cord injured mice

Almad, Akshata ; Lash, A Todd ; Wei, Ping ; Lovett-Racke, Amy E ; Mctigue, Dana M

Experimental neurology, December 2011, Vol.232(2), pp.309-17 [Peer Reviewed Journal]

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Pharmacological preconditioning with gemfibrozil preserves cardiac function after heart transplantation

Benke, Kálmán ; Mátyás, Csaba ; Sayour, Alex Ali ; Oláh, Attila ; Németh, Balázs Tamás ; Ruppert, Mihály ; Szabó, Gábor ; Kökény, Gábor ; Horváth, Eszter Mária ; Hartyánszky, István ; Szabolcs, Zoltán ; Merkely, Béla ; Radovits, Tamás

Scientific reports, 27 October 2017, Vol.7(1), pp.14232 [Peer Reviewed Journal]

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Impact of the CYP2C8 *3 polymorphism on the drug-drug interaction between gemfibrozil and pioglitazone

Aquilante, Christina L ; Kosmiski, Lisa A ; Bourne, David W A ; Bushman, Lane R ; Daily, Elizabeth B ; Hammond, Kyle P ; Hopley, Charles W ; Kadam, Rajendra S ; Kanack, Alexander T ; Kompella, Uday B ; Le, Merry ; Predhomme, Julie A ; Rower, Joseph E ; Sidhom, Maha S

British journal of clinical pharmacology, January 2013, Vol.75(1), pp.217-26 [Peer Reviewed Journal]

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Gemfibrozil, a lipid-lowering drug, induces suppressor of cytokine signaling 3 in glial cells: implications for neurodegenerative disorders

Ghosh, Arunava ; Pahan, Kalipada

The Journal of biological chemistry, 03 August 2012, Vol.287(32), pp.27189-203 [Peer Reviewed Journal]

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Effects of gemfibrozil on lipid metabolism, steroidogenesis, and reproduction in the fathead minnow (Pimephales promelas)

Skolness, Sarah Y ; Durhan, Elizabeth J ; Jensen, Kathleen M ; Kahl, Michael D ; Makynen, Elizabeth A ; Villeneuve, Daniel L ; Ankley, Gerald T

Environmental toxicology and chemistry, November 2012, Vol.31(11), pp.2615-24 [Peer Reviewed Journal]

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Repaglinide-gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism

Gan, Jinping ; Chen, Weiqi ; Shen, Hong ; Gao, Ling ; Hong, Yang ; Tian, Yuan ; Li, Wenying ; Zhang, Yueping ; Tang, Yuwei ; Zhang, Hongjian ; Humphreys, William Griffith ; Rodrigues, A David

British journal of clinical pharmacology, December 2010, Vol.70(6), pp.870-80 [Peer Reviewed Journal]

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Evidence of direct smooth muscle relaxant effects of the fibrate gemfibrozil

Phelps, Laura E ; Peuler, Jacob D

Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2010, Vol.46(3), pp.125-42 [Peer Reviewed Journal]

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Gemfibrozil, a lipid-lowering drug, inhibits the induction of nitric-oxide synthase in human astrocytes

Pahan, Kalipada ; Jana, Malabendu ; Liu, Xiaojuan ; Taylor, Bradley S ; Wood, Charles ; Fischer, Susan M

The Journal of biological chemistry, 29 November 2002, Vol.277(48), pp.45984-91 [Peer Reviewed Journal]

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Gemfibrozil increases the specific binding of rat-cortex nuclear extracts to a PPRE probe

Sanguino, Elena ; Ramón, Miguel ; Roglans, Núria ; Alegret, Marta ; Sánchez, Rosa M ; Vázquez-Carrera, Manuel ; Laguna, Juan C

Life sciences, 24 October 2003, Vol.73(23), pp.2927-37 [Peer Reviewed Journal]

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Effects of gemfibrozil on triglyceride metabolism in Dahl salt-sensitive rats

Donnelly, R ; Plato, P A ; Chang, H ; Reaven, G M

The Journal of pharmacology and experimental therapeutics, August 1994, Vol.270(2), pp.809-13 [Peer Reviewed Journal]

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Gemfibrozil, food and drug administration-approved lipid-lowering drug, increases longevity in mouse model of late infantile neuronal ceroid lipofuscinosis

Ghosh, Arunava ; Rangasamy, Suresh Babu ; Modi, Khushbu K ; Pahan, Kalipada

Journal of neurochemistry, May 2017, Vol.141(3), pp.423-435 [Peer Reviewed Journal]

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16
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Effect of gemfibrozil and fenofibrate on the pharmacokinetics of atorvastatin

Whitfield, Lloyd R ; Porcari, Anthony R ; Alvey, Christine ; Abel, Robert ; Bullen, William ; Hartman, Daniel

Journal of clinical pharmacology, March 2011, Vol.51(3), pp.378-88 [Peer Reviewed Journal]

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17
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Activation of peroxisome proliferator-activated receptor α induces lysosomal biogenesis in brain cells: implications for lysosomal storage disorders

Ghosh, Arunava ; Jana, Malabendu ; Modi, Khushbu ; Gonzalez, Frank J ; Sims, Katherine B ; Berry-Kravis, Elizabeth ; Pahan, Kalipada

The Journal of biological chemistry, 17 April 2015, Vol.290(16), pp.10309-24 [Peer Reviewed Journal]

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18
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Induction of P450 3A1/2 and 2C6 by gemfibrozil in Sprague-Dawley rats

Liu, Aiming ; Yang, Julin ; Zhao, Xin ; Jiao, Xiaolan ; Zhao, Weihong ; Ma, Qing ; Tang, Zhiyuan ; Dai, Renke

Pharmacological reports : PR, 2011, Vol.63(1), pp.157-64 [Peer Reviewed Journal]

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19
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The fibrate gemfibrozil is a NO- and haem-independent activator of soluble guanylyl cyclase: in vitro studies

Sharina, I G ; Sobolevsky, M ; Papakyriakou, A ; Rukoyatkina, N ; Spyroulias, G A ; Gambaryan, S ; Martin, E

British journal of pharmacology, May 2015, Vol.172(9), pp.2316-29 [Peer Reviewed Journal]

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20
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Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-β

Jana, Malabendu ; Mondal, Susanta ; Gonzalez, Frank J ; Pahan, Kalipada

The Journal of biological chemistry, 05 October 2012, Vol.287(41), pp.34134-48 [Peer Reviewed Journal]

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21
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Impact of obesity on hypertension-induced cardiac remodeling: role of oxidative stress and its modulation by gemfibrozil treatment in rats

Singh, Randhir ; Singh, Amrit Pal ; Singh, Manjeet ; Krishan, Pawan

Free radical biology & medicine, 15 January 2011, Vol.50(2), pp.363-70 [Peer Reviewed Journal]

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22
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PPARα-dependent increase of mouse urine output by gemfibrozil and fenofibrate

Song, Danjun ; Luo, Min ; Dai, Manyun ; Bu, Shizhong ; Wang, Weihua ; Zhang, Burong ; Gonzalez, Frank J ; Liu, Aiming

Canadian journal of physiology and pharmacology, February 2017, Vol.95(2), pp.199-205 [Peer Reviewed Journal]

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23
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Protein-DNA interactions at a drug-responsive element of the human apolipoprotein A-I gene

Zhang, X ; Chen, Z Q ; Wang, Z ; Mohan, W ; Tam, S P

The Journal of biological chemistry, 25 October 1996, Vol.271(43), pp.27152-60 [Peer Reviewed Journal]

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24
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Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats

Macan, Marija ; Vrkić, Nada ; Vrdoljak, Ana Lucić ; Radić, Božica ; Bradamante, Vlasta

Acta biochimica Polonica, 2010, Vol.57(3), pp.321-6 [Peer Reviewed Journal]

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25
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Chronic treatment with fibrates elevates superoxide dismutase in adult mouse brain microvessels

Wang, Guangming ; Liu, Xiaowei ; Guo, Qingmin ; Namura, Shobu

Brain research, 04 November 2010, Vol.1359, pp.247-55 [Peer Reviewed Journal]

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26
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Stimulatory effect of clofibrate and gemfibrozil administration on the formation of fatty acid esters of estradiol by rat liver microsomes

Xu, S ; Zhu, B T ; Conney, A H

The Journal of pharmacology and experimental therapeutics, January 2001, Vol.296(1), pp.188-97 [Peer Reviewed Journal]

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27
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Inhibition of rat liver microsomal fatty acid chain elongation by gemfibrozil in vitro

Sánchez, R M ; Viñals, M ; Alegret, M ; Vázquez, M ; Adzet, T ; Merlos, M ; Laguna, J C

FEBS letters, 23 March 1992, Vol.300(1), pp.89-92 [Peer Reviewed Journal]

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28
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Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression

Miller, C W ; Ntambi, J M

Proceedings of the National Academy of Sciences of the United States of America, 03 September 1996, Vol.93(18), pp.9443-8 [Peer Reviewed Journal]

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29
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Peroxisome Proliferator-Activated Receptor α Activation Suppresses Cytochrome P450 Induction Potential in Mice Treated with Gemfibrozil

Shi, Cunzhong ; Min, Luo ; Yang, Julin ; Dai, Manyun ; Song, Danjun ; Hua, Huiying ; Xu, Gangming ; Gonzalez, Frank J ; Liu, Aiming

Basic & clinical pharmacology & toxicology, September 2017, Vol.121(3), pp.169-174 [Peer Reviewed Journal]

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30
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Gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor α: implications for late infantile Batten disease therapy

Ghosh, Arunava ; Corbett, Grant T ; Gonzalez, Frank J ; Pahan, Kalipada

The Journal of biological chemistry, 09 November 2012, Vol.287(46), pp.38922-35 [Peer Reviewed Journal]

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31
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PPARα agonists inhibit inflammatory activation of macrophages through upregulation of β-defensin 1

Ann, Soo-Jin ; Chung, Ji Hyung ; Park, Byung Hee ; Kim, Soo Hyuk ; Jang, Jiyoung ; Park, Sungha ; Kang, Seok-Min ; Lee, Sang-Hak

Atherosclerosis, June 2015, Vol.240(2), pp.389-97 [Peer Reviewed Journal]

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32
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Fibrates inhibit the apoptosis of Batten disease lymphoblast cells via autophagy recovery and regulation of mitochondrial membrane potential

Hong, Minho ; Song, Ki Duk ; Lee, Hak-Kyo ; Yi, Sunshin ; Lee, Yong Seok ; Heo, Tae-Hwe ; Jun, Hyun Sik ; Kim, Sung-Jo

In vitro cellular & developmental biology. Animal, March 2016, Vol.52(3), pp.349-355 [Peer Reviewed Journal]

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33
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Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data

Kim, Soo-Jin ; Toshimoto, Kota ; Yao, Yoshiaki ; Yoshikado, Takashi ; Sugiyama, Yuichi

Journal of pharmaceutical sciences, September 2017, Vol.106(9), pp.2715-2726 [Peer Reviewed Journal]

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34
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Assessment of the drug interaction potential and single- and repeat-dose pharmacokinetics of the BRAF inhibitor dabrafenib

Suttle, A Benjamin ; Grossmann, Kenneth F ; Ouellet, Daniele ; Richards-Peterson, Lauren E ; Aktan, Gursel ; Gordon, Michael S ; Lorusso, Patricia M ; Infante, Jeffrey R ; Sharma, Sunil ; Kendra, Kari ; Patel, Manish ; Pant, Shubham ; Arkenau, Hendrik-Tobias ; Middleton, Mark R ; Blackman, Samuel C ; Botbyl, Jeff ; Carson, Stanley W

Journal of clinical pharmacology, April 2015, Vol.55(4), pp.392-400 [Peer Reviewed Journal]

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35
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Gemfibrozil has antidepressant effects in mice: Involvement of the hippocampal brain-derived neurotrophic factor system

Ni, Yu-Fei ; Wang, Hao ; Gu, Qiu-Yan ; Wang, Fei-Ying ; Wang, Ying-Jie ; Wang, Jin-Liang ; Jiang, Bo

Journal of psychopharmacology (Oxford, England), April 2018, Vol.32(4), pp.469-481 [Peer Reviewed Journal]

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36
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Involvement of phosphatidylinositol 3-kinase-mediated up-regulation of I kappa B alpha in anti-inflammatory effect of gemfibrozil in microglia

Jana, Malabendu ; Jana, Arundhati ; Liu, Xiaojuan ; Ghosh, Sankar ; Pahan, Kalipada

Journal of immunology (Baltimore, Md. : 1950), 15 September 2007, Vol.179(6), pp.4142-52 [Peer Reviewed Journal]

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37
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Gemfibrozil treatment of hypertriglyceridemia: improvement on fibrinolysis without change of insulin resistance

Jeng, J R ; Jeng, C Y ; Sheu, W H ; Lee, M M ; Huang, S H ; Shieh, S M

American heart journal, September 1997, Vol.134(3), pp.565-71 [Peer Reviewed Journal]

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Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil

Shitara, Yoshihisa ; Hirano, Masaru ; Sato, Hitoshi ; Sugiyama, Yuichi

The Journal of pharmacology and experimental therapeutics, October 2004, Vol.311(1), pp.228-36 [Peer Reviewed Journal]

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