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Studies Directed toward the Synthesis of the Unusual Antileukemic Diterpene Jatrophatrione. 2. Functionalization of Advanced Polycyclic Precursors to the 9-Epi and 8,9-Dehydro Congeners

Paquette, Leo A ; Edmondson, Scott D ; Monck, Nathaniel ; Rogers, Robin D

The Journal of organic chemistry, 30 April 1999, Vol.64(9), pp.3255-3265 [Peer Reviewed Journal]

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Design, synthesis, and evaluation of conformationally restricted acetanilides as potent and selective β3 adrenergic receptor agonists for the treatment of overactive bladder

Moyes, Christopher R ; Berger, Richard ; Goble, Stephen D ; Harper, Bart ; Shen, Dong-Ming ; Wang, Liping ; Bansal, Alka ; Brown, Patricia N ; Chen, Airu S ; Dingley, Karen H ; Di Salvo, Jerry ; Fitzmaurice, Aileen ; Gichuru, Loise N ; Hurley, Amanda L ; Jochnowitz, Nina ; Miller, Randall R ; Mistry, Shruty ; Nagabukuro, Hiroshi ; Salituro, Gino M ; Sanfiz

Journal of medicinal chemistry, 27 February 2014, Vol.57(4), pp.1437-53 [Peer Reviewed Journal]

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Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder

Edmondson, Scott D ; Zhu, Cheng ; Kar, Nam Fung ; Di Salvo, Jerry ; Nagabukuro, Hiroshi ; Sacre-Salem, Beatrice ; Dingley, Karen ; Berger, Richard ; Goble, Stephen D ; Morriello, Gregori ; Harper, Bart ; Moyes, Christopher R ; Shen, Dong-Ming ; Wang, Liping ; Ball, Richard ; Fitzmaurice, Aileen ; Frenkl, Tara ; Gichuru, Loise N ; Ha, Sookhee ; Hurley

Journal of medicinal chemistry, 28 January 2016, Vol.59(2), pp.609-23 [Peer Reviewed Journal]

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The Total Synthesis of Spirotryprostatin A

Edmondson, Scott D. ; Danishefsky, Samuel J.

Angewandte Chemie International Edition, 04 May 1998, Vol.37(8), pp.1138-1140 [Peer Reviewed Journal]

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Conformational Analysis of Poly(spirotetrahydrofuranyl)cyclohexyl Systems. The Preference of Multiple C−O Bonds for Equatorial Occupancy
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Conformational Analysis of Poly(spirotetrahydrofuranyl)cyclohexyl Systems. The Preference of Multiple C−O Bonds for Equatorial Occupancy

Paquette, Leo A. ; Stepanian, Marshall ; Branan, Bruce M. ; Edmondson, Scott D. ; Bauer, Cary B. ; Rogers, Robin D.

Journal of the American Chemical Society, 01/1996, Vol.118(18), pp.4504-4505 [Peer Reviewed Journal]

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Palladium-Catalyzed Coupling of Vinylogous Amides with Aryl Halides: Applications to the Synthesis of Heterocycles
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Palladium-Catalyzed Coupling of Vinylogous Amides with Aryl Halides: Applications to the Synthesis of Heterocycles

Edmondson, Scott D. ; Mastracchio, Anthony ; Parmee, Emma R.

Organic Letters, 04/2000, Vol.2(8), pp.1109-1112 [Peer Reviewed Journal]

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7
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Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists

Wang, Liping ; Hubert, James A ; Lee, Susan J ; Pan, Jie ; Qian, Su ; Reitman, Marc L ; Strack, Alison M ; Weingarth, Drew T ; Macneil, Douglas J ; Weber, Ann E ; Edmondson, Scott D

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(10), pp.2911-2915 [Peer Reviewed Journal]

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Discovery of benzamides as potent human β3 adrenergic receptor agonists

Zhu, Cheng ; Kar, Nam F ; Li, Bing ; Costa, Melissa ; Dingley, Karen H ; Di Salvo, Jerry ; Ha, Sookhee N ; Hurley, Amanda L ; Li, Xiaofang ; Miller, Randy R ; Salituro, Gino M ; Struthers, Mary ; Weber, Ann E ; Hale, Jeffrey J ; Edmondson, Scott D

Bioorganic & Medicinal Chemistry Letters, 01 January 2016, Vol.26(1), pp.55-59 [Peer Reviewed Journal]

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Studies Directed toward the Synthesis of the Unusual Antileukemic Diterpene Jatrophatrione. 1. A Solution to the Problem of Chirality Merger during Elaboration of the Entire Carbotricyclic Framework

Paquette, Leo A ; Nakatani, Shogo ; Zydowsky, Thomas M ; Edmondson, Scott D ; Sun, Li-Qiang ; Skerlj, Renato

The Journal of organic chemistry, 30 April 1999, Vol.64(9), pp.3244-3254 [Peer Reviewed Journal]

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Investigation of piperazine benzamides as human β3 adrenergic receptor agonists for the treatment of overactive bladder

Harper, Bart H ; Wang, Liping ; Zhu, Cheng ; Kar, Nam F ; Li, Bing ; Moyes, Christopher R ; Goble, Stephen D ; Costa, Melissa ; Dingley, Karen ; Di Salvo, Jerry ; Ha, Sookhee N ; Hurley, Amanda ; Li, Xiaofang ; Miller, Randy R ; Nagabukuro, Hiroshi ; Salituro, Gino M ; Smith, Sean ; Struthers, Mary ; Hale, Jeffrey J ; Edmondson, Scott D

Bioorganic & Medicinal Chemistry Letters, 15 February 2017, Vol.27(4), pp.1094-1098 [Peer Reviewed Journal]

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A concise route to the tetracyclic core of phorbol

Paquette, Leo A ; Sauer, Daryl R ; Edmondson, Scott D ; Friedrich, Dirk

Tetrahedron, 1994, Vol.50(14), pp.4071-4086 [Peer Reviewed Journal]

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Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity

Scapin, Giovanna ; Patel, Sangita B ; Chung, Christine ; Varnerin, Jeffrey P ; Edmondson, Scott D ; Mastracchio, Anthony ; Parmee, Emma R ; Singh, Suresh B ; Becker, Joseph W ; Van Der Ploeg, Lex H T ; Tota, Michael R

Biochemistry, 25 May 2004, Vol.43(20), pp.6091-100 [Peer Reviewed Journal]

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Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with Activity in Rodents

Adams, Gregory L ; Velazquez, Francisco ; Jayne, Charles ; Shah, Unmesh ; Miao, Shouwu ; Ashley, Eric R ; Madeira, Maria ; Akiyama, Taro E ; Di Salvo, Jerry ; Suzuki, Takao ; Wang, Nengxue ; Truong, Quang ; Gilbert, Eric ; Zhou, Dan ; Verras, Andreas ; Kirkland, Melissa ; Pachanski, Michele ; Powles, Maryann ; Yin, Wu ; Ujjainwalla

ACS medicinal chemistry letters, 12 January 2017, Vol.8(1), pp.96-101 [Peer Reviewed Journal]

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14
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Discovery of phenyl acetamides as potent and selective GPR119 agonists

Zhu, Cheng ; Wang, Liping ; Zhu, Yuping ; Guo, Zack Zhiqiang ; Liu, Ping ; Hu, Zhiyong ; Szewczyk, Jason W ; Kang, Ling ; Chicchi, Gary ; Ehrhardt, Anka ; Woods, Andrea ; Seo, Toru ; Woods, Morgan ; van Heek, Margaret ; Dingley, Karen H ; Pang, Jianmei ; Salituro, Gino M ; Powell, Joyce ; Terebetski, Jenna L ; Hornak, Viktor

Bioorganic & Medicinal Chemistry Letters, 01 March 2017, Vol.27(5), pp.1124-1128 [Peer Reviewed Journal]

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15
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Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β 3 adrenergic receptor agonists

Morriello, Gregori J ; Wendt, Harvey R ; Bansal, Alka ; Salvo, Jerry Di ; Feighner, Scott ; He, Jiafang ; Hurley, Amanda L ; Hreniuk, Donna L ; Salituro, Gino M ; Reddy, Marat Vijay ; Galloway, Sheila M ; Mcgettigan, Katherine K ; Laws, George ; Mcknight, Crystal ; Doss, George A ; Tsou, Nancy N ; Black, Regina M ; Morris, Judy ; Ball, Richard G ; Sanfiz, Anthony T

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(6), pp.1865-1870 [Peer Reviewed Journal]

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16
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Heterocyclic acetamide and benzamide derivatives as potent and selective β 3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles

Goble, Stephen D ; Wang, Liping ; Howell, K. Lulu ; Bansal, Alka ; Berger, Richard ; Brockunier, Linda ; Disalvo, Jerry ; Feighner, Scott ; Harper, Bart ; He, Jiafang ; Hurley, Amanda ; Hreniuk, Donna ; Parmee, Emma ; Robbins, Michael ; Salituro, Gino ; Sanfiz, Anthony ; Streckfuss, Eric ; Watkins, Eloisa ; Weber, Ann E ; Struthers, Mary

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(6), pp.1895-1899 [Peer Reviewed Journal]

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17
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Proteolysis targeting chimeras (PROTACs) in ‘beyond rule-of-five’ chemical space: Recent progress and future challenges

Edmondson, Scott D ; Yang, Bin ; Fallan, Charlene

Bioorganic & Medicinal Chemistry Letters, 01 July 2019, Vol.29(13), pp.1555-1564 [Peer Reviewed Journal]

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18
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Totalsynthese von Spirotryprostatin A

Edmondson, ScottD. ; Danishefsky, Samuel J.

Angewandte Chemie, 20 April 1998, Vol.110(8), pp.1190-1193 [Peer Reviewed Journal]

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19
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Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes

Guo, Liangqin ; Parker, Dann L ; Zang, Yi ; Sweis, Ramzi F ; Liu, Weiguo ; Sherer, Edward C ; Buist, Nicole ; Terebetski, Jenna ; Kelly, Terri ; Bugianesi, Randal ; Priest, Birgit T ; Dingley, Karen H ; Li, Xiaofang ; Mitelman, Stan ; Salituro, Gino ; Trujillo, Maria E ; Pachanski, Michele ; Kirkland, Melissa ; Powles, Mary Ann ; Eiermann

ACS medicinal chemistry letters, 08 December 2016, Vol.7(12), pp.1107-1111 [Peer Reviewed Journal]

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20
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Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes

Liu, Ping ; Hu, Zhiyong ; Dubois, Byron G ; Moyes, Christopher R ; Hunter, David N ; Zhu, Cheng ; Kar, Nam Fung ; Zhu, Yuping ; Garfunkle, Joie ; Kang, Ling ; Chicchi, Gary ; Ehrhardt, Anka ; Woods, Andrea ; Seo, Toru ; Woods, Morgan ; Van Heek, Margaret ; Dingley, Karen H ; Pang, Jianmei ; Salituro, Gino M ; Powell

ACS medicinal chemistry letters, 13 August 2015, Vol.6(8), pp.936-41 [Peer Reviewed Journal]

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21
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(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-1,2,4triazolo1,5-a-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Edmondson, Scott D ; Mastracchio, Anthony ; Mathvink, Robert J ; He, Jiafang ; Harper, Bart ; Park, You-Jung ; Beconi, Maria ; Di Salvo, Jerry ; Eiermann, George J ; He, Huaibing ; Leiting, Barbara ; Leone, Joseph F ; Levorse, Dorothy A ; Lyons, Kathryn ; Patel, Reshma A ; Patel, Sangita B ; Petrov, Aleksandr ; Scapin, Giovanna ; Shang, Jackie ; Roy

Journal of medicinal chemistry, 15 June 2006, Vol.49(12), pp.3614-27 [Peer Reviewed Journal]

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22
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Crystallization and preliminary X‐ray diffraction analysis of the catalytic domain of recombinant human phosphodiesterase 3B

Patel, Sangita B. ; Varnerin, Jeffrey P. ; Tota, Michael R. ; Edmondson, Scott D. ; Parmee, Emma R. ; Becker, Joseph W. ; Scapin, Giovanna

Acta Crystallographica Section D, January 2004, Vol.60(1), pp.169-171 [Peer Reviewed Journal]

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23
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Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors

Edmondson, Scott D ; Mastracchio, Anthony ; Cox, Jason M ; Eiermann, George J ; He, Huaibing ; Lyons, Kathryn A ; Patel, Reshma A ; Patel, Sangita B ; Petrov, Aleksandr ; Scapin, Giovanna ; Wu, Joseph K ; Xu, Shiyao ; Zhu, Bing ; Thornberry, Nancy A ; Roy, Ranabir Sinha ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 01 August 2009, Vol.19(15), pp.4097-4101 [Peer Reviewed Journal]

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24
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Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors

Cox, Jason M ; Harper, Bart ; Mastracchio, Anthony ; Leiting, Barbara ; Sinha Roy, Ranabir ; Patel, Reshma A ; Wu, Joseph K ; Lyons, Kathryn A ; He, Huaibing ; Xu, Shiyao ; Zhu, Bing ; Thornberry, Nancy A ; Weber, Ann E ; Edmondson, Scott D

Bioorganic & Medicinal Chemistry Letters, 15 August 2007, Vol.17(16), pp.4579-4583 [Peer Reviewed Journal]

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25
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2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity

Berger, Richard ; Zhu, Cheng ; Hansen, Alexa R ; Harper, Bart ; Chen, Zhesheng ; Holt, Tom G ; Hubert, James ; Lee, Susan J ; Pan, Jie ; Qian, Su ; Reitman, Marc L ; Strack, Alison M ; Weingarth, Drew T ; Wolff, Michael ; Macneil, Douglas J ; Weber, Ann E ; Edmondson, Scott D

Bioorganic & Medicinal Chemistry Letters, 01 September 2008, Vol.18(17), pp.4833-4837 [Peer Reviewed Journal]

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26
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Discovery of imidazole carboxamides as potent and selective CCK1R agonists

Zhu, Cheng ; Hansen, Alexa R ; Bateman, Thomas ; Chen, Zhesheng ; Holt, Tom G ; Hubert, James A ; Karanam, Bindhu V ; Lee, Susan J ; Pan, Jie ; Qian, Su ; Reddy, Vijay B.G ; Reitman, Marc L ; Strack, Alison M ; Tong, Vincent ; Weingarth, Drew T ; Wolff, Michael S ; Macneil, Doug J ; Weber, Ann E ; Duffy, Joseph L ; Edmondson, Scott D

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(15), pp.4393-4396 [Peer Reviewed Journal]

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27
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Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors

Edmondson, Scott D ; Wei, Lan ; Xu, Jinyou ; Shang, Jackie ; Xu, Shiyao ; Pang, Jianmei ; Chaudhary, Ashok ; Dean, Dennis C ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathryn A ; Patel, Reshma A ; Patel, Sangita B ; Scapin, Giovanna ; Wu, Joseph K ; Beconi, Maria G ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(7), pp.2409-2413 [Peer Reviewed Journal]

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28
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CCDC 1421635: Experimental Crystal Structure Determination

Edmondson, Scott D. ; Zhu, Cheng ; Kar, Nam Fung ; Di Salvo, Jerry ; Nagabukuro, Hiroshi ; Sacre-Salem, Beatrice ; Dingley, Karen ; Berger, Richard ; Goble, Stephen D. ; Morriello, Gregori ; Harper, Bart ; Moyes, Christopher R. ; Shen, Dong-Ming ; Wang, Liping ; Ball, Richard ; Fitzmaurice, Aileen ; Frenkl, Tara ; Gichuru, Loise N. ; Ha, Sookhee ; Hurley, Amanda L. ; Jochnowitz, Nina ; Levorse, Dorothy ; Mistry, Shruty ; Miller, Randy R. ; Ormes, James ; Salituro, Gino M. ; Sanfiz, Anthony ; Stevenson, Andra S. ; Villa, Katherine ; Zamlynny, Beata ; Green, Stuart ; Struthers, Mary ; Weber, Ann E.

2016

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29
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Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: Close analogs of JANUVIA™ (sitagliptin phosphate)

Kim, Dooseop ; Kowalchick, Jennifer E ; Edmondson, Scott D ; Mastracchio, Anthony ; Xu, Jinyou ; Eiermann, George J ; Leiting, Barbara ; Wu, Joseph K ; Pryor, Kellyann D ; Patel, Reshma A ; He, Huaibing ; Lyons, Kathryn A ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(12), pp.3373-3377 [Peer Reviewed Journal]

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30
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Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors

Xu, Jinyou ; Wei, Lan ; Mathvink, Robert ; Edmondson, Scott D ; Mastracchio, Anthony ; Eiermann, George J ; He, Huaibing ; Leone, Joseph F ; Leiting, Barbara ; Lyons, Kathryn A ; Marsilio, Frank ; Patel, Reshma A ; Petrov, Aleksandr ; Wu, Joseph K ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(5), pp.1346-1349 [Peer Reviewed Journal]

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31
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Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors

Xu, Jinyou ; Wei, Lan ; Mathvink, Robert J ; Edmondson, Scott D ; Eiermann, George J ; He, Huaibing ; Leone, Joseph F ; Leiting, Barbara ; Lyons, Kathryn A ; Marsilio, Frank ; Patel, Reshma A ; Patel, Sangita B ; Petrov, Aleksandr ; Scapin, Giovanna ; Wu, Joseph K ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(20), pp.5373-5377 [Peer Reviewed Journal]

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32
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Discovery of potent and selective orally bioavailable β-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors

Edmondson, Scott D ; Mastracchio, Anthony ; Duffy, Joseph L ; Eiermann, George J ; He, Huaibing ; Ita, Ida ; Leiting, Barbara ; Leone, Joseph F ; Lyons, Kathryn A ; Makarewicz, Amanda M ; Patel, Reshma A ; Petrov, Aleksandr ; Wu, Joseph K ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(12), pp.3048-3052 [Peer Reviewed Journal]

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33
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4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors

Parmee, Emma R ; He, Jiafang ; Mastracchio, Anthony ; Edmondson, Scott D ; Colwell, Larry ; Eiermann, George ; Feeney, William P ; Habulihaz, Bahanu ; He, Huaibing ; Kilburn, Ruth ; Leiting, Barbara ; Lyons, Kathryn ; Marsilio, Frank ; Patel, Reshma A ; Petrov, Aleksandr ; Di Salvo, Jerry ; Wu, Joseph K ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(1), pp.43-46 [Peer Reviewed Journal]

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34
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Potent and selective proline derived dipeptidyl peptidase IV inhibitors

Edmondson, Scott D ; Mastracchio, Anthony ; Beconi, Maria ; Colwell, Lawrence F ; Habulihaz, Bahanu ; He, Huaibing ; Kumar, Sanjeev ; Leiting, Barbara ; Lyons, Kathryn A ; Mao, Ann ; Marsilio, Frank ; Patel, Reshma A ; Wu, Joseph K ; Zhu, Lan ; Thornberry, Nancy A ; Weber, Ann E ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 18 October 2004, Vol.14(20), pp.5151-5155 [Peer Reviewed Journal]

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35
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Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors

Edmondson, Scott D ; Mastracchio, Anthony ; He, Jiafang ; Chung, Christine C ; Forrest, Michael J ; Hofsess, Scott ; Macintyre, Euan ; Metzger, Joseph ; O'Connor, Naphtali ; Patel, Kajal ; Tong, Xinchun ; Tota, Michael R ; Van Der Ploeg, Lex H.T ; Varnerin, Jeff P ; Fisher, Michael H ; Wyvratt, Matthew J ; Weber, Ann E ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(22), pp.3983-3987 [Peer Reviewed Journal]

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35 Results  for Everything (Includes Articles)