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Linagliptin, a dipeptidyl peptidase-4 inhibitor in development for the treatment of type 2 diabetes mellitus: a Phase I, randomized, double-blind, placebo-controlled trial of single and multiple escalating doses in healthy adult male Japanese subjects

Sarashina, Akiko ; Sesoko, Shogo ; Nakashima, Mitsuyoshi ; Hayashi, Naoyuki ; Taniguchi, Atsushi ; Horie, Yoshiharu ; Graefe-Mody, Eva U ; Woerle, Hans-Juergen ; Dugi, Klaus A

Clinical therapeutics, June 2010, Vol.32(6), pp.1188-204 [Peer Reviewed Journal]

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Use of Dipeptidyl-Peptidase-4 Inhibitors and the Risk of Pneumonia: A Population-Based Cohort Study

Wvan Der Zanden, Rogier ; De Vries, Frank ; Lalmohamed, Arief ; Driessen, Johanna H M ; De Boer, Anthonius ; Rohde, Gernot ; Neef, Cees ; Den Heijer, Casper

PloS one, 2015, Vol.10(10), pp.e0139367 [Peer Reviewed Journal]

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DPP-4 inhibitor attenuates toxic effects of indoxyl sulfate on kidney tubular cells

Wang, Wei-Jie ; Chang, Chen-Hung ; Sun, Mao-Feng ; Hsu, Sheng-Feng ; Weng, Ching-Sung

PloS one, 2014, Vol.9(4), pp.e93447 [Peer Reviewed Journal]

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Effects of Inhibiting Dipeptidyl Peptidase-4 (DPP4) in Cows with Subclinical Ketosis

Schulz, Kirsten ; Frahm, Jana ; Kersten, Susanne ; Meyer, Ulrich ; Rehage, Jürgen ; Piechotta, Marion ; Meyerholz, Maria ; Breves, Gerhard ; Reiche, Dania ; Sauerwein, Helga ; Dänicke, Sven

PloS one, 2015, Vol.10(8), pp.e0136078 [Peer Reviewed Journal]

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A DPP-4 inhibitor suppresses fibrosis and inflammation on experimental autoimmune myocarditis in mice

Hirakawa, Hiroyuki ; Zempo, Hirofumi ; Ogawa, Masahito ; Watanabe, Ryo ; Suzuki, Jun-Ichi ; Akazawa, Hiroshi ; Komuro, Issei ; Isobe, Mitsuaki

PloS one, 2015, Vol.10(3), pp.e0119360 [Peer Reviewed Journal]

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Susceptibility of milk protein-derived peptides to dipeptidyl peptidase IV (DPP-IV) hydrolysis

Nongonierma, Alice B ; Fitzgerald, Richard J

Food Chemistry, 15 February 2014, Vol.145, pp.845-852 [Peer Reviewed Journal]

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An in silico model to predict the potential of dietary proteins as sources of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides

Nongonierma, Alice B ; Fitzgerald, Richard J

Food Chemistry, 15 December 2014, Vol.165, pp.489-498 [Peer Reviewed Journal]

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Review of linagliptin for the treatment of type 2 diabetes mellitus

Neumiller, Joshua J ; Setter, Stephen M

Clinical therapeutics, May 2012, Vol.34(5), pp.993-1005 [Peer Reviewed Journal]

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9
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Dipeptidyl peptidase IV inhibitor MK-0626 attenuates pancreatic islet injury in tacrolimus-induced diabetic rats

Jin, Long ; Lim, Sun Woo ; Doh, Kyoung Chan ; Piao, Shang Guo ; Jin, Jian ; Heo, Seong Beom ; Chung, Byung Ha ; Yang, Chul Woo

PloS one, 2014, Vol.9(6), pp.e100798 [Peer Reviewed Journal]

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Linagliptin Ameliorates Methylglyoxal-Induced Peritoneal Fibrosis in Mice

Nagai, Takuo ; Doi, Shigehiro ; Nakashima, Ayumu ; Irifuku, Taisuke ; Sasaki, Kensuke ; Ueno, Toshinori ; Masaki, Takao

PloS one, 2016, Vol.11(8), pp.e0160993 [Peer Reviewed Journal]

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Attenuation of renovascular damage in Zucker diabetic fatty rat by NWT-03, an egg protein hydrolysate with ACE- and DPP4-inhibitory Activity

Wang, Yumei ; Landheer, Sjoerd ; Van Gilst, Wiek H ; Van Amerongen, Aart ; Hammes, Hans-Peter ; Henning, Robert H ; Deelman, Leo E ; Buikema, Hendrik

PloS one, 2012, Vol.7(10), pp.e46781 [Peer Reviewed Journal]

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The Dose-Dependent Organ-Specific Effects of a Dipeptidyl Peptidase-4 Inhibitor on Cardiovascular Complications in a Model of Type 2 Diabetes

Moon, Ju-Young ; Woo, Jong Shin ; Seo, Jung-Woo ; Lee, Arah ; Kim, Dong Jin ; Kim, Yang-Gyun ; Kim, Se-Yeun ; Lee, Kyung Hye ; Lim, Sung-Jig ; Cheng, Xian Wu ; Lee, Sang-Ho ; Kim, Weon

PloS one, 2016, Vol.11(3), pp.e0150745 [Peer Reviewed Journal]

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Effects of DPP-4 inhibitors on the heart in a rat model of uremic cardiomyopathy

Chaykovska, Lyubov ; Von Websky, Karoline ; Rahnenführer, Jan ; Alter, Markus ; Heiden, Susi ; Fuchs, Holger ; Runge, Frank ; Klein, Thomas ; Hocher, Berthold

PloS one, 2011, Vol.6(11), pp.e27861 [Peer Reviewed Journal]

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Penetration of new antidiabetic medications in East Asian countries and the United States: A cross-national comparative study

Kubota, Kiyoshi ; Kamijima, Yukari ; Kao Yang, Yea-Huei ; Kimura, Shinya ; Chia-Cheng Lai, Edward ; Man, Kenneth K C ; Ryan, Patrick ; Schuemie, Martijn ; Stang, Paul ; Su, Chien-Chou ; Wong, Ian C K ; Zhang, Yinghong ; Setoguchi, Soko

PloS one, 2018, Vol.13(12), pp.e0208796 [Peer Reviewed Journal]

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Efficacy and safety of dipeptidyl peptidase-4 inhibitors in type 2 diabetes mellitus patients with moderate to severe renal impairment: a systematic review and meta-analysis

Cheng, Dongsheng ; Fei, Yang ; Liu, Yumei ; Li, Junhui ; Chen, Yuqiang ; Wang, Xiaoxia ; Wang, Niansong

PloS one, 2014, Vol.9(10), pp.e111543 [Peer Reviewed Journal]

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Trelagliptin (SYR-472, Zafatek), Novel Once-Weekly Treatment for Type 2 Diabetes, Inhibits Dipeptidyl Peptidase-4 (DPP-4) via a Non-Covalent Mechanism

Grimshaw, Charles E ; Jennings, Andy ; Kamran, Ruhi ; Ueno, Hikaru ; Nishigaki, Nobuhiro ; Kosaka, Takuo ; Tani, Akiyoshi ; Sano, Hiroki ; Kinugawa, Yoshinobu ; Koumura, Emiko ; Shi, Lihong ; Takeuchi, Koji

PloS one, 2016, Vol.11(6), pp.e0157509 [Peer Reviewed Journal]

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17
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Identification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (part I): virtual screening and activity assays

Guasch, Laura ; Ojeda, Maria José ; González-Abuín, Noemí ; Sala, Esther ; Cereto-Massagué, Adrià ; Mulero, Miquel ; Valls, Cristina ; Pinent, Montserrat ; Ardévol, Anna ; Garcia-Vallvé, Santiago ; Pujadas, Gerard

PloS one, 2012, Vol.7(9), pp.e44971 [Peer Reviewed Journal]

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18
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Preventive effect of dipeptidyl peptidase-4 inhibitor on atherosclerosis is mainly attributable to incretin's actions in nondiabetic and diabetic apolipoprotein E-null mice

Terasaki, Michishige ; Nagashima, Masaharu ; Nohtomi, Kyoko ; Kohashi, Kyoko ; Tomoyasu, Masako ; Sinmura, Kyoko ; Nogi, Yukinori ; Katayama, Yuki ; Sato, Kengo ; Itoh, Fumiko ; Watanabe, Takuya ; Hirano, Tsutomu

PloS one, 2013, Vol.8(8), pp.e70933 [Peer Reviewed Journal]

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19
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Effects of dipeptidyl-peptidase 4 inhibitor about vascular inflammation in a metabolic syndrome model

Renna, Nicolas F ; Diez, Emiliano A ; Miatello, Roberto M

PloS one, 2014, Vol.9(9), pp.e106563 [Peer Reviewed Journal]

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20
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Cost-effectiveness of second-line antihyperglycemic therapy in patients with type 2 diabetes mellitus inadequately controlled on metformin

Klarenbach, Scott ; Cameron, Chris ; Singh, Sumeet ; Ur, Ehud

Canadian Medical Association. Journal, Nov 8, 2011, Vol.183(16), pp.E1213-20 [Peer Reviewed Journal]

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21
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Saxagliptin, alogliptin, and cardiovascular outcomes

White, William ; Zannad, Faiez

New England Journal of Medicine, 30 January 2014, p.484 [Peer Reviewed Journal]

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22
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A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice

Matsubara, Junichi ; Sugiyama, Seigo ; Sugamura, Koichi ; Nakamura, Taishi ; Fujiwara, Yukio ; Akiyama, Eiichi ; Kurokawa, Hirofumi ; Nozaki, Toshimitsu ; Ohba, Keisuke ; Konishi, Masaaki ; Maeda, Hirofumi ; Izumiya, Yasuhiro ; Kaikita, Koichi ; Sumida, Hitoshi ; Jinnouchi, Hideaki ; Matsui, Kunihiko ; Kim-Mitsuyama, Shokei ; Takeya, Motohiro ; Ogawa, Hisao

Journal of the American College of Cardiology, 17 January 2012, Vol.59(3), pp.265-76 [Peer Reviewed Journal]

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23
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Impact ofSitagliptinon Carotid Intima-Media Thickness in Patients With Coronary Artery Disease and Impaired Glucose Tolerance or Mild Diabetes Mellitus

Ishikawa, Shinji ; Shimano, Masayuki ; Watarai, Masato ; Koyasu, Masayoshi ; Uchikawa, Tomohiro ; Ishii, Hideki ; Inden, Yasuya ; Takemoto, Kenji ; Murohara, Toyoaki

The American Journal of Cardiology, Aug 1, 2014, Vol.114(3), pp.384-8 [Peer Reviewed Journal]

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24
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Inhibition of dipeptidyl peptidase IV and xanthine oxidase by amino acids and dipeptides

Nongonierma, Alice B ; Mooney, Catherine ; Shields, Denis C ; Fitzgerald, Richard J

Food Chemistry, 01 November 2013, Vol.141(1), pp.644-653 [Peer Reviewed Journal]

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25
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A Common Susceptibility Gene for Type 2 Diabetes Is Associated with Drug Response to a DPP-4 Inhibitor: Pharmacogenomic Cohort in Okinawa Japan

Osada, Uru Nezu ; Sunagawa, Hiroshi ; Terauchi, Yasuo ; Ueda, Shinichiro

PloS one, 2016, Vol.11(5), pp.e0154821 [Peer Reviewed Journal]

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26
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Active subfractions of Abelmoschus esculentus substantially prevent free fatty acid-induced β cell apoptosis via inhibiting dipeptidyl peptidase-4

Huang, Chien-Ning ; Wang, Chau-Jong ; Lee, Yi-Ju ; Peng, Chiung-Huei

PloS one, 2017, Vol.12(7), pp.e0180285 [Peer Reviewed Journal]

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27
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Beneficial Effects of Evogliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, on Adiposity with Increased Ppargc1a in White Adipose Tissue in Obese Mice

Chae, Yu-Na ; Kim, Tae-Hyoung ; Kim, Mi-Kyung ; Shin, Chang-Yell ; Jung, Il-Hoon ; Sohn, Yong Sung ; Son, Moon-Ho

PloS one, 2015, Vol.10(12), pp.e0144064 [Peer Reviewed Journal]

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28
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Glucagon-like peptide-1(9-36) inhibits chemokine-induced migration of human CD4-positive lymphocytes

Liberman, Ana ; Esser, Melanie ; Marx, Nikolaus ; Burgmaier, Mathias

PloS one, 2013, Vol.8(3), pp.e58445 [Peer Reviewed Journal]

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29
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The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Preserves Endothelial Function in Mesenteric Arteries from Type 1 Diabetic Rats without Decreasing Plasma Glucose

Salheen, Salheen M ; Panchapakesan, Usha ; Pollock, Carol A ; Woodman, Owen L

PloS one, 2015, Vol.10(11), pp.e0143941 [Peer Reviewed Journal]

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30
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The dipeptidyl peptidase-4 inhibitor des-fluoro-sitagliptin regulates brown adipose tissue uncoupling protein levels in mice with diet-induced obesity

Shimasaki, Takanobu ; Masaki, Takayuki ; Mitsutomi, Kimihiko ; Ueno, Daisuke ; Gotoh, Koro ; Chiba, Seiichi ; Kakuma, Tetsuya ; Yoshimatsu, Hironobu

PloS one, 2013, Vol.8(5), pp.e63626 [Peer Reviewed Journal]

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31
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Hemoglobin glycation index as a useful predictor of therapeutic responses to dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes

Chen, Yu-Wei ; Wang, Jun-Sing ; Sheu, Wayne H-H ; Lin, Shih-Yi ; Lee, I-Te ; Song, Yuh-Min ; Fu, Chia-Po ; Lee, Chia-Lin

PloS one, 2017, Vol.12(2), pp.e0171753 [Peer Reviewed Journal]

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32
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Identification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (Part II): in silico prediction in antidiabetic extracts

Guasch, Laura ; Sala, Esther ; Ojeda, María José ; Valls, Cristina ; Bladé, Cinta ; Mulero, Miquel ; Blay, Mayte ; Ardévol, Anna ; Garcia-Vallvé, Santiago ; Pujadas, Gerard

PloS one, 2012, Vol.7(9), pp.e44972 [Peer Reviewed Journal]

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33
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The DPP4 Inhibitor Linagliptin Protects from Experimental Diabetic Retinopathy

Dietrich, Nadine ; Kolibabka, Matthias ; Busch, Stephanie ; Bugert, Petra ; Kaiser, Ulrike ; Lin, Jihong ; Fleming, Thomas ; Morcos, Michael ; Klein, Thomas ; Schlotterer, Andrea ; Hammes, Hans-Peter

PloS one, 2016, Vol.11(12), pp.e0167853 [Peer Reviewed Journal]

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34
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Inhibiting DPP4 in a mouse model of HHT1 results in a shift towards regenerative macrophages and reduces fibrosis after myocardial infarction

Dingenouts, Calinda K E ; Bakker, Wineke ; Lodder, Kirsten ; Wiesmeijer, Karien C ; Moerkamp, Asja T ; Maring, Janita A ; Arthur, Helen M ; Smits, Anke M ; Goumans, Marie-José

PloS one, 2017, Vol.12(12), pp.e0189805 [Peer Reviewed Journal]

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35
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Efficacy and safety of saxagliptin in patients with type 2 diabetes: A systematic review and meta-analysis

Men, Peng ; Li, Xiao-Tong ; Tang, Hui-Lin ; Zhai, Suo-Di

PloS one, 2018, Vol.13(5), pp.e0197321 [Peer Reviewed Journal]

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36
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Efficacy and tolerability of linagliptin added to a sulfonylurea regimen in patients with inadequately controlled type 2 diabetes mellitus: an 18-week, multicenter, randomized, double-blind, placebo-controlled trial

Lewin, Andrew J ; Arvay, Lisa ; Liu, Dacheng ; Patel, Sanjay ; Von Eynatten, Maximilian ; Woerle, Hans-Juergen

Clinical therapeutics, September 2012, Vol.34(9), pp.1909-19.e15 [Peer Reviewed Journal]

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37