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Addition of Alanyl-Glutamine to Dialysis Fluid Restores Peritoneal Cellular Stress Responses - A First-In-Man Trial

Kratochwill, Klaus ; Boehm, Michael ; Herzog, Rebecca ; Gruber, Katharina ; Lichtenauer, Anton Michael ; Kuster, Lilian ; Csaicsich, Dagmar ; Gleiss, Andreas ; Alper, Seth L ; Aufricht, Christoph ; Vychytil, Andreas

PloS one, 2016, Vol.11(10), pp.e0165045 [Peer Reviewed Journal]

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WIP1 phosphatase as a potential therapeutic target in neuroblastoma

Richter, Mark ; Dayaram, Tajhal ; Gilmartin, Aidan G ; Ganji, Gopinath ; Pemmasani, Sandhya Kiran ; Van Der Key, Harjeet ; Shohet, Jason M ; Donehower, Lawrence A ; Kumar, Rakesh

PloS one, 2015, Vol.10(2), pp.e0115635 [Peer Reviewed Journal]

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Supplementation with L-Glutamine and L-Alanyl-L-Glutamine Changes Biochemical Parameters and Jejunum Morphophysiology in Type 1 Diabetic Wistar Rats

Da Rosa, Carlos Vinicius D ; Azevedo, Silvia C S F ; Bazotte, Roberto B ; Peralta, Rosane M ; Buttow, Nilza C ; Pedrosa, Maria Montserrat D ; De Godoi, Vilma A F ; Natali, Maria Raquel M

PloS one, 2015, Vol.10(12), pp.e0143005 [Peer Reviewed Journal]

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The efflux inhibitor phenylalanine-arginine beta-naphthylamide (PAβN) permeabilizes the outer membrane of gram-negative bacteria

Lamers, Ryan P ; Cavallari, Joseph F ; Burrows, Lori L

PloS one, 2013, Vol.8(3), pp.e60666 [Peer Reviewed Journal]

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In vivo notch signaling blockade induces abnormal spermatogenesis in the mouse

Murta, Daniel ; Batista, Marta ; Trindade, Alexandre ; Silva, Elisabete ; Henrique, Domingos ; Duarte, António ; Lopes-Da-Costa, Luís

PloS one, 2014, Vol.9(11), pp.e113365 [Peer Reviewed Journal]

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MDL28170, a calpain inhibitor, affects Trypanosoma cruzi metacyclogenesis, ultrastructure and attachment to Rhodnius prolixus midgut

Ennes-Vidal, Vítor ; Menna-Barreto, Rubem F S ; Santos, André L S ; Branquinha, Marta H ; D'Avila-Levy, Claudia M

PloS one, 04 April 2011, Vol.6(4), pp.e18371 [Peer Reviewed Journal]

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Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis

Chaparro, Juan D ; Cheng, Timmy ; Tran, Uyen Phuong ; Andrade, Rosa M ; Brenner, Sara B T ; Hwang, Grace ; Cohn, Shara ; Hirata, Ken ; Mckerrow, James H ; Reed, Sharon L

PloS one, 2018, Vol.13(3), pp.e0193982 [Peer Reviewed Journal]

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Suppression of Human T Cell Proliferation Mediated by the Cathepsin B Inhibitor, z-FA-FMK Is Due to Oxidative Stress

Rajah, Tanuja ; Chow, Sek Chuen

PloS one, 2015, Vol.10(4), pp.e0123711 [Peer Reviewed Journal]

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Testing Danegaptide Effects on Kidney Function after Ischemia/Reperfusion Injury in a New Porcine Two Week Model

Amdisen, Chris ; Keller, Anna K ; Hansen, Rie Schultz ; Nørregaard, Rikke ; Krag, Søren Palmelund ; Møldrup, Ulla ; Pedersen, Michael ; Jespersen, Bente ; Birn, Henrik

PloS one, 2016, Vol.11(10), pp.e0164109 [Peer Reviewed Journal]

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Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects

Chakraborty, Ranjita ; Vepuri, Vidya ; Mhatre, Siddhita D ; Paddock, Brie E ; Miller, Sean ; Michelson, Sarah J ; Delvadia, Radha ; Desai, Arkit ; Vinokur, Marianna ; Melicharek, David J ; Utreja, Suruchi ; Khandelwal, Preeti ; Ansaloni, Sara ; Goldstein, Lee E ; Moir, Robert D ; Lee, Jeremy C ; Tabb, Loni P ; Saunders, Aleister J ; Marenda, Daniel R

PloS one, 2011, Vol.6(6), pp.e20799 [Peer Reviewed Journal]

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The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells

Krepler, Clemens ; Chunduru, Srinivas K ; Halloran, Molly B ; He, Xu ; Xiao, Min ; Vultur, Adina ; Villanueva, Jessie ; Mitsuuchi, Yasuhiro ; Neiman, Eric M ; Benetatos, Christopher ; Nathanson, Katherine L ; Amaravadi, Ravi K ; Pehamberger, Hubert ; Mckinlay, Mark ; Herlyn, Meenhard

Clinical cancer research : an official journal of the American Association for Cancer Research, 01 April 2013, Vol.19(7), pp.1784-94 [Peer Reviewed Journal]

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Effect of a Smac Mimetic (TL32711, Birinapant) on the Apoptotic Program and Apoptosis Biomarkers Examined with Validated Multiplex Immunoassays Fit for Clinical Use

Srivastava, Apurva K ; Jaganathan, Soumya ; Stephen, Laurie ; Hollingshead, Melinda G ; Layhee, Adam ; Damour, Eric ; Govindharajulu, Jeevan Prasaad ; Donohue, Jennifer ; Esposito, Dominic ; Mapes, James P ; Kinders, Robert J ; Takebe, Naoko ; Tomaszewski, Joseph E ; Kummar, Shivaani ; Doroshow, James H ; Parchment, Ralph E

Clinical cancer research : an official journal of the American Association for Cancer Research, 15 February 2016, Vol.22(4), pp.1000-10 [Peer Reviewed Journal]

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Peptide tyrosine-tyrosine combined with its receptors exhibits an anti-cancer potential in pancreatic cancer MiaPaCa-2 cell

Li, Hongxia ; Wang, Zhixin ; Dong, Lei ; Jiang, Jiong ; Xu, Xinsen ; Zhou, Lei ; Wan, Yong

Chinese medical journal, 2014, Vol.127(24), pp.4235-42 [Peer Reviewed Journal]

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Immunomodulating effects of Vilon and its analogue in the culture of human and animal thymus cells

Sevostianova, N N ; Linkova, N S ; Polyakova, V O ; Chervyakova, N A ; Kostylev, A V ; Durnova, A O ; Kvetnoy, I M ; Abdulragimov, R I ; Khavinson, V H

Bulletin of experimental biology and medicine, February 2013, Vol.154(4), pp.562-5 [Peer Reviewed Journal]

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15
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Cytotoxicity and Mechanism of Action of the Marine-Derived Fungal Metabolite Trichodermamide B and Synthetic Analogues

Jans, Petra E ; Mfuh, Adelphe M ; Arman, Hadi D ; Shaffer, Corena V ; Larionov, Oleg V ; Mooberry, Susan L

Journal of natural products, 24 March 2017, Vol.80(3), pp.676-683 [Peer Reviewed Journal]

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16
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Effects of Alanyl-Glutamine Treatment on the Peritoneal Dialysis Effluent Proteome Reveal Pathomechanism-Associated Molecular Signatures

Herzog, Rebecca ; Boehm, Michael ; Unterwurzacher, Markus ; Wagner, Anja ; Parapatics, Katja ; Májek, Peter ; Mueller, André C ; Lichtenauer, Anton ; Bennett, Keiryn L ; Alper, Seth L ; Vychytil, Andreas ; Aufricht, Christoph ; Kratochwill, Klaus

Molecular & cellular proteomics : MCP, March 2018, Vol.17(3), pp.516-532 [Peer Reviewed Journal]

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17
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The calpain inhibitor MDL28170 induces the expression of apoptotic markers in Leishmania amazonensis promastigotes

Marinho, Fernanda A ; Gonçalves, Keyla C S ; Oliveira, Simone S C ; Gonçalves, Diego S ; Matteoli, Filipe P ; Seabra, Sergio H ; Oliveira, Ana Carolina S ; Bellio, Maria ; Oliveira, Selma S ; Souto-Padrón, Thaïs ; D'Avila-Levy, Claudia M ; Santos, André L S ; Branquinha, Marta H

PloS one, 2014, Vol.9(1), pp.e87659 [Peer Reviewed Journal]

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18
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Effects of DAPT and Atoh1 overexpression on hair cell production and hair bundle orientation in cultured Organ of Corti from neonatal rats

Zhao, Li-Dong ; Guo, Wei-Wei ; Lin, Chang ; Li, Li-Xian ; Sun, Jian-He ; Wu, Nan ; Ren, Li-Li ; Li, Xin-Xin ; Liu, Hui-Zhan ; Young, Wie-Yen ; Gao, Wei-Qiang ; Yang, Shi-Ming

PloS one, 2011, Vol.6(10), pp.e23729 [Peer Reviewed Journal]

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19
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Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism

Bigaud, Marc ; Dincer, Zuhal ; Bollbuck, Birgit ; Dawson, Janet ; Beckmann, Nicolau ; Beerli, Christian ; Fishli-Cavelti, Gina ; Nahler, Michaela ; Angst, Daniela ; Janser, Philipp ; Otto, Heike ; Rosner, Elisabeth ; Hersperger, Rene ; Bruns, Christian ; Quancard, Jean

PloS one, 2016, Vol.11(12), pp.e0168252 [Peer Reviewed Journal]

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20
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Inhibition of glioma cell lysosome exocytosis inhibits glioma invasion

Liu, Yu ; Zhou, Yijiang ; Zhu, Keqing

PloS one, 2012, Vol.7(9), pp.e45910 [Peer Reviewed Journal]

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21
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The selectivity of galardin and an azasugar-based hydroxamate compound for human matrix metalloproteases and bacterial metalloproteases

Sylte, Ingebrigt ; Dawadi, Rangita ; Malla, Nabin ; Von Hofsten, Susannah ; Nguyen, Tra-Mi ; Solli, Ann Iren ; Berg, Eli ; Adekoya, Olayiwola A ; Svineng, Gunbjørg ; Winberg, Jan-Olof

PloS one, 2018, Vol.13(8), pp.e0200237 [Peer Reviewed Journal]

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22
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Timely inhibition of Notch signaling by DAPT promotes cardiac differentiation of murine pluripotent stem cells

Liu, Yinan ; Li, Peng ; Liu, Kaiyu ; He, Qihua ; Han, Shuo ; Sun, Xiaofeng ; Li, Tao ; Shen, Li

PloS one, 2014, Vol.9(10), pp.e109588 [Peer Reviewed Journal]

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23
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Modulators of γ-secretase activity can facilitate the toxic side-effects and pathogenesis of Alzheimer's disease

Svedružić, Željko M ; Popović, Katarina ; Šendula-Jengić, Vesna

PloS one, 2013, Vol.8(1), pp.e50759 [Peer Reviewed Journal]

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24
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Aromatic amino acid-leucine dipeptides exhibit anxiolytic-like activity in young mice

Mizushige, Takafumi ; Kanegawa, Norimasa ; Yamada, Ayako ; Ota, Ami ; Kanamoto, Ryuhei ; Ohinata, Kousaku

Neuroscience letters, 24 May 2013, Vol.543, pp.126-9 [Peer Reviewed Journal]

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25
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Biosynthesis, Synthesis, and Activities of Barnesin A, a NRPS-PKS Hybrid Produced by an Anaerobic Epsilonproteobacterium

Rischer, Maja ; Raguž, Luka ; Guo, Huijuan ; Keiff, Francois ; Diekert, Gabriele ; Goris, Tobias ; Beemelmanns, Christine

ACS chemical biology, 17 August 2018, Vol.13(8), pp.1990-1995 [Peer Reviewed Journal]

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26
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Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors

Gealageas, Ronan ; Schneider, Séverine ; Humbert, Jean-Paul ; Bertin, Isabelle ; Schmitt, Martine ; Laboureyras, Emilie ; Dugave, Christophe ; Mollereau, Catherine ; Simonnet, Guy ; Bourguignon, Jean-Jacques ; Simonin, Frédéric ; Bihel, Frédéric

Bioorganic & medicinal chemistry letters, 15 December 2012, Vol.22(24), pp.7471-4 [Peer Reviewed Journal]

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27
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L-Alanyl-Glutamine Attenuates Oxidative Stress in Liver Transplantation Patients

Barros, M A P ; Vasconcelos, P R L ; Souza, C M ; Andrade, G M ; Moraes, M O ; Costa, P E G ; Coelho, G R ; Garcia, J H P

Transplantation proceedings, October 2015, Vol.47(8), pp.2478-82 [Peer Reviewed Journal]

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28
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Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity

Schnaider, Lee ; Brahmachari, Sayanti ; Schmidt, Nathan W ; Mensa, Bruk ; Shaham-Niv, Shira ; Bychenko, Darya ; Adler-Abramovich, Lihi ; Shimon, Linda J W ; Kolusheva, Sofiya ; Degrado, William F ; Gazit, Ehud

Nature communications, 08 November 2017, Vol.8(1), pp.1365 [Peer Reviewed Journal]

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29
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Experimental study of antinociceptive potency of dipeptide GB-115 during chemical and thermal stimulation

Kolik, L G ; Zhukov, V N ; Gudasheva, T A ; Seredenin, S B

Bulletin of experimental biology and medicine, August 2012, Vol.153(4), pp.468-71 [Peer Reviewed Journal]

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30
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Enhanced transdermal delivery of 5-aminolevulinic acid and a dipeptide by iontophoresis

Krishnan, Gayathri ; Roberts, Michael S ; Grice, Jeffrey ; Anissimov, Yuri G ; Benson, Heather A E

Biopolymers, 2011, Vol.96(2), pp.166-71 [Peer Reviewed Journal]

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31
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RF9 powerfully stimulates gonadotrophin secretion in the ewe: evidence for a seasonal threshold of sensitivity

Caraty, A ; Blomenröhr, M ; Vogel, G M T ; Lomet, D ; Briant, C ; Beltramo, M

Journal of neuroendocrinology, May 2012, Vol.24(5), pp.725-36 [Peer Reviewed Journal]

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32
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Molecular aspects of anti-atherosclerotic effects of short peptides

Khavinson, V Kh ; Lin'Kova, N S ; Evlashkina, E V ; Durnova, A O ; Kozlov, K L ; Gutop, O E

Bulletin of experimental biology and medicine, November 2014, Vol.158(1), pp.159-63 [Peer Reviewed Journal]

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33
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Toward very potent, non-covalent organophosphonate inhibitors of cathepsin C and related enzymes by 2-amino-1-hydroxy-alkanephosphonates dipeptides

Drąg, Marcin ; Wieczerzak, Ewa ; Pawełczak, Małgorzata ; Berlicki, Łukasz ; Grzonka, Zbigniew ; Kafarski, Paweł

Biochimie, August 2013, Vol.95(8), pp.1640-9 [Peer Reviewed Journal]

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34
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Remodeling of rat stromal-vascular cells to brite/beige adipocytes by prolyl-hydroxyproline

Minaguchi, Jun A ; Ogata, Sakino ; Takahashi, Naoki ; Hirose, Takuya ; Ueda, Hiromi ; Takehana, Kazushige

The Journal of veterinary medical science, 23 March 2017, Vol.79(3), pp.547-553 [Peer Reviewed Journal]

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35
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Alanyl-glutamine promotes intestinal epithelial cell homeostasis in vitro and in a murine model of weanling undernutrition

Ueno, Priscilla M ; Oriá, Reinaldo B ; Maier, Elizabeth A ; Guedes, Marjorie ; De Azevedo, Orleancio G ; Wu, David ; Willson, Tara ; Hogan, Simon P ; Lima, Aldo A M ; Guerrant, Richard L ; Polk, D Brent ; Denson, Lee A ; Moore, Sean R

American journal of physiology. Gastrointestinal and liver physiology, October 2011, Vol.301(4), pp.G612-22 [Peer Reviewed Journal]

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36
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Lysosomal membrane permeabilization induces cell death in human mast cells

Melo, F R ; Lundequist, A ; Calounova, G ; Wernersson, S ; Pejler, G

Scandinavian journal of immunology, October 2011, Vol.74(4), pp.354-62 [Peer Reviewed Journal]

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Epithelial mesenchymal transition and pancreatic tumor initiating CD44+/EpCAM+ cells are inhibited by γ-secretase inhibitor IX

Palagani, Vindhya ; El Khatib, Mona ; Kossatz, Uta ; Bozko, Przemyslaw ; Müller, Martin R ; Manns, Michael P ; Krech, Till ; Malek, Nisar P ; Plentz, Ruben R

PloS one, 2012, Vol.7(10), pp.e46514 [Peer Reviewed Journal]

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