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Differentiating passive from transporter-mediated uptake by PepT1: a comparison and evaluation of four methods

Scow, Jeffrey S ; Madhavan, Srivats ; Chaudhry, Rizwan M ; Zheng, Ye ; Duenes, Judith A ; Sarr, Michael G

The Journal of surgical research, September 2011, Vol.170(1), pp.17-23 [Peer Reviewed Journal]

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Pharmacokinetics and metabolism of N-N-3-(3-hydroxy-4-methoxyphenyl) propyl-α-aspartyl-L-phenylalanine 1-methyl ester, monohydrate (advantame) in the rat, dog, and man

Ubukata, K ; Nakayama, A ; Mihara, R

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, November 2011, Vol.49 Suppl 1, pp.S8-29 [Peer Reviewed Journal]

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Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding

Vig, Balvinder S ; Stouch, Terry R ; Timoszyk, Julita K ; Quan, Yong ; Wall, Doris A ; Smith, Ronald L ; Faria, Teresa N

Journal of medicinal chemistry, 15 June 2006, Vol.49(12), pp.3636-44 [Peer Reviewed Journal]

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In vitro and in vivo evaluation of a primaquine prodrug without red blood cell membrane destabilization property

Davanço, Marcelo Gomes ; Campos, Michel Leandro ; Nogueira, Marco Antonio ; Campos, Silvio Lopes ; Marques, Ricardo Vian ; Santos, Jean Leandro ; Chin, Chung Man ; Fonseca, Luiz Marcos ; Peccinini, Rosângela Gonçalves

Biopharmaceutics & Drug Disposition, Nov 2012, Vol.33(8), pp.437-45 [Peer Reviewed Journal]

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The antiinflammatory action and pharmacokinetics of a novel glucosamine-based di-peptide aminosugar

Gilzad-Kohan, Mohammad H ; Kaur, Kamaljit ; Jamali, Fakhreddin

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2013, Vol.16(2), pp.279-88 [Peer Reviewed Journal]

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Effect of rifampicin on the pharmacokinetics and pharmacodynamics of saxagliptin, a dipeptidyl peptidase-4 inhibitor, in healthy subjects

Upreti, Vijay V ; Boulton, David W ; Li, Li ; Ching, Agatha ; Su, Hong ; Lacreta, Frank P ; Patel, Chirag G

British journal of clinical pharmacology, July 2011, Vol.72(1), pp.92-102 [Peer Reviewed Journal]

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Enhanced visualization of small peptides absorbed in rat small intestine by phytic-acid-aided matrix-assisted laser desorption/ionization-imaging mass spectrometry

Hong, Seong-Min ; Tanaka, Mitsuru ; Yoshii, Saori ; Mine, Yoshinori ; Matsui, Toshiro

Analytical chemistry, 05 November 2013, Vol.85(21), pp.10033-9 [Peer Reviewed Journal]

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Phase I study of TP300 in patients with advanced solid tumors with pharmacokinetic, pharmacogenetic and pharmacodynamic analyses

Anthoney, D ; Naik, Jay ; Macpherson, Iain ; Crawford, Donna ; Hartley, John ; Hartley, Janet ; Saito, Tomohisa ; Abe, Masaichi ; Jones, Keith ; Miwa, Masanori ; Twelves, Christopher ; Evans, Trj

BMC Cancer, 2012, Vol.12, p.536 [Peer Reviewed Journal]

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A pharmacometric approach to quantify the impact of chronic kidney disease and hemodialysis on systemic drug exposure: application to saxagliptin

Zhang, Liping ; Boulton, David W ; Pfister, Marc

Journal of clinical pharmacology, January 2012, Vol.52(1 Suppl), pp.126S-33S [Peer Reviewed Journal]

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Distribution of glycylsarcosine and cefadroxil among cerebrospinal fluid, choroid plexus, and brain parenchyma after intracerebroventricular injection is markedly different between wild-type and Pept2 null mice

Smith, David ; Hu, Yongjun ; Shen, Hong ; Nagaraja, Tavarekere ; Fenstermacher, Joseph ; Keep, Richard

Journal of Cerebral Blood Flow and Metabolism, Jan 2011, Vol.31(1), pp.250-61 [Peer Reviewed Journal]

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Pharmacokinetic Study of Saxagliptin in Healthy Chinese Subjects

Li, Haiyan ; Yang, Li ; Tou, Conrad ; Patel, Chirag ; Zhao, June

Clinical Drug Investigation, Jul 2012, Vol.32(7), pp.465-73 [Peer Reviewed Journal]

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Bioequivalence of Saxagliptin/Metformin Immediate Release (IR) Fixed-Dose Combination Tablets and Single-Component Saxagliptin and Metformin IR Tablets in Healthy Adult Subjects

Upreti, Vijay ; Keung, Chi-Fung ; Boulton, David ; Chang, Ming ; Li, Li ; Tang, Angela ; Hsiang, Bonnie ; Quamina-Edghill, Donette ; Frevert, Ernst ; Lacreta, Frank

Clinical Drug Investigation, May 2013, Vol.33(5), pp.365-74 [Peer Reviewed Journal]

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Bioequivalence of Saxagliptin/Metformin Extended-Release (XR) Fixed-Dose Combination Tablets and Single-Component Saxagliptin and Metformin XR Tablets in Healthy Adult Subjects

Boulton, David ; Smith, Charles ; Li, L ; Huang, Jian ; Tang, Angela ; Lacreta, Frank

Clinical Drug Investigation, Sep 2011, Vol.31(9), pp.619-30 [Peer Reviewed Journal]

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The pharmacokinetics, pharmacodynamics, safety and tolerability following 7 days daily oral treatment with NN703 in healthy male subjects

Zdravkovic, M ; Christiansen, T ; Eliot, L ; Agersoe, H ; Thomsen, M S ; Falch, J F ; Søgaard, B ; Ynddal, L ; Ilondo, M M

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, February 2001, Vol.11(1), pp.41-8 [Peer Reviewed Journal]

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Peptide prodrugs: improved oral absorption of lopinavir, a HIV protease inhibitor

Agarwal, Sheetal ; Boddu, S H S ; Jain, Ritesh ; Samanta, Swapan ; Pal, Dhananjay ; Mitra, Ashim K

International journal of pharmaceutics, 09 July 2008, Vol.359(1-2), pp.7-14 [Peer Reviewed Journal]

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16
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Quantitative prediction of oral absorption of PEPT1 substrates based on in vitro uptake into Caco-2 cells

Shimizu, Rikako ; Sukegawa, Tomomi ; Tsuda, Yasuyuki ; Itoh, Tomoo

International journal of pharmaceutics, 16 April 2008, Vol.354(1-2), pp.104-10 [Peer Reviewed Journal]

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17
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Experimental study of the pharmacokinetics of a tryptophan-containing dipeptide GB-115

Boyko, S ; Kolyvanov, G ; Zherdev, V ; Gudasheva, T ; Kiryanova, E ; Seredenin, S

Bulletin of Experimental Biology and Medicine, Sep 2007, Vol.144(3), pp.312-3 [Peer Reviewed Journal]

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18
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Lactobacillus casei Alters hPEPT1-Mediated Glycylsarcosine Uptake in Caco-2 Cells1,2

Neudeck, Brien ; Loeb, Jennifer ; Faith, Nancy

The Journal of Nutrition, May 2004, Vol.134(5), pp.1120-3 [Peer Reviewed Journal]

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19
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Antithrombotic effects of LB30870, a potent, orally active, selective and direct thrombin inhibitor, and pharmacokinetics of its prodrug

Park, Hee Dong ; Lee, Sung-Hack ; Kim, Tae Hoon ; Lee, Sun Hwa ; Cho, Kwan Hyung ; Kim, Aeri

Bioorganic & medicinal chemistry letters, 01 September 2013, Vol.23(17), pp.4779-84 [Peer Reviewed Journal]

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20
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Simultaneous oral therapeutic and intravenous ¹⁴C-microdoses to determine the absolute oral bioavailability of saxagliptin and dapagliflozin

Boulton, David W ; Kasichayanula, Sreeneeranj ; Keung, Chi Fung Anther ; Arnold, Mark E ; Christopher, Lisa J ; Xu, Xiaohui Sophia ; Lacreta, Frank

British journal of clinical pharmacology, March 2013, Vol.75(3), pp.763-8 [Peer Reviewed Journal]

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21
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Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs

Omkvist, Diana Højmark ; Trangbæk, Dennis Jespersen ; Mildon, Jemma ; Paine, James S ; Brodin, Birger ; Begtrup, Mikael ; Nielsen, Carsten Uhd

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, February 2011, Vol.77(2), pp.327-31 [Peer Reviewed Journal]

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22
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Influences of processed rhubarbs on the activities of four CYP isozymes and the metabolism of saxagliptin in rats based on probe cocktail and pharmacokinetics approaches

Gao, Jingwen ; Shi, Zhan ; Zhu, Shuzhen ; Li, George Q ; Yan, Ru ; Yao, Meicun

Journal of ethnopharmacology, 30 January 2013, Vol.145(2), pp.566-72 [Peer Reviewed Journal]

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23
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Influence of Renal or Hepatic Impairment on the Pharmacokinetics of Saxagliptin

Boulton, David ; Li, Li ; Frevert, Ernst ; Tang, Angela ; Castaneda, Lorna ; Vachharajani, Nimish ; Kornhauser, David ; Patel, Chirag

Clinical Pharmacokinetics, Apr 2011, Vol.50(4), pp.253-65 [Peer Reviewed Journal]

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24
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Matrix-assisted laser desorption/ionization imaging mass spectrometry of intraperitoneally injected danegaptide (ZP1609) for treatment of stroke-reperfusion injury in mice

Wang, Jasmine S H ; Freitas-Andrade, Moises ; Bechberger, John F ; Naus, Christian C ; Yeung, Ken K-C ; Whitehead, Shawn N

Rapid communications in mass spectrometry : RCM, 30 June 2018, Vol.32(12), pp.951-958 [Peer Reviewed Journal]

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25
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Pharmacokinetics and Biodistribution of Aurantiamide and Aurantiamide Acetate in Rats after Oral Administration of Portulaca oleracea L. Extracts

Chen, Lijiang ; Liu, Yang ; Jia, Dechao ; Yang, Jia ; Zhao, Jinhua ; Chen, Changlan ; Liu, Hongsheng ; Liang, Xiao

Journal of agricultural and food chemistry, 04 May 2016, Vol.64(17), pp.3445-55 [Peer Reviewed Journal]

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26
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Mechanisms for clearance of released N-acetylaspartylglutamate in crayfish nerve fibers: implications for axon-glia signaling

Urazaev, A K ; Buttram, J G ; Deen, J P ; Gafurov, B S ; Slusher, B S ; Grossfeld, R M ; Lieberman, E M

Neuroscience, 2001, Vol.107(4), pp.697-703 [Peer Reviewed Journal]

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27
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Permeation of a myristoylated dipeptide across the buccal mucosa: topological distribution and evaluation of tissue integrity

Veuillez, F ; Rieg, F Falson ; Guy, R H ; Deshusses, J ; Buri, P

International journal of pharmaceutics, 01 January 2002, Vol.231(1), pp.1-9 [Peer Reviewed Journal]

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28
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Role and relevance of peptide transporter 2 (PEPT2) in the kidney and choroid plexus: in vivo studies with glycylsarcosine in wild-type and PEPT2 knockout mice

Ocheltree, Scott M ; Shen, Hong ; Hu, Yongjun ; Keep, Richard F ; Smith, David E

The Journal of pharmacology and experimental therapeutics, October 2005, Vol.315(1), pp.240-7 [Peer Reviewed Journal]

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29
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Design, synthesis, photochemical properties and cytotoxic activities of water-soluble caged L-leucyl-L-leucine methyl esters that control apoptosis of immune cells

Mizuta, Hironori ; Watanabe, Soichiro ; Sakurai, Yuji ; Nishiyama, Keiko ; Furuta, Toshiaki ; Kobayashi, Yoshiro ; Iwamura, Michiko

Bioorganic & medicinal chemistry, March 2002, Vol.10(3), pp.675-83 [Peer Reviewed Journal]

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30
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Effect of a high-fat meal on the pharmacokinetics of saxagliptin in healthy subjects

Patel, Chirag G ; Zhang, Jenny ; Li, Li ; Gooding, Lara ; Croop, Robert ; Li, Tong ; Boulton, David W

Journal of clinical pharmacology, October 2010, Vol.50(10), pp.1211-6 [Peer Reviewed Journal]

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31
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Effect of sucrose on the metabolic disposition of aspartame

Stegink, L D ; Brummel, M C ; Persoon, T J ; Filer, L J ; Bell, E F ; Ziegler, E E

The American journal of clinical nutrition, August 1990, Vol.52(2), pp.335-41 [Peer Reviewed Journal]

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32
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Removal of glycylglutamine from plasma by individual tissues: Mechanism and impact on amino acid fluxes in postabsorption and starvation

Adibi, Siamak ; Lochs, Herbert ; Abumrad, Naji ; Daniel, Hannelore ; Vazquez, Jorge

The Journal of Nutrition, Feb 1993, Vol.123(2), pp.325-31 [Peer Reviewed Journal]

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33
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Glycyl-L-proline transport in rabbit enterocyte basolateral-membrane vesicles

Dyer, J ; Beechey, R B ; Gorvel, J P ; Smith, R T ; Wootton, R ; Shirazi-Beechey, S P

The Biochemical journal, 01 August 1990, Vol.269(3), pp.565-71 [Peer Reviewed Journal]

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34
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Absorption rates of L-tryptophan, L-methionine, and L-methionyl-L-tryptophan by rat intestine in vitro and in vivo

Sakamoto, K ; Ryu, K ; Yabe, Y

Nutrition (Burbank, Los Angeles County, Calif.), 1990, Vol.6(3), pp.229-32 [Peer Reviewed Journal]

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35
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Modification of cefixime bioavailability by nifedipine in humans: involvement of the dipeptide carrier system

Duverne, C ; Bouten, A ; Deslandes, A ; Westphal, J F ; Trouvin, J H ; Farinotti, R ; Carbon, C

Antimicrobial agents and chemotherapy, November 1992, Vol.36(11), pp.2462-7 [Peer Reviewed Journal]

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36
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The peptide transporter PepT2 mediates the uptake of the glutathione precursor CysGly in astroglia-rich primary cultures

Dringen, R ; Hamprecht, B ; Bröer, S

Journal of neurochemistry, July 1998, Vol.71(1), pp.388-93 [Peer Reviewed Journal]

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