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Selective catalytic hydrodefluorination as a key step for the synthesis of hitherto inaccessible aminopyridine derivatives

Podolan, Gabriel ; Lentz, Dieter ; Reissig, Hans-Ulrich

Angewandte Chemie (International ed. in English), 02 September 2013, Vol.52(36), pp.9491-4 [Peer Reviewed Journal]

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Unusual approach to 3-aryl-2-aminopyridines through a radical mechanism: synthesis and theoretical rationale from quantum mechanical calculations

Camacho-Artacho, Marta ; Abet, Valentina ; Frutos, Luis M ; Gago, Federico ; Alvarez-Builla, Julio ; Burgos, Carolina

The Journal of organic chemistry, 04 March 2011, Vol.76(5), pp.1452-5 [Peer Reviewed Journal]

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General and mild preparation of 2-aminopyridines

Londregan, Allyn T ; Jennings, Sandra ; Wei, Liuqing

Organic letters, 19 November 2010, Vol.12(22), pp.5254-7 [Peer Reviewed Journal]

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Two new zinc(II) acetates with 3- and 4-aminopyridine: syntheses and structural properties

Dojer, Brina ; Pevec, Andrej ; Belaj, Ferdinand ; Kristl, Matjaž

Acta chimica Slovenica, 2015, Vol.62(2), pp.312-8 [Peer Reviewed Journal]

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2-Aminopyridines via reaction of pyridine N-oxides and activated isocyanides

Vamos, Mitchell ; Cosford, Nicholas D P

The Journal of organic chemistry, 07 March 2014, Vol.79(5), pp.2274-80 [Peer Reviewed Journal]

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Microwave assisted synthesis and solid-state characterization of lithocholyl amides of isomeric aminopyridines

Ahonen, Kari V ; Lahtinen, Manu K ; Valkonen, Arto M ; Dracínský, Martin ; Kolehmainen, Erkki T

Steroids, February 2011, Vol.76(3), pp.261-8 [Peer Reviewed Journal]

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Studies on 3-oxoalkanenitriles: novel rearrangement reactions observed in studies of the chemistry of 3-heteroaroyl-3-oxoalkanenitriles as novel routes to 2-dialkylaminopyridines

Al-Matar, Hamad M ; Khalil, Khaled D ; Al-Kanderi, Mona F ; Elnagdi, Mohamed H

Molecules (Basel, Switzerland), 18 January 2012, Vol.17(1), pp.897-909 [Peer Reviewed Journal]

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Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells

Medda, Federico ; Sells, Earlphia ; Chang, Hui-Hua ; Dietrich, Justin ; Chappeta, Shashi ; Smith, Breland ; Gokhale, Vijay ; Meuillet, Emmanuelle J ; Hulme, Christopher

Bioorganic & medicinal chemistry letters, 15 January 2013, Vol.23(2), pp.528-31 [Peer Reviewed Journal]

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Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines

González Cabrera, Diego ; Douelle, Frederic ; Younis, Yassir ; Feng, Tzu-Shean ; Le Manach, Claire ; Nchinda, Aloysius T ; Street, Leslie J ; Scheurer, Christian ; Kamber, Jolanda ; White, Karen L ; Montagnat, Oliver D ; Ryan, Eileen ; Katneni, Kasiram ; Zabiulla, K Mohammed ; Joseph, Jayan T ; Bashyam, Sridevi ; Waterson, David ; Witty, Michael J ; Charman, Susan A ; Wittlin, Sergio ; Chibale, Kelly

Journal of medicinal chemistry, 27 December 2012, Vol.55(24), pp.11022-30 [Peer Reviewed Journal]

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Iron-catalyzed formation of 2-aminopyridines from diynes and cyanamides

Lane, Timothy K ; D'Souza, Brendan R ; Louie, Janis

The Journal of organic chemistry, 07 September 2012, Vol.77(17), pp.7555-63 [Peer Reviewed Journal]

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3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential

Younis, Yassir ; Douelle, Frederic ; Feng, Tzu-Shean ; González Cabrera, Diego ; Le Manach, Claire ; Nchinda, Aloysius T ; Duffy, Sandra ; White, Karen L ; Shackleford, David M ; Morizzi, Julia ; Mannila, Janne ; Katneni, Kasiram ; Bhamidipati, Ravi ; Zabiulla, K Mohammed ; Joseph, Jayan T ; Bashyam, Sridevi ; Waterson, David ; Witty, Michael J ; Hardick, David ; Wittlin, Sergio ; Avery, Vicky ; Charman, Susan A ; Chibale, Kelly

Journal of medicinal chemistry, 12 April 2012, Vol.55(7), pp.3479-87 [Peer Reviewed Journal]

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A mild method for the formation and in situ reaction of imidoyl chlorides: conversion of pyridine-1-oxides to 2-aminopyridine amides

Manley, Peter J ; Bilodeau, Mark T

Organic letters, 05 September 2002, Vol.4(18), pp.3127-9 [Peer Reviewed Journal]

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Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening

Lauria, Antonino ; Abbate, Ilenia ; Gentile, Carla ; Angileri, Francesca ; Martorana, Annamaria ; Almerico, Anna Maria

Journal of medicinal chemistry, 25 April 2013, Vol.56(8), pp.3424-8 [Peer Reviewed Journal]

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An efficient, regioselective amination of 3,5-disubstituted pyridine N-oxides using saccharin as an ammonium surrogate

Farrell, Robert P ; Silva Elipe, Maria Victoria ; Bartberger, Michael D ; Tedrow, Jason S ; Vounatsos, Filisaty

Organic letters, 04 January 2013, Vol.15(1), pp.168-71 [Peer Reviewed Journal]

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Iron-catalyzed cycloaddition reaction of diynes and cyanamides at room temperature

Wang, Chunxiang ; Wang, Dongping ; Xu, Fen ; Pan, Bin ; Wan, Boshun

The Journal of organic chemistry, 05 April 2013, Vol.78(7), pp.3065-72 [Peer Reviewed Journal]

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Synthesis of Novel Fluoropicolinate Herbicides by Cascade Cyclization of Fluoroalkyl Alkynylimines

Johnson, Peter L ; Renga, James M ; Galliford, Christopher V ; Whiteker, Gregory T ; Giampietro, Natalie C

Organic letters, 19 June 2015, Vol.17(12), pp.2905-7 [Peer Reviewed Journal]

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Regioselective Iron-Catalyzed 2 + 2 + 2 Cycloaddition Reaction Forming 4,6-Disubstituted 2-Aminopyridines from Terminal Alkynes and Cyanamides

Spahn, Nathan A ; Nguyen, Minh H ; Renner, Jonas ; Lane, Timothy K ; Louie, Janis

The Journal of organic chemistry, 06 January 2017, Vol.82(1), pp.234-242 [Peer Reviewed Journal]

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18
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Rapid identification of a novel small molecule phosphodiesterase 10A (PDE10A) tracer

Hu, Essa ; Ma, Ji ; Biorn, Christopher ; Lester-Zeiner, Dianna ; Cho, Robert ; Rumfelt, Shannon ; Kunz, Roxanne K ; Nixey, Thomas ; Michelsen, Klaus ; Miller, Silke ; Shi, Jianxia ; Wong, Jamie ; Hill Della Puppa, Geraldine ; Able, Jessica ; Talreja, Santosh ; Hwang, Dah-Ren ; Hitchcock, Stephen A ; Porter, Amy ; Immke, David ; Allen, Jennifer R ; Treanor, James ; Chen, Hang

Journal of medicinal chemistry, 24 May 2012, Vol.55(10), pp.4776-87 [Peer Reviewed Journal]

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Preparation of 2-aminopyridoimidazoles and 2-aminobenzimidazoles via phosphorus oxychloride-mediated cyclization of aminoureas

Deasy, Rebecca E ; Slattery, Catherine N ; Maguire, Anita R ; Kjell, Douglas P ; Hawk, Mai Khanh N ; Joo, Jung Min ; Gu, Rui Lin ; Moynihan, Humphrey

The Journal of organic chemistry, 18 April 2014, Vol.79(8), pp.3688-95 [Peer Reviewed Journal]

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20
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Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors

Ho, Koc-Kan ; Parnell, K Mark ; Yuan, Yi ; Xu, Yong ; Kultgen, Steven G ; Hamblin, Steven ; Hendrickson, Thomas F ; Luo, Bai ; Foulks, Jason M ; Mccullar, Michael V ; Kanner, Steven B

Bioorganic & medicinal chemistry letters, 15 January 2013, Vol.23(2), pp.569-73 [Peer Reviewed Journal]

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21
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Microwave-assisted synthesis of Weinreb and MAP aryl amides via Pd-catalyzed Heck aminocarbonylation using Mo(CO)6 or W(CO)6

Wieckowska, Anna ; Fransson, Rebecca ; Odell, Luke R ; Larhed, Mats

The Journal of organic chemistry, 04 February 2011, Vol.76(3), pp.978-81 [Peer Reviewed Journal]

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22
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2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution

Connolly, Stephen ; Aberg, Anders ; Arvai, Andrew ; Beaton, Haydn G ; Cheshire, David R ; Cook, Anthony R ; Cooper, Sally ; Cox, David ; Hamley, Peter ; Mallinder, Phil ; Millichip, Ian ; Nicholls, David J ; Rosenfeld, Robin J ; St-Gallay, Stephen A ; Tainer, John ; Tinker, Alan C ; Wallace, Alan V

Journal of medicinal chemistry, 03 June 2004, Vol.47(12), pp.3320-3 [Peer Reviewed Journal]

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23
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Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzoh1,6naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer

Liu, Qingsong ; Wang, Jinhua ; Kang, Seong A ; Thoreen, Carson C ; Hur, Wooyoung ; Ahmed, Tausif ; Sabatini, David M ; Gray, Nathanael S

Journal of medicinal chemistry, 10 March 2011, Vol.54(5), pp.1473-80 [Peer Reviewed Journal]

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24
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A metal-free tandem demethylenation/C(sp2)-H cycloamination process of N-benzyl-2-aminopyridines via C-C and C-N bond cleavage

Liang, Dongdong ; He, Yimiao ; Liu, Lanying ; Zhu, Qiang

Organic letters, 05 July 2013, Vol.15(13), pp.3476-9 [Peer Reviewed Journal]

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25
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Potent agonists of the protease activated receptor 2 (PAR2)

Boitano, Scott ; Flynn, Andrea N ; Schulz, Stephanie M ; Hoffman, Justin ; Price, Theodore J ; Vagner, Josef

Journal of medicinal chemistry, 10 March 2011, Vol.54(5), pp.1308-13 [Peer Reviewed Journal]

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26
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Potent and selective aminopyrimidine-based B-Raf inhibitors with favorable physicochemical and pharmacokinetic properties

Mathieu, Simon ; Gradl, Stefan N ; Ren, Li ; Wen, Zhaoyang ; Aliagas, Ignacio ; Gunzner-Toste, Janet ; Lee, Wendy ; Pulk, Rebecca ; Zhao, Guiling ; Alicke, Bruno ; Boggs, Jason W ; Buckmelter, Alex J ; Choo, Edna F ; Dinkel, Victoria ; Gloor, Susan L ; Gould, Stephen E ; Hansen, Joshua D ; Hastings, Gregg ; Hatzivassiliou, Georgia ; Laird, Ellen R ; Moreno, David ; Ran, Yingqing ; Voegtli, Walter C ; Wenglowsky, Steve ; Grina, Jonas ; Rudolph, Joachim

Journal of medicinal chemistry, 22 March 2012, Vol.55(6), pp.2869-81 [Peer Reviewed Journal]

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27
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Unprecedented catalytic activity of Fe(NO3)3·9H2O: regioselective synthesis of 2-nitroimidazopyridines via oxidative amination

Monir, Kamarul ; Bagdi, Avik Kumar ; Ghosh, Monoranjan ; Hajra, Alakananda

Organic letters, 05 September 2014, Vol.16(17), pp.4630-3 [Peer Reviewed Journal]

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28
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Identification of a new class of glucokinase activators through structure-based design

Hinklin, Ronald J ; Boyd, Steven A ; Chicarelli, Mark J ; Condroski, Kevin R ; Dewolf, Walter E ; Lee, Patrice A ; Lee, Waiman ; Singh, Ajay ; Thomas, Laurie ; Voegtli, Walter C ; Williams, Lance ; Aicher, Thomas D

Journal of medicinal chemistry, 10 October 2013, Vol.56(19), pp.7669-78 [Peer Reviewed Journal]

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29
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Synthesis and CYP26A1 inhibitory activity of novel methyl 3-4-(arylamino)phenyl-3-(azole)-2,2-dimethylpropanoates

Gomaa, Mohamed S ; Lim, Andrew S T ; Lau, S C Wilson ; Watts, Ann-Marie ; Illingworth, Nicola A ; Bridgens, Caroline E ; Veal, Gareth J ; Redfern, Christopher P F ; Brancale, Andrea ; Armstrong, Jane L ; Simons, Claire

Bioorganic & medicinal chemistry, 15 October 2012, Vol.20(20), pp.6080-8 [Peer Reviewed Journal]

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30
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Solvent-free synthesis of novel steroidal 2-aminopyridines

Zhang, Yan-Ling ; Li, Ya-Fei ; Shi, Xiao-Li ; Yu, Bin ; Shi, Yun-Kai ; Liu, Hong-Min

Steroids, November 2016, Vol.115, pp.147-153 [Peer Reviewed Journal]

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31
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Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors

Brand, Stephen ; Cleghorn, Laura A T ; Mcelroy, Stuart P ; Robinson, David A ; Smith, Victoria C ; Hallyburton, Irene ; Harrison, Justin R ; Norcross, Neil R ; Spinks, Daniel ; Bayliss, Tracy ; Norval, Suzanne ; Stojanovski, Laste ; Torrie, Leah S ; Frearson, Julie A ; Brenk, Ruth ; Fairlamb, Alan H ; Ferguson, Michael A J ; Read, Kevin D ; Wyatt, Paul G ; Gilbert, Ian H

Journal of medicinal chemistry, 12 January 2012, Vol.55(1), pp.140-52 [Peer Reviewed Journal]

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32
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Proton exchange reactions in isotope chemistry (II) synthesis of stable isotope-labeled LCQ908

Jian, Zhigang ; Ray, Tapan ; Wu, Amy ; Jones, Lawrence ; Forseth, Ry

Journal of labelled compounds & radiopharmaceuticals, October 2014, Vol.57(12), pp.670-3 [Peer Reviewed Journal]

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33
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Synthesis of aminopyridines and aminopyridones by cobalt-catalyzed 2+2+2 cycloadditions involving yne-ynamides: scope, limitations, and mechanistic insights

Garcia, Pierre ; Evanno, Yannick ; George, Pascal ; Sevrin, Mireille ; Ricci, Gino ; Malacria, Max ; Aubert, Corinne ; Gandon, Vincent

Chemistry (Weinheim an der Bergstrasse, Germany), 02 April 2012, Vol.18(14), pp.4337-44 [Peer Reviewed Journal]

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34
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Design, synthesis and biological evaluation of novel imidazopyridines as potential antidiabetic GSK3β inhibitors

Lee, Seung-Chul ; Kim, Hyun Tae ; Park, Choul-Hong ; Lee, Do Young ; Chang, Ho-Jin ; Park, Soobong ; Cho, Joong Myung ; Ro, Sunggu ; Suh, Young-Ger

Bioorganic & medicinal chemistry letters, 01 July 2012, Vol.22(13), pp.4221-4 [Peer Reviewed Journal]

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35
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Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation

Hanan, Emily J ; Eigenbrot, Charles ; Bryan, Marian C ; Burdick, Daniel J ; Chan, Bryan K ; Chen, Yuan ; Dotson, Jennafer ; Heald, Robert A ; Jackson, Philip S ; La, Hank ; Lainchbury, Michael D ; Malek, Shiva ; Purkey, Hans E ; Schaefer, Gabriele ; Schmidt, Stephen ; Seward, Eileen M ; Sideris, Steve ; Tam, Christine ; Wang, Shumei ; Yeap, Siew Kuen ; Yen, Ivana ; Yin, Jianping ; Yu, Christine ; Zilberleyb, Inna ; Heffron, Timothy P

Journal of medicinal chemistry, 11 December 2014, Vol.57(23), pp.10176-91 [Peer Reviewed Journal]

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Modification of the aminopyridine unit of 2'-deoxyaminopyridinyl-pseudocytidine allowing triplex formation at CG interruptions in homopurine sequences

Wang, Lei ; Taniguchi, Yosuke ; Okamura, Hidenori ; Sasaki, Shigeki

Nucleic acids research, 28 September 2018, Vol.46(17), pp.8679-8688 [Peer Reviewed Journal]

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