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14 Results  for Everything (Includes Articles)

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Selective Targeting of CTNNB1- , KRAS- or MYC- Driven Cell Growth by Combinations of Existing Drugs

Uitdehaag, Joost C. M ; De Roos, Jeroen A. D. M ; Van Doornmalen, Antoon M ; Prinsen, Martine B. W ; Spijkers-Hagelstein, Jill A. P ; De Vetter, Judith R. F ; De Man, Jos ; Buijsman, Rogier C ; Zaman, Guido J. R Haass, Nikolas K. (editor)

PLoS ONE, 2015, Vol.10(5) [Peer Reviewed Journal]

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Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance

Willemsen-Seegers, Nicole ; Uitdehaag, Joost C.M ; Prinsen, Martine B.W ; de Vetter, Judith R.F ; de Man, Jos ; Sawa, Masaaki ; Kawase, Yusuke ; Buijsman, Rogier C ; Zaman, Guido J.R

Journal of Molecular Biology, 17 February 2017, Vol.429(4), pp.574-586 [Peer Reviewed Journal]

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Comparison of the cancer gene targeting and biochemical selectivities of all targeted kinase inhibitors approved for clinical use

Uitdehaag, Joost C M ; De Roos, Jeroen A D M ; Van Doornmalen, Antoon M ; Prinsen, Martine B W ; De Man, Jos ; Tanizawa, Yoshinori ; Kawase, Yusuke ; Yoshino, Kohichiro ; Buijsman, Rogier C ; Zaman, Guido J R

PloS one, 2014, Vol.9(3), pp.e92146 [Peer Reviewed Journal]

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Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity

Uitdehaag, Joost C.M ; de Man, Jos ; Willemsen-Seegers, Nicole ; Prinsen, Martine B.W ; Libouban, Marion A.A ; Sterrenburg, Jan Gerard ; de Wit, Joeri J.P ; de Vetter, Judith R.F ; de Roos, Jeroen A.D.M ; Buijsman, Rogier C ; Zaman, Guido J.R

Journal of Molecular Biology, 07 July 2017, Vol.429(14), pp.2211-2230 [Peer Reviewed Journal]

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A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets

Uitdehaag, Joost Cm ; Verkaar, Folkert ; Alwan, Husam ; De Man, Jos ; Buijsman, Rogier C ; Zaman, Guido Jr

British Journal of Pharmacology, June 2012, Vol.166(3), pp.858-876 [Peer Reviewed Journal]

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High-Throughput Fluorescence-Based Screening Assays for Tryptophan-Catabolizing Enzymes

Seegers, Nicole ; van Doornmalen, Antoon M ; Uitdehaag, Joost C. M ; de Man, Jos ; Buijsman, Rogier C ; Zaman, Guido J. R

Journal of Biomolecular Screening, October 2014, Vol.19(9), pp.1266-1274 [Peer Reviewed Journal]

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7
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Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors

Ray, Peter ; Wright, Jane ; Adam, Julia ; Bennett, Johnathan ; Boucharens, Sylviane ; Black, Darcey ; Cook, Andrew ; Brown, Angus R ; Epemolu, Ola ; Fletcher, Dan ; Haunso, Anders ; Huggett, Margaret ; Jones, Phil ; Laats, Steven ; Lyons, Amanda ; Mestres, Jordi ; de Man, Jos ; Morphy, Richard ; Rankovic, Zoran ; Sherborne, Brad

Bioorganic & Medicinal Chemistry Letters, 01 January 2011, Vol.21(1), pp.97-101 [Peer Reviewed Journal]

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TTK Inhibitors as a Targeted Therapy for (-catenin) Mutant Cancers

Zaman, Guido J R ; De Roos, Jeroen A D M ; Libouban, Marion A A ; Prinsen, Martine B W ; De Man, Jos ; Buijsman, Rogier C ; Uitdehaag, Joost C M

Molecular cancer therapeutics, November 2017, Vol.16(11), pp.2609-2617 [Peer Reviewed Journal]

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Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines

Libouban, Marion A A ; De Roos, Jeroen A D M ; Uitdehaag, Joost C M ; Willemsen-Seegers, Nicole ; Mainardi, Sara ; Dylus, Jelle ; De Man, Jos ; Tops, Bastiaan ; Meijerink, Jules P P ; Storchová, Zuzana ; Buijsman, Rogier C ; Medema, René H ; Zaman, Guido J R

Oncotarget, 13 June 2017, Vol.8(24), pp.38309-38325 [Peer Reviewed Journal]

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Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors

Ray, Peter ; Wright, Jane ; Adam, Julia ; Boucharens, Sylviane ; Black, Darcey ; Brown, Angus R ; Epemolu, Ola ; Fletcher, Dan ; Huggett, Margaret ; Jones, Phil ; Laats, Steven ; Lyons, Amanda ; De Man, Jos ; Morphy, Richard ; Sherborne, Brad ; Sherry, Lorcan ; Straten, Nicole Van ; Westwood, Paul ; York, Mark

Bioorganic & medicinal chemistry letters, 15 February 2011, Vol.21(4), pp.1084-8 [Peer Reviewed Journal]

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Discovery of 8-Amino-imidazo[1,5- a ]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis

Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Yu, Younong ; Vaccaro, Henry ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cooper, Alan ; de Man, Jos ; Kaptein, Allard ; Maloney, Kevin ; Hornak, Viktor ; Gao, Ying-Duo ; Fischmann, Thierry O ; Raaijmakers, Hans ; Vu-Pham, Diep ; Presland, Jeremy ; Mansueto, My ; Xu, Zangwei ; Leccese, Erica ; Zhang-Hoover, Jie ; Knemeyer, Ian ; Garlisi, Charles G ; Bays, Nathan ; Stivers, Peter ; Brandish, Philip E ; Hicks, Alexandra ; Kim, Ronald ; Kozlowski, Joseph A Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

ACS Medicinal Chemistry Letters, 11 February 2016, Vol.7(2) [Peer Reviewed Journal]

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Cell Panel Profiling Reveals Conserved Therapeutic Clusters and Differentiates the Mechanism of Action of Different PI3K/mTOR, Aurora Kinase and EZH2 Inhibitors

Uitdehaag, Joost C M ; De Roos, Jeroen A D M ; Prinsen, Martine B W ; Willemsen-Seegers, Nicole ; De Vetter, Judith R F ; Dylus, Jelle ; Van Doornmalen, Antoon M ; Kooijman, Jeffrey ; Sawa, Masaaki ; Van Gerwen, Suzanne J C ; De Man, Jos ; Buijsman, Rogier C ; Zaman, Guido J R

Molecular cancer therapeutics, December 2016, Vol.15(12), pp.3097-3109 [Peer Reviewed Journal]

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Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158

Grobben, Yvonne ; Uitdehaag, Joost C.M ; Willemsen-Seegers, Nicole ; Tabak, Werner W.A ; de Man, Jos ; Buijsman, Rogier C ; Zaman, Guido J.R

Journal of Structural Biology: X, 2020, Vol.4 [Peer Reviewed Journal]

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Combined Cellular and Biochemical Profiling to Identify Predictive Drug Response Biomarkers for Kinase Inhibitors Approved for Clinical Use between 2013 and 2017

Uitdehaag, Joost C M ; Kooijman, Jeffrey J ; De Roos, Jeroen A D M ; Prinsen, Martine B W ; Dylus, Jelle ; Willemsen-Seegers, Nicole ; Kawase, Yusuke ; Sawa, Masaaki ; De Man, Jos ; Van Gerwen, Suzanne J C ; Buijsman, Rogier C ; Zaman, Guido J R

Molecular cancer therapeutics, February 2019, Vol.18(2), pp.470-481 [Peer Reviewed Journal]

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