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28 Results  for Everything (Includes Articles)

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1
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Metal-mediated protein stabilization

Arnold, Frances H ; Zhang, Ji-Hu

Trends in Biotechnology, 1994, Vol.12(5), pp.189-192 [Peer Reviewed Journal]

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Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

Qi, Wei ; Chan, Homan ; Teng, Lin ; Li, Ling ; Chuai, Shannon ; Zhang, Ruipeng ; Zeng, Jue ; Li, Min ; Fan, Hong ; Lin, Ying ; Gu, Justin ; Ardayfio, Ophelia ; Zhang, Ji-Hu ; Yan, Xiaoxia ; Fang, Jialuo ; Mi, Yuan ; Zhang, Man ; Zhou, Tao ; Feng, Grace ; Chen, Zijun ; Li, Guobin ; Yang, Teddy ; Zhao, Kehao ; Liu, Xianghui ; Yu, Zhengtian ; Lu, Chris X ; Atadja, Peter ; Li, En

Proceedings of the National Academy of Sciences of the United States of America, 26 December 2012, Vol.109(52), pp.21360-5 [Peer Reviewed Journal]

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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Chen, Ying-Nan P ; Lamarche, Matthew J ; Chan, Ho Man ; Fekkes, Peter ; Garcia-Fortanet, Jorge ; Acker, Michael G ; Antonakos, Brandon ; Chen, Christine Hiu-Tung ; Chen, Zhouliang ; Cooke, Vesselina G ; Dobson, Jason R ; Deng, Zhan ; Fei, Feng ; Firestone, Brant ; Fodor, Michelle ; Fridrich, Cary ; Gao, Hui ; Grunenfelder, Denise ; Hao, Huai-Xiang ; Jacob, Jaison ; Ho, Samuel ; Hsiao, Kathy ; Kang, Zhao B ; Karki, Rajesh ; Kato, Mitsunori ; Larrow, Jay ; La Bonte, Laura R ; Lenoir, Francois ; Liu, Gang ; Liu, Shumei ; Majumdar, Dyuti ; Meyer, Matthew J ; Palermo, Mark ; Perez, Lawrence ; Pu, Minying ; Price, Edmund ; Quinn, Christopher ; Shakya, Subarna ; Shultz, Michael D ; Slisz, Joanna ; Venkatesan, Kavitha ; Wang, Ping ; Warmuth, Markus ; Williams, Sarah ; Yang, Guizhi ; Yuan, Jing ; Zhang, Ji-Hu ; Zhu, Ping ; Ramsey, Timothy ; Keen, Nicholas J ; Sellers, William R ; Stams, Travis ; Fortin, Pascal D

Nature, 07 July 2016, Vol.535(7610), pp.148-52 [Peer Reviewed Journal]

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4
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Directed evolution of a fucosidase from a galactosidase by DNA shuffling and screening

Zhang, Ji-Hu ; Dawes, Glenn ; Stemmer, Willem

Proceedings of the National Academy of Sciences of the United States of America, Apr 29, 1997, Vol.94(9), pp.4504-4509 [Peer Reviewed Journal]

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Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED

Li, Ling ; Zhang, Hailong ; Zhang, Man ; Zhao, Mengxi ; Feng, Lijian ; Luo, Xiao ; Gao, Zhenting ; Huang, Ying ; Ardayfio, Ophelia ; Zhang, Ji-Hu ; Lin, Ying ; Fan, Hong ; Mi, Yuan ; Li, Guobin ; Liu, Lei ; Feng, Leying ; Luo, Fangjun ; Teng, Lin ; Qi, Wei ; Ottl, Johannes ; Lingel, Andreas ; Bussiere, Dirksen E ; Yu, Zhengtian ; Atadja, Peter ; Lu, Chris ; Li, En ; Gu, Justin ; Zhao, Kehao

PloS one, 2017, Vol.12(1), pp.e0169855 [Peer Reviewed Journal]

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6
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Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

Garcia Fortanet, Jorge ; Chen, Christine Hiu-Tung ; Chen, Ying-Nan P ; Chen, Zhouliang ; Deng, Zhan ; Firestone, Brant ; Fekkes, Peter ; Fodor, Michelle ; Fortin, Pascal D ; Fridrich, Cary ; Grunenfelder, Denise ; Ho, Samuel ; Kang, Zhao B ; Karki, Rajesh ; Kato, Mitsunori ; Keen, Nick ; Labonte, Laura R ; Larrow, Jay ; Lenoir, Francois ; Liu, Gang ; Liu, Shumei ; Lombardo, Franco ; Majumdar, Dyuti ; Meyer, Matthew J ; Palermo, Mark ; Perez, Lawrence ; Pu, Minying ; Ramsey, Timothy ; Sellers, William R ; Shultz, Michael D ; Stams, Travis ; Towler, Christopher ; Wang, Ping ; Williams, Sarah L ; Zhang, Ji-Hu ; Lamarche, Matthew J Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

Journal of Medicinal Chemistry, 08 September 2016, Vol.59(17) [Peer Reviewed Journal]

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7
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Matrix-Based Activity Pattern Classification as a Novel Method for the Characterization of Enzyme Inhibitors Derived from High-Throughput Screening

Auld, Douglas S ; Jimenez, Marta ; Yue, Kimberley ; Busby, Scott ; Chen, Yu-Chi ; Bowes, Scott ; Wendel, Greg ; Smith, Thomas ; Zhang, Ji-Hu

Journal of Biomolecular Screening, December 2016, Vol.21(10), pp.1075-1089 [Peer Reviewed Journal]

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8
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Application of Titration-Based Screening for the Rapid Pilot Testing of High-Throughput Assays

Zhang, Ji-Hu ; Kang, Zhao B ; Ardayfio, Ophelia ; Ho, Pei-I ; Smith, Thomas ; Wallace, Iain ; Bowes, Scott ; Hill, W. Adam ; Auld, Douglas S

Journal of Biomolecular Screening, June 2014, Vol.19(5), pp.651-660 [Peer Reviewed Journal]

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9
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Compound set enrichment: a novel approach to analysis of primary HTS data

Varin, Thibault ; Gubler, Hanspeter ; Parker, Christian N ; Zhang, Ji-Hu ; Raman, Pichai ; Ertl, Peter ; Schuffenhauer, Ansgar

Journal of chemical information and modeling, 27 December 2010, Vol.50(12), pp.2067-78 [Peer Reviewed Journal]

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10
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Assay Development and Screening of Human DGAT1 Inhibitors with an LC/MS-Based Assay: Application of Mass Spectrometry for Large-Scale Primary Screening

Zhang, Ji-Hu ; Roddy, Thomas P ; Ho, Pei-I ; Horvath, Christopher R ; Vickers, Chad ; Stout, Steven ; Hubbard, Brian ; Wang, Y. Karen ; Hill, W. Adam ; Bojanic, Dejan

Journal of Biomolecular Screening, July 2010, Vol.15(6), pp.695-702 [Peer Reviewed Journal]

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11
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3,5-Diarylazoles as novel and selective inhibitors of protein kinase D

Gamber, Gabriel G ; Meredith, Erik ; Zhu, Qingming ; Yan, Wanlin ; Rao, Chang ; Capparelli, Michael ; Burgis, Robin ; Enyedy, Istvan ; Zhang, Ji-Hu ; Soldermann, Nicolas ; Beattie, Kimberley ; Rozhitskaya, Olga ; Koch, Keith A ; Pagratis, Nikos ; Hosagrahara, Vinayak ; Vega, Richard B ; Mckinsey, Timothy A ; Monovich, Lauren

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(5), pp.1447-1451 [Peer Reviewed Journal]

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12
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Development of a Homogeneous, Fluorescence Resonance Energy Transfer-Based in Vitro Recruitment Assay for Peroxisome Proliferator-Activated Receptor δ via Selection of Active LXXLL Coactivator Peptides

Drake, Katherine A ; Zhang, Ji-Hu ; Harrison, Richard K ; Mcgeehan, Gerald M

Analytical Biochemistry, 01 May 2002, Vol.304(1), pp.63-69 [Peer Reviewed Journal]

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13
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Identification of orally available naphthyridine protein kinase D inhibitors

Meredith, Erik L ; Ardayfio, Ophelia ; Beattie, Kimberly ; Dobler, Markus R ; Enyedy, Istvan ; Gaul, Christoph ; Hosagrahara, Vinayak ; Jewell, Charles ; Koch, Keith ; Lee, Wendy ; Lehmann, Hansjoerg ; Mckinsey, Timothy A ; Miranda, Karl ; Pagratis, Nikos ; Pancost, Margaret ; Patnaik, Anup ; Phan, Dillon ; Plato, Craig ; Qian, Ming ; Rajaraman, Vasumathy ; Rao, Chang ; Rozhitskaya, Olga ; Ruppen, Thomas ; Shi, Jie ; Siska, Sarah J ; Springer, Clayton ; Van Eis, Maurice ; Vega, Richard B ; Von Matt, Anette ; Yang, Lihua ; Yoon, Taeyoung ; Zhang, Ji-Hu ; Zhu, Na ; Monovich, Lauren G

Journal of medicinal chemistry, 12 August 2010, Vol.53(15), pp.5400-21 [Peer Reviewed Journal]

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14
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Mass Spectrometric Techniques for Label-free High-Throughput Screening in Drug Discovery

Roddy, Thomas ; Horvath, Christopher ; Stout, Steven ; Kenney, Kristin ; Ho, Pei-I ; Zhang, Ji-Hu ; Vickers, Chad ; Kaushik, Virendar ; Hubbard, Brian ; Wang, Y

Analytical Chemistry, Nov 1, 2007, Vol.79(21), p.8207 [Peer Reviewed Journal]

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15
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A High-Throughput Homogeneous Assay for Reverse Transcriptase Using Generic Reagents and Time-Resolved Fluorescence Detection

Zhang, Ji-Hu ; Chen, Tongming ; Nguyen, Son H ; Oldenburg, Kevin R

Analytical Biochemistry, 01 June 2000, Vol.281(2), pp.182-186 [Peer Reviewed Journal]

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16
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Discovery and Characterization of Allosteric WNK Kinase Inhibitors

Yamada, Ken ; Zhang, Ji-Hu ; Xie, Xiaoling ; Reinhardt, Juergen ; Xie, Amy Qiongshu ; Lasala, Daniel ; Kohls, Darcy ; Yowe, David ; Burdick, Debra ; Yoshisue, Hajime ; Wakai, Hiromichi ; Schmidt, Isabel ; Gunawan, Jason ; Yasoshima, Kayo ; Yue, Q Kimberley ; Kato, Mitsunori ; Mogi, Muneto ; Idamakanti, Neeraja ; Kreder, Natasha ; Drueckes, Peter ; Pandey, Pramod ; Kawanami, Toshio ; Huang, Waanjeng ; Yagi, Yukiko I ; Deng, Zhan ; Park, Hyi-Man

ACS chemical biology, 16 December 2016, Vol.11(12), pp.3338-3346 [Peer Reviewed Journal]

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17
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Development of a Carbon Dioxide-Capture Assay in Microtiter Plate for Aspartyl-β-hydroxylase

Zhang, Ji-Hu ; Qi, Richard C.C ; Chen, Tongming ; Chung, Thomas D.Y ; Stern, Andrew M ; Hollis, Gregory F ; Copeland, Robert A ; Oldenburg, Kevin R

Analytical Biochemistry, 01 July 1999, Vol.271(2), pp.137-142 [Peer Reviewed Journal]

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18
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Further Comparison of Primary Hit Identification by Different Assay Technologies and Effects of Assay Measurement Variability

Wu, Xiang ; Sills, Matthew A ; Zhang, Ji-Hu

Journal of Biomolecular Screening, September 2005, Vol.10(6), pp.581-589 [Peer Reviewed Journal]

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19
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Evaluation of Division-Arrested Cells for Cell-Based High-Throughput Screening and Profiling

Digan, Mary Ellen ; Pou, Chantevy ; Niu, Honglin ; Zhang, Ji-Hu

Journal of Biomolecular Screening, September 2005, Vol.10(6), pp.615-623 [Peer Reviewed Journal]

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20
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Probing the Primary Screening Efficiency by Multiple Replicate Testing: A Quantitative Analysis of Hit Confirmation and False Screening Results of a Biochemical Assay

Zhang, Ji-Hu ; Wu, Xiang ; Sills, Matthew A

Journal of Biomolecular Screening, October 2005, Vol.10(7), pp.695-704 [Peer Reviewed Journal]

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21
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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Zhang, Ji-Hu ; Chung, Thomas D. Y ; Oldenburg, Kevin R

Journal of Biomolecular Screening, April 1999, Vol.4(2), pp.67-73 [Peer Reviewed Journal]

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22
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Amino-acid sequences of the alpha- and beta-subunits of hemerythrin from Lingula reevii

Negri, Armando ; Tedeschi, Gabriella ; Bonomi, Francesco ; Zhang, Ji-Hu ; Kurtz, Donald M

Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular Enzymology, 1994, Vol.1208(2), pp.277-285 [Peer Reviewed Journal]

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23
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Conversion of non-functional to functional iron following reconstitution of hemerythrin

Zhang, Ji-Hu ; Kurtz, Donald M ; Xia, Yao-Min ; Debrunner, Peter G

Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular Enzymology, 1992, Vol.1122(3), pp.293-298 [Peer Reviewed Journal]

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24
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Direct mass spectrometric determination of bead bound compounds in a combinatorial lead discovery application

Blom, Karl F. ; Combs, Andrew P. ; Rockwell, Arlene L. ; Oldenburg, Kevin R. ; Zhang, JiHu ; Chen, Tongming

Rapid Communications in Mass Spectrometry, 15 September 1998, Vol.12(17), pp.1192-1198 [Peer Reviewed Journal]

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25
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Myohemerythrin from the sipunculid, Phascolopsis gouldii: purification, properties and amino acid sequence

Long, Russell C ; Zhang, Ji-Hu ; Kurtz, Donald M ; Negri, Armando ; Tedeschi, Grabiella ; Bonomi, Francesco

Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular Enzymology, 1992, Vol.1122(2), pp.136-142 [Peer Reviewed Journal]

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26
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Primary structure of myohemerythrin from [formula omitted]

Zhang, Ji-Hu ; Long, Russell C ; Kurtz, Donald M ; Negri, Armando ; Tedeschi, Gabriella ; Bonomi, Francesco

Journal of Inorganic Biochemistry, 1991, Vol.43(2), pp.537-537 [Peer Reviewed Journal]

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27
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Metal substitutions at the diiron sites of hemerythrin and myohemerythrin

Zhang, Ji-Hu ; Kurtz, Donald M ; Xia, Yao-Min ; Debrunner, Peter G ; Whitehead, Joyce P ; Maroney, Michael J

Journal of Inorganic Biochemistry, 1991, Vol.43(2), pp.539-539 [Peer Reviewed Journal]

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28
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Ligand and coactivator recruitment preferences of peroxisome proliferator activated receptor α

Mukherjee, Ranjan ; Sun, Shaoxian ; Santomenna, Linda ; Miao, Bowman ; Walton, Harry ; Liao, Boshan ; Locke, Kenneth ; Zhang, Ji-Hu ; Nguyen, Sonny H ; Zhang, Li Tao ; Murphy, Kathleen ; Ross, Harold O ; Xia, M.X ; Teleha, Christopher ; Chen, S.-Y ; Selling, Bernard ; Wynn, Richard ; Burn, Timothy ; Young, Peter R

Journal of Steroid Biochemistry and Molecular Biology, 2002, Vol.81(3), pp.217-225 [Peer Reviewed Journal]

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