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14 Results  for Everything (Includes Articles)

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Correction to Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure-Activity Relationships of Novel 1-(Imidazo1,2-apyridin-6-yl)pyridin-2(1H)-one Derivatives

Igawa, Hideyuki ; Takahashi, Masashi ; Kakegawa, Keiko ; Kina, Asato ; Ikoma, Minoru ; Aida, Jumpei ; Yasuma, Tsuneo ; Kawata, Yayoi ; Ashina, Shuntaro ; Yamamoto, Syunsuke ; Kundu, Mrinalkanti ; Khamrai, Uttam ; Hirabayashi, Hideki ; Nakayama, Masaharu ; Nagisa, Yasutaka ; Kasai, Shizuo ; Maekawa, Tsuyoshi

Journal of medicinal chemistry, 14 April 2016, Vol.59(7), pp.3577 [Peer Reviewed Journal]

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Discovery of novel and potent orally active calcium-sensing receptor antagonists that stimulate pulselike parathyroid hormone secretion: synthesis and structure-activity relationships of tetrahydropyrazolopyrimidine derivatives

Yoshida, Masato ; Mori, Akira ; Kotani, Etsuo ; Oka, Masahiro ; Makino, Haruhiko ; Fujita, Hisashi ; Ban, Junko ; Ikeda, Yukihiro ; Kawamoto, Tomohiro ; Goto, Mika ; Kimura, Hiroyuki ; Baba, Atsuo ; Yasuma, Tsuneo

Journal of medicinal chemistry, 10 March 2011, Vol.54(5), pp.1430-40 [Peer Reviewed Journal]

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Design, synthesis, and biological activity of potent and orally available G protein-coupled receptor 40 agonists

Sasaki, Shinobu ; Kitamura, Shuji ; Negoro, Nobuyuki ; Suzuki, Masami ; Tsujihata, Yoshiyuki ; Suzuki, Nobuhiro ; Santou, Takashi ; Kanzaki, Naoyuki ; Harada, Masataka ; Tanaka, Yasuhiro ; Kobayashi, Makoto ; Tada, Norio ; Funami, Miyuki ; Tanaka, Toshimasa ; Yamamoto, Yoshio ; Fukatsu, Kohji ; Yasuma, Tsuneo ; Momose, Yu

Journal of medicinal chemistry, 10 March 2011, Vol.54(5), pp.1365-78 [Peer Reviewed Journal]

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Optimization of (2,3-dihydro-1-benzofuran-3-yl)acetic acids: discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent

Negoro, Nobuyuki ; Sasaki, Shinobu ; Mikami, Satoshi ; Ito, Masahiro ; Tsujihata, Yoshiyuki ; Ito, Ryo ; Suzuki, Masami ; Takeuchi, Koji ; Suzuki, Nobuhiro ; Miyazaki, Junichi ; Santou, Takashi ; Odani, Tomoyuki ; Kanzaki, Naoyuki ; Funami, Miyuki ; Morohashi, Akio ; Nonaka, Masami ; Matsunaga, Shinichiro ; Yasuma, Tsuneo ; Momose, Yu

Journal of medicinal chemistry, 26 April 2012, Vol.55(8), pp.3960-74 [Peer Reviewed Journal]

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Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G protein-coupled receptor 40 agonists for the treatment of type 2 diabetes

Mikami, Satoshi ; Kitamura, Shuji ; Negoro, Nobuyuki ; Sasaki, Shinobu ; Suzuki, Masami ; Tsujihata, Yoshiyuki ; Miyazaki, Takeshi ; Ito, Ryo ; Suzuki, Nobuhiro ; Miyazaki, Junichi ; Santou, Takashi ; Kanzaki, Naoyuki ; Funami, Miyuki ; Tanaka, Toshimasa ; Yasuma, Tsuneo ; Momose, Yu

Journal of medicinal chemistry, 26 April 2012, Vol.55(8), pp.3756-76 [Peer Reviewed Journal]

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Identification of fused-ring alkanoic acids with improved pharmacokinetic profiles that act as G protein-coupled receptor 40/free fatty acid receptor 1 agonists

Negoro, Nobuyuki ; Sasaki, Shinobu ; Ito, Masahiro ; Kitamura, Shuji ; Tsujihata, Yoshiyuki ; Ito, Ryo ; Suzuki, Masami ; Takeuchi, Koji ; Suzuki, Nobuhiro ; Miyazaki, Junichi ; Santou, Takashi ; Odani, Tomoyuki ; Kanzaki, Naoyuki ; Funami, Miyuki ; Tanaka, Toshimasa ; Yasuma, Tsuneo ; Momose, Yu

Journal of medicinal chemistry, 23 February 2012, Vol.55(4), pp.1538-52 [Peer Reviewed Journal]

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7
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Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure-Activity Relationships of Novel 1-(Imidazo1,2-apyridin-6-yl)pyridin-2(1H)-one Derivatives

Igawa, Hideyuki ; Takahashi, Masashi ; Kakegawa, Keiko ; Kina, Asato ; Ikoma, Minoru ; Aida, Jumpei ; Yasuma, Tsuneo ; Kawata, Yayoi ; Ashina, Shuntaro ; Yamamoto, Syunsuke ; Kundu, Mrinalkanti ; Khamrai, Uttam ; Hirabayashi, Hideki ; Nakayama, Masaharu ; Nagisa, Yasutaka ; Kasai, Shizuo ; Maekawa, Tsuyoshi

Journal of medicinal chemistry, 11 February 2016, Vol.59(3), pp.1116-39 [Peer Reviewed Journal]

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Synthesis and structure–activity relationship of tetrahydropyrazolopyrimidine derivatives—A novel structural class of potent calcium-sensing receptor antagonists

Yoshida, Masato ; Mori, Akira ; Inaba, Atsuhiro ; Oka, Masahiro ; Makino, Haruhiko ; Yamaguchi, Masashi ; Fujita, Hisashi ; Kawamoto, Tomohiro ; Goto, Mika ; Kimura, Hiroyuki ; Baba, Atsuo ; Yasuma, Tsuneo

Bioorganic & Medicinal Chemistry, 2010, Vol.18(24), pp.8501-8511 [Peer Reviewed Journal]

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Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition

Igawa, Hideyuki ; Takahashi, Masashi ; Shirasaki, Mikio ; Kakegawa, Keiko ; Kina, Asato ; Ikoma, Minoru ; Aida, Jumpei ; Yasuma, Tsuneo ; Okuda, Shoki ; Kawata, Yayoi ; Noguchi, Toshihiro ; Yamamoto, Syunsuke ; Fujioka, Yasushi ; Kundu, Mrinalkanti ; Khamrai, Uttam ; Nakayama, Masaharu ; Nagisa, Yasutaka ; Kasai, Shizuo ; Maekawa, Tsuyoshi

Bioorganic & Medicinal Chemistry, 01 June 2016, Vol.24(11), pp.2486-2503 [Peer Reviewed Journal]

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Novel and potent calcium-sensing receptor antagonists: Discovery of (5R)-N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide monotosylate (TAK-075) as an orally active bone anabolic agent

Yoshida, Masato ; Mori, Akira ; Morimoto, Shinji ; Kotani, Etsuo ; Oka, Masahiro ; Notoya, Kohei ; Makino, Haruhiko ; Ono, Midori ; Shirasaki, Mikio ; Tada, Norio ; Fujita, Hisashi ; Ban, Junko ; Ikeda, Yukihiro ; Kawamoto, Tomohiro ; Goto, Mika ; Kimura, Hiroyuki ; Baba, Atsuo ; Yasuma, Tsuneo

Bioorganic & Medicinal Chemistry, 15 March 2011, Vol.19(6), pp.1881-1894 [Peer Reviewed Journal]

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11
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TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats

Tsujihata, Yoshiyuki ; Ito, Ryo ; Suzuki, Masami ; Harada, Ayako ; Negoro, Nobuyuki ; Yasuma, Tsuneo ; Momose, Yu ; Takeuchi, Koji

The Journal of pharmacology and experimental therapeutics, October 2011, Vol.339(1), pp.228-37 [Peer Reviewed Journal]

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12
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Nad(p) +-nad(p)h models. 50. Stereo-controlled reduction of methyl 2-oxo-3-methylpentanoate

Ohno, Atsuyoshi ; Joung, Hee Lee ; Yasuma, Tsuneo ; Oka, Shinzaburo

Tetrahedron Letters, 1984, Vol.25(19), pp.1995-1998 [Peer Reviewed Journal]

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13
Synthesis of Peptide Aldehyde Derivatives as Selective Inhibitors of Human Cathepsin L and Their Inhibitory Effect on Bone Resorption 1
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Synthesis of Peptide Aldehyde Derivatives as Selective Inhibitors of Human Cathepsin L and Their Inhibitory Effect on Bone Resorption 1

Yasuma, Tsuneo ; Oi, Satoru ; Choh, Nobuo ; Nomura, Toshiyuki ; Furuyama, Naoki ; Nishimura, Atsushi ; Fujisawa, Yukio ; Sohda, Takashi

Journal of Medicinal Chemistry, 10/1998, Vol.41(22), pp.4301-4308 [Peer Reviewed Journal]

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14
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Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist

Negoro, Nobuyuki ; Sasaki, Shinobu ; Mikami, Satoshi ; Ito, Masahiro ; Suzuki, Masami ; Tsujihata, Yoshiyuki ; Ito, Ryo ; Harada, Ayako ; Takeuchi, Koji ; Suzuki, Nobuhiro ; Miyazaki, Junichi ; Santou, Takashi ; Odani, Tomoyuki ; Kanzaki, Naoyuki ; Funami, Miyuki ; Tanaka, Toshimasa ; Kogame, Akifumi ; Matsunaga, Shinichiro ; Yasuma, Tsuneo ; Momose

ACS medicinal chemistry letters, 09 September 2010, Vol.1(6), pp.290-4 [Peer Reviewed Journal]

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