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The role of anthropogenic and natural factors in shaping the geochemical evolution of groundwater in the Subei Lake basin, Ordos energy base, Northwestern China

Liu, Fei ; Song, Xianfang ; Yang, Lihu ; Han, Dongmei ; Zhang, Yinghua ; Ma, Ying ; Bu, Hongmei

Science of the Total Environment, 15 December 2015, Vol.538, pp.327-340 [Peer Reviewed Journal]

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Impacting Global Health Through Equipment Repurposing: Measurable Progress Through the Accumulation of Many Tiny Victories

Buist, Nicole L ; Minnihan, Ellen C ; Young, Katherine ; Yang, Lihu

Journal of Pharmaceutical Sciences, March 2018, Vol.107(3), pp.788-793 [Peer Reviewed Journal]

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Facile cleavage of the carbamate linker of hydroxymethyl resin and its application in syntheses requiring strongly acidic conditions

Yang, Lihu

Tetrahedron Letters, 2000, Vol.41(36), pp.6981-6984 [Peer Reviewed Journal]

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A simple and efficient procedure for the synthesis of benzimidazoles using air as the oxidant

Lin, Songnian ; Yang, Lihu

Tetrahedron Letters, 2005, Vol.46(25), pp.4315-4319 [Peer Reviewed Journal]

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5
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Solid phase synthesis of ‘head-to-tail’ cyclic peptides using a sulfonamide ‘safety-catch’ linker: the cleavage by cyclization approach

Yang, Lihu ; Morriello, Greg

Tetrahedron Letters, 1999, Vol.40(47), pp.8197-8200 [Peer Reviewed Journal]

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6
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Solid phase synthesis of Fmoc N-methyl amino acids: Application of the Fukuyama amine synthesis

Yang, Lihu ; Chiu, Kuenley

Tetrahedron Letters, 1997, Vol.38(42), pp.7307-7310 [Peer Reviewed Journal]

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7
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Stable isotopic compositions of precipitation in China

Liu, Jianrong ; Song, Xianfang ; Yuan, Guofu ; Sun, Xiaomin ; Yang, Lihu

Tellus B: Chemical and Physical Meteorology, 01 January 2014, Vol.66(1) [Peer Reviewed Journal]

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8
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Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2

Yang, Lihu ; Berk, Scott ; Rohrer, Susan ; Mosley, Ralph

Proceedings of the National Academy of Sciences of the United States of America, Sep 1, 1998, Vol.95(18), pp.10836-10841 [Peer Reviewed Journal]

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9
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A general method for the preparation of 3-acyl-4-cyano-5-amino-pyrazoles

Ge, Min ; Cline, Eric ; Yang, Lihu

Tetrahedron Letters, 2006, Vol.47(32), pp.5797-5799 [Peer Reviewed Journal]

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10
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BaCO3 targets produced from dissolved carbonate in groundwater for direct AMS measurement

Yang, Lihu ; Rayda, Vladyslav ; Zhao, Xiaolei ; Murseli, Sarah ; Song, Xianfang ; Clark, Ian D

Nuclear Inst. and Methods in Physics Research, B, 01 December 2018, Vol.436, pp.186-190 [Peer Reviewed Journal]

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11
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The interaction between surface water and groundwater and its effect on water quality in the Second Songhua River basin, northeast China

Zhang, Bing ; SONG, XIANFANG ; ZHANG, YINGHUA ; MA, YING ; TANG, CHANGYUAN ; YANG, LIHU ; WANG, ZHONG-LIANG

Journal of Earth System Science, 2016, Vol.125(7), pp.1495-1507 [Peer Reviewed Journal]

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12
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An expeditious synthesis of 3-(difluoromethoxy)- and 3-(trifluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridines

Guiadeen, Deodialsingh ; Kothandaraman, Shankaran ; Yang, Lihu ; Mills, Sander G ; Maccoss, Malcolm

Tetrahedron Letters, 2008, Vol.49(44), pp.6368-6370 [Peer Reviewed Journal]

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13
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Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity

Zhou, Changyou ; Garcia-Calvo, Margareta ; Pinto, Shirly ; Lombardo, Matthew ; Feng, Zhe ; Bender, Kate ; Pryor, Kellyann D ; Bhatt, Urmi R ; Chabin, Renee M ; Geissler, Wayne M ; Shen, Zhu ; Tong, Xinchun ; Zhang, Zhoupeng ; Wong, Kenny K ; Roy, Ranabir Sinha ; Chapman, Kevin T ; Yang, Lihu ; Xiong, Yusheng

Journal of medicinal chemistry, 14 October 2010, Vol.53(19), pp.7251-63 [Peer Reviewed Journal]

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14
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Synthetic approaches toward mitomycins. I. Stereoselective synthesis of a tetracyclic intermediate

Fukuyama, Tohru ; Yang, Lihu

Tetrahedron Letters, 1986, Vol.27(52), pp.6299-6300 [Peer Reviewed Journal]

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15
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Dual targeting of CCR2 and CX3CR1 in an arterial injury model of vascular inflammation

Jerath Maya R ; Liu Peng ; Struthers Mary ; Demartino Julie A ; Peng Roche ; Peterson Laurence B ; Cumiskey Anne-Marie ; Yang Lihu ; Rojas Mauricio ; Patel Dhavalkumar D ; Fong Alan M

Thrombosis Journal, 01 September 2010, Vol.8(1), p.14 [Peer Reviewed Journal]

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16
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Concise preparation of 8-trifluoromethyltetrahydro-6 H-pyrido [1,2- a] pyrazine-6-one

Kothandaraman, Shankaran ; Guiadeen, Deodialsingh ; Butora, Gabor ; Doss, George ; Mills, Sander G ; Maccoss, Malcolm ; Yang, Lihu

Tetrahedron Letters, 2009, Vol.50(28), pp.4050-4053 [Peer Reviewed Journal]

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17
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The renewability and quality of shallow groundwater in Sanjiang and Songnen Plain, Northeast China

Zhang, Bing ; Song, Xian-Fang ; Zhang, Ying-Hua ; Han, Dong-Mei ; Tang, Chang-Yuan ; Yang, Lihu ; Wang, Zhong-Liang

Journal of Integrative Agriculture, January 2017, Vol.16(1), pp.229-238 [Peer Reviewed Journal]

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18
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Antidiabetic Activity of a Highly Potent and Selective Non-Peptidal Somatostatin Receptor Subtype-2 Agonist

Strowski, Mathias ; Cashen, Doreen ; Birzin, Elizabeth ; Yang, Lihu

Diabetes, Jun 2005, Vol.54, p.A411 [Peer Reviewed Journal]

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19
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Synthesis of 2′-β- C-methyl-neplanocin derivatives as anti-HCV agents

Liao, Xibin ; Butora, Gabor ; Olsen, David B ; Carroll, Steven S ; Mcmasters, Daniel R ; Leone, Joseph F ; Stahlhut, Mark ; Doss, George A ; Yang, Lihu ; Maccoss, Malcolm

Tetrahedron Letters, 2008, Vol.49(26), pp.4149-4152 [Peer Reviewed Journal]

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20
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Dual targeting of CCR2 and CX3CR1 in an arterial injury model of vascular inflammation

Jerath, Maya ; Liu, Peng ; Struthers, Mary ; Demartino, Julie ; Peng, Roche ; Peterson, Laurence ; Cumiskey, Anne-Marie ; Yang, Lihu ; Rojas, Mauricio ; Patel, Dhavalkumar ; Fong, Alan

Thrombosis Journal, 2010, Vol.8, p.14 [Peer Reviewed Journal]

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21
Discovery of a Potent and Orally Bioavailable CCR2 and CCR5 Dual Antagonist
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Discovery of a Potent and Orally Bioavailable CCR2 and CCR5 Dual Antagonist

Pasternak, Alexander ; Goble, Stephen D. ; Struthers, Mary ; Vicario, Pasquale P. ; Ayala, Julia M. ; Di Salvo, Jerry ; Kilburn, Ruth ; Wisniewski, Thomas ; Demartino, Julie A. ; Mills, Sander G. ; Yang, Lihu

ACS Medicinal Chemistry Letters, 04/08/2010, Vol.1(1), pp.14-18 [Peer Reviewed Journal]

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22
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3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists

Walsh, Shawn P ; Severino, Alexandra ; Zhou, Changyou ; He, Jiafang ; Liang, Gui-Bai ; Tan, Carina P ; Cao, Jin ; Eiermann, George J ; Xu, Ling ; Salituro, Gino ; Howard, Andrew D ; Mills, Sander G ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(11), pp.3390-3394 [Peer Reviewed Journal]

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23
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Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

Lin, Songnian ; Malkani, Sunita ; Lombardo, Matthew ; Yang, Lihu ; Mills, Sander G ; Chapman, Kevin ; Thompson, James E ; Zhang, Wen Xiao ; Wang, Ruixiu ; Cubbon, Rose M ; O’neill, Edward A ; Hale, Jeffrey J

Bioorganic & Medicinal Chemistry Letters, 15 November 2015, Vol.25(22), pp.5402-5408 [Peer Reviewed Journal]

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24
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Novel, orally bioavailable gamma-aminoamide CC chemokine receptor 2 (CCR2) antagonists

Pasternak, Alexander ; Marino, Dominick ; Vicario, Pasquale P ; Ayala, Julia Marie ; Cascierri, Margaret A ; Parsons, William ; Mills, Sander G ; Maccoss, Malcolm ; Yang, Lihu

Journal of medicinal chemistry, 10 August 2006, Vol.49(16), pp.4801-4 [Peer Reviewed Journal]

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25
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Correction: Chen, S. et al. The Tradeoff Analysis for Remote Sensing Image Fusion Using Expanded Spectral Angle Mapper. Sensors 2008, 8, 520-528

Chen, Shaohui ; Su, Hongbo ; Zhang, Renhua ; Tian, Jing ; Yang, Lihu

Sensors, 2012, Vol.12(9), p.12374 [Peer Reviewed Journal]

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26
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Linking High-Throughput Screens to Identify MoAs and Novel Inhibitors of Mycobacterium tuberculosis Dihydrofolate Reductase

Santa Maria, John P ; Park, Yumi ; Yang, Lihu ; Murgolo, Nicholas ; Altman, Michael D ; Zuck, Paul ; Adam, Greg ; Chamberlin, Chad ; Saradjian, Peter ; Dandliker, Peter ; Boshoff, Helena I M ; Barry, Clifton E ; Garlisi, Charles ; Olsen, David B ; Young, Katherine ; Glick, Meir ; Nickbarg, Elliott ; Kutchukian, Peter S

ACS chemical biology, 15 September 2017, Vol.12(9), pp.2448-2456 [Peer Reviewed Journal]

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27
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Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one

Tang, Haifeng ; de Jesus, Reynald K ; Walsh, Shawn P ; Zhu, Yuping ; Yan, Yan ; Priest, Birgit T ; Swensen, Andrew M ; Alonso-Galicia, Magdalena ; Felix, John P ; Brochu, Richard M ; Bailey, Timothy ; Thomas-Fowlkes, Brande ; Zhou, Xiaoyan ; Pai, Lee-Yuh ; Hampton, Caryn ; Hernandez, Melba ; Owens, Karen ; Roy, Sophie ; Kaczorowski, Gregory J ; Yang, Lihu ; Garcia, Maria L ; Pasternak, Alexander

Bioorganic & Medicinal Chemistry Letters, 01 November 2013, Vol.23(21), pp.5829-5832 [Peer Reviewed Journal]

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28
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Macrocyclic renin inhibitors: Synthesis of a subnanomolar, orally active cysteine derived inhibitor

Yang, Lihu ; Weber, Ann E ; Greenlee, William J ; Patchett, Arthur A

Tetrahedron Letters, 1993, Vol.34(44), pp.7035-7038 [Peer Reviewed Journal]

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29
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Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists

Yang, Lihu ; Butora, Gabor ; Jiao, Richard X ; Pasternak, Alex ; Zhou, Changyou ; Parsons, William H ; Mills, Sander G ; Vicario, Pasquale P ; Ayala, Julia M ; Cascieri, Margaret A ; Maccoss, Malcolm

Journal of medicinal chemistry, 31 May 2007, Vol.50(11), pp.2609-11 [Peer Reviewed Journal]

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30
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Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure

Tang, Haifeng ; Zhu, Yuping ; Teumelsan, Nardos ; Walsh, Shawn P ; Shahripour, Aurash ; Priest, Birgit T ; Swensen, Andrew M ; Felix, John P ; Brochu, Richard M ; Bailey, Timothy ; Thomas-Fowlkes, Brande ; Pai, Lee-Yuh ; Hampton, Caryn ; Corona, Aaron ; Hernandez, Melba ; Metzger, Joseph ; Forrest, Michael ; Zhou, Xiaoyan ; Owens, Karen ; Tong, Vincent ; Parmee, Emma ; Roy, Sophie ; Kaczorowski, Gregory J ; Yang, Lihu ; Alonso-Galicia, Magdalena ; Garcia, Maria L ; Pasternak, Alexander

ACS medicinal chemistry letters, 14 July 2016, Vol.7(7), pp.697-701 [Peer Reviewed Journal]

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31
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Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics

Tang, Haifeng ; Walsh, Shawn P ; Yan, Yan ; De Jesus, Reynalda K ; Shahripour, Aurash ; Teumelsan, Nardos ; Zhu, Yuping ; Ha, Sookhee ; Owens, Karen A ; Thomas-Fowlkes, Brande S ; Felix, John P ; Liu, Jessica ; Kohler, Martin ; Priest, Birgit T ; Bailey, Timothy ; Brochu, Richard ; Alonso-Galicia, Magdalena ; Kaczorowski, Gregory J ; Roy, Sophie ; Yang, Lihu ; Mills, Sander G ; Garcia, Maria L ; Pasternak, Alexander

ACS medicinal chemistry letters, 10 May 2012, Vol.3(5), pp.367-72 [Peer Reviewed Journal]

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32
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Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold

Zhu, Yuping ; de Jesus, Reynalda K ; Tang, Haifeng ; Walsh, Shawn P ; Jiang, Jinlong ; Gu, Xin ; Teumelsan, Nardos ; Shahripour, Aurash ; Pio, Barbara ; Ding, Fa-Xiang ; Ha, Sookhee ; Priest, Birgit T ; Swensen, Andrew M ; Alonso-Galicia, Magdalena ; Felix, John P ; Brochu, Richard M ; Bailey, Timothy ; Thomas-Fowlkes, Brande ; Zhou, Xiaoyan ; Pai, Lee-Yuh ; Hampton, Caryn ; Hernandez, Melba ; Owens, Karen ; Ehrhart, Juliann ; Roy, Sophie ; Kaczorowski, Gregory J ; Yang, Lihu ; Parmee, Emma R ; Sullivan, Kathleen ; Garcia, Maria L ; Pasternak, Alexander

Bioorganic & Medicinal Chemistry Letters, 01 December 2016, Vol.26(23), pp.5695-5702 [Peer Reviewed Journal]

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33
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Stimulation of Glucose-Dependent Insulin Secretion by a Potent, Selective sst3 Antagonist

Pasternak, Alexander ; Feng, Zhe ; De Jesus, Reynalda ; Ye, Zhixiong ; He, Shuwen ; Dobbelaar, Peter ; Bradley, Scott A ; Chicchi, Gary G ; Tsao, Kwei-Lan ; Trusca, Dorina ; Eiermann, George J ; Li, Cai ; Feng, Yue ; Wu, Margaret ; Shao, Qing ; Zhang, Bei B ; Nargund, Ravi ; Mills, Sander G ; Howard, Andrew D ; Yang, Lihu ; Zhou, Yun-Ping

ACS medicinal chemistry letters, 12 April 2012, Vol.3(4), pp.289-93 [Peer Reviewed Journal]

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34
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Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation

Walsh, Shawn P ; Shahripour, Aurash ; Tang, Haifeng ; de Jesus, Reynalda K ; Teumelsan, Nardos ; Zhu, Yuping ; Frie, Jessica ; Priest, Birgit T ; Swensen, Andrew M ; Alonso-Galicia, Magdalena ; Felix, John P ; Brochu, Richard M ; Bailey, Timothy ; Thomas-Fowlkes, Brande ; Zhou, Xiaoyan ; Pai, Lee-Yuh ; Hampton, Caryn ; Hernandez, Melba ; Owens, Karen ; Ehrhart, Juliann ; Roy, Sophie ; Kaczorowski, Gregory J ; Yang, Lihu ; Garcia, Maria L ; Pasternak, Alexander

Bioorganic & Medicinal Chemistry Letters, 01 May 2016, Vol.26(9), pp.2339-2343 [Peer Reviewed Journal]

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35
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Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities

Tang, Haifeng ; Yan, Yan ; Feng, Zhe ; de Jesus, Reynalda K ; Yang, Lihu ; Levorse, Dorothy A ; Owens, Karen A ; Akiyama, Taro E ; Bergeron, Raynald ; Castriota, Gino A ; Doebber, Thomas W ; Ellsworth, Kenneth P ; Lassman, Michael E ; Li, Cai ; Wu, Margaret S ; Zhang, Bei B ; Chapman, Kevin T ; Mills, Sander G ; Berger, Joel P ; Pasternak, Alexander

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(20), pp.6088-6092 [Peer Reviewed Journal]

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36
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Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists

Zhou, Changyou ; Tang, Cheng ; Chang, Eric ; Ge, Min ; Lin, Songnian ; Cline, Eric ; Tan, Carina P ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George J ; Petrov, Aleksandr ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro E ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel ; Howard, Andrew D ; Thornberry, Nancy ; Mills, Sander G ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(3), pp.1298-1301 [Peer Reviewed Journal]

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