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8 Results  for Everything (Includes Articles)

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Identification of Direct Target Engagement Biomarkers for Kinase-Targeted Therapeutics (Discovery of Kinase Drug-Target Biomarkers)

Paweletz, Cloud P ; Andersen, Jannik N ; Pollock, Roy ; Nagashima, Kumiko ; Hayashi, Mansuo L ; Yu, Shangshuan U ; Guo, Hongbo ; Bobkova, Ekaterina V ; Xu, Zangwei ; Northrup, Alan ; Blume-Jensen, Peter ; Hendrickson, Ronald C ; Chi, An Kashanchi, Fatah (Editor)

PLoS ONE, 2011, Vol.6(10), p.e26459 [Peer Reviewed Journal]

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Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor

Nagashima, Kumiko ; Shumway, Stuart D ; Sathyanarayanan, Sriram ; Chen, Albert H ; Dolinski, Brian ; Xu, Youyuan ; Keilhack, Heike ; Nguyen, Thi ; Wiznerowicz, Maciej ; Li, Lixia ; Lutterbach, Bart A ; Chi, An ; Paweletz, Cloud ; Allison, Timothy ; Yan, Youwei ; Munshi, Sanjeev K ; Klippel, Anke ; Kraus, Manfred ; Bobkova, Ekaterina V ; Deshmukh

The Journal of biological chemistry, 25 February 2011, Vol.286(8), pp.6433-48 [Peer Reviewed Journal]

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Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screening

Bobkova, Ekaterina V ; Weber, Michael J ; Xu, Zangwei ; Zhang, Yan-Ling ; Jung, Joon ; Blume-Jensen, Peter ; Northrup, Alan ; Kunapuli, Priya ; Andersen, Jannik N ; Kariv, Ilona

The Journal of biological chemistry, 11 June 2010, Vol.285(24), pp.18838-46 [Peer Reviewed Journal]

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Discovery of novel BTK inhibitors with carboxylic acids

Gao, Xiaolei ; Wang, James ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Selyutin, Oleg ; Yu, Wensheng ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Cooper, Alan ; Zhu, Hugh ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann

Bioorganic & medicinal chemistry letters, 15 March 2017, Vol.27(6), pp.1471-1477 [Peer Reviewed Journal]

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Integration of Affinity Selection–Mass Spectrometry and Functional Cell-Based Assays to Rapidly Triage Druggable Target Space within the NF-κB Pathway

Kutilek, Victoria D ; Andrews, Christine L ; Richards, Matthew P ; Xu, Zangwei ; Sun, Tianxiao ; Chen, Yiping ; Hashke, Andrew ; Smotrov, Nadya ; Fernandez, Rafael ; Nickbarg, Elliott B ; Chamberlin, Chad ; Sauvagnat, Berengere ; Curran, Patrick J ; Boinay, Ryan ; Saradjian, Peter ; Allen, Samantha J ; Byrne, Noel ; Elsen, Nathaniel L ; Ford, Rachael E ; Hall, Dawn L

Journal of Biomolecular Screening, July 2016, Vol.21(6), pp.608-619 [Peer Reviewed Journal]

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Discovery of 3-morpholino-imidazole1,5-apyrazine BTK inhibitors for rheumatoid arthritis

Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Zhu, Hugh ; Desai, Jagdish ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann, Thierry O ; Presland, Jeremy ; Mansueto

Bioorganic & medicinal chemistry letters, 15 August 2017, Vol.27(16), pp.3939-3943 [Peer Reviewed Journal]

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Discovery of 8-Amino-imidazo[1,5- a ]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis

Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Yu, Younong ; Vaccaro, Henry ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cooper, Alan ; de Man, Jos ; Kaptein, Allard ; Maloney, Kevin ; Hornak, Viktor ; Gao, Ying-Duo ; Fischmann, Thierry O ; Raaijmakers, Hans ; Vu-Pham, Diep ; Presland, Jeremy ; Mansueto, My ; Xu, Zangwei ; Leccese, Erica ; Zhang-Hoover, Jie ; Knemeyer, Ian ; Garlisi, Charles G ; Bays, Nathan ; Stivers, Peter ; Brandish, Philip E ; Hicks, Alexandra ; Kim, Ronald ; Kozlowski, Joseph A Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

ACS Medicinal Chemistry Letters, 11 February 2016, Vol.7(2) [Peer Reviewed Journal]

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Development of High-Throughput TR-FRET and AlphaScreen® Assays for Identification of Potent Inhibitors of PDK1

Xu, Zangwei ; Nagashima, Kumiko ; Sun, Dongyu ; Rush, Thomas ; Northrup, Alan ; Andersen, Jannik N ; Kariv, Ilona ; Bobkova, Ekaterina V

Journal of Biomolecular Screening, December 2009, Vol.14(10), pp.1257-1262 [Peer Reviewed Journal]

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