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1,3,8-Triazaspiro4.5decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia

Vachal, Petr ; Miao, Shouwu ; Pierce, Joan M ; Guiadeen, Deodial ; Colandrea, Vincent J ; Wyvratt, Matthew J ; Salowe, Scott P ; Sonatore, Lisa M ; Milligan, James A ; Hajdu, Richard ; Gollapudi, Anantha ; Keohane, Carol A ; Lingham, Russell B ; Mandala, Suzanne M ; Demartino, Julie A ; Tong, Xinchun ; Wolff, Michael ; Steinhuebel, Dietrich ; Kieczykowski, Gerard R ; Fleitz

Journal of medicinal chemistry, 12 April 2012, Vol.55(7), pp.2945-59 [Peer Reviewed Journal]

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Asymmetric Synthesis of Chiral, Nonracemic Trifluoromethyl-Substituted Piperidines and Decahydroquinolines
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Asymmetric Synthesis of Chiral, Nonracemic Trifluoromethyl-Substituted Piperidines and Decahydroquinolines

Jiang, Jinlong ; Devita, Robert J. ; Doss, George A. ; Goulet, Mark T. ; Wyvratt, Matthew J.

Journal of the American Chemical Society, 01/1999, Vol.121(3), pp.593-594 [Peer Reviewed Journal]

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Synthesis of 2-aryltryptamines with palladium catalyzed cross-coupling of 2-bromotryptamines and arylboronic acids

Chu, Lin ; Fisher, Michael H ; Goulet, Mark T ; Wyvratt, Matthew J

Tetrahedron Letters, 1997, Vol.38(22), pp.3871-3874 [Peer Reviewed Journal]

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Improved syntheses of fluorinated tertiary butylamines

Ok, Dong ; Fisher, Michael H ; Wyvratt, Matthew J ; Meinke, Peter T

Tetrahedron Letters, 1999, Vol.40(20), pp.3831-3834 [Peer Reviewed Journal]

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Synthesis of side chain truncated 3"-aldehyde, 3"-carboxylic acid, and 1"-aldehyde from nodulisporic acid A

Chakravarty, Prasun K ; Tyagarajan, Sriram ; Shih, Thomas L ; Salva, Steve ; Snedden, Christine ; Wyvratt, Matthew J ; Fisher, Michael H ; Meinke, Peter T

Organic letters, 18 April 2002, Vol.4(8), pp.1291-4 [Peer Reviewed Journal]

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FK‐506–A Novel Immunosuppressant

Parsons, William H. ; Sigal, Nolan H. ; Wyvratt, Matthew J.

Annals of the New York Academy of Sciences, June 1993, Vol.685(1), pp.22-36 [Peer Reviewed Journal]

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Tryptophan-replacement and indole-modified apicidins: synthesis of potent and selective antiprotozoal agents

Colletti, Steven L ; Li, Chunshi ; Fisher, Michael H ; Wyvratt, Matthew J ; Meinke, Peter T

Tetrahedron Letters, 2000, Vol.41(41), pp.7825-7829 [Peer Reviewed Journal]

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Synthesis of side chain modified apicidin derivatives: potent mechanism-based histone deacetylase inhibitors

Meinke, Peter T ; Colletti, Steven L ; Ayer, Michelle B ; Darkin-Rattray, Sandra J ; Myers, Robert W ; Schmatz, Dennis M ; Wyvratt, Matthew J ; Fisher, Michael H

Tetrahedron Letters, 2000, Vol.41(41), pp.7831-7835 [Peer Reviewed Journal]

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Domino diels-alder reactions. II. A four-step conversion of cyclopentadienide to triquinacene

Wyvratt, Matthew J ; Paquette, Leo A

Tetrahedron Letters, 1974, Vol.15(28), pp.2433-2436 [Peer Reviewed Journal]

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Design and synthesis of histone deacetylase inhibitors: the development of apicidin transition state analogs

Colletti, Steven L ; Myers, Robert W ; Darkin-Rattray, Sandra J ; Schmatz, Dennis M ; Fisher, Michael H ; Wyvratt, Matthew J ; Meinke, Peter T

Tetrahedron Letters, 2000, Vol.41(41), pp.7837-7841 [Peer Reviewed Journal]

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Synthesis of Nodulisporic Acid 2‘ ‘-Oxazoles and 2‘ ‘-Thiazoles
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Synthesis of Nodulisporic Acid 2‘ ‘-Oxazoles and 2‘ ‘-Thiazoles

Berger, Richard ; Shoop, Wesley L. ; Pivnichny, James V. ; Warmke, Lynn M. ; Zakson-Aiken, Michelle ; Owens, Karen A. ; Demontigny, Pierre ; Schmatz, Dennis M. ; Wyvratt, Matthew J. ; Fisher, Michael H. ; Meinke, Peter T. ; Colletti, Steven L.

Organic Letters, 11/2001, Vol.3(23), pp.3715-3718 [Peer Reviewed Journal]

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Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

Hong, Qingmei ; Bakshi, Raman K ; Palucki, Brenda L ; Park, Min K ; Ye, Zhixiong ; He, Shuwen ; Pollard, Patrick G ; Sebhat, Iyassu K ; Liu, Jian ; Guo, Liangqin ; Cashen, Doreen E ; Martin, William J ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Tamvakopoulos, Constantin ; Peng, Qianping ; Miller, Randy R ; Stearns, Ralph A ; Chen, Howard Y

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(8), pp.2330-2334 [Peer Reviewed Journal]

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Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

Sebhat, Iyassu K ; Franklin, Christopher ; Lo, Michael M-C ; Chen, David ; Jewell, James P ; Miller, Randy ; Pang, Jianmei ; Palyha, Oksana ; Kan, Yanqing ; Kelly, Theresa M ; Guan, Xiao-Ming ; Marsh, Donald J ; Kosinski, Jennifer A ; Metzger, Joseph M ; Lyons, Kathryn ; Dragovic, Jasminka ; Guzzo, Peter R ; Henderson, Alan J ; Reitman, Marc L ; Nargund

ACS medicinal chemistry letters, 13 January 2011, Vol.2(1), pp.43-7 [Peer Reviewed Journal]

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Discovery of the development candidate N-tert-butyl nodulisporamide: a safe and efficacious once monthly oral agent for the control of fleas and ticks on companion animals

Meinke, Peter T ; Colletti, Steven L ; Fisher, Michael H ; Wyvratt, Matthew J ; Shih, Thomas L ; Ayer, Michelle B ; Li, Chunshi ; Lim, Julie ; Ok, Dong ; Salva, Steve ; Warmke, Lynn M ; Zakson, Michelle ; Michael, Bruce F ; Demontigny, Pierre ; Ostlind, Dan A ; Fink, David ; Drag, Marlene ; Schmatz, Dennis M ; Shoop, Wesley L

Journal of medicinal chemistry, 11 June 2009, Vol.52(11), pp.3505-15 [Peer Reviewed Journal]

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15
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Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines

Kim, Dooseop ; Kowalchick, Jennifer E ; Brockunier, Linda L ; Parmee, Emma R ; Eiermann, George J ; Fisher, Michael H ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathryn ; Scapin, Giovanna ; Patel, Sangita B ; Petrov, Aleksandr ; Pryor, Kellyann D ; Roy, Ranabir Sinha ; Wu, Joseph K ; Zhang, Xiaoping ; Wyvratt, Matthew J ; Zhang, Bei B ; Zhu, Lan ; Thornberry

Journal of medicinal chemistry, 14 February 2008, Vol.51(3), pp.589-602 [Peer Reviewed Journal]

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Next generation therapeutics: Drug discovery in the 21st Century Editorial overview

Wyvratt, Matthew J ; Doherty, Annette

Current Opinion in Chemical Biology, 2000, Vol.4(4), pp.369-370 [Peer Reviewed Journal]

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17
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Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality

Liu, Ping ; Lanza, Thomas J ; Chioda, Marc ; Jones, Carrie ; Chobanian, Harry R ; Guo, Yan ; Chang, Linda ; Kelly, Theresa M ; Kan, Yanqing ; Palyha, Oksana ; Guan, Xiao-Ming ; Marsh, Donald J ; Metzger, Joseph M ; Ramsay, Katie ; Wang, Sheng-Ping ; Strack, Alison M ; Miller, Randy ; Pang, Jianmei ; Lyons, Kathy ; Dragovic

ACS medicinal chemistry letters, 08 December 2011, Vol.2(12), pp.933-7 [Peer Reviewed Journal]

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18
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Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain

Chobanian, Harry R ; Guo, Yan ; Liu, Ping ; Chioda, Marc D ; Fung, Selena ; Lanza, Thomas J ; Chang, Linda ; Bakshi, Raman K ; Dellureficio, James P ; Hong, Qingmei ; Mclaughlin, Mark ; Belyk, Kevin M ; Krska, Shane W ; Makarewicz, Amanda K ; Martel, Elliot J ; Leone, Joseph F ; Frey, Lisa ; Karanam, Bindhu ; Madeira, Maria ; Alvaro

ACS medicinal chemistry letters, 12 June 2014, Vol.5(6), pp.717-21 [Peer Reviewed Journal]

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19
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Discovery of potent, selective, and orally bioavailable 3 H-spiro[isobenzofuran-1,4′-piperidine] based melanocortin subtype-4 receptor agonists

Guo, Liangqin ; Ye, Zhixiong ; Liu, Jian ; He, Shuwen ; Bakshi, Raman K ; Sebhat, Iyassu K ; Dobbelaar, Peter H ; Hong, Qingmei ; Jian, Tianying ; Dellureficio, James P ; Tsou, Nancy N ; Ball, Richard G ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Tamvakopoulos, Constantin ; Peng, Qianping ; Chen, Howard Y ; Chen, Airu S ; Martin, William J

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(16), pp.4895-4900 [Peer Reviewed Journal]

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Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity

He, Shuwen ; Ye, Zhixiong ; Dobbelaar, Peter H ; Sebhat, Iyassu K ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Lai, Yingjie ; Franklin, Christopher L ; Bakshi, Raman K ; Dellureficio, James P ; Hong, Qingmei ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Strack, Alison M ; Tamvakopoulos, Constantin ; Peng, Qianping ; Miller, Randy R ; Stearns, Ralph A

Bioorganic & Medicinal Chemistry Letters, 01 August 2010, Vol.20(15), pp.4399-4405 [Peer Reviewed Journal]

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21
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Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity

Liu, Jian ; He, Shuwen ; Jian, Tianying ; Dobbelaar, Peter H ; Sebhat, Iyassu K ; Lin, Linus S ; Goodman, Allan ; Guo, Cheng ; Guzzo, Peter R ; Hadden, Mark ; Henderson, Alan J ; Pattamana, Kevin ; Ruenz, Megan ; Sargent, Bruce J ; Swenson, Brian ; Yet, Larry ; Tamvakopoulos, Constantin ; Peng, Qianping ; Pan, Jie ; Kan, Yanqing

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(7), pp.2074-2077 [Peer Reviewed Journal]

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22
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Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist

He, Shuwen ; Ye, Zhixiong ; Dobbelaar, Peter H ; Sebhat, Iyassu K ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Lai, Yingjie ; Franklin, Christopher L ; Bakshi, Raman K ; Dellureficio, James P ; Hong, Qingmei ; Tsou, Nancy N ; Ball, Richard G ; Cashen, Doreen E ; Martin, William J ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Tamvakopoulos, Constantin

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(7), pp.2106-2110 [Peer Reviewed Journal]

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23
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Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands

Hong, Qingmei ; Bakshi, Raman K ; Dellureficio, James ; He, Shuwen ; Ye, Zhixiong ; Dobbelaar, Peter H ; Sebhat, Iyassu K ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Tang, Rui ; Kalyani, Rubana N ; Macneil, Tanya ; Vongs, Aurawan ; Rosenblum, Charles I ; Weinberg, David H ; Peng, Qingping ; Tamvakopoulos, Constantin ; Miller, Randy R ; Stearns, Ralph A

Bioorganic & Medicinal Chemistry Letters, 01 August 2010, Vol.20(15), pp.4483-4486 [Peer Reviewed Journal]

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24
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Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity

He, Shuwen ; Ye, Zhixiong ; Dobbelaar, Peter H ; Bakshi, Raman K ; Hong, Qingmei ; Dellureficio, James P ; Sebhat, Iyassu K ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Lai, Yingjie ; Franklin, Christopher L ; Reibarkh, Mikhail ; Holmes, Mark A ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Tamvakopoulos, Constantin ; Peng, Qianping ; Miller, Randy R

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(22), pp.6524-6532 [Peer Reviewed Journal]

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25
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Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists

He, Shuwen ; Dobbelaar, Peter H ; Liu, Jian ; Jian, Tianying ; Sebhat, Iyassu K ; Lin, Linus S ; Goodman, Allan ; Guo, Cheng ; Guzzo, Peter R ; Hadden, Mark ; Henderson, Alan J ; Ruenz, Megan ; Sargent, Bruce J ; Yet, Larry ; Kelly, Theresa M ; Palyha, Oksana ; Kan, Yanqing ; Pan, Jie ; Chen, Howard ; Marsh, Donald J

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(6), pp.1913-1917 [Peer Reviewed Journal]

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Synthesis of Apicidin-Derived Quinolone Derivatives:  Parasite-Selective Histone Deacetylase Inhibitors and Antiproliferative Agents
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Synthesis of Apicidin-Derived Quinolone Derivatives:  Parasite-Selective Histone Deacetylase Inhibitors and Antiproliferative Agents

Meinke, Peter T. ; Colletti, Steven L. ; Doss, George ; Myers, Robert W. ; Gurnett, Anne M. ; Dulski, Paula M. ; Darkin-Rattray, Sandra J. ; Allocco, John J. ; Galuska, Stefan ; Schmatz, Dennis M. ; Wyvratt, Matthew J. ; Fisher, Michael H.

Journal of Medicinal Chemistry, 12/2000, Vol.43(25), pp.4919-4922 [Peer Reviewed Journal]

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27
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(2R)-4-oxo-4-3-(trifluoromethyl)-5,6-dihydro1,2,4triazolo4,3-apyrazin-7(8H)-yl-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Kim, Dooseop ; Wang, Liping ; Beconi, Maria ; Eiermann, George J ; Fisher, Michael H ; He, Huaibing ; Hickey, Gerard J ; Kowalchick, Jennifer E ; Leiting, Barbara ; Lyons, Kathryn ; Marsilio, Frank ; Mccann, Margaret E ; Patel, Reshma A ; Petrov, Aleksandr ; Scapin, Giovanna ; Patel, Sangita B ; Roy, Ranabir Sinha ; Wu, Joseph K ; Wyvratt, Matthew J ; Zhang

Journal of medicinal chemistry, 13 January 2005, Vol.48(1), pp.141-51 [Peer Reviewed Journal]

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28
A Potent, Nonpeptidyl 1 H -Quinolone Antagonist for the Gonadotropin-Releasing Hormone Receptor
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A Potent, Nonpeptidyl 1 H -Quinolone Antagonist for the Gonadotropin-Releasing Hormone Receptor

Devita, Robert J. ; Walsh, Thomas F. ; Young, Jonathan R. ; Jiang, Jinlong ; Ujjainwalla, Feroze ; Toupence, Richard B. ; Parikh, Mamta ; Huang, Song X. ; Fair, Jason A. ; Goulet, Mark T. ; Wyvratt, Matthew J. ; Lo, Jane-L. ; Ren, Ning ; Yudkovitz, Joel B. ; Yang, Yi T. ; Cheng, Kang ; Cui, Jisong ; Mount, George ; Rohrer, Susan P. ; Schaeffer, James M. ; Rhodes, Linda ; Drisko, Jennifer E. ; Mcgowan, Erin ; Macintyre, D. Euan ; Vincent, Styliani ; Carlin, Josephine R. ; Cameron, Judith ; Smith, Roy G.

Journal of Medicinal Chemistry, 03/2001, Vol.44(6), pp.917-922 [Peer Reviewed Journal]

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29
A Potent, Orally Bioavailable Benzazepinone Growth Hormone Secretagogue
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A Potent, Orally Bioavailable Benzazepinone Growth Hormone Secretagogue

Devita, Robert J. ; Bochis, Richard ; Frontier, Alison J. ; Kotliar, Andrew ; Fisher, Michael H. ; Schoen, William R. ; Wyvratt, Matthew J. ; Cheng, Kang ; Chan, Wanda W.-S. ; Butler, Bridget ; Jacks, Thomas M. ; Hickey, Gerard J. ; Schleim, Klaus D. ; Leung, Kwan ; Chen, Zhesheng ; Chiu, S.-H. Lee ; Feeney, William P. ; Cunningham, Paul K. ; Smith, Roy G.

Journal of Medicinal Chemistry, 05/1998, Vol.41(10), pp.1716-1728 [Peer Reviewed Journal]

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30
Discovery of a Potent, Orally Bioavailable β 3 Adrenergic Receptor Agonist, ( R )- N -[4-[2-[[2-Hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide
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Discovery of a Potent, Orally Bioavailable β 3 Adrenergic Receptor Agonist, ( R )- N -[4-[2-[[2-Hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide

Mathvink, Robert J. ; Tolman, J. Samuel ; Chitty, Dawn ; Candelore, Mari R. ; Cascieri, Margaret A. ; Colwell, Lawrence F. ; Deng, Liping ; Feeney, William P. ; Forrest, Michael J. ; Hom, Gary J. ; Macintyre, D. Euan ; Miller, Randall R. ; Stearns, Ralph A. ; Tota, Laurie ; Wyvratt, Matthew J. ; Fisher, Michael H. ; Weber, Ann E.

Journal of Medicinal Chemistry, 10/2000, Vol.43(21), pp.3832-3836 [Peer Reviewed Journal]

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31
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Heterocyclic Derivatives of 2-(3,5-Dimethylphenyl)tryptamine as GnRH Receptor Antagonists

Lin, Peter ; Parikh, Mamta ; Lo, Jane-Ling ; Yang, Yi Tien ; Cheng, Kang ; Smith, Roy G ; Fisher, Michael H ; Wyvratt, Matthew J ; Goulet, Mark T

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(8), pp.1077-1080 [Peer Reviewed Journal]

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32
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SAR studies of novel 5-substituted 2-arylindoles as nonpeptidyl GnRH receptor antagonists

Chu, Lin ; Lo, Jane-Ling ; Yang, Yi-Tien ; Cheng, Kang ; Smith, Roy G ; Fisher, Michael H ; Wyvratt, Matthew J ; Goulet, Mark T

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(4), pp.515-517 [Peer Reviewed Journal]

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33
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2-(3,5-Dimethylphenyl)tryptamine Derivatives that Bind to the GnRH Receptor

Lin, Peter ; Marino, Dominick ; Lo, Jane-Ling ; Yang, Yi Tien ; Cheng, Kang ; Smith, Roy G ; Fisher, Michael H ; Wyvratt, Matthew J ; Goulet, Mark T

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(8), pp.1073-1076 [Peer Reviewed Journal]

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Design and syntheses of melanocortin subtype-4 receptor agonists. Part 2: Discovery of the dihydropyridazinone motif

Ujjainwalla, Feroze ; Warner, Daniel ; Snedden, Christine ; Grisson, Ricky D ; Walsh, Thomas F ; Wyvratt, Matthew J ; Kalyani, Rubana N ; Macneil, Tanya ; Tang, Rui ; Weinberg, David H ; Van Der Ploeg, Lex ; Goulet, Mark T

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(18), pp.4023-4028 [Peer Reviewed Journal]

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35
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Syntheses and structure–activity relationship studies of piperidine-substituted quinolones as nonpeptide gonadotropin releasing hormone antagonists

Jiang, Jinlong ; Devita, Robert J ; Goulet, Mark T ; Wyvratt, Matthew J ; Lo, Jane-L ; Ren, Ning ; Yudkovitz, Joel B ; Cui, Jisong ; Yang, Yi T ; Cheng, Kang ; Rohrer, Susan P

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(7), pp.1795-1798 [Peer Reviewed Journal]

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