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36 Results  for Everything (Includes Articles)

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1
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FK-506--a novel immunosuppressant

Parsons, W H ; Sigal, N H ; Wyvratt, M J

Annals of the New York Academy of Sciences, 23 June 1993, Vol.685, pp.22-36 [Peer Reviewed Journal]

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2
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Synthesis of nodulisporic acid 2' '-oxazoles and 2' '-thiazoles

Berger, R ; Shoop, W L ; Pivnichny, J V ; Warmke, L M ; Zakson-Aiken, M ; Owens, K A ; Demontigny, P ; Schmatz, D M ; Wyvratt, M J ; Fisher, M H ; Meinke, P T ; Colletti, S L

Organic letters, 15 November 2001, Vol.3(23), pp.3715-8 [Peer Reviewed Journal]

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3
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Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents

Meinke, P T ; Colletti, S L ; Doss, G ; Myers, R W ; Gurnett, A M ; Dulski, P M ; Darkin-Rattray, S J ; Allocco, J J ; Galuska, S ; Schmatz, D M ; Wyvratt, M J ; Fisher, M H

Journal of medicinal chemistry, 14 December 2000, Vol.43(25), pp.4919-22 [Peer Reviewed Journal]

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A potent, nonpeptidyl 1H-quinolone antagonist for the gonadotropin-releasing hormone receptor

Devita, R J ; Walsh, T F ; Young, J R ; Jiang, J ; Ujjainwalla, F ; Toupence, R B ; Parikh, M ; Huang, S X ; Fair, J A ; Goulet, M T ; Wyvratt, M J ; Lo, J L ; Ren, N ; Yudkovitz, J B ; Yang, Y T ; Cheng, K ; Cui, J ; Mount, G ; Rohrer, S P ; Schaeffer

Journal of medicinal chemistry, 15 March 2001, Vol.44(6), pp.917-22 [Peer Reviewed Journal]

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5
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A potent, orally bioavailable benzazepinone growth hormone secretagogue

Devita, R J ; Bochis, R ; Frontier, A J ; Kotliar, A ; Fisher, M H ; Schoen, W R ; Wyvratt, M J ; Cheng, K ; Chan, W W ; Butler, B ; Jacks, T M ; Hickey, G J ; Schleim, K D ; Leung, K ; Chen, Z ; Chiu, S L ; Feeney, W P ; Cunningham, P K ; Smith, R G

Journal of medicinal chemistry, 07 May 1998, Vol.41(10), pp.1716-28 [Peer Reviewed Journal]

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6
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Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-4-2-2-hydroxy-2-(3-pyridinyl)ethylaminoethylphenyl-4-4 -4-(trifluoromethyl)phenylthiazol-2-ylbenzenesulfonamide

Mathvink, R J ; Tolman, J S ; Chitty, D ; Candelore, M R ; Cascieri, M A ; Colwell, L F ; Deng, L ; Feeney, W P ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Miller, R R ; Stearns, R A ; Tota, L ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Journal of medicinal chemistry, 19 October 2000, Vol.43(21), pp.3832-6 [Peer Reviewed Journal]

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7
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Heterocyclic derivatives of 2-(3,5-dimethylphenyl)tryptamine as GnRH receptor antagonists

Lin, P ; Parikh, M ; Lo, J L ; Yang, Y T ; Cheng, K ; Smith, R G ; Fisher, M H ; Wyvratt, M J ; Goulet, M T

Bioorganic & medicinal chemistry letters, 23 April 2001, Vol.11(8), pp.1077-80 [Peer Reviewed Journal]

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2-(3,5-Dimethylphenyl)tryptamine derivatives that bind to the GnRH receptor

Lin, P ; Marino, D ; Lo, J L ; Yang, Y T ; Cheng, K ; Smith, R G ; Fisher, M H ; Wyvratt, M J ; Goulet, M T

Bioorganic & medicinal chemistry letters, 23 April 2001, Vol.11(8), pp.1073-6 [Peer Reviewed Journal]

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9
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SAR studies of novel 5-substituted 2-arylindoles as nonpeptidyl GnRH receptor antagonists

Chu, L ; Lo, J L ; Yang, Y T ; Cheng, K ; Smith, R G ; Fisher, M H ; Wyvratt, M J ; Goulet, M T

Bioorganic & medicinal chemistry letters, 26 February 2001, Vol.11(4), pp.515-7 [Peer Reviewed Journal]

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10
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Human beta3 adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties

Brockunier, L L ; Candelore, M R ; Cascieri, M A ; Liu, Y ; Tota, L ; Wyvratt, M J ; Fisher, M H ; Weber, A E ; Parmee, E R

Bioorganic & medicinal chemistry letters, 12 February 2001, Vol.11(3), pp.379-82 [Peer Reviewed Journal]

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11
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Initial structure-activity relationship of a novel class of nonpeptidyl GnRH receptor antagonists: 2-arylindoles

Chu, L ; Hutchins, J E ; Weber, A E ; Lo, J L ; Yang, Y T ; Cheng, K ; Smith, R G ; Fisher, M H ; Wyvratt, M J ; Goulet, M T

Bioorganic & medicinal chemistry letters, 26 February 2001, Vol.11(4), pp.509-13 [Peer Reviewed Journal]

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12
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Systemic efficacy of nodulisporamides against fleas on dogs

Shoop, W L ; Zakson-Aiken, M ; Gregory, L M ; Michael, B F ; Pivnichny, J ; Meinke, P T ; Fisher, M H ; Wyvratt, M J ; Pikounis, B ; Schmatz, D M

The Journal of parasitology, October 2001, Vol.87(5), pp.1150-4 [Peer Reviewed Journal]

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13
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Potent, elective human beta3 adrenergic receptor agonists containing a substituted indoline-5-sulfonamide pharmacophore

Mathvink, R J ; Barritta, A M ; Candelore, M R ; Cascieri, M A ; Deng, L ; Tota, L ; Strader, C D ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 05 July 1999, Vol.9(13), pp.1869-74 [Peer Reviewed Journal]

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14
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Identification and initial structure-activity relationships of a novel non-peptide quinolone GnRH receptor antagonist

Devita, R J ; Hollings, D D ; Goulet, M T ; Wyvratt, M J ; Fisher, M H ; Lo, J L ; Yang, Y T ; Cheng, K ; Smith, R G

Bioorganic & medicinal chemistry letters, 06 September 1999, Vol.9(17), pp.2615-20 [Peer Reviewed Journal]

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15
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Investigation of the 4-O-alkylamine substituent of non-peptide quinolone GnRH receptor antagonists

Devita, R J ; Goulet, M T ; Wyvratt, M J ; Fisher, M H ; Lo, J L ; Yang, Y T ; Cheng, K ; Smith, R G

Bioorganic & medicinal chemistry letters, 06 September 1999, Vol.9(17), pp.2621-4 [Peer Reviewed Journal]

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16
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Acyclic structural variants of growth hormone secretagogue L-692,429

Lin, P ; Pisano, J M ; Schoen, W R ; Cheng, K ; Chan, W W ; Butler, B S ; Smith, R G ; Fisher, M H ; Wyvratt, M J

Bioorganic & medicinal chemistry letters, 15 November 1999, Vol.9(22), pp.3237-42 [Peer Reviewed Journal]

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17
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C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study

Goulet, M T ; Sinclair, P J ; Wong, F ; Staruch, M J ; Dumont, F J ; Cryan, J G ; Wiederrecht, G J ; Wyvratt, M J ; Parsons, W H

Bioorganic & medicinal chemistry letters, 19 July 1999, Vol.9(14), pp.2085-8 [Peer Reviewed Journal]

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18
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Potent, selective benzenesulfonamide agonists of the human beta 3 adrenergic receptor

Weber, A E ; Mathvink, R J ; Perkins, L ; Hutchins, J E ; Candelore, M R ; Tota, L ; Strader, C D ; Wyvratt, M J ; Fisher, M H

Bioorganic & medicinal chemistry letters, 05 May 1998, Vol.8(9), pp.1101-6 [Peer Reviewed Journal]

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19
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Discovery of L-755,507: a subnanomolar human beta 3 adrenergic receptor agonist

Parmee, E R ; Ok, H O ; Candelore, M R ; Tota, L ; Deng, L ; Strader, C D ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 05 May 1998, Vol.8(9), pp.1107-12 [Peer Reviewed Journal]

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20
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Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2

Colletti, S L ; Myers, R W ; Darkin-Rattray, S J ; Gurnett, A M ; Dulski, P M ; Galuska, S ; Allocco, J J ; Ayer, M B ; Li, C ; Lim, J ; Crumley, T M ; Cannova, C ; Schmatz, D M ; Wyvratt, M J ; Fisher, M H ; Meinke, P T

Bioorganic & medicinal chemistry letters, 22 January 2001, Vol.11(2), pp.113-7 [Peer Reviewed Journal]

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21
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Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1

Colletti, S L ; Myers, R W ; Darkin-Rattray, S J ; Gurnett, A M ; Dulski, P M ; Galuska, S ; Allocco, J J ; Ayer, M B ; Li, C ; Lim, J ; Crumley, T M ; Cannova, C ; Schmatz, D M ; Wyvratt, M J ; Fisher, M H ; Meinke, P T

Bioorganic & medicinal chemistry letters, 22 January 2001, Vol.11(2), pp.107-11 [Peer Reviewed Journal]

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22
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Potent antagonists of gonadotropin releasing hormone receptors derived from quinolone-6-carboxamides

Walsh, T F ; Toupence, R B ; Young, J R ; Huang, S X ; Ujjainwalla, F ; Devita, R J ; Goulet, M T ; Wyvratt, M J ; Fisher, M H ; Lo, J L ; Ren, N ; Yudkovitz, J B ; Yang, Y T ; Cheng, K ; Smith, R G

Bioorganic & medicinal chemistry letters, 06 March 2000, Vol.10(5), pp.443-7 [Peer Reviewed Journal]

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23
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3-Pyridylethanolamines: potent and selective human beta 3 adrenergic receptor agonists

Naylor, E M ; Colandrea, V J ; Candelore, M R ; Cascieri, M A ; Colwell, L F ; Deng, L ; Feeney, W P ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Strader, C D ; Tota, L ; Wang, P R ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 03 November 1998, Vol.8(21), pp.3087-92 [Peer Reviewed Journal]

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24
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C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential

Goulet, M T ; Mcalpine, S R ; Staruch, M J ; Koprak, S ; Dumont, F J ; Cryan, J G ; Wiederrecht, G J ; Rosa, R ; Wilusz, M B ; Peterson, L B ; Wyvratt, M J ; Parsons, W H

Bioorganic & medicinal chemistry letters, 18 August 1998, Vol.8(16), pp.2253-8 [Peer Reviewed Journal]

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25
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Human beta3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides

Brockunier, L L ; Parmee, E R ; Ok, H O ; Candelore, M R ; Cascieri, M A ; Colwell, L F ; Deng, L ; Feeney, W P ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Tota, L ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 18 September 2000, Vol.10(18), pp.2111-4 [Peer Reviewed Journal]

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26
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Chemical modification of nodulisporic acid A: preliminary structure-activity relationships

Meinke, P T ; Ayer, M B ; Colletti, S L ; Li, C ; Lim, J ; Ok, D ; Salva, S ; Schmatz, D M ; Shih, T L ; Shoop, W L ; Warmke, L M ; Wyvratt, M J ; Zakson-Aiken, M ; Fisher, M H

Bioorganic & medicinal chemistry letters, 16 October 2000, Vol.10(20), pp.2371-4 [Peer Reviewed Journal]

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27
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Substituted oxazole benzenesulfonamides as potent human beta3 adrenergic receptor agonists

Ok, H O ; Reigle, L B ; Candelore, M R ; Cascieri, M A ; Colwell, L F ; Deng, L ; Feeney, W P ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Strader, C D ; Tota, L ; Wang, P ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 17 July 2000, Vol.10(14), pp.1531-4 [Peer Reviewed Journal]

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28
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Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human beta3 adrenergic receptor agonists

Parmee, E R ; Brockunier, L L ; He, J ; Singh, S B ; Candelore, M R ; Cascieri, M A ; Deng, L ; Liu, Y ; Tota, L ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 16 October 2000, Vol.10(20), pp.2283-6 [Peer Reviewed Journal]

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29
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Quinolones as gonadotropin releasing hormone (GnRH) antagonists: simultaneous optimization of the C(3)-aryl and C(6)-substituents

Young, J R ; Huang, S X ; Chen, I ; Walsh, T F ; Devita, R J ; Wyvratt, M J ; Goulet, M T ; Ren, N ; Lo, J ; Yang, Y T ; Yudkovitz, J B ; Cheng, K ; Smith, R G

Bioorganic & medicinal chemistry letters, 07 August 2000, Vol.10(15), pp.1723-7 [Peer Reviewed Journal]

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30
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Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity

Armstrong, H M ; Wong, F ; Holmes, M A ; Sinclair, P J ; Goulet, M T ; Dumont, F J ; Staruch, M J ; Koprak, S ; Peterson, L B ; Rosa, R ; Wilusz, M B ; Wiederrecht, G J ; Cryan, J G ; Wyvratt, M J ; Parsons, W H

Bioorganic & medicinal chemistry letters, 19 July 1999, Vol.9(14), pp.2089-94 [Peer Reviewed Journal]

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31
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Peptidomimetic regulation of growth hormone secretion

Smith, R G ; Van Der Ploeg, L H ; Howard, A D ; Feighner, S D ; Cheng, K ; Hickey, G J ; Wyvratt, M J ; Fisher, M H ; Nargund, R P ; Patchett, A A

Endocrine reviews, October 1997, Vol.18(5), pp.621-45 [Peer Reviewed Journal]

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32
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Potent, selective 3-pyridylethanolamine beta3 adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore

Mathvink, R J ; Tolman, J S ; Chitty, D ; Candelore, M R ; Cascieri, M A ; Colwell, L F ; Deng, L ; Feeney, W P ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Tota, L ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 04 September 2000, Vol.10(17), pp.1971-3 [Peer Reviewed Journal]

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33
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Human beta3 adrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides

Naylor, E M ; Parmee, E R ; Colandrea, V J ; Perkins, L ; Brockunier, L ; Candelore, M R ; Cascieri, M A ; Colwell, L F ; Deng, L ; Feeney, W P ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Strader, C D ; Tota, L ; Wang, P R ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 08 March 1999, Vol.9(5), pp.755-8 [Peer Reviewed Journal]

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34
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Discovery of an orally bioavailable alkyl oxadiazole beta3 adrenergic receptor agonist

Feng, D D ; Biftu, T ; Candelore, M R ; Cascieri, M A ; Colwell, L F ; Deng, L ; Feeney, W P ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Miller, R R ; Stearns, R A ; Strader, C D ; Tota, L ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 03 July 2000, Vol.10(13), pp.1427-9 [Peer Reviewed Journal]

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35
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Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective beta3 adrenergic receptor agonist antiobesity agents

Biftu, T ; Feng, D D ; Liang, G B ; Kuo, H ; Qian, X ; Naylor, E M ; Colandrea, V J ; Candelore, M R ; Cascieri, M A ; Colwell, L F ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Stearns, R A ; Strader, C D ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 03 July 2000, Vol.10(13), pp.1431-4 [Peer Reviewed Journal]

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36
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L-770,644: a potent and selective human beta3 adrenergic receptor agonist with improved oral bioavailability

Shih, T L ; Candelore, M R ; Cascieri, M A ; Chiu, S H ; Colwell, L F ; Deng, L ; Feeney, W P ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Miller, R R ; Stearns, R A ; Strader, C D ; Tota, L ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 03 May 1999, Vol.9(9), pp.1251-4 [Peer Reviewed Journal]

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