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Catalytic Epoxidation of Alkenes with Oxone. 2. Fluoro Ketones

Denmark, Scott E ; Wu, Zhicai ; Crudden, Cathleen M ; Matsuhashi, Hayao

The Journal of organic chemistry, 28 November 1997, Vol.62(24), pp.8288-8289 [Peer Reviewed Journal]

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2
6-Oxo-1,1,4,4-tetramethyl-1,4-diazepinium Salts. A New Class of Catalysts for Efficient Epoxidation of Olefins with Oxone †
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6-Oxo-1,1,4,4-tetramethyl-1,4-diazepinium Salts. A New Class of Catalysts for Efficient Epoxidation of Olefins with Oxone †

Denmark, Scott E. ; Wu, Zhicai

The Journal of Organic Chemistry, 05/1998, Vol.63(9), pp.2810-2811 [Peer Reviewed Journal]

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Dioxiranes Are the Active Agents in Ketone-Catalyzed Epoxidations with Oxone
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Dioxiranes Are the Active Agents in Ketone-Catalyzed Epoxidations with Oxone

Denmark, Scott E. ; Wu, Zhicai

The Journal of Organic Chemistry, 12/1997, Vol.62(26), pp.8964-8965 [Peer Reviewed Journal]

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4
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Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors

Cernak, Tim ; Gesmundo, Nathan J ; Dykstra, Kevin ; Yu, Yang ; Wu, Zhicai ; Shi, Zhi-Cai ; Vachal, Petr ; Sperbeck, Donald ; He, Shuwen ; Murphy, Beth Ann ; Sonatore, Lisa ; Williams, Steven ; Madeira, Maria ; Verras, Andreas ; Reiter, Maud ; Lee, Claire Heechoon ; Cuff, James ; Sherer, Edward C ; Kuethe, Jeffrey ; Goble, Stephen ; Perrotto, Nicholas ; Pinto, Shirly ; Shen, Dong-Ming ; Nargund, Ravi ; Balkovec, James ; Devita, Robert J ; Dreher, Spencer D

Journal of medicinal chemistry, 11 May 2017, Vol.60(9), pp.3594-3605 [Peer Reviewed Journal]

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Synthesis of Unsymmetrical Biaryls from Arylsilacyclobutanes
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Synthesis of Unsymmetrical Biaryls from Arylsilacyclobutanes

Denmark, Scott E. ; Wu, Zhicai

Organic Letters, 11/1999, Vol.1(9), pp.1495-1498 [Peer Reviewed Journal]

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6
Insights into Long-Range Structural Effects on the Stereochemistry of Aldol Condensations:  A Practical Total Synthesis of Desoxyepothilone F
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Insights into Long-Range Structural Effects on the Stereochemistry of Aldol Condensations:  A Practical Total Synthesis of Desoxyepothilone F

Lee, Chul Bom ; Wu, Zhicai ; Zhang, Fei ; Chappell, Mark D. ; Stachel, Shawn J. ; Chou, Ting-Chao ; Guan, Yongbiao ; Danishefsky, Samuel J.

Journal of the American Chemical Society, 06/2001, Vol.123(22), pp.5249-5259 [Peer Reviewed Journal]

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7
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Subtle Variations in the Long‐Range Transmission of Stereochemical Information: Matched and Mismatched Aldol Reactions

Wu, Zhicai ; Zhang, Fei ; Danishefsky, Samuel J.

Angewandte Chemie International Edition, 15 December 2000, Vol.39(24), pp.4505-4508 [Peer Reviewed Journal]

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8
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A Three‐Step Entry to the Aspirochlorine Family of Antifungal Agents

Wu, Zhicai ; Williams, Lawrence J. ; Danishefsky, Samuel J.

Angewandte Chemie International Edition, 03 November 2000, Vol.39(21), pp.3866-3868 [Peer Reviewed Journal]

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9
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Discovery of substituted (4-phenyl-1H-imidazol-2-yl)methanamine as potent somatostatin receptor 3 agonists

Lai, Zhong ; He, Shuwen ; Sherer, Edward C ; Wu, Zhicai ; Yu, Yang ; Ball, Richard ; Hong, Qingmei ; Yang, David X ; Guo, Liangqing ; Li, Derun ; Tuang, Quang ; Chicchi, Gary G ; Trusca, Dorina ; Tsao, Kwei-Lan ; Zhou, Yun-Ping ; Howard, Andrew D ; Nargund, Ravi P ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 01 September 2015, Vol.25(17), pp.3520-3525 [Peer Reviewed Journal]

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10
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Probing the SAR of dEpoB via chemical synthesis: a total synthesis evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B

Chappell, Mark D ; Harris, Christina R ; Kuduk, Scott D ; Balog, Aaron ; Wu, Zhicai ; Zhang, Fei ; Lee, Chul Bom ; Stachel, Shawn J ; Danishefsky, Samuel J ; Chou, Ting-Chao ; Guan, Yongbiao

The Journal of organic chemistry, 01 November 2002, Vol.67(22), pp.7730-6 [Peer Reviewed Journal]

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11
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Discovery of aminoheterocycles as potent and brain penetrant prolylcarboxypeptidase inhibitors

Wu, Zhicai ; Yang, Cangming ; Graham, Thomas H ; Verras, Andreas ; Chabin, Renee M ; Xu, Suoyu ; Tong, Xinchun ; Xie, Dan ; Lassman, Mike E ; Bhatt, Urmi R ; Garcia-Calvo, Margarita M ; Shen, Zhu ; Chen, Qing ; Bleasby, Kelly ; Sinharoy, Ranabir ; Hale, Jeffrey J ; Tata, James R ; Pinto, Shirly ; Colletti, Steven L ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 February 2012, Vol.22(4), pp.1727-1730 [Peer Reviewed Journal]

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12
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Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine

Wu, Zhicai ; Yang, Cangming ; Xiong, Yusheng ; Feng, Zhe ; Lombardo, Matthew ; Verras, Andreas ; Chabin, Renee M ; Xu, Suoyu ; Tong, Xinchun ; Xie, Dan ; Lassman, Mike E ; Bhatt, Urmi R ; Garcia-Calvo, Margarita M ; Geissler, Wayne ; Shen, Zhu ; Chen, Qing ; Sinharoy, Ranabir ; Hale, Jeffrey J ; Tata, James R ; Pinto, Shirly ; Shen, Dong-Ming ; Colletti, Steven L

Bioorganic & Medicinal Chemistry Letters, 15 February 2012, Vol.22(4), pp.1774-1778 [Peer Reviewed Journal]

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13
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Imidazopyridine CB2 agonists: Optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy

Trotter, B. Wesley ; Nanda, Kausik K ; Burgey, Christopher S ; Potteiger, Craig M ; Deng, James Z ; Green, Ahren I ; Hartnett, John C ; Kett, Nathan R ; Wu, Zhicai ; Henze, Darrell A ; Penna, Kimberly Della ; Desai, Reshma ; Leitl, Michael D ; Lemaire, Wei ; White, Rebecca B ; Yeh, Suzie ; Urban, Mark O ; Kane, Stefanie A ; Hartman, George D ; Bilodeau, Mark T

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(8), pp.2354-2358 [Peer Reviewed Journal]

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14
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Mineralocorticoid receptor antagonists: Identification of heterocyclic amide replacements in the oxazolidinedione series

Cox, Jason M ; Chu, Hong D ; Yang, Christine ; Shen, Hong C ; Wu, Zhicai ; Balsells, Jaume ; Crespo, Alejandro ; Brown, Patricia ; Zamlynny, Beata ; Wiltsie, Judyann ; Clemas, Joseph ; Gibson, Jack ; Contino, Lisa ; Lisnock, Jeanmarie ; Zhou, Gaochao ; Garcia-Calvo, Margarita ; Bateman, Thomas ; Xu, Ling ; Tong, Xinchun ; Crook, Martin ; Sinclair, Peter

Bioorganic & Medicinal Chemistry Letters, 01 April 2014, Vol.24(7), pp.1681-1684 [Peer Reviewed Journal]

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15
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Discovery of novel oxazolidinedione derivatives as potent and selective mineralocorticoid receptor antagonists

Yang, Christine ; Shen, Hong C ; Wu, Zhicai ; Chu, Hong D ; Cox, Jason M ; Balsells, Jaume ; Crespo, Alejandro ; Brown, Patricia ; Zamlynny, Beata ; Wiltsie, Judyann ; Clemas, Joseph ; Gibson, Jack ; Contino, Lisa ; Lisnock, Jeanmarie ; Zhou, Gaochao ; Garcia-Calvo, Margarita ; Bateman, Tom ; Xu, Ling ; Tong, Xinchun ; Crook, Martin ; Sinclair, Peter

Bioorganic & Medicinal Chemistry Letters, 01 August 2013, Vol.23(15), pp.4388-4392 [Peer Reviewed Journal]

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16
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Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores

Dong, Shuzhi ; Vangelder, Kelsey ; Shi, Zhi-Cai ; Yu, Yang ; Wu, Zhicai ; Ferguson, Ron ; Guo, Zack Zhiqiang ; Tang, Haifeng ; Frie, Jessica ; Fu, Qinghong ; Gu, Xin ; Priest, Birgit T ; Thomas-Fowlkes, Brande ; Weinglass, Adam ; Margulis, Michael ; Liu, Jessica ; Pai, Lee-Yuh ; Hampton, Caryn ; Haimbach, Robin E ; Owens, Karen ; Tong, Vincent ; Xu, Shiyao ; Hu, Mengwei ; Zingaro, Gloria J ; Morissette, Pierre ; Ehrhart, Juliann ; Roy, Sophie ; Sullivan, Kathleen ; Pasternak, Alexander

Bioorganic & Medicinal Chemistry Letters, 01 June 2017, Vol.27(11), pp.2559-2566 [Peer Reviewed Journal]

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17
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Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics

Wolkenberg, Scott E ; Nolt, M. Brad ; Bilodeau, Mark T ; Trotter, B. Wesley ; Manley, Peter J ; Kett, Nathan R ; Nanda, Kausik K ; Wu, Zhicai ; Cato, Matthew J ; Kane, Stefanie A ; Kiss, Laszlo ; Spencer, Robert H ; Wang, Jixin ; Lynch, Joseph J ; Regan, Christopher P ; Stump, Gary L ; Li, Bing ; White, Rebecca ; Yeh, Suzie ; Dinsmore, Christopher J ; Lindsley, Craig W ; Hartman, George D

Bioorganic & Medicinal Chemistry Letters, 15 February 2017, Vol.27(4), pp.1062-1069 [Peer Reviewed Journal]

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18
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Diamine Derivatives as Novel Small-Molecule, Potent, and Subtype-Selective Somatostatin SST3 Receptor Agonists

Li, Derun ; Wu, Zhicai ; Yu, Yang ; Ball, Richard G ; Guo, Liangqin ; Sherer, Edward ; He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Qi, Hongbo ; Truong, Quang ; Yang, David X ; Chicchi, Gary G ; Tsao, Kwei-Lan ; Trusca, Dorina ; Trujillo, Maria ; Pachanski, Michele ; Eiermann, George J ; Howard, Andrew D ; Zhou, Yun-Ping ; Zhang, Bei B ; Nargund, Ravi P ; Hagmann, William K

ACS medicinal chemistry letters, 12 June 2014, Vol.5(6), pp.690-5 [Peer Reviewed Journal]

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19
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Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Wu, Zhicai ; Yu, Yang ; Kim, David W ; Ting, Pauline C ; Kuethe, Jeffrey T ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sperbeck, Donald M ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Murphy, Beth A ; Gorski, Judith N ; Liu, Jinqi ; Chen, Dunlu ; Chen, Xiaoli ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

ACS medicinal chemistry letters, 08 August 2013, Vol.4(8), pp.773-8 [Peer Reviewed Journal]

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20
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Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Yang, David X ; Ting, Pauline C ; Kuethe, Jeffrey T ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sonatore, Lisa M ; Wiltsie, Judyann ; Liu, Jinqi ; Gorski, Judith N ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

ACS medicinal chemistry letters, 09 October 2014, Vol.5(10), pp.1082-7 [Peer Reviewed Journal]

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21
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Subtle Variations in the Long‐Range Transmission of Stereochemical Information: Matched and Mismatched Aldol Reactions

Wu, Zhicai ; Zhang, Fei ; Danishefsky, Samuel J.

Angewandte Chemie, 15 December 2000, Vol.112(24), pp.4679-4682 [Peer Reviewed Journal]

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22
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Length of chain segment motion needed for crystallization

Qian, Renyuan ; Wu, Zhicai ; Xue, Zhaohong ; Yan, Ruifang

Macromolecular Rapid Communications, January 1995, Vol.16(1), pp.19-23 [Peer Reviewed Journal]

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23
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A Three‐Step Entry to the Aspirochlorine Family of Antifungal Agents

Wu, Zhicai ; Williams, Lawrence J. ; Danishefsky, Samuel J.

Angewandte Chemie, 03 November 2000, Vol.112(21), pp.4024-4026 [Peer Reviewed Journal]

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24
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Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors

Hartnett, John C ; Barnett, Stanley F ; Bilodeau, Mark T ; Defeo-Jones, Deborah ; Hartman, George D ; Huber, Hans E ; Jones, Raymond E ; Kral, Astrid M ; Robinson, Ronald G ; Wu, Zhicai

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(6), pp.2194-2197 [Peer Reviewed Journal]

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25
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Rapid assembly of diverse and potent allosteric Akt inhibitors

Wu, Zhicai ; Robinson, Ronald G ; Fu, Sheng ; Barnett, Stanley F ; Defeo-Jones, Deborah ; Jones, Raymond E ; Kral, Astrid M ; Huber, Hans E ; Kohl, Nancy E ; Hartman, George D ; Bilodeau, Mark T

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(6), pp.2211-2214 [Peer Reviewed Journal]

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26
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Development of Pyridopyrimidines as Potent Akt1/2 Inhibitors

Wu, Zhicai ; Hartnett, John C ; Neilson, Lou Anne ; Robinson, Ronald G ; Fu, Sheng ; Barnett, Stanley F ; Defeo-Jones, Deborah ; Jones, Raymond E ; Kral, Astrid M ; Huber, Hans E ; Hartman, George D ; Bilodeau, Mark T

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(4), pp.1274-1279 [Peer Reviewed Journal]

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27
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CCDC 147018: Experimental Crystal Structure Determination

Wu, Zhicai ; Williams, L.J. ; Danishefsky, S.J.

2001

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28
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Design and synthesis of 3,7-diarylimidazopyridines as inhibitors of the VEGF-receptor KDR

Wu, Zhicai ; Fraley, Mark E ; Bilodeau, Mark T ; Kaufman, Mildred L ; Tasber, Edward S ; Balitza, Adrienne E ; Hartman, George D ; Coll, Kathleen E ; Rickert, Keith ; Shipman, Jennifer ; Shi, Bin ; Sepp-Lorenzino, Laura ; Thomas, Kenneth A

Bioorganic & medicinal chemistry letters, 23 February 2004, Vol.14(4), pp.909-12 [Peer Reviewed Journal]

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29
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Design and synthesis of 3,7-diarylimidazopyridines as inhibitors of the VEGF-receptor KDR

Wu, Zhicai ; Fraley, Mark E ; Bilodeau, Mark T ; Kaufman, Mildred L ; Tasber, Edward S ; Balitza, Adrienne E ; Hartman, George D ; Coll, Kathleen E ; Rickert, Keith ; Shipman, Jennifer ; Shi, Bin ; Sepp-Lorenzino, Laura ; Thomas, Kenneth A

Bioorganic & Medicinal Chemistry Letters, 23 February 2004, Vol.14(4), pp.909-912 [Peer Reviewed Journal]

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30
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Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)

Yu, Yang ; Wu, Zhicai ; Shi, Zhi-Cai ; He, Shuwen ; Lai, Zhong ; Cernak, Timothy A ; Vachal, Petr ; Liu, Min ; Liu, Jian ; Hong, Qingmei ; Jian, Tianying ; Guiadeen, Deodial ; Krikorian, Arto ; Sperbeck, Donald M ; Verras, Andreas ; Sonatore, Lisa M ; Murphy, Beth A ; Wiltsie, Judyann ; Chung, Christine C ; Gorski, Judith N ; Liu, Jinqi ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; De Vita, Robert J ; Pinto, Shirly ; Nargund, Ravi P

Bioorganic & Medicinal Chemistry Letters, 01 June 2019, Vol.29(11), pp.1380-1385 [Peer Reviewed Journal]

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31
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Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety

He, Shuwen ; Lai, Zhong ; Hong, Qingmei ; Shang, Jackie ; Reibarkh, Mikhail ; Kuethe, Jeffrey T ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Verras, Andreas ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Murphy, Beth A ; Gorski, Judith N ; Liu, Jinqi ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

Bioorganic & Medicinal Chemistry Letters, 15 May 2019, Vol.29(10), pp.1182-1186 [Peer Reviewed Journal]

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