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Results 1 - 50 of 198  for Everything (Includes Articles)

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1
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Duewell, Peter ; Kono, Hajime ; Rayner, Katey J ; Sirois, Cherilyn M ; Vladimer, Gregory ; Bauernfeind, Franz G ; Abela, George S ; Franchi, Luigi ; Nuñez, Gabriel ; Schnurr, Max ; Espevik, Terje ; Lien, Egil ; Fitzgerald, Katherine A ; Rock, Kenneth L ; Moore, Kathryn J ; Wright, Samuel D ; Hornung, Veit ; Latz, Eicke

Nature (London), 2010, Vol.464 (7293), p.1357-1361 [Peer Reviewed Journal]

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2
High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3
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High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3

De Nardo, Dominic ; Labzin, Larisa I ; Kono, Hajime ; Seki, Reiko ; Schmidt, Susanne V ; Beyer, Marc ; Xu, Dakang ; Zimmer, Sebastian ; Lahrmann, Catharina ; Schildberg, Frank A ; Vogelhuber, Johanna ; Kraut, Michael ; Ulas, Thomas ; Kerksiek, Anja ; Krebs, Wolfgang ; Bode, Niklas ; Grebe, Alena ; Fitzgerald, Michael L ; Hernandez, Nicholas J ; Williams, Bryan R G ; Knolle, Percy ; Kneilling, Manfred ; Röcken, Martin ; Lütjohann, Dieter ; Wright, Samuel D ; Schultze, Joachim L ; Latz, Eicke

Nature immunology, 2013, Vol.15 (2), p.152-160 [Peer Reviewed Journal]

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3
A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease
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A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease

PrabhuDas, Mercy R ; Baldwin, Cynthia L ; Bollyky, Paul L ; Bowdish, Dawn M. E ; Drickamer, Kurt ; Febbraio, Maria ; Herz, Joachim ; Kobzik, Lester ; Krieger, Monty ; Loike, John ; McVicker, Benita ; Means, Terry K ; Moestrup, Soren K ; Post, Steven R ; Sawamura, Tatsuya ; Silverstein, Samuel ; Speth, Robert C ; Telfer, Janice C ; Thiele, Geoffrey M ; Wang, Xiang-Yang ; Wright, Samuel D ; El Khoury, Joseph

The Journal of immunology (1950), 2017, Vol.198 (10), p.3775-3789 [Peer Reviewed Journal]

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4
Antagonism of the Prostaglandin D₂ Receptor 1 Suppresses Nicotinic Acid-Induced Vasodilation in Mice and Humans
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Antagonism of the Prostaglandin D₂ Receptor 1 Suppresses Nicotinic Acid-Induced Vasodilation in Mice and Humans

Kang Cheng ; Tsuei-Ju Wu ; Kenneth K. Wu ; Claudio Sturino ; Kathleen Metters ; Keith Gottesdiener ; Samuel D. Wright ; Zhaoyin Wang ; Gary O'Neill ; Eseng Lai ; M. Gerard Waters

Proceedings of the National Academy of Sciences - PNAS, 2006-04-25, Vol.103 (17), p.6682-6687 [Peer Reviewed Journal]

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5
Moderate Renal Impairment Does Not Impact the Ability of CSL112 (Apolipoprotein A‐I [Human]) to Enhance Cholesterol Efflux Capacity
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Moderate Renal Impairment Does Not Impact the Ability of CSL112 (Apolipoprotein A‐I [Human]) to Enhance Cholesterol Efflux Capacity

Gille, Andreas ; Duffy, Danielle ; Tortorici, Michael A ; Wright, Samuel D ; Deckelbaum, Lawrence I ; D'Andrea, Denise M

The Journal of Clinical Pharmacology, 2019-03, Vol.59 (3), p.427-436 [Peer Reviewed Journal]

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6
Effects of pH and Low Density Lipoprotein (LDL) on PCSK9-dependent LDL Receptor Regulation
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Effects of pH and Low Density Lipoprotein (LDL) on PCSK9-dependent LDL Receptor Regulation

Timothy S. Fisher ; Paola Lo Surdo ; Shilpa Pandit ; Marco Mattu ; Joseph C. Santoro ; Doug Wisniewski ; Richard T. Cummings ; Alessandra Calzetta ; Rose M. Cubbon ; Paul A. Fischer ; Anil Tarachandani ; Raffaele De Francesco ; Samuel D. Wright ; Carl P. Sparrow ; Andrea Carfi ; Ayesha Sitlani

Journal of Biological Chemistry, 2007-07-13, Vol.282 (28), p.20502-20512 [Peer Reviewed Journal]

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7
27-Hydroxycholesterol Is an Endogenous Ligand for Liver X Receptor in Cholesterol-loaded Cells
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27-Hydroxycholesterol Is an Endogenous Ligand for Liver X Receptor in Cholesterol-loaded Cells

Fu, Xuan ; Menke, John G ; Chen, Yuli ; Zhou, Gaochao ; MacNaul, Karen L ; Wright, Samuel D ; Sparrow, Carl P ; Lund, Erik G

The Journal of biological chemistry, 2001, Vol.276 (42), p.38378-38387 [Peer Reviewed Journal]

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8
Evaluation of potential antiplatelet effects of CSL112 (Apolipoprotein A-I [Human]) in patients with atherosclerosis: results from a phase 2a study
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Evaluation of potential antiplatelet effects of CSL112 (Apolipoprotein A-I [Human]) in patients with atherosclerosis: results from a phase 2a study

Paul A Gurbel ; Udaya S Tantry ; Denise D’Andrea ; Thomas Chung ; John H Alexander ; Kevin P Bliden ; Samuel D Wright ; Pierluigi Tricoci

Journal of thrombosis and thrombolysis, 2018-05-01, Vol.45 (4), p.469-476 [Peer Reviewed Journal]

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9
Farnesoid X Receptor Activates Transcription of the Phospholipid Pump MDR3
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Farnesoid X Receptor Activates Transcription of the Phospholipid Pump MDR3

Li Huang ; Annie Zhao ; Jane-L. Lew ; Theresa Zhang ; Yaroslav Hrywna ; John R. Thompson ; Nuria de Pedro ; Inmaculada Royo ; Richard A. Blevins ; Fernando Peláez ; Samuel D. Wright ; Jisong Cui

Journal of Biological Chemistry, 2003-12-19, Vol.278 (51), p.51085-51090 [Peer Reviewed Journal]

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10
The Farnesoid X Receptor Controls Gene Expression in a Ligand- and Promoter-selective Fashion
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The Farnesoid X Receptor Controls Gene Expression in a Ligand- and Promoter-selective Fashion

Jane-L. Lew ; Annie Zhao ; Jinghua Yu ; Li Huang ; Nuria de Pedro ; Fernando Peláez ; Samuel D. Wright ; Jisong Cui

Journal of Biological Chemistry, 2004-03-05, Vol.279 (10), p.8856-8861 [Peer Reviewed Journal]

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11
Guggulsterone Is a Farnesoid X Receptor Antagonist in Coactivator Association Assays but Acts to Enhance Transcription of Bile Salt Export Pump
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Guggulsterone Is a Farnesoid X Receptor Antagonist in Coactivator Association Assays but Acts to Enhance Transcription of Bile Salt Export Pump

Jisong Cui ; Li Huang ; Annie Zhao ; Jane-L. Lew ; Jinghua Yu ; Soumya Sahoo ; Peter T. Meinke ; Inmaculada Royo ; Fernando Peláez ; Samuel D. Wright

Journal of Biological Chemistry, 2003-03-21, Vol.278 (12), p.10214-10220 [Peer Reviewed Journal]

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12
CSL112, A NOVEL FORMULATION OF HUMAN APOA-I, ROBUSTLY ENHANCES THE ABILITY OF SERUM TO EFFLUX CHOLESTEROL
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CSL112, A NOVEL FORMULATION OF HUMAN APOA-I, ROBUSTLY ENHANCES THE ABILITY OF SERUM TO EFFLUX CHOLESTEROL

Easton, Rachael ; Gille, Andreas ; Leary, Elizabeth ; Shear, Chuck ; Rader, Daniel ; Wright, Samuel D

JACC (Journal of the American College of Cardiology), 2012, Vol.59 (13), p.E490-E490 [Peer Reviewed Journal]

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13
Nicotinic Acid Receptor Agonists Differentially Activate Downstream Effectors
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Nicotinic Acid Receptor Agonists Differentially Activate Downstream Effectors

Richman, Jeremy G ; Kanemitsu-Parks, Martha ; Gaidarov, Ibragim ; Cameron, Jill S ; Griffin, Peter ; Zheng, Hong ; Guerra, Nuvia C ; Cham, Linda ; Maciejewski-Lenoir, Dominique ; Behan, Dominic P ; Boatman, Doug ; Chen, Ruoping ; Skinner, Philip ; Ornelas, Pricilla ; Waters, M. Gerard ; Wright, Samuel D ; Semple, Graeme ; Connolly, Daniel T

The Journal of biological chemistry, 2007, Vol.282 (25), p.18028-18036 [Peer Reviewed Journal]

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14
Pharmacokinetics and Safety of CSL112 (Apolipoprotein A-I [Human]) in Adults With Moderate Renal Impairment and Normal Renal Function
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Pharmacokinetics and Safety of CSL112 (Apolipoprotein A-I [Human]) in Adults With Moderate Renal Impairment and Normal Renal Function

Tortorici, Michael A ; Duffy, Danielle ; Evans, Rebecca ; Feaster, John ; Gille, Andreas ; Mant, Timothy G. K ; Wright, Samuel D ; D'Andrea, Denise

Clinical pharmacology in drug development, 2019, Vol.8 (5), p.628-636 [Peer Reviewed Journal]

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15
Lithocholic Acid Decreases Expression of Bile Salt Export Pump through Farnesoid X Receptor Antagonist Activity
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Lithocholic Acid Decreases Expression of Bile Salt Export Pump through Farnesoid X Receptor Antagonist Activity

Yu, Jinghua ; Lo, Jane-L ; Huang, Li ; Zhao, Annie ; Metzger, Edward ; Adams, Alan ; Meinke, Peter T ; Wright, Samuel D ; Cui, Jisong

The Journal of biological chemistry, 2002, Vol.277 (35), p.31441-31447 [Peer Reviewed Journal]

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16
11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature
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11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature

Luo, Mingjuan J ; Thieringer, Rolf ; Springer, Martin S ; Wright, Samuel D ; Hermanowski-Vosatka, Anne ; Plump, Andrew ; Balkovec, James M ; Cheng, Kang ; Ding, Gloria J ; Kawka, Douglas W ; Koo, Gloria C ; Grand, Cheryl B. Le ; Luo, Qi ; Maletic, Milana M ; Malkowitz, Lorraine ; Shah, Kashmira ; Singer, Irwin ; Waddell, Sherman T ; Wu, Kenneth K ; Yuan, Jeffrey ; Zhu, Jun ; Stepaniants, Serguei ; Yang, Xia ; Lum, Pek Yee ; Wang, I-Ming

Physiological genomics, 2013, Vol.45 (1), p.47-57 [Peer Reviewed Journal]

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17
The selective peroxisomal proliferator-activated receptor-gamma agonist has an additive effect on plaque regression in combination with simvastatin in experimental atherosclerosis: in vivo study by high-resolution magnetic resonance imaging
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The selective peroxisomal proliferator-activated receptor-gamma agonist has an additive effect on plaque regression in combination with simvastatin in experimental atherosclerosis: in vivo study by high-resolution magnetic resonance imaging

Corti, Roberto ; Osende, Julio I ; Fallon, John T ; Fuster, Valentin ; Mizsei, Gabor ; Jneid, Hani ; Wright, Samuel D ; Chaplin, William F ; Badimon, Juan J

Journal of the American College of Cardiology, 2004-02-04, Vol.43 (3), p.464 [Peer Reviewed Journal]

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18
CSL112, A NOVEL FORMULATION OF HUMAN APOA-I, RAPIDLY ACTIVATES LECITHIN-CHOLESTEROL ACYLTRANSFERASE UPON INFUSION INTO RABBITS AND MONKEYS
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CSL112, A NOVEL FORMULATION OF HUMAN APOA-I, RAPIDLY ACTIVATES LECITHIN-CHOLESTEROL ACYLTRANSFERASE UPON INFUSION INTO RABBITS AND MONKEYS

Easton, Rachael ; Diditchenko, Svetlana ; Spycher, Martin ; Edler, Monika ; Bolli, Reinhard ; Bossart, Olivia ; Stadler, Dominik ; Pragst, Ingo ; Haynes, Jill ; Wright, Samuel D ; AG, CSL Behring

JACC (Journal of the American College of Cardiology), 2012, Vol.59 (13), p.E492-E492 [Peer Reviewed Journal]

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19
CSL112, A NOVEL FORMULATION OF HUMAN APOA-I, RAPIDLY ENHANCES CHOLESTEROL EFFLUX CAPACITY OF PLASMA FOLLOWING INFUSION
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CSL112, A NOVEL FORMULATION OF HUMAN APOA-I, RAPIDLY ENHANCES CHOLESTEROL EFFLUX CAPACITY OF PLASMA FOLLOWING INFUSION

Easton, Rachael ; Diditchenko, Svetlana ; Spycher, Martin ; Waelchli, Marcel ; Imboden, Martin ; Schenk, Sabrina ; Pragst, Ingo ; Wright, Samuel D ; AG, CSL Behring

JACC (Journal of the American College of Cardiology), 2012, Vol.59 (13), p.E491-E491 [Peer Reviewed Journal]

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20
A Potent Synthetic LXR Agonist Is More Effective than Cholesterol Loading at Inducing ABCA1 mRNA and Stimulating Cholesterol Efflux
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A Potent Synthetic LXR Agonist Is More Effective than Cholesterol Loading at Inducing ABCA1 mRNA and Stimulating Cholesterol Efflux

Sparrow, Carl P ; Baffic, Joanne ; Lam, My-Hanh ; Lund, Erik G ; Adams, Alan D ; Fu, Xuan ; Hayes, Nancy ; Jones, A. Brian ; Macnaul, Karen L ; Ondeyka, John ; Singh, Sheo ; Wang, Jianhua ; Zhou, Gaochao ; Moller, David E ; Wright, Samuel D ; Menke, John G

The Journal of biological chemistry, 2002, Vol.277 (12), p.10021-10027 [Peer Reviewed Journal]

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21
Dual Mechanisms of ABCA1 Regulation by Geranylgeranyl Pyrophosphate
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Dual Mechanisms of ABCA1 Regulation by Geranylgeranyl Pyrophosphate

Gan, Xiaodong ; Kaplan, Rebecca ; Menke, John G ; MacNaul, Karen ; Chen, Yuli ; Sparrow, Carl P ; Zhou, Gaochao ; Wright, Samuel D ; Cai, Tian-Quan

The Journal of biological chemistry, 2001, Vol.276 (52), p.48702-48708 [Peer Reviewed Journal]

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22
A multiple ascending dose study of CSL112, an infused formulation of ApoA‐I
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A multiple ascending dose study of CSL112, an infused formulation of ApoA‐I

Easton, Rachael ; Gille, Andreas ; D'Andrea, Denise ; Davis, Roslyn ; Wright, Samuel D ; Shear, Charles

Journal of clinical pharmacology, 2014-03, Vol.54 (3), p.301-310 [Peer Reviewed Journal]

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23
Neutralization and Transfer of Lipopolysaccharide by Phospholipid Transfer Protein
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Neutralization and Transfer of Lipopolysaccharide by Phospholipid Transfer Protein

Eric Hailman ; John J. Albers ; Gertrud Wolfbauer ; An-Yue Tu ; Samuel D. Wright

Journal of Biological Chemistry, 1996-05-24, Vol.271 (21), p.12172-12178 [Peer Reviewed Journal]

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24
Plasma Lipopolysaccharide-binding Protein Is Found Associated with a Particle Containing Apolipoprotein A-I, Phospholipid, and Factor H-related Proteins
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Plasma Lipopolysaccharide-binding Protein Is Found Associated with a Particle Containing Apolipoprotein A-I, Phospholipid, and Factor H-related Proteins

C. Thomas Park ; Samuel D. Wright

Journal of Biological Chemistry, 1996-07-26, Vol.271 (30), p.18054-18060 [Peer Reviewed Journal]

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25
Human Kininogen Gene Is Transactivated by the Farnesoid X Receptor
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Human Kininogen Gene Is Transactivated by the Farnesoid X Receptor

Annie Zhao ; Jane-L. Lew ; Li Huang ; Jinghua Yu ; Theresa Zhang ; Yaroslav Hrywna ; John R. Thompson ; Nuria de Pedro ; Richard A. Blevins ; Fernando Peláez ; Samuel D. Wright ; Jisong Cui

Journal of Biological Chemistry, 2003-08-01, Vol.278 (31), p.28765-28770 [Peer Reviewed Journal]

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26
The Amino Acid Residues Asparagine 354 and Isoleucine 372 of Human Farnesoid X Receptor Confer the Receptor with High Sensitivity to Chenodeoxycholate
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The Amino Acid Residues Asparagine 354 and Isoleucine 372 of Human Farnesoid X Receptor Confer the Receptor with High Sensitivity to Chenodeoxycholate

Jisong Cui ; Thomas S. Heard ; Jinghua Yu ; Jane-L. Lo ; Li Huang ; Ying Li ; James M. Schaeffer ; Samuel D. Wright

Journal of Biological Chemistry, 2002-07-19, Vol.277 (29), p.25963-25969 [Peer Reviewed Journal]

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27
Reconstituted high-density lipoprotein can elevate plasma alanine aminotransferase by transient depletion of hepatic cholesterol: role of the phospholipid component
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Reconstituted high-density lipoprotein can elevate plasma alanine aminotransferase by transient depletion of hepatic cholesterol: role of the phospholipid component

Herzog, Eva ; Pragst, Ingo ; Waelchli, Marcel ; Gille, Andreas ; Schenk, Sabrina ; Mueller-Cohrs, Jochen ; Diditchenko, Svetlana ; Zanoni, Paolo ; Cuchel, Marina ; Seubert, Andreas ; Rader, Daniel J ; Wright, Samuel D

Journal of applied toxicology, 2016, Vol.36 (8), p.1038-1047 [Peer Reviewed Journal]

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28
Identification of a Lipopolysaccharide Binding Domain in CD14 between Amino Acids 57 and 64
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Identification of a Lipopolysaccharide Binding Domain in CD14 between Amino Acids 57 and 64

Todd S.-C. Juan ; Eric Hailman ; Michael J. Kelley ; Leigh A. Busse ; Elyse Davy ; Cyril J. Empig ; Linda O. Narhi ; Samuel D. Wright ; Henri S. Lichenstein

Journal of Biological Chemistry, 1995-03-10, Vol.270 (10), p.5219-5224 [Peer Reviewed Journal]

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29
CD11c/CD18 on neutrophils recognizes a domain at the N terminus of the A alpha chain of fibrinogen
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CD11c/CD18 on neutrophils recognizes a domain at the N terminus of the A alpha chain of fibrinogen

Loike, J. D ; Sodeik, B ; Cao, L ; Leucona, S ; Weitz, J. I ; Detmers, P. A ; Wright, S. D ; Silverstein, S. C

Proceedings of the National Academy of Sciences - PNAS, 1991, Vol.88 (3), p.1044-1048 [Peer Reviewed Journal]

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30
Identification of a Domain in Soluble CD14 Essential for Lipopolysaccharide (LPS) Signaling but Not LPS Binding
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Identification of a Domain in Soluble CD14 Essential for Lipopolysaccharide (LPS) Signaling but Not LPS Binding

Juan, Todd S.-C ; Hailman, Eric ; Kelley, Michael J ; Wright, Samuel D ; Lichenstein, Henri S

The Journal of biological chemistry, 1995, Vol.270 (29), p.17237-17242 [Peer Reviewed Journal]

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31
Soluble CD14 Truncated at Amino Acid 152 Binds Lipopolysaccharide (LPS) and Enables Cellular Response to LPS
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Soluble CD14 Truncated at Amino Acid 152 Binds Lipopolysaccharide (LPS) and Enables Cellular Response to LPS

Todd S.-C. Juan ; Michael J. Kelley ; David A. Johnson ; Leigh A. Busse ; Eric Hailman ; Samuel D. Wright ; Henri S. Lichenstein

Journal of Biological Chemistry, 1995-01-20, Vol.270 (3), p.1382-1387 [Peer Reviewed Journal]

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32
Energetics of Leukocyte Integrin Activation
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Energetics of Leukocyte Integrin Activation

Tian-Quan Cai ; Samuel D. Wright

Journal of Biological Chemistry, 1995-06-16, Vol.270 (24), p.14358-14365 [Peer Reviewed Journal]

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33
CD14 and Immune Response to Lipopolysaccharide
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CD14 and Immune Response to Lipopolysaccharide

Charles R. Maliszewski ; Samuel D. Wright

Science (American Association for the Advancement of Science), 1991-05-31, Vol.252 (5010), p.1321-1322 [Peer Reviewed Journal]

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34
CSL112 (Apolipoprotein A-I [Human]) Enhances Cholesterol Efflux Similarly in Healthy Individuals and Stable Atherosclerotic Disease Patients
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CSL112 (Apolipoprotein A-I [Human]) Enhances Cholesterol Efflux Similarly in Healthy Individuals and Stable Atherosclerotic Disease Patients

Gille, Andreas ; D’Andrea, Denise ; Tortorici, Michael A ; Hartel, Gunter ; Wright, Samuel D

Arteriosclerosis, thrombosis, and vascular biology, 2018, Vol.38 (4), p.953-963 [Peer Reviewed Journal]

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35
Enhanced HDL Functionality in Small HDL Species Produced Upon Remodeling of HDL by Reconstituted HDL, CSL112