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Multiple receptors for endotoxin

Wright, Samuel D

Current Opinion in Immunology, 1991, Vol.3(1), pp.83-90 [Peer Reviewed Journal]

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CSL112, A NOVEL FORMULATION OF HUMAN APOA-I, ROBUSTLY ENHANCES THE ABILITY OF SERUM TO EFFLUX CHOLESTEROL

Easton, Rachael ; Gille, Andreas ; Leary, Elizabeth ; Shear, Chuck ; Rader, Daniel ; Wright, Samuel D

Journal of the American College of Cardiology, 27 March 2012, Vol.59(13), pp.E490-E490 [Peer Reviewed Journal]

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CSL112, A NOVEL FORMULATION OF HUMAN APOA-I, RAPIDLY ENHANCES CHOLESTEROL EFFLUX CAPACITY OF PLASMA FOLLOWING INFUSION

Easton, Rachael ; Diditchenko, Svetlana ; Spycher, Martin ; Waelchli, Marcel ; Imboden, Martin ; Schenk, Sabrina ; Pragst, Ingo ; Wright, Samuel D ; AG, Csl Behring

Journal of the American College of Cardiology, 27 March 2012, Vol.59(13), pp.E491-E491 [Peer Reviewed Journal]

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CSL112, A NOVEL FORMULATION OF HUMAN APOA-I, RAPIDLY ACTIVATES LECITHIN-CHOLESTEROL ACYLTRANSFERASE UPON INFUSION INTO RABBITS AND MONKEYS

Easton, Rachael ; Diditchenko, Svetlana ; Spycher, Martin ; Edler, Monika ; Bolli, Reinhard ; Bossart, Olivia ; Stadler, Dominik ; Pragst, Ingo ; Haynes, Jill ; Wright, Samuel D ; AG, Csl Behring

Journal of the American College of Cardiology, 27 March 2012, Vol.59(13), pp.E492-E492 [Peer Reviewed Journal]

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Duewell, Peter ; Kono, Hajime ; Rayner, Katey J ; Sirois, Cherilyn M ; Vladimer, Gregory ; Bauernfeind, Franz G ; Abela, George S ; Franchi, Luigi ; Nuñez, Gabriel ; Schnurr, Max ; Espevik, Terje ; Lien, Egil ; Fitzgerald, Katherine A ; Rock, Kenneth L ; Moore, Kathryn J ; Wright, Samuel D ; Hornung, Veit ; Latz, Eicke

Nature, 29 April 2010, Vol.464(7293), pp.1357-61 [Peer Reviewed Journal]

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Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: modifications of the oxazolidinone ring leading to the discovery of anacetrapib

Smith, Cameron J ; Ali, Amjad ; Hammond, Milton L ; Li, Hong ; Lu, Zhijian ; Napolitano, Joann ; Taylor, Gayle E ; Thompson, Christopher F ; Anderson, Matt S ; Chen, Ying ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Sparrow, Carl P ; Wright, Samuel D ; Cumiskey, Anne-Marie ; Latham, Melanie ; Peterson, Laurence B ; Rosa

Journal of medicinal chemistry, 14 July 2011, Vol.54(13), pp.4880-95 [Peer Reviewed Journal]

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A multiple ascending dose study of CSL112, an infused formulation of ApoA‐I

Easton, Rachael ; Gille, Andreas ; D' Andrea, Denise ; Davis, Roslyn ; Wright, Samuel D. ; Shear, Charles

Journal of Clinical Pharmacology, March 2014, Vol.54(3), pp.301-310 [Peer Reviewed Journal]

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CSL112 (Apolipoprotein A-I Human) Enhances Cholesterol Efflux Similarly in Healthy Individuals and Stable Atherosclerotic Disease Patients

Gille, Andreas ; D'Andrea, Denise ; Tortorici, Michael A ; Hartel, Gunter ; Wright, Samuel D

Arteriosclerosis, thrombosis, and vascular biology, April 2018, Vol.38(4), pp.953-963 [Peer Reviewed Journal]

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CSL112 enhances biomarkers of reverse cholesterol transport after single and multiple infusions in healthy subjects

Gille, Andreas ; Easton, Rachael ; D'Andrea, Denise ; Wright, Samuel D ; Shear, Charles L

Arteriosclerosis, thrombosis, and vascular biology, September 2014, Vol.34(9), pp.2106-14 [Peer Reviewed Journal]

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Structure-function relationships in reconstituted HDL: Focus on antioxidative activity and cholesterol efflux capacity

Cukier, Alexandre M.O ; Therond, Patrice ; Didichenko, Svetlana A ; Guillas, Isabelle ; Chapman, M. John ; Wright, Samuel D ; Kontush, Anatol

BBA - Molecular and Cell Biology of Lipids, September 2017, Vol.1862(9), pp.890-900 [Peer Reviewed Journal]

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11
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Reconstituted high-density lipoproteins acutely reduce soluble brain Aβ levels in symptomatic APP/PS1 mice

Robert, Jérôme ; Stukas, Sophie ; Button, Emily ; Cheng, Wai Hang ; Lee, Michael ; Fan, Jianjia ; Wilkinson, Anna ; Kulic, Iva ; Wright, Samuel D ; Wellington, Cheryl L

BBA - Molecular Basis of Disease, May 2016, Vol.1862(5), pp.1027-1036 [Peer Reviewed Journal]

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Novel formulation of a reconstituted high-density lipoprotein (CSL112) dramatically enhances ABCA1-dependent cholesterol efflux

Diditchenko, Svetlana ; Gille, Andreas ; Pragst, Ingo ; Stadler, Dominik ; Waelchli, Marcel ; Hamilton, Ross ; Leis, Andrew ; Wright, Samuel D

Arteriosclerosis, thrombosis, and vascular biology, September 2013, Vol.33(9), pp.2202-11 [Peer Reviewed Journal]

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13
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Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans

Cheng, Kang ; Wu, Tsuei-Ju ; Wu, Kenneth K ; Sturino, Claudio ; Metters, Kathleen ; Gottesdiener, Keith ; Wright, Samuel D ; Wang, Zhaoyin ; O'Neill, Gary ; Lai, Eseng ; Waters, M Gerard

Proceedings of the National Academy of Sciences of the United States of America, 25 April 2006, Vol.103(17), pp.6682-7 [Peer Reviewed Journal]

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14
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The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion

Lew, Jane-L ; Zhao, Annie ; Yu, Jinghua ; Huang, Li ; De Pedro, Nuria ; Peláez, Fernando ; Wright, Samuel D ; Cui, Jisong

The Journal of biological chemistry, 05 March 2004, Vol.279(10), pp.8856-61 [Peer Reviewed Journal]

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The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate

Cui, Jisong ; Heard, Thomas S ; Yu, Jinghua ; Lo, Jane-L ; Huang, Li ; Li, Ying ; Schaeffer, James M ; Wright, Samuel D

The Journal of biological chemistry, 19 July 2002, Vol.277(29), pp.25963-9 [Peer Reviewed Journal]

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16
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Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity

Yu, Jinghua ; Lo, Jane-L ; Huang, Li ; Zhao, Annie ; Metzger, Edward ; Adams, Alan ; Meinke, Peter T ; Wright, Samuel D ; Cui, Jisong

The Journal of biological chemistry, 30 August 2002, Vol.277(35), pp.31441-7 [Peer Reviewed Journal]

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17
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Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump

Cui, Jisong ; Huang, Li ; Zhao, Annie ; Lew, Jane-L ; Yu, Jinghua ; Sahoo, Soumya ; Meinke, Peter T ; Royo, Inmaculada ; Pelaez, Fernando ; Wright, Samuel D

The Journal of biological chemistry, 21 March 2003, Vol.278(12), pp.10214-20 [Peer Reviewed Journal]

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Reconstituted high‐density lipoprotein can elevate plasma alanine aminotransferase by transient depletion of hepatic cholesterol: role of the phospholipid component

Herzog, Eva ; Pragst, Ingo ; Waelchli, Marcel ; Gille, Andreas ; Schenk, Sabrina ; Mueller‐Cohrs, Jochen ; Diditchenko, Svetlana ; Zanoni, Paolo ; Cuchel, Marina ; Seubert, Andreas ; Rader, Daniel J. ; Wright, Samuel D.

Journal of Applied Toxicology, August 2016, Vol.36(8), pp.1038-1047 [Peer Reviewed Journal]

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19
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Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal-Induced Inflammatory Responses by Reducing Complement Activation

Niyonzima, Nathalie ; Samstad, Eivind O ; Aune, Marie H ; Ryan, Liv ; Bakke, Siril S ; Rokstad, Anne Mari ; Wright, Samuel D ; Damås, Jan K ; Mollnes, Tom E ; Latz, Eicke ; Espevik, Terje

Journal of immunology (Baltimore, Md. : 1950), 01 July 2015, Vol.195(1), pp.257-64 [Peer Reviewed Journal]

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20
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Circulating HDL levels control hypothalamic astrogliosis via apoA-I

Götz, Anna ; Lehti, Maarit ; Donelan, Elizabeth ; Striese, Cynthia ; Cucuruz, Sebastian ; Sachs, Stephan ; Yi, Chun-Xia ; Woods, Stephen C ; Wright, Samuel D ; Müller, Timo D ; Tschöp, Matthias H ; Gao, Yuanqing ; Hofmann, Susanna M

Journal of lipid research, September 2018, Vol.59(9), pp.1649-1659 [Peer Reviewed Journal]

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21
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Evaluation of potential antiplatelet effects of CSL112 (Apolipoprotein A-I [Human]) in patients with atherosclerosis: results from a phase 2a study

Gurbel, Paul ; Tantry, Udaya ; D’Andrea, Denise ; Chung, Thomas ; Alexander, John ; Bliden, Kevin ; Wright, Samuel ; Tricoci, Pierluigi

Journal of Thrombosis and Thrombolysis, 2018, Vol.45(4), pp.469-476 [Peer Reviewed Journal]

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22
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Enhanced HDL Functionality in Small HDL Species Produced Upon Remodeling of HDL by Reconstituted HDL, CSL112: Effects on Cholesterol Efflux, Anti-Inflammatory and Antioxidative Activity

Didichenko, Svetlana A ; Navdaev, Alexei V ; Cukier, Alexandre M O ; Gille, Andreas ; Schuetz, Patrick ; Spycher, Martin O ; Thérond, Patrice ; Chapman, M John ; Kontush, Anatol ; Wright, Samuel D

Circulation research, 02 September 2016, Vol.119(6), pp.751-63 [Peer Reviewed Journal]

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23
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Discovery of substituted biphenyl oxazolidinone inhibitors of cholesteryl ester transfer protein

Thompson, Christopher F ; Ali, Amjad ; Quraishi, Nazia ; Lu, Zhijian ; Hammond, Milton L ; Sinclair, Peter J ; Anderson, Matt S ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Sparrow, Carl P ; Wright, Samuel D

ACS medicinal chemistry letters, 09 June 2011, Vol.2(6), pp.424-7 [Peer Reviewed Journal]

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24
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The selective peroxisomal proliferator-activated receptor-gamma agonist has an additive effect on plaque regression in combination with simvastatin in experimental atherosclerosis

Corti, Roberto ; Osende, Julio I ; Fallon, John T ; Fuster, Valentin ; Mizsei, Gabor ; Jneid, Hani ; Wright, Samuel D ; Chaplin, William F ; Badimon, Juan J

Journal of the American College of Cardiology, 04 February 2004, Vol.43(3), pp.464-473 [Peer Reviewed Journal]

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25
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PPAR γ-agonist induces regression of atherosclerotic plaques: invivo study by high resolution magnetic resonance imaging

Corti, Roberto ; Osende, Julio I ; Fuster, Valentin ; Wright, Samuel D ; Fayad, Zahi A ; Dickstein, Elisha ; Fallon, John T ; Badimon, Juan J

Journal of the American College of Cardiology, 06 March 2002, Vol.39, pp.248-249 [Peer Reviewed Journal]

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26
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Toll, A New Piece in the Puzzle of Innate Immunity

Wright, Samuel D

The Journal of Experimental Medicine, 1999, Vol.189(4), p.605-609 [Peer Reviewed Journal]

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27
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2-(4-Carbonylphenyl)benzoxazole inhibitors of CETP: Scaffold design and advancement in HDLc-raising efficacy

Sweis, Ramzi F ; Hunt, Julianne A ; Kallashi, Florida ; Hammond, Milton L ; Chen, Ying ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Cumiskey, Anne-Marie ; Latham, Melanie ; Rosa, Raymond ; Peterson, Larry ; Sparrow, Carl P ; Wright, Samuel D ; Anderson, Matt S ; Sinclair, Peter J

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(6), pp.1890-1895 [Peer Reviewed Journal]

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28
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SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors

Lu, Zhijian ; Chen, Yi-Heng ; Napolitano, Joann B ; Taylor, Gayle ; Ali, Amjad ; Hammond, Milton L ; Deng, Qiaolin ; Tan, Eugene ; Tong, Xinchun ; Xu, Suoyu S ; Latham, Melanie J ; Peterson, Laurence B ; Anderson, Matt S ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Chen, Ying ; Sparrow, Carl P ; Wright, Samuel D

Bioorganic & Medicinal Chemistry Letters, 01 January 2012, Vol.22(1), pp.199-203 [Peer Reviewed Journal]

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29
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63 : Investigating the anti-inflammatory effects of HDL in macrophages

Nardo, Dominic De ; Labzin, Larisa ; Kono, Hajime ; Seki, Reiko ; Schmidt, Susanne ; Vogelhuber, Johanna ; Kraut, Michael ; Kerksiek, Anja ; Krebs, Wolfgang ; Bode, Niklas ; Grebe, Alena ; Zimmer, Sebastian ; Kneilling, Manfred ; Röcken, Martin ; Lütjohann, Dieter ; Wright, Samuel D ; Schultze, Joachim ; Latz, Eicke

Cytokine, September 2013, Vol.63(3), pp.258-258 [Peer Reviewed Journal]

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30
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Reconstituted HDL Elicits Marked Changes in Plasma Lipids Following Single-Dose Injection in C57Bl/6 Mice

Chen, Zhu ; O'Neill, Edward A ; Meurer, Roger D ; Gagen, Karen ; Luell, Silvi ; Wang, Sheng-Ping ; Ichetovkin, Marina ; Frantz-Wattley, Betsy ; Eveland, Suzanne ; Strack, Alison M ; Fisher, Timothy S ; Johns, Douglas G ; Sparrow, Carl P ; Wright, Samuel D ; Hubbard, Brian K ; Carballo-Jane, Ester

Journal of Cardiovascular Pharmacology and Therapeutics, September 2012, Vol.17(3), pp.315-323 [Peer Reviewed Journal]

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31
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Infusion of Reconstituted High-Density Lipoprotein, CSL112, in Patients With Atherosclerosis: Safety and Pharmacokinetic Results From a Phase 2a Randomized Clinical Trial

Tricoci, Pierluigi ; D'Andrea, Denise M ; Gurbel, Paul A ; Yao, Zhenling ; Cuchel, Marina ; Winston, Brion ; Schott, Robert ; Weiss, Robert ; Blazing, Michael A ; Cannon, Louis ; Bailey, Alison ; Angiolillo, Dominick J ; Gille, Andreas ; Shear, Charles L ; Wright, Samuel D ; Alexander, John H

Journal of the American Heart Association, 25 August 2015, Vol.4(8), pp.e002171 [Peer Reviewed Journal]

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32
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2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety

Smith, Cameron J ; Ali, Amjad ; Chen, Liya ; Hammond, Milton L ; Anderson, Matt S ; Chen, Ying ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Sparrow, Carl P ; Wright, Samuel D ; Sinclair, Peter J

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(1), pp.346-349 [Peer Reviewed Journal]

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33
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High fat fed hamster, a unique animal model for treatment of diabetic dyslipidemia with peroxisome proliferator activated receptor alpha selective agonists

Wang, Pei-Ran ; Guo, Qiu ; Ippolito, Marc ; Wu, Margaret ; Milot, Denise ; Ventre, John ; Doebber, Tom ; Wright, Samuel D ; Chao, Yu-Sheng

European Journal of Pharmacology, 2001, Vol.427(3), pp.285-293 [Peer Reviewed Journal]

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34
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Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation

Fisher, Timothy S ; Lo Surdo, Paola ; Pandit, Shilpa ; Mattu, Marco ; Santoro, Joseph C ; Wisniewski, Doug ; Cummings, Richard T ; Calzetta, Alessandra ; Cubbon, Rose M ; Fischer, Paul A ; Tarachandani, Anil ; De Francesco, Raffaele ; Wright, Samuel D ; Sparrow, Carl P ; Carfi, Andrea ; Sitlani, Ayesha

The Journal of biological chemistry, 13 July 2007, Vol.282(28), pp.20502-12 [Peer Reviewed Journal]

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35
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Human kininogen gene is transactivated by the farnesoid X receptor

Zhao, Annie ; Lew, Jane-L ; Huang, Li ; Yu, Jinghua ; Zhang, Theresa ; Hrywna, Yaroslav ; Thompson, John R ; De Pedro, Nuria ; Blevins, Richard A ; Peláez, Fernando ; Wright, Samuel D ; Cui, Jisong

The Journal of biological chemistry, 01 August 2003, Vol.278(31), pp.28765-70 [Peer Reviewed Journal]

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36
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Farnesoid X receptor activates transcription of the phospholipid pump MDR3

Huang, Li ; Zhao, Annie ; Lew, Jane-L ; Zhang, Theresa ; Hrywna, Yaroslav ; Thompson, John R ; De Pedro, Nuria ; Royo, Inmaculada ; Blevins, Richard A ; Peláez, Fernando ; Wright, Samuel D ; Cui, Jisong

The Journal of biological chemistry, 19 December 2003, Vol.278(51), pp.51085-90 [Peer Reviewed Journal]

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High density lipoprotein mediates anti-inflammatory transcriptional reprogramming of macrophages via the transcriptional repressor ATF3

De Nardo, Dominic ; Labzin, Larisa I. ; Kono, Hajime ; Seki, Reiko ; Schmidt, Susanne V. ; Beyer, Marc ; Xu, Dakang ; Zimmer, Sebastian ; Lahrmann, Catharina ; Schildberg, Frank A. ; Vogelhuber, Johanna ; Kraut, Michael ; Ulas, Thomas ; Kerksiek, Anja ; Krebs, Wolfgang ; Bode, Niklas ; Grebe, Alena ; Fitzgerald, Michael L. ; Hernandez, Nicholas J. ; Williams, Bryan ; Knolle, Percy ; Kneilling, Manfred ; Röcken, Martin ; Lütjohann, Dieter ; Wright, Samuel D. ; Schultze, Joachim L. ; Latz, Eicke

De Nardo, D., L. I. Labzin, H. Kono, R. Seki, S. V. Schmidt, M. Beyer, D. Xu, et al. 2014. “High density lipoprotein mediates anti-inflammatory transcriptional reprogramming of macrophages via the transcriptional repressor ATF3.” Nature immunology 15 (2): 152-160. doi:10.1038/ni.2784. http://dx.doi.org/10.1038/ni.2784. [Peer Reviewed Journal]

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