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23 Results  for Everything (Includes Articles)

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A peptide-based fluorescence resonance energy transfer assay for Bacillus anthracis lethal factor protease

Cummings, Richard T ; Salowe, Scott P ; Cunningham, Barry R ; Wiltsie, Judyann ; Park, Young Whan ; Sonatore, Lisa M ; Wisniewski, Douglas ; Douglas, Cameron M ; Hermes, Jeffrey D ; Scolnick, Edward M

Proceedings of the National Academy of Sciences of the United States of America, 14 May 2002, Vol.99(10), pp.6603-6 [Peer Reviewed Journal]

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Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase

Walker, Scott ; Labroli, Marc ; Painter, Ronald ; Wiltsie, Judyann ; Sherborne, Brad ; Murgolo, Nicholas ; Sher, Xinwei ; Mann, Paul ; Zuck, Paul ; Garlisi, Charles ; Su, Jing ; Kargman, Stacia ; Li, Xiao ; Scapin, Giovanna ; Salowe, Scott ; Devito, Kristine ; Sheth, Payal ; Buist, Nichole ; Tan, Christopher ; Black, Todd ; Roemer, Terry

PLoS One, Jul 2017, Vol.12(7), p.e0180965 [Peer Reviewed Journal]

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The catalytic flexibility of tRNAIle-lysidine synthetase can generate alternative tRNA substrates for isoleucyl-tRNA synthetase

Salowe, Scott P ; Wiltsie, Judyann ; Hawkins, Julio C ; Sonatore, Lisa M

The Journal of biological chemistry, 10 April 2009, Vol.284(15), pp.9656-62 [Peer Reviewed Journal]

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In Vitro Assays for the Discovery of PCSK9 Autoprocessing Inhibitors

Salowe, Scott P ; Zhang, Lei ; Zokian, Hratch J ; Gesell, Jennifer J ; Zink, Deborah L ; Wiltsie, Judyann ; Ai, Xi ; Kavana, Michael ; Pinto, Shirly

Journal of Biomolecular Screening, December 2016, Vol.21(10), pp.1034-1041 [Peer Reviewed Journal]

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5
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The role of a parasite-specific allosteric site in the distinctive activation behavior of Eimeria tenella cGMP-dependent protein kinase

Salowe, Scott P ; Wiltsie, Judyann ; Liberator, Paul A ; Donald, Robert G K

Biochemistry, 02 April 2002, Vol.41(13), pp.4385-91 [Peer Reviewed Journal]

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Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities

Singh, Sheo B ; Goetz, Michael A ; Smith, Scott K ; Zink, Deborah L ; Polishook, Jon ; Onishi, Russell ; Salowe, Scott ; Wiltsie, Judyann ; Allocco, John ; Sigmund, Janet ; Dorso, Karen ; de La Cruz, Mercedes ; Martín, Jesús ; Vicente, Francisca ; Genilloud, Olga ; Donald, Robert G.K ; Phillips, John W

Bioorganic & Medicinal Chemistry Letters, 01 December 2012, Vol.22(23), pp.7127-7130 [Peer Reviewed Journal]

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Heterocyclic core analogs of a direct thrombin inhibitor

Blizzard, Timothy A ; Singh, Sanjay ; Patil, Basanagoud ; Chidurala, Naresh ; Komanduri, Venukrishnan ; Debnath, Samarpita ; Belyakov, Sergei ; Crespo, Alejandro ; Struck, Alice ; Kurtz, Marc ; Wiltsie, Judyann ; Shen, Xun ; Sonatore, Lisa ; Arocho, Marta ; Lewis, Dale ; Ogletree, Martin ; Biftu, Tesfaye

Bioorganic & Medicinal Chemistry Letters, 15 February 2014, Vol.24(4), pp.1111-1115 [Peer Reviewed Journal]

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8
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Pyrazoles as non-classical bioisosteres in prolylcarboxypeptidase (PrCP) inhibitors

Graham, Thomas H ; Shu, Min ; Verras, Andreas ; Chen, Qing ; Garcia-Calvo, Margarita ; Li, Xiaohua ; Lisnock, Jeanmarie ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 01 April 2014, Vol.24(7), pp.1657-1660 [Peer Reviewed Journal]

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Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors

Shen, Hong C ; Ding, Fa-Xiang ; Jiang, Jinlong ; Verras, Andreas ; Chabin, Renee M ; Xu, Suoyu ; Tong, Xinchun ; Chen, Qing ; Xie, Dan ; Lassman, Mike E ; Bhatt, Urmi R ; Garcia-Calvo, Margarita M ; Geissler, Wayne ; Shen, Zhu ; Murphy, Beth Ann ; Gorski, Judith N ; Wiltsie, Judyann ; Sinharoy, Ranabir ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 February 2012, Vol.22(4), pp.1550-1556 [Peer Reviewed Journal]

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Mineralocorticoid receptor antagonists: Identification of heterocyclic amide replacements in the oxazolidinedione series

Cox, Jason M ; Chu, Hong D ; Yang, Christine ; Shen, Hong C ; Wu, Zhicai ; Balsells, Jaume ; Crespo, Alejandro ; Brown, Patricia ; Zamlynny, Beata ; Wiltsie, Judyann ; Clemas, Joseph ; Gibson, Jack ; Contino, Lisa ; Lisnock, Jeanmarie ; Zhou, Gaochao ; Garcia-Calvo, Margarita ; Bateman, Thomas ; Xu, Ling ; Tong, Xinchun ; Crook, Martin ; Sinclair, Peter

Bioorganic & Medicinal Chemistry Letters, 01 April 2014, Vol.24(7), pp.1681-1684 [Peer Reviewed Journal]

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A new class of prolylcarboxypeptidase inhibitors, Part 2: The aminocyclopentanes

Graham, Thomas H ; Liu, Wensheng ; Verras, Andreas ; Reibarkh, Mikhail ; Bleasby, Kelly ; Bhatt, Urmi R ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; Gorski, Judith N ; He, Huaibing ; Lassman, Michael E ; Lisnock, Jeanmarie ; Li, Xiaohua ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Xie, Dan ; Xu, Suoyu ; Xiao, Jianying ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 April 2012, Vol.22(8), pp.2818-2822 [Peer Reviewed Journal]

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12
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Discovery of novel non-steroidal reverse indole mineralocorticoid receptor antagonists

Ogawa, Anthony K ; Bunte, Ellen Vande ; Mal, Rudrajit ; Lan, Ping ; Sun, Zhongxiang ; Crespo, Alejandro ; Wiltsie, Judyann ; Clemas, Joseph ; Gibson, Jack ; Contino, Lisa ; Lisnock, Jeanmarie ; Zhou, Gaochao ; Garcia-Calvo, Margarita ; Jochnowitz, Nina ; Ma, Xiuying ; Pan, Yi ; Brown, Patricia ; Zamlynny, Beata ; Bateman, Thomas ; Leung, Dennis ; Xu, Ling ; Tong, Xinchun ; Liu, Kun ; Crook, Martin ; Sinclair, Peter

Bioorganic & Medicinal Chemistry Letters, 15 June 2016, Vol.26(12), pp.2866-2869 [Peer Reviewed Journal]

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13
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Discovery of novel oxazolidinedione derivatives as potent and selective mineralocorticoid receptor antagonists

Yang, Christine ; Shen, Hong C ; Wu, Zhicai ; Chu, Hong D ; Cox, Jason M ; Balsells, Jaume ; Crespo, Alejandro ; Brown, Patricia ; Zamlynny, Beata ; Wiltsie, Judyann ; Clemas, Joseph ; Gibson, Jack ; Contino, Lisa ; Lisnock, Jeanmarie ; Zhou, Gaochao ; Garcia-Calvo, Margarita ; Bateman, Tom ; Xu, Ling ; Tong, Xinchun ; Crook, Martin ; Sinclair, Peter

Bioorganic & Medicinal Chemistry Letters, 01 August 2013, Vol.23(15), pp.4388-4392 [Peer Reviewed Journal]

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14
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Discovery of benzimidazole oxazolidinediones as novel and selective nonsteroidal mineralocorticoid receptor antagonists

Yang, Christine ; Balsells, Jaume ; Chu, Hong D ; Cox, Jason M ; Crespo, Alejandro ; Ma, Xiuying ; Contino, Lisa ; Brown, Patricia ; Gao, Sheng ; Zamlynny, Beata ; Wiltsie, Judyann ; Clemas, Joseph ; Lisnock, Jeanmarie ; Gibson, Jack ; Zhou, Gaochao ; Garcia-Calvo, Margarita ; Bateman, Thomas J ; Tong, Vincent ; Xu, Ling ; Crook, Martin ; Sinclair, Peter ; Shen, Hong C

ACS medicinal chemistry letters, 09 April 2015, Vol.6(4), pp.461-5 [Peer Reviewed Journal]

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15
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Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors

Debenham, John S ; Graham, Thomas H ; Verras, Andreas ; Zhang, Yong ; Clements, Matthew J ; Kuethe, Jeffrey T ; Madsen-Duggan, Christina ; Liu, Wensheng ; Bhatt, Urmi R ; Chen, Dunlu ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; He, Huaibing ; Li, Xiaohua ; Lisnock, Jeanmarie ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Xu, Suoyu ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 01 December 2013, Vol.23(23), pp.6228-6233 [Peer Reviewed Journal]

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16
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A new class of prolylcarboxypeptidase inhibitors, Part 1: Discovery and evaluation

Graham, Thomas H ; Liu, Wensheng ; Verras, Andreas ; Sebhat, Iyassu K ; Xiong, Yusheng ; Bleasby, Kelly ; Bhatt, Urmi R ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; Gorski, Judith N ; He, Huaibing ; Lassman, Michael E ; Lisnock, Jeanmarie ; Li, Xiaohua ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Xiao, Jianying ; Xie, Dan ; Xu, Suoyu ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 April 2012, Vol.22(8), pp.2811-2817 [Peer Reviewed Journal]

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17
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Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Wu, Zhicai ; Yu, Yang ; Kim, David W ; Ting, Pauline C ; Kuethe, Jeffrey T ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sperbeck, Donald M ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Murphy, Beth A ; Gorski, Judith N ; Liu, Jinqi ; Chen, Dunlu ; Chen, Xiaoli ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

ACS medicinal chemistry letters, 08 August 2013, Vol.4(8), pp.773-8 [Peer Reviewed Journal]

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18
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Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Yang, David X ; Ting, Pauline C ; Kuethe, Jeffrey T ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sonatore, Lisa M ; Wiltsie, Judyann ; Liu, Jinqi ; Gorski, Judith N ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

ACS medicinal chemistry letters, 09 October 2014, Vol.5(10), pp.1082-7 [Peer Reviewed Journal]

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19
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Purification and molecular characterization of cGMP-dependent protein kinase from Apicomplexan parasites. A novel chemotherapeutic target

Gurnett, Anne M ; Liberator, Paul A ; Dulski, Paula M ; Salowe, Scott P ; Donald, Robert G K ; Anderson, Jennifer W ; Wiltsie, Judyann ; Diaz, Carmen A ; Harris, Georgiana ; Chang, Ben ; Darkin-Rattray, Sandra J ; Nare, Bakela ; Crumley, Tami ; Blum, Penny Sue ; Misura, Andrew S ; Tamas, Tamas ; Sardana, Mohinder K ; Yuan, Jeffrey ; Biftu, Tesfaye ; Schmatz, Dennis M

The Journal of biological chemistry, 03 May 2002, Vol.277(18), pp.15913-22 [Peer Reviewed Journal]

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20
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Toxoplasma gondii cyclic GMP-dependent kinase: chemotherapeutic targeting of an essential parasite protein kinase

Donald, Robert G K ; Allocco, John ; Singh, Suresh B ; Nare, Bakela ; Salowe, Scott P ; Wiltsie, Judyann ; Liberator, Paul A

Eukaryotic cell, June 2002, Vol.1(3), pp.317-28 [Peer Reviewed Journal]

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21
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The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection

Xiong, Yusheng ; Wiltsie, Judyann ; Woods, Andrea ; Guo, Jian ; Pivnichny, James V ; Tang, Wei ; Bansal, Alka ; Cummings, Richard T ; Cunningham, Barry R ; Friedlander, Arthur M ; Douglas, Cameron M ; Salowe, Scott P ; Zaller, Dennis M ; Scolnick, Edward M ; Schmatz, Dennis M ; Bartizal, Kenneth ; Hermes, Jeffrey D ; Maccoss, Malcolm ; Chapman, Kevin T

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(4), pp.964-968 [Peer Reviewed Journal]

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22
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Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)

Yu, Yang ; Wu, Zhicai ; Shi, Zhi-Cai ; He, Shuwen ; Lai, Zhong ; Cernak, Timothy A ; Vachal, Petr ; Liu, Min ; Liu, Jian ; Hong, Qingmei ; Jian, Tianying ; Guiadeen, Deodial ; Krikorian, Arto ; Sperbeck, Donald M ; Verras, Andreas ; Sonatore, Lisa M ; Murphy, Beth A ; Wiltsie, Judyann ; Chung, Christine C ; Gorski, Judith N ; Liu, Jinqi ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; De Vita, Robert J ; Pinto, Shirly ; Nargund, Ravi P

Bioorganic & Medicinal Chemistry Letters, 01 June 2019, Vol.29(11), pp.1380-1385 [Peer Reviewed Journal]

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23
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Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety

He, Shuwen ; Lai, Zhong ; Hong, Qingmei ; Shang, Jackie ; Reibarkh, Mikhail ; Kuethe, Jeffrey T ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Verras, Andreas ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Murphy, Beth A ; Gorski, Judith N ; Liu, Jinqi ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

Bioorganic & Medicinal Chemistry Letters, 15 May 2019, Vol.29(10), pp.1182-1186 [Peer Reviewed Journal]

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