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Digital chemistry in the Journal of Medicinal Chemistry

Gilson, Michael K ; Georg, Gunda ; Wang, Shaomeng

Journal of medicinal chemistry, 27 February 2014, Vol.57(4), pp.1137 [Peer Reviewed Journal]

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Inducing Protein Degradation as a Therapeutic Strategy

Crews, Craig M ; Georg, Gunda ; Wang, Shaomeng

Journal of medicinal chemistry, 09 June 2016, Vol.59(11), pp.5129-30 [Peer Reviewed Journal]

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The making of I-BET762, a BET bromodomain inhibitor now in clinical development

Zhao, Yujun ; Yang, Chao-Yie ; Wang, Shaomeng

Journal of medicinal chemistry, 10 October 2013, Vol.56(19), pp.7498-500 [Peer Reviewed Journal]

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AM-8553: a novel MDM2 inhibitor with a promising outlook for potential clinical development

Bernard, Denzil ; Zhao, Yujun ; Wang, Shaomeng

Journal of medicinal chemistry, 14 June 2012, Vol.55(11), pp.4934-5 [Peer Reviewed Journal]

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Current Medicinal Chemistry Research in India: Progress and Opportunities

Georg, Gunda I ; Wang, Shaomeng

Journal of medicinal chemistry, 09 March 2017, Vol.60(5), pp.1619 [Peer Reviewed Journal]

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6
Alzheimer’s Disease Special Thematic Issue: Call for Papers
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Alzheimer’s Disease Special Thematic Issue: Call for Papers

Georg, Gunda I. ; Wang, Shaomeng

Journal of Medicinal Chemistry, 04/12/2012, Vol.55(7), pp.2914-2914 [Peer Reviewed Journal]

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LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor

Chen, Jianyong ; Jiang, Cheng ; Wang, Shaomeng

Journal of medicinal chemistry, 25 July 2013, Vol.56(14), pp.5673-4 [Peer Reviewed Journal]

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Plagiarism
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Plagiarism

Georg, Gunda I. ; Wang, Shaomeng

Journal of Medicinal Chemistry, 01/10/2013, Vol.56(1), pp.1-1 [Peer Reviewed Journal]

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Hepatitis C virus (HCV) therapies special thematic issue: call for papers

Georg, Gunda I ; Wang, Shaomeng

Journal of medicinal chemistry, 24 January 2013, Vol.56(2), pp.387 [Peer Reviewed Journal]

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10
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Allosteric Inactivation of Polycomb Repressive Complex 2 (PRC2) by Inhibiting Its Adapter Protein: Embryonic Ectodomain Development (EED)

Yang, Chao-Yie ; Wang, Shaomeng

Journal of medicinal chemistry, 23 March 2017, Vol.60(6), pp.2212-2214 [Peer Reviewed Journal]

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11
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Transition in leadership: opportunities and challenges

Wang, Shaomeng ; Georg, Gunda I

Journal of medicinal chemistry, 12 January 2012, Vol.55(1), pp.1 [Peer Reviewed Journal]

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12
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High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein-Protein Interaction

Karatas, Hacer ; Townsend, Elizabeth C ; Cao, Fang ; Chen, Yong ; Bernard, Denzil ; Liu, Liu ; Lei, Ming ; Dou, Yali ; Wang, Shaomeng Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

Journal of the American Chemical Society (Online), 12 February 2013, Vol.135(2) [Peer Reviewed Journal]

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13
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Allosteric Modulators of Drug Targets Special Issue

Haskell-Luevano, Carrie ; Georg, Gunda I ; Wang, Shaomeng ; Meanwell, Nicholas

Journal of medicinal chemistry, 22 February 2018, Vol.61(4), pp.1381 [Peer Reviewed Journal]

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14
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Absolute quantitative (1)h NMR spectroscopy for compound purity determination

Cushman, Mark ; Georg, Gunda I ; Holzgrabe, Ulrike ; Wang, Shaomeng

Journal of medicinal chemistry, 26 November 2014, Vol.57(22), pp.9219 [Peer Reviewed Journal]

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Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment

Zhao, Yujun ; Aguilar, Angelo ; Bernard, Denzil ; Wang, Shaomeng

Journal of medicinal chemistry, 12 February 2015, Vol.58(3), pp.1038-52 [Peer Reviewed Journal]

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16
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Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors

Zhao, Yujun ; Liu, Liu ; Sun, Wei ; Lu, Jianfeng ; Mceachern, Donna ; Li, Xiaoqin ; Yu, Shanghai ; Bernard, Denzil ; Ochsenbein, Philippe ; Ferey, Vincent ; Carry, Jean-Christophe ; Deschamps, Jeffrey R ; Sun, Duxin ; Wang, Shaomeng

Journal of the American Chemical Society, 15 May 2013, Vol.135(19), pp.7223-34 [Peer Reviewed Journal]

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17
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Behavioral sensitization to cocaine in rats: evidence for temporal differences in dopamine D 3 and D 2 receptor sensitivity

Collins, Gregory ; Truong, Yen ; Levant, Beth ; Chen, Jianyong ; Wang, Shaomeng ; Woods, James

Psychopharmacology, 2011, Vol.215(4), pp.609-620 [Peer Reviewed Journal]

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18
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Effects of pramipexole on the reinforcing effectiveness of stimuli that were previously paired with cocaine reinforcement in rats

Collins, Gregory ; Cunningham, Alyssa ; Chen, Jianyong ; Wang, Shaomeng ; Newman, Amy ; Woods, James

Psychopharmacology, 2012, Vol.219(1), pp.123-135 [Peer Reviewed Journal]

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19
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Epigenetics: Novel Therapeutics Targeting Epigenetics

Conway, Stuart J ; Woster, Patrick M ; Greenlee, William J ; Georg, Gunda ; Wang, Shaomeng

Journal of medicinal chemistry, 25 February 2016, Vol.59(4), pp.1247-8 [Peer Reviewed Journal]

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20
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Epigenetics: novel therapeutics targeting epigenetics

Conway, Stuart J ; Woster, Patrick M ; Shen, Jing-Kang ; Georg, Gunda ; Wang, Shaomeng

Journal of medicinal chemistry, 22 January 2015, Vol.58(2), pp.523-4 [Peer Reviewed Journal]

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21
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Tranylcypromine substituted cis-hydroxycyclobutylnaphthamides as potent and selective dopamine D₃ receptor antagonists

Chen, Jianyong ; Levant, Beth ; Jiang, Cheng ; Keck, Thomas M ; Newman, Amy Hauck ; Wang, Shaomeng

Journal of medicinal chemistry, 12 June 2014, Vol.57(11), pp.4962-8 [Peer Reviewed Journal]

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22
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Design of triazole-stapled BCL9 α-helical peptides to target the β-catenin/B-cell CLL/lymphoma 9 (BCL9) protein-protein interaction

Kawamoto, Steven A ; Coleska, Adriana ; Ran, Xu ; Yi, Han ; Yang, Chao-Yie ; Wang, Shaomeng

Journal of medicinal chemistry, 09 February 2012, Vol.55(3), pp.1137-46 [Peer Reviewed Journal]

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23
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E2F1-Dependent Oncogenic Addiction of Melanoma Cells to MDM2

Verhaegen, Monique ; Checinska, Agnieszka ; Riblett, Mary Beth ; Wang, Shaomeng ; Soengas, María S

Oncogene, 2012, Vol.31(7), p.828-841 [Peer Reviewed Journal]

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24
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The Ecstasy and Agony of Assay Interference Compounds

Aldrich, Courtney ; Bertozzi, Carolyn ; Georg, Gunda I ; Kiessling, Laura ; Lindsley, Craig ; Liotta, Dennis ; Merz, Kenneth M ; Schepartz, Alanna ; Wang, Shaomeng

Biochemistry, 14 March 2017, Vol.56(10), pp.1363-1366 [Peer Reviewed Journal]

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25
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Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

Asangani, Irfan A ; Dommeti, Vijaya L ; Wang, Xiaoju ; Malik, Rohit ; Cieslik, Marcin ; Yang, Rendong ; Escara-Wilke, June ; Wilder-Romans, Kari ; Dhanireddy, Sudheer ; Engelke, Carl ; Iyer, Mathew K ; Jing, Xiaojun ; Wu, Yi-Mi ; Cao, Xuhong ; Qin, Zhaohui S ; Wang, Shaomeng ; Feng, Felix Y ; Chinnaiyan, Arul M

Nature, 12 June 2014, Vol.510(7504), pp.278-82 [Peer Reviewed Journal]

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26
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Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents

Peng, Yuefeng ; Sun, Haiying ; Lu, Jianfeng ; Liu, Liu ; Cai, Qian ; Shen, Rong ; Yang, Chao-Yie ; Yi, Han ; Wang, Shaomeng

Journal of medicinal chemistry, 12 January 2012, Vol.55(1), pp.106-14 [Peer Reviewed Journal]

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27
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Structure-Based Design of High-Affinity Macrocyclic Peptidomimetics to Block the Menin-Mixed Lineage Leukemia 1 (MLL1) Protein–Protein Interaction

Zhou, Haibin ; Liu, Liu ; Huang, Jing ; Bernard, Denzil ; Karatas, Hacer ; Navarro, Alexandro ; Lei, Ming ; Wang, Shaomeng Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

Journal of Medicinal Chemistry, 17 January 2013, Vol.56(3) [Peer Reviewed Journal]

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28
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Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannich ring-opening-cyclization reaction mechanism in spiro-oxindoles

Aguilar, Angelo ; Sun, Wei ; Liu, Liu ; Lu, Jianfeng ; Mceachern, Donna ; Bernard, Denzil ; Deschamps, Jeffrey R ; Wang, Shaomeng

Journal of medicinal chemistry, 26 December 2014, Vol.57(24), pp.10486-98 [Peer Reviewed Journal]

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29
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Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 (TRF2) Protein-Protein Interaction in the Shelterin Complex

Ran, Xu ; Liu, Liu ; Yang, Chao-Yie ; Lu, Jianfeng ; Chen, Yong ; Lei, Ming ; Wang, Shaomeng

Journal of medicinal chemistry, 14 January 2016, Vol.59(1), pp.328-34 [Peer Reviewed Journal]

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30
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Hepatic TRAF2 Regulates Glucose Metabolism Through Enhancing Glucagon Responses

Chen, Zheng ; Sheng, Liang ; Shen, Hong ; Zhao, Yujun ; Wang, Shaomeng ; Brink, Robert ; Rui, Liangyou

Diabetes, Mar 2012, pp.566-73 [Peer Reviewed Journal]

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31
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Significant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug Treatment

Hoffman-Luca, C. Gianna ; Yang, Chao-Yie ; Lu, Jianfeng ; Ziazadeh, Daniel ; Mceachern, Donna ; Debussche, Laurent ; Wang, Shaomeng Gartel, Andrei L. (editor)

PLoS ONE, 2015, Vol.10(6) [Peer Reviewed Journal]

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32
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BM-1197: A Novel and Specific Bcl-2/Bcl-xL Inhibitor Inducing Complete and Long-Lasting Tumor Regression In Vivo

Bai, Longchuan ; Chen, Jianfang ; Mceachern, Donna ; Liu, Liu ; Zhou, Haibin ; Aguilar, Angelo ; Wang, Shaomeng

PLoS One, Jun 2014, p.e99404 [Peer Reviewed Journal]

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33
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Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo

Hoffman-Luca, C Gianna ; Ziazadeh, Daniel ; Mceachern, Donna ; Zhao, Yujun ; Sun, Wei ; Debussche, Laurent ; Wang, Shaomeng

Clinical cancer research : an official journal of the American Association for Cancer Research, 01 June 2015, Vol.21(11), pp.2558-68 [Peer Reviewed Journal]

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34
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Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction

Karatas, Hacer ; Townsend, Elizabeth C ; Bernard, Denzil ; Dou, Yali ; Wang, Shaomeng

Journal of medicinal chemistry, 22 July 2010, Vol.53(14), pp.5179-85 [Peer Reviewed Journal]

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35
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Binding free energy contributions of interfacial waters in HIV-1 protease/inhibitor complexes

Lu, Yipin ; Yang, Chao-Yie ; Wang, Shaomeng

Journal of the American Chemical Society, 13 September 2006, Vol.128(36), pp.11830-9 [Peer Reviewed Journal]

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36
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A potent and highly efficacious Bcl-2/Bcl-xL inhibitor

Aguilar, Angelo ; Zhou, Haibin ; Chen, Jianfang ; Liu, Liu ; Bai, Longchuan ; Mceachern, Donna ; Yang, Chao-Yie ; Meagher, Jennifer ; Stuckey, Jeanne ; Wang, Shaomeng

Journal of medicinal chemistry, 11 April 2013, Vol.56(7), pp.3048-3067 [Peer Reviewed Journal]

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37
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Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold

Zhou, Haibin ; Chen, Jianfang ; Meagher, Jennifer L ; Yang, Chao-Yie ; Aguilar, Angelo ; Liu, Liu ; Bai, Longchuan ; Cong, Xin ; Cai, Qian ; Fang, Xueliang ; Stuckey, Jeanne A ; Wang, Shaomeng

Journal of medicinal chemistry, 24 May 2012, Vol.55(10), pp.4664-82 [Peer Reviewed Journal]

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