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Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators

Lusher, Scott J ; Raaijmakers, Hans C A ; Vu-Pham, Diep ; Dechering, Koen ; Lam, Tsang Wai ; Brown, Angus R ; Hamilton, Niall M ; Nimz, Olaf ; Bosch, Rolien ; Mcguire, Ross ; Oubrie, Arthur ; De Vlieg, Jacob

The Journal of biological chemistry, 07 October 2011, Vol.286(40), pp.35079-86 [Peer Reviewed Journal]

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X-ray structures of progesterone receptor ligand binding domain in its agonist state reveal differing mechanisms for mixed profiles of 11β-substituted steroids

Lusher, Scott J ; Raaijmakers, Hans C A ; Vu-Pham, Diep ; Kazemier, Bert ; Bosch, Rolien ; Mcguire, Ross ; Azevedo, Rita ; Hamersma, Hans ; Dechering, Koen ; Oubrie, Arthur ; Van Duin, Marcel ; De Vlieg, Jacob

The Journal of biological chemistry, 08 June 2012, Vol.287(24), pp.20333-43 [Peer Reviewed Journal]

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Discovery of 8-Amino-imidazo[1,5- a ]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis

Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Yu, Younong ; Vaccaro, Henry ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cooper, Alan ; de Man, Jos ; Kaptein, Allard ; Maloney, Kevin ; Hornak, Viktor ; Gao, Ying-Duo ; Fischmann, Thierry O ; Raaijmakers, Hans ; Vu-Pham, Diep ; Presland, Jeremy ; Mansueto, My ; Xu, Zangwei ; Leccese, Erica ; Zhang-Hoover, Jie ; Knemeyer, Ian ; Garlisi, Charles G ; Bays, Nathan ; Stivers, Peter ; Brandish, Philip E ; Hicks, Alexandra ; Kim, Ronald ; Kozlowski, Joseph A Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

ACS Medicinal Chemistry Letters, 11 February 2016, Vol.7(2) [Peer Reviewed Journal]

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