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Reduction of microalbuminuria in patients with type 2 diabetes: the Shiga Microalbuminuria Reduction Trial (SMART)

Uzu, Takashi ; Sawaguchi, Makoto ; Maegawa, Hiroshi ; Kashiwagi, Atsunori

Diabetes care, June 2007, Vol.30(6), pp.1581-3 [Peer Reviewed Journal]

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Furosemide-associated nephrocalcinosis and renal cysts

Uzu, Takashi ; Araki, Shin-Ichi ; Isshiki, Keiji ; Maegawa, Hiroshi

Kidney International, 01 September 2011, Vol.80(5), pp.556-556 [Peer Reviewed Journal]

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Multiple osteoporotic fractures in a patient with CKD stage G3b

Uzu, Takashi ; Araki, Shin-Ichi ; Araki, Hisazumi ; Kume, Shinji ; Maegawa, Hiroshi

Kidney International, May 2015, Vol.87(5), pp.1077-1077 [Peer Reviewed Journal]

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GW501516, a PPARδ Agonist, Ameliorates Tubulointerstitial Inflammation in Proteinuric Kidney Disease via Inhibition of TAK1-NFκB Pathway in Mice (PPARδ Agonist in Proteinuric Kidney Disease)

Yang, Xu ; Kume, Shinji ; Tanaka, Yuki ; Isshiki, Keiji ; Araki, Shin-ichi ; Chin-Kanasaki, Masami ; Sugimoto, Toshiro ; Koya, Daisuke ; Haneda, Masakazu ; Sugaya, Takeshi ; Li, Detian ; Han, Ping ; Nishio, Yoshihiko ; Kashiwagi, Atsunori ; Maegawa, Hiroshi ; Uzu, Takashi Chatziantoniou, Christos (Editor)

PLoS ONE, 2011, Vol.6(9), p.e25271 [Peer Reviewed Journal]

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Predictive effects of urinary liver-type fatty acid-binding protein for deteriorating renal function and incidence of cardiovascular disease in type 2 diabetic patients without advanced nephropathy

Araki, Shin-Ichi ; Haneda, Masakazu ; Koya, Daisuke ; Sugaya, Takeshi ; Isshiki, Keiji ; Kume, Shinji ; Kashiwagi, Atsunori ; Uzu, Takashi ; Maegawa, Hiroshi

Diabetes care, May 2013, Vol.36(5), pp.1248-53 [Peer Reviewed Journal]

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MicroRNA148b-3p inhibits mTORC1-dependent apoptosis in diabetes by repressing TNFR2 in proximal tubular cells

Kuwagata, Shogo ; Kume, Shinji ; Chin-Kanasaki, Masami ; Araki, Hisazumi ; Araki, Shinichi ; Nakazawa, Jun ; Sugaya, Takeshi ; Koya, Daisuke ; Haneda, Masakazu ; Maegawa, Hiroshi ; Uzu, Takashi

Kidney International, December 2016, Vol.90(6), pp.1211-1225 [Peer Reviewed Journal]

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Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

Kume, Shinji ; Uzu, Takashi ; Horiike, Kihachiro ; Chin-Kanasaki, Masami ; Isshiki, Keiji ; Araki, Shin-Ichi ; Sugimoto, Toshiro ; Haneda, Masakazu ; Kashiwagi, Atsunori ; Koya, Daisuke

The Journal of clinical investigation, April 2010, Vol.120(4), pp.1043-55 [Peer Reviewed Journal]

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8
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Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes

Maeda, Shiro ; Araki, Shin-Ichi ; Babazono, Tetsuya ; Toyoda, Masao ; Umezono, Tomoya ; Kawai, Koichi ; Imanishi, Masahito ; Uzu, Takashi ; Watada, Hirotaka ; Suzuki, Daisuke ; Kashiwagi, Atsunori ; Iwamoto, Yasuhiko ; Kaku, Kohei ; Kawamori, Ryuzo ; Nakamura, Yusuke

Diabetes, August 2010, Vol.59(8), pp.2075-9 [Peer Reviewed Journal]

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9
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Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy

Tagawa, Atsuko ; Yasuda, Mako ; Kume, Shinji ; Yamahara, Kosuke ; Nakazawa, Jun ; Chin-Kanasaki, Masami ; Araki, Hisazumi ; Araki, Shin-Ichi ; Koya, Daisuke ; Asanuma, Katsuhiko ; Kim, Eun-Hee ; Haneda, Masakazu ; Kajiwara, Nobuyuki ; Hayashi, Kazuyuki ; Ohashi, Hiroshi ; Ugi, Satoshi ; Maegawa, Hiroshi ; Uzu, Takashi

Diabetes, March 2016, Vol.65(3), pp.755-67 [Peer Reviewed Journal]

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Association between urinary type IV collagen level and deterioration of renal function in type 2 diabetic patients without overt proteinuria

Araki, Shin-Ichi ; Haneda, Masakazu ; Koya, Daisuke ; Isshiki, Keiji ; Kume, Shinji ; Sugimoto, Toshiro ; Kawai, Hiromichi ; Nishio, Yoshihiko ; Kashiwagi, Atsunori ; Uzu, Takashi ; Maegawa, Hiroshi

Diabetes care, August 2010, Vol.33(8), pp.1805-10 [Peer Reviewed Journal]

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11
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Role of Nutrient-Sensing Signals in the Pathogenesis of Diabetic Nephropathy

Kume, Shinji ; Koya, Daisuke ; Uzu, Takashi ; Maegawa, Hiroshi

BioMed Research International, 2014, Vol.2014 [Peer Reviewed Journal]

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12
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Emerging role of mammalian autophagy in ketogenesis to overcome starvation

Takagi, Ayano ; Kume, Shinji ; Maegawa, Hiroshi ; Uzu, Takashi

Autophagy, 02 April 2016, Vol.12(4), pp.709-710 [Peer Reviewed Journal]

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13
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Fenofibrate, a PPARα agonist, has renoprotective effects in mice by enhancing renal lipolysis

Tanaka, Yuki ; Kume, Shinji ; Araki, Shin-Ichi ; Isshiki, Keiji ; Chin-Kanasaki, Masami ; Sakaguchi, Masayoshi ; Sugimoto, Toshiro ; Koya, Daisuke ; Haneda, Masakazu ; Kashiwagi, Atsunori ; Maegawa, Hiroshi ; Uzu, Takashi

Kidney International, 02 April 2011, Vol.79(8), pp.871-882 [Peer Reviewed Journal]

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14
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The Influence of a Single Nucleotide Polymorphism within CNDP1 on Susceptibility to Diabetic Nephropathy in Japanese Women with Type 2 Diabetes

Kurashige, Mahiro ; Imamura, Minako ; Araki, Shin-Ichi ; Suzuki, Daisuke ; Babazono, Tetsuya ; Uzu, Takashi ; Umezono, Tomoya ; Toyoda, Masao ; Kawai, Koichi ; Imanishi, Masahito ; Hanaoka, Kazushige ; Maegawa, Hiroshi ; Uchigata, Yasuko ; Hosoya, Tatsuo ; Maeda, Shiro

PLoS One, Jan 2013, Vol.8(1), p.e54064 [Peer Reviewed Journal]

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15
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Predictive Properties of Plasma Amino Acid Profile for Cardiovascular Disease in Patients with Type 2 Diabetes

Kume, Shinji ; Araki, Shin-Ichi ; Ono, Nobukazu ; Shinhara, Atsuko ; Muramatsu, Takahiko ; Araki, Hisazumi ; Isshiki, Keiji ; Nakamura, Kazuki ; Miyano, Hiroshi ; Koya, Daisuke ; Haneda, Masakazu ; Ugi, Satoshi ; Kawai, Hiromichi ; Kashiwagi, Atsunori ; Uzu, Takashi ; Maegawa, Hiroshi

PLoS One, Jun 2014, Vol.9(6), p.e101219 [Peer Reviewed Journal]

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16
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4-Hydroxy Hexenal Derived from Docosahexaenoic Acid Protects Endothelial Cells via Nrf2 Activation

Ishikado, Atsushi ; Morino, Katsutaro ; Nishio, Yoshihiko ; Nakagawa, Fumiyuki ; Mukose, Atsushi ; Sono, Yoko ; Yoshioka, Nagisa ; Kondo, Keiko ; Sekine, Osamu ; Yoshizaki, Takeshi ; Ugi, Satoshi ; Uzu, Takashi ; Kawai, Hiromichi ; Makino, Taketoshi ; Okamura, Tomio ; Yamamoto, Masayuki ; Kashiwagi, Atsunori ; Maegawa, Hiroshi Schunck, Wolf-Hagen (editor)

PLoS ONE, 2013, Vol.8(7) [Peer Reviewed Journal]

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17
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Emerging role of podocyte autophagy in the progression of diabetic nephropathy

Yasuda-Yamahara, Mako ; Kume, Shinji ; Tagawa, Atsuko ; Maegawa, Hiroshi ; Uzu, Takashi

Autophagy, 01 December 2015, Vol.11(12), pp.2385-2386 [Peer Reviewed Journal]

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18
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The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy

Yamahara, Kosuke ; Yasuda, Mako ; Kume, Shinji ; Koya, Daisuke ; Maegawa, Hiroshi ; Uzu, Takashi Kanasaki, Keizo

Journal of Diabetes Research, 2013, Vol.2013, 9 pages [Peer Reviewed Journal]

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19
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Comparative Effects of Direct Renin Inhibitor and Angiotensin Receptor Blocker on Albuminuria in Hypertensive Patients with Type 2 Diabetes. A Randomized Controlled Trial

Uzu, Takashi ; Araki, Shin-Ichi ; Kashiwagi, Atsunori ; Haneda, Masakazu ; Koya, Daisuke ; Yokoyama, Hiroki ; Kida, Yasuo ; Ikebuchi, Motoyoshi ; Nakamura, Takaaki ; Nishimura, Masataka ; Takahara, Noriko ; Obata, Toshiyuki ; Omichi, Nobuyuki ; Sakamoto, Katsuhiko ; Shingu, Ryosuke ; Taki, Hideki ; Nagai, Yoshio ; Tokuda, Hiroaki ; Kitada, Munehiro ; Misawa

PLoS One, Dec 2016, Vol.11(12), p.e0164936 [Peer Reviewed Journal]

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20
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Relation of the expression of transcriptional factor TFAP2B to that of adipokines in subcutaneous and omental adipose tissues

Ugi, Satoshi ; Nishio, Yoshihiko ; Yamamoto, Hiroshi ; Ikeda, Kazuhiro ; Kobayashi, Masaaki ; Tsukada, Shuichi ; Kondo, Motoyuki ; Morino, Katsutaro ; Obata, Toshiyuki ; Yoshizaki, Takeshi ; Uzu, Takashi ; Naitoh, Hiroyuki ; Tani, Toru ; Maeda, Shiro ; Kashiwagi, Atsunori ; Maegawa, Hiroshi

Obesity (Silver Spring, Md.), July 2010, Vol.18(7), pp.1277-82 [Peer Reviewed Journal]

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21
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Renoprotective effect of DPP-4 inhibitors against free fatty acid-bound albumin-induced renal proximal tubular cell injury

Tanaka, Yuki ; Kume, Shinji ; Chin-Kanasaki, Masami ; Araki, Hisazumi ; Araki, Shin-Ichi ; Ugi, Satoshi ; Sugaya, Takeshi ; Uzu, Takashi ; Maegawa, Hiroshi

Biochemical and Biophysical Research Communications, 12 February 2016, Vol.470(3), pp.539-545 [Peer Reviewed Journal]

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22
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Autophagy as a Therapeutic Target in Diabetic Nephropathy

Tanaka, Yuki ; Kume, Shinji ; Kitada, Munehiro ; Kanasaki, Keizo ; Uzu, Takashi ; Maegawa, Hiroshi ; Koya, Daisuke Lee, Ki-Up

Experimental Diabetes Research, 2012, Vol.2012, 12 pages [Peer Reviewed Journal]

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23
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An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects

Ma, Lijun ; Murea, Mariana ; Snipes, James A ; Marinelarena, Alejandra ; Krüger, Jacqueline ; Hicks, Pamela J ; Langberg, Kurt A ; Bostrom, Meredith A ; Cooke, Jessica N ; Suzuki, Daisuke ; Babazono, Tetsuya ; Uzu, Takashi ; Tang, Sydney C W ; Mondal, Ashis K ; Sharma, Neeraj K ; Kobes, Sayuko ; Antinozzi, Peter A ; Davis, Matthew ; Das

PloS one, 2013, Vol.8(2), pp.e56193 [Peer Reviewed Journal]

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24
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Oral glucose‐stimulated serum C ‐peptide predicts successful switching from insulin therapy to liraglutide monotherapy in Japanese patients with type 2 diabetes and renal impairment

Araki, Hisazumi ; Tanaka, Yuki ; Yoshida, Syohei ; Morita, Yoshikata ; Kume, Shinji ; Isshiki, Keiji ; Araki, Shin‐Ichi ; Uzu, Takashi ; Kashiwagi, Atsunori ; Maegawa, Hiroshi

Journal of Diabetes Investigation, July 2014, Vol.5(4), pp.435-441 [Peer Reviewed Journal]

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25
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The effects of blood pressure control levels on the renoprotection of type 2 diabetic patients without overt proteinuria

Uzu, Takashi ; Kida, Yasuo ; Yamauchi, Atsushi ; Kume, Shinji ; Isshiki, Keiji ; Araki, Shin-Ichi ; Koya, Daisuke ; Haneda, Masakazu ; Kashiwagi, Atsunori ; Maegawa, Hiroshi ; Kikkawa, Ryuichi

Journal of the American Society of Hypertension, March 2012, Vol.6(2), pp.124-131 [Peer Reviewed Journal]

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26
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Successful Renal Replacement Therapy for a Patient with Severe Hemophilia after Surgical Treatment of Intracranial Hemorrhage and Hydrocephalus

Kato, Noriko ; Chin-Kanasaki, Masami ; Tanaka, Yuki ; Yasuda, Mako ; Yokomaku, Yukiyo ; Sakaguchi, Masayoshi ; Isshiki, Keiji ; Araki, Shin-ichi ; Ohta, Shigeru ; Uzu, Takashi Haase-Fielitz, A ; Saxena, A. K

Case Reports in Nephrology, 2011, Vol.2011, 3 pages [Peer Reviewed Journal]

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27
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Association between urinary angiotensinogen levels and renal and cardiovascular prognoses in patients with type 2 diabetes mellitus

Sawaguchi, Makoto ; Araki, Shin‐Ichi ; Kobori, Hiroyuki ; Urushihara, Maki ; Haneda, Masakazu ; Koya, Daisuke ; Kashiwagi, Atsunori ; Uzu, Takashi ; Maegawa, Hiroshi

Journal of Diabetes Investigation, June 2012, Vol.3(3), pp.318-324 [Peer Reviewed Journal]

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28
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Role of angiotensin II-mediated AMPK inactivation on obesity-related salt-sensitive hypertension

Deji, Naoko ; Kume, Shinji ; Araki, Shin-Ichi ; Isshiki, Keiji ; Araki, Hisazumi ; Chin-Kanasaki, Masami ; Tanaka, Yuki ; Nishiyama, Akira ; Koya, Daisuke ; Haneda, Masakazu ; Kashiwagi, Atsunori ; Maegawa, Hiroshi ; Uzu, Takashi

Biochemical and Biophysical Research Communications, 17 February 2012, Vol.418(3), pp.559-564 [Peer Reviewed Journal]

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29
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Overexpression of acetyl CoA carboxylase β exacerbates podocyte injury in the kidney of streptozotocin-induced diabetic mice

Tanaka, Yuki ; Kume, Shinji ; Maeda, Shiro ; Osawa, Norihisa ; Takeda, Naoko ; Chin-Kanasaki, Masami ; Isshiki, Keiji ; Ugi, Satoshi ; Oshima, Itsuki ; Uzu, Takashi ; Maegawa, Hiroshi ; Araki, Shin-Ichi

Biochemical and Biophysical Research Communications, 01 January 2018, Vol.495(1), pp.1115-1121 [Peer Reviewed Journal]

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30
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Factors associated with progression of diabetic nephropathy in Japanese elderly patients with type 2 diabetes: Sub‐analysis of the Japanese Elderly Diabetes Intervention Trial

Araki, Shin‐Ichi ; Nishio, Yoshihiko ; Araki, Atsushi ; Umegaki, Hiroyuki ; Sakurai, Takashi ; Iimuro, Satoshi ; Ohashi, Yasuo ; Uzu, Takashi ; Maegawa, Hiroshi ; Kashiwagi, Atsunori ; Ito, Hideki

Geriatrics & Gerontology International, April 2012, Vol.12, pp.127-133 [Peer Reviewed Journal]

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31
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Fructose induces tubulointerstitial injury in the kidney of mice

Aoyama, Masahiro ; Isshiki, Keiji ; Kume, Shinji ; Chin-Kanasaki, Masami ; Araki, Hisazumi ; Araki, Shin-Ichi ; Koya, Daisuke ; Haneda, Masakazu ; Kashiwagi, Atsunori ; Maegawa, Hiroshi ; Uzu, Takashi

Biochemical and Biophysical Research Communications, 09 March 2012, Vol.419(2), pp.244-249 [Peer Reviewed Journal]

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32
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Lamp-2 deficiency prevents high-fat diet-induced obese diabetes via enhancing energy expenditure

Yasuda-Yamahara, Mako ; Kume, Shinji ; Yamahara, Kosuke ; Nakazawa, Jun ; Chin-Kanasaki, Masami ; Araki, Hisazumi ; Araki, Shin-Ichi ; Koya, Daisuke ; Haneda, Masakzu ; Ugi, Satoshi ; Maegawa, Hiroshi ; Uzu, Takashi

Biochemical and Biophysical Research Communications, 18 September 2015, Vol.465(2), pp.249-255 [Peer Reviewed Journal]

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33
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Stearoyl-CoA Desaturase-1 Protects Cells against Lipotoxicity-Mediated Apoptosis in Proximal Tubular Cells

Iwai, Tamaki ; Kume, Shinji ; Chin-Kanasaki, Masami ; Kuwagata, Shogo ; Araki, Hisazumi ; Takeda, Naoko ; Sugaya, Takeshi ; Uzu, Takashi ; Maegawa, Hiroshi ; Araki, Shin-Ichi Cai, Lu (editor) ; Wang, Yuehui (editor) ; Zhang, Zhiguo (editor)

International Journal of Molecular Sciences, 2016, Vol.17(11) [Peer Reviewed Journal]

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34
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Glycated Albumin Predicts the Risk of Mortality in Type 2 Diabetic Patients on Hemodialysis: Evaluation of a Target Level for Improving Survival

Isshiki, Keiji ; Nishio, Toshiki ; Isono, Motohide ; Makiishi, Tetsuya ; Shikano, Tsutomu ; Tomita, Koubin ; Nishio, Toshiji ; Kanasaki, Masami ; Maegawa, Hiroshi ; Uzu, Takashi

Therapeutic Apheresis and Dialysis, October 2014, Vol.18(5), pp.434-442 [Peer Reviewed Journal]

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35
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Safety and efficacy of skin patches containing loxoprofen sodium in diabetic patients with overt nephropathy

Araki, Hisazumi ; Kuwagata, Shogo ; Soumura, Mariko ; Yamahara, Kosuke ; Morita, Yoshikata ; Kume, Shinji ; Isshiki, Keiji ; Araki, Shin-ichi ; Kashiwagi, Atsunori ; Maegawa, Hiroshi ; Uzu, Takashi

Clinical and Experimental Nephrology, 2014, Vol.18(3), pp.487-491 [Peer Reviewed Journal]

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36
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Autophagy regulates inflammation in adipocytes

Yoshizaki, Takeshi ; Kusunoki, Chisato ; Kondo, Motoyuki ; Yasuda, Mako ; Kume, Shinji ; Morino, Katsutaro ; Sekine, Osamu ; Ugi, Satoshi ; Uzu, Takashi ; Nishio, Yoshihiko ; Kashiwagi, Atsunori ; Maegawa, Hiroshi

Biochemical and Biophysical Research Communications, 06 January 2012, Vol.417(1), pp.352-357 [Peer Reviewed Journal]

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