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1
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Studies on the Dimerization of 2-Benzylidene-1-indanone

Berthelette, Carl ; Mccooye, Chris ; Leblanc, Yves ; Trimble, Laird A ; Tsou, Nancy N

The Journal of organic chemistry, 27 June 1997, Vol.62(13), pp.4339-4342 [Peer Reviewed Journal]

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An exception to the normal Mitsunobu reaction with phenols; the formation of hydrazones from salicylaldehydes

Girard, Mario ; Murphy, Philippe ; Tsou, Nancy N

Tetrahedron Letters, 2005, Vol.46(14), pp.2449-2452 [Peer Reviewed Journal]

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Preparation of 2,5,7-trithiabicyclo2.2.1heptane from 1,2-bis-triisopropylsilanylsulfanyl alkenes

Gareau, Yves ; Juteau, Hélène ; Tsou, Nancy N ; Ball, Richard G

Organic letters, 05 January 2006, Vol.8(1), pp.59-61 [Peer Reviewed Journal]

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Asymmetric synthesis of dihydroquinazolinones via directed ortho metalation and addition to tert-butanesulfinyl imines

Rajapakse, Hemaka A ; Young, Mary Beth ; Zhu, Hong ; Charlton, Samantha ; Tsou, Nancy N

Tetrahedron Letters, 2005, Vol.46(51), pp.8909-8912 [Peer Reviewed Journal]

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A New Planar Chiral Bisphosphine Ligand for Asymmetric Catalysis:  Highly Enantioselective Hydrogenations under Mild Conditions
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A New Planar Chiral Bisphosphine Ligand for Asymmetric Catalysis:  Highly Enantioselective Hydrogenations under Mild Conditions

Pye, Philip J. ; Rossen, Kai ; Reamer, Robert A. ; Tsou, Nancy N. ; Volante, R. P. ; Reider, Paul J.

Journal of the American Chemical Society, 07/1997, Vol.119(26), pp.6207-6208 [Peer Reviewed Journal]

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Asymmetric Synthesis of α,α-Difluoro-β-amino Acid Derivatives from Enantiomerically Pure N-tert- Butylsulfinimines
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Asymmetric Synthesis of α,α-Difluoro-β-amino Acid Derivatives from Enantiomerically Pure N-tert- Butylsulfinimines

Staas, Donnette D. ; Savage, Kelly L. ; Homnick, Carl F. ; Tsou, Nancy N. ; Ball, Richard G.

The Journal of Organic Chemistry, 11/2002, Vol.67(23), pp.8276-8279 [Peer Reviewed Journal]

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Asymmetric synthesis of alpha,alpha-difluoro-beta-amino acid derivatives from enantiomerically pure N-tert-butylsulfinimines

Staas, Donnette D ; Savage, Kelly L ; Homnick, Carl F ; Tsou, Nancy N ; Ball, Richard G

The Journal of organic chemistry, 15 November 2002, Vol.67(23), pp.8276-9 [Peer Reviewed Journal]

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Diastereoselective triple radical cyclization of a bromomethyldimethylsilyl allyl ether

Kende, Andrew S ; Journet, Michel ; Ball, Richard G ; Tsou, Nancy N

Tetrahedron Letters, 1996, Vol.37(35), pp.6295-6298 [Peer Reviewed Journal]

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9
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Diastereoselective Friedel-Crafts alkylation of indoles with chiral alpha-phenyl benzylic cations. Asymmetric synthesis of anti-1,1,2-triarylalkanes

Chung, John Y L ; Mancheno, Danny ; Dormer, Peter G ; Variankaval, Narayan ; Ball, Richard G ; Tsou, Nancy N

Organic letters, 17 July 2008, Vol.10(14), pp.3037-40 [Peer Reviewed Journal]

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Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy

Singh, Sheo B ; Jayasuriya, Hiranthi ; Ondeyka, John G ; Herath, Kithsiri B ; Zhang, Chaowei ; Zink, Deborah L ; Tsou, Nancy N ; Ball, Richard G ; Basilio, Angela ; Genilloud, Olga ; Diez, Maria Teresa ; Vicente, Francisca ; Pelaez, Fernando ; Young, Katherine ; Wang, Jun

Journal of the American Chemical Society, 13 September 2006, Vol.128(36), pp.11916-20 [Peer Reviewed Journal]

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Isolation, Structure, and Absolute Stereochemistry of Platensimycin, A Broad Spectrum Antibiotic Discovered Using an Antisense Differential Sensitivity Strategy [ J. Am. Chem. Soc. 2006 , 128 , 11916−11920].
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Isolation, Structure, and Absolute Stereochemistry of Platensimycin, A Broad Spectrum Antibiotic Discovered Using an Antisense Differential Sensitivity Strategy [ J. Am. Chem. Soc. 2006 , 128 , 11916−11920].

Singh, Sheo B. ; Jayasuriya, Hiranthi ; Ondeyka, John G. ; Herath, Kithsiri B. ; Zhang, Chaowei ; Zink, Deborah L. ; Tsou, Nancy N. ; Ball, Richard G. ; Basilio, Angela ; Genilloud, Olga ; Diez, Maria Teresa ; Vicente, Francisca ; Pelaez, Fernando ; Young, Katherine ; Wang, Jun

Journal of the American Chemical Society, 12/2006, Vol.128(48), pp.15547-15547 [Peer Reviewed Journal]

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Isolation and structure elucidation of coleophomones A and B, novel inhibitors of bacterial cell wall transglycosylase

Wilson, Kenneth E ; Tsou, Nancy N ; Guan, Ziqiang ; Ruby, Carolyn L ; Pelaez, Fernando ; Gorrochategui, Julian ; Vicente, Francisca ; Onishi, H.Russell

Tetrahedron Letters, 2000, Vol.41(45), pp.8705-8709 [Peer Reviewed Journal]

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Crystallization‐Induced Diastereoselection: Asymmetric Synthesis of Substance P Inhibitors

Pye, Philip J. ; Rossen, Kai ; Weissman, Steven A. ; Maliakal, Ashok ; Reamer, Robert A. ; Ball, Richard ; Tsou, Nancy N. ; Volante, R. P. ; Reider, Paul J.

Chemistry – A European Journal, 15 March 2002, Vol.8(6), pp.1372-1376 [Peer Reviewed Journal]

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Crystallization-induced diastereoselection: asymmetric synthesis of substance P inhibitors

Pye, Philip J ; Rossen, Kai ; Weissman, Steven A ; Maliakal, Ashok ; Reamer, Robert A ; Ball, Richard ; Tsou, Nancy N ; Volante, R P ; Reider, Paul J

Chemistry (Weinheim an der Bergstrasse, Germany), 15 March 2002, Vol.8(6), pp.1372-6 [Peer Reviewed Journal]

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15
Cover Picture: Chem. Eur. J. 6/2002
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Cover Picture: Chem. Eur. J. 6/2002

Pye, Philip J. ; Rossen, Kai ; Weissman, Steven A. ; Maliakal, Ashok ; Reamer, Robert A. ; Ball, Richard ; Tsou, Nancy N. ; Volante, R. P. ; Reider, Paul J.

Chemistry - A European Journal, 3/15/2002, Vol.8(6), p.1249 [Peer Reviewed Journal]

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16
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Conformational analysis and receptor docking of N-(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl-2-methyl-2-{5-(trifluoromethyl)pyridin-2-yloxy}propanamide (taranabant, MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist

Lin, Linus S ; Ha, Sookhee ; Ball, Richard G ; Tsou, Nancy N ; Castonguay, Laurie A ; Doss, George A ; Fong, Tung M ; Shen, Chun-Pyn ; Xiao, Jing Chen ; Goulet, Mark T ; Hagmann, William K

Journal of medicinal chemistry, 10 April 2008, Vol.51(7), pp.2108-14 [Peer Reviewed Journal]

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17
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Efficient synthesis of NK(1) receptor antagonist aprepitant using a crystallization-induced diastereoselective transformation

Brands, Karel M J ; Payack, Joseph F ; Rosen, Jonathan D ; Nelson, Todd D ; Candelario, Alexander ; Huffman, Mark A ; Zhao, Matthew M ; Li, Jing ; Craig, Bridgette ; Song, Zhiguo J ; Tschaen, David M ; Hansen, Karl ; Devine, Paul N ; Pye, Philip J ; Rossen, Kai ; Dormer, Peter G ; Reamer, Robert A ; Welch, Christopher J ; Mathre, David J ; Tsou, Nancy N ; Mcnamara, James M ; Reider, Paul J

Journal of the American Chemical Society, 26 February 2003, Vol.125(8), pp.2129-35 [Peer Reviewed Journal]

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18
Nodulisporic Acid A, a Novel and Potent Insecticide from a Nodulisporium Sp. Isolation, Structure Determination, and Chemical Transformations
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Nodulisporic Acid A, a Novel and Potent Insecticide from a Nodulisporium Sp. Isolation, Structure Determination, and Chemical Transformations

Ondeyka, John G. ; Helms, Gregory L. ; Hensens, Otto D. ; Goetz, Michael A. ; Zink, Deborah L. ; Tsipouras, Athanasios ; Shoop, Wesley L. ; Slayton, Lyndia ; Dombrowski, Anne W. ; Polishook, Jon D. ; Ostlind, Dan A. ; Tsou, Nancy N. ; Ball, Richard G. ; Singh, Sheo B.

Journal of the American Chemical Society, 09/1997, Vol.119(38), pp.8809-8816 [Peer Reviewed Journal]

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19
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Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β 3 adrenergic receptor agonists

Morriello, Gregori J ; Wendt, Harvey R ; Bansal, Alka ; Salvo, Jerry Di ; Feighner, Scott ; He, Jiafang ; Hurley, Amanda L ; Hreniuk, Donna L ; Salituro, Gino M ; Reddy, Marat Vijay ; Galloway, Sheila M ; Mcgettigan, Katherine K ; Laws, George ; Mcknight, Crystal ; Doss, George A ; Tsou, Nancy N ; Black, Regina M ; Morris, Judy ; Ball, Richard G ; Sanfiz, Anthony T ; Streckfuss, Eric ; Struthers, Mary ; Edmondson, Scott D

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(6), pp.1865-1870 [Peer Reviewed Journal]

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20
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3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channels

Collins, Ian ; Moyes, Christopher ; Davey, William B ; Rowley, Michael ; Bromidge, Frances A ; Quirk, Kathleen ; Atack, John R ; Mckernan, Ruth M ; Thompson, Sally-Ann ; Wafford, Keith ; Dawson, Gerard R ; Pike, Andrew ; Sohal, Bindi ; Tsou, Nancy N ; Ball, Richard G ; Castro, José L

Journal of medicinal chemistry, 25 April 2002, Vol.45(9), pp.1887-900 [Peer Reviewed Journal]

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21
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Discovery of potent, selective, and orally bioavailable 3 H-spiro[isobenzofuran-1,4′-piperidine] based melanocortin subtype-4 receptor agonists

Guo, Liangqin ; Ye, Zhixiong ; Liu, Jian ; He, Shuwen ; Bakshi, Raman K ; Sebhat, Iyassu K ; Dobbelaar, Peter H ; Hong, Qingmei ; Jian, Tianying ; Dellureficio, James P ; Tsou, Nancy N ; Ball, Richard G ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Tamvakopoulos, Constantin ; Peng, Qianping ; Chen, Howard Y ; Chen, Airu S ; Martin, William J ; Macintyre, D. Euan ; Strack, Alison M ; Fong, Tung M ; Wyvratt, Matthew J ; Nargund, Ravi P

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(16), pp.4895-4900 [Peer Reviewed Journal]

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22
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Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist

He, Shuwen ; Ye, Zhixiong ; Dobbelaar, Peter H ; Sebhat, Iyassu K ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Lai, Yingjie ; Franklin, Christopher L ; Bakshi, Raman K ; Dellureficio, James P ; Hong, Qingmei ; Tsou, Nancy N ; Ball, Richard G ; Cashen, Doreen E ; Martin, William J ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Tamvakopoulos, Constantin ; Peng, Qianping ; Miller, Randy R ; Stearns, Ralph A ; Chen, Howard Y ; Chen, Airu S ; Strack, Alison M ; Fong, Tung M ; Macintyre, D. Euan ; Wyvratt, Matthew J ; Nargund, Ravi P

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(7), pp.2106-2110 [Peer Reviewed Journal]

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23
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1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity

Vachal, Petr ; Fletcher, Joan M ; Fong, Tung M ; Huang, Cathy C R-R ; Lao, Julie ; Xiao, Jing C ; Shen, Chun-Pyn ; Strack, Alison M ; Shearman, Lauren ; Stribling, Sloan ; Chen, Richard Z ; Frassetto, Andrea ; Tong, Xinchun ; Wang, Junying ; Ball, Richard G ; Tsou, Nancy N ; Hickey, Gerard J ; Thompson, Donald F ; Faidley, Terry D ; Nicolich, Susan ; Achanfuo-Yeboah, Joana ; Hora, Donald F ; Hale, Jeffrey J ; Hagmann, William K

Journal of medicinal chemistry, 23 April 2009, Vol.52(8), pp.2550-8 [Peer Reviewed Journal]

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24
Cyclization of 2- and 3-indolylthiobenzoic, phenylacetic and nicotinic acids and esters to novel indole-containing tetracyclic ring systems
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Cyclization of 2- and 3-indolylthiobenzoic, phenylacetic and nicotinic acids and esters to novel indole-containing tetracyclic ring systems

Hamel, Pierre ; Girard, Mario ; Tsou, Nancy N.

Journal of Heterocyclic Chemistry, 05/1999, Vol.36(3), pp.643-652 [Peer Reviewed Journal]

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25
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Cyclization of 2‐ and 3‐indolylthiobenzoic, phenylacetic and nicotinic acids and esters to novel indole‐containing tetracyclic ring systems

Hamel, Pierre ; Girard, Mario ; Tsou, Nancy N.

Journal of Heterocyclic Chemistry, May 1999, Vol.36(3), pp.643-652 [Peer Reviewed Journal]

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26
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Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity

Friesen, Richard W ; Ducharme, Yves ; Ball, Richard G ; Blouin, Marc ; Boulet, Louise ; Côté, Bernard ; Frenette, Richard ; Girard, Mario ; Guay, Daniel ; Huang, Zheng ; Jones, Thomas R ; Laliberté, France ; Lynch, Joseph J ; Mancini, Joseph ; Martins, Evelyn ; Masson, Paul ; Muise, Eric ; Pon, Douglas J ; Siegl, Peter K S ; Styhler, Angela ; Tsou, Nancy N ; Turner, Mervyn J ; Young, Robert N ; Girard, Yves

Journal of medicinal chemistry, 05 June 2003, Vol.46(12), pp.2413-26 [Peer Reviewed Journal]

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27
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Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents

Desolms, S Jane ; Ciccarone, Terrence M ; Mactough, Suzanne C ; Shaw, Anthony W ; Buser, Carolyn A ; Ellis-Hutchings, Michelle ; Fernandes, Christine ; Hamilton, Kelly A ; Huber, Hans E ; Kohl, Nancy E ; Lobell, Robert B ; Robinson, Ronald G ; Tsou, Nancy N ; Walsh, Eileen S ; Graham, Samuel L ; Beese, Lorena S ; Taylor, Jeffrey S

Journal of medicinal chemistry, 03 July 2003, Vol.46(14), pp.2973-84 [Peer Reviewed Journal]

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28
Structural Optimization Affording 2-( R )-(1-( R )-3,5-Bis(trifluoromethyl)phenylethoxy)-3-( S )-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist
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Structural Optimization Affording 2-( R )-(1-( R )-3,5-Bis(trifluoromethyl)phenylethoxy)-3-( S )-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

Hale, Jeffrey J. ; Mills, Sander G. ; Maccoss, Malcolm ; Finke, Paul E. ; Cascieri, Margaret A. ; Sadowski, Sharon ; Ber, Elzbieta ; Chicchi, Gary G. ; Kurtz, Marc ; Metzger, Joseph ; Eiermann, George ; Tsou, Nancy N. ; Tattersall, F. David ; Rupniak, Nadia M. J. ; Williams, Angela R. ; Rycroft, Wayne ; Hargreaves, Richard ; Macintyre, D. Euan

Journal of Medicinal Chemistry, 11/1998, Vol.41(23), pp.4607-4614 [Peer Reviewed Journal]

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29
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Conformational studies of 3-amino-1-alkyl-cyclopentane carboxamide CCR2 antagonists leading to new spirocyclic antagonists

Pasternak, Alexander ; Goble, Stephen D ; Doss, George A ; Tsou, Nancy N ; Butora, Gabor ; Vicario, Pasquale P ; Ayala, Julia Marie ; Struthers, Mary ; Demartino, Julie A ; Mills, Sander G ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(4), pp.1374-1377 [Peer Reviewed Journal]

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30
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Aryl sulfones: a new class of γ-secretase inhibitors

Teall, Martin ; Oakley, Paul ; Harrison, Timothy ; Shaw, Duncan ; Kay, Euan ; Elliott, Jason ; Gerhard, Ute ; Castro, José L ; Shearman, Mark ; Ball, Richard G ; Tsou, Nancy N

Bioorganic & Medicinal Chemistry Letters, 16 May 2005, Vol.15(10), pp.2685-2688 [Peer Reviewed Journal]

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31
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The discovery of potent, selective, and orally bioavailable hNK 1 antagonists derived from pyrrolidine

Lin, Peter ; Chang, Lehua ; Devita, Robert J ; Young, Jonathan R ; Eid, Ronsar ; Tong, Xinchun ; Zheng, Song ; Ball, Richard G ; Tsou, Nancy N ; Chicchi, Gary G ; Kurtz, Marc M ; Tsao, Kwei-Lan C ; Wheeldon, Alan ; Carlson, Emma J ; Eng, Waisi ; Burns, H. Donald ; Hargreaves, Richard J ; Mills, Sander G

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(18), pp.5191-5198 [Peer Reviewed Journal]

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32
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A potent and orally active HIV-1 integrase inhibitor

Egbertson, Melissa S ; Moritz, H. Marie ; Melamed, Jeffrey Y ; Han, Wei ; Perlow, Debra S ; Kuo, Michelle S ; Embrey, Mark ; Vacca, Joseph P ; Zrada, Matthew M ; Cortes, Amanda R ; Wallace, Audrey ; Leonard, Yvonne ; Hazuda, Daria J ; Miller, Michael D ; Felock, Peter J ; Stillmock, Kara A ; Witmer, Marc V ; Schleif, William ; Gabryelski, Lori J ; Moyer, Gregory ; Ellis, Joan D ; Jin, Lixia ; Xu, Wei ; Braun, Matthew P ; Kassahun, Kellem ; Tsou, Nancy N ; Young, Steven D

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(5), pp.1392-1398 [Peer Reviewed Journal]

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33
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Cyclopentane-based human NK1 antagonists. Part 2: Development of potent, orally active, water-soluble derivatives

Meurer, Laura C ; Finke, Paul E ; Owens, Karen A ; Tsou, Nancy N ; Ball, Richard G ; Mills, Sander G ; Maccoss, Malcolm ; Sadowski, Sharon ; Cascieri, Margaret A ; Tsao, Kwei-Lan ; Chicchi, Gary G ; Egger, Linda A ; Luell, Silvi ; Metzger, Joseph M ; Macintyre, D. Euan ; Rupniak, Nadia M.J ; Williams, Angela R ; Hargreaves, Richard J

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(17), pp.4504-4511 [Peer Reviewed Journal]

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34
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A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells

Embrey, Mark W ; Wai, John S ; Funk, Timothy W ; Homnick, Carl F ; Perlow, Debbie S ; Young, Steven D ; Vacca, Joseph P ; Hazuda, Daria J ; Felock, Peter J ; Stillmock, Kara A ; Witmer, Marc V ; Moyer, Gregory ; Schleif, William A ; Gabryelski, Lori J ; Jin, Lixia ; Chen, I-Wu ; Ellis, Joan D ; Wong, Bradley K ; Lin, Jiunn H ; Leonard, Yvonne M ; Tsou, Nancy N ; Zhuang, Linghang

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(20), pp.4550-4554 [Peer Reviewed Journal]

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35
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Benzamide derivatives as blockers of Kv1.3 ion channel

Miao, Shouwu ; Bao, Jianming ; Garcia, Maria L ; Goulet, Joung L ; Hong, Xingfang J ; Kaczorowski, Gregory J ; Kayser, Frank ; Koo, Gloria C ; Kotliar, Andrew ; Schmalhofer, William A ; Shah, Kashmira ; Sinclair, Peter J ; Slaughter, Robert S ; Springer, Marty S ; Staruch, Mary Jo ; Tsou, Nancy N ; Wong, Frederick ; Parsons, William H ; Rupprecht, Kathleen M

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(6), pp.1161-1164 [Peer Reviewed Journal]

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36
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Preussomerin D from the Endophyte Hormonema Dematioides

Polishook, Jon D ; Dombrowski, Anne W ; Tsou, Nancy N ; Salituro, Gino M ; Curotto, James E

Mycologia, 01 January 1993, Vol.85(1), pp.62-64 [Peer Reviewed Journal]

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