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Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks

Qu, Meng ; Duffy, Tomas ; Hirota, Tsuyoshi ; Kay, Steve A

Proceedings of the National Academy of Sciences of the United States of America, 26 December 2018, Vol.115(52), pp.E12305-E12312 [Peer Reviewed Journal]

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Targeting glucocorticoid side effects: selective glucocorticoid receptor modulator or glucocorticoid‐induced leucine zipper? A perspective

Ayroldi, Emira ; Macchiarulo, Antonio ; Riccardi, Carlo

FASEB Journal, December 2014, Vol.28(12), pp.5055-5070 [Peer Reviewed Journal]

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Anti-inflammatory glucocorticoids: Changing concepts

Newton, Robert

European Journal of Pharmacology, 05 February 2014, Vol.724, pp.231-236 [Peer Reviewed Journal]

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Harnessing the benefits of PPARβ/δ agonists

Mackenzie, Louise S ; Lione, Lisa

Life Sciences, 18 December 2013, Vol.93(25-26), pp.963-967 [Peer Reviewed Journal]

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JTP-117968, a novel selective glucocorticoid receptor modulator, exhibits improved transrepression/transactivation dissociation

Kurimoto, Takafumi ; Tamai, Isao ; Miyai, Atsuko ; Kosugi, Yoshinori ; Nakagawa, Takashi ; Yamamoto, Yasuo ; Deai, Katsuya ; Misaki, Shohei ; Bessho, Yuki ; Negoro, Tamotsu ; Yamaguchi, Takayuki ; Hata, Takahiro ; Matsushita, Mutsuyoshi

European Journal of Pharmacology, 15 May 2017, Vol.803, pp.179-186 [Peer Reviewed Journal]

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Probing Dominant Negative Behavior of Glucocorticoid Receptor β through a Hybrid Structural and Biochemical Approach

Min, Jungki ; Perera, Lalith ; Krahn, Juno M ; Jewell, Christine M ; Moon, Andrea F ; Cidlowski, John A ; Pedersen, Lars C

Molecular and cellular biology, 15 April 2018, Vol.38(8) [Peer Reviewed Journal]

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Detection of protein–protein interactions in plants using the transrepressive activity of the EAR motif repression domain

Matsui, Kyoko ; Ohme‐Takagi, Masaru

Plant Journal, February 2010, Vol.61(4), pp.570-578 [Peer Reviewed Journal]

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Mécanismes d’action des glucocorticoïdes

Dejean, C ; Richard, D

La Revue de médecine interne, May 2013, Vol.34(5), pp.264-268 [Peer Reviewed Journal]

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Regulatory and Mechanistic Actions of Glucocorticoids on T and Inflammatory Cells

Ana C. Liberman ; Maia L. Budziñski ; Clara Sokn ; Romina Paula Gobbini ; Anja Steininger ; Eduardo Arzt ; Eduardo Arzt

Frontiers in Endocrinology, 01 May 2018, Vol.9 [Peer Reviewed Journal]

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Structure-activity relationships of rosiglitazone for peroxisome proliferator-activated receptor gamma transrepression

Toyota, Yosuke ; Nomura, Sayaka ; Makishima, Makoto ; Hashimoto, Yuichi ; Ishikawa, Minoru

Bioorganic & Medicinal Chemistry Letters, 15 June 2017, Vol.27(12), pp.2776-2780 [Peer Reviewed Journal]

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Dexamethasone and RU24858 Induce Survival and Growth Factor Receptor Bound protein 2, Leukotriene B4 Receptor 1 and Annexin-1 expression in primary Human Neutrophils

Janka-Junttila, Mirkka ; Hasala, Hannele ; Adcock, Ian ; Moilanen, Eeva ; Kankaanranta, Hannu

Journal of Cell Death, January 2012, Vol.5 [Peer Reviewed Journal]

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Crosstalk between the peroxisome proliferator-activated receptor γ (PPARγ) and the vitamin D receptor (VDR) in human breast cancer cells: PPARγ binds to VDR and inhibits 1α,25-dihydroxyvitamin D3 mediated transactivation

Alimirah, Fatouma ; Peng, Xinjian ; Yuan, Liang ; Mehta, Rajeshwari R ; Von Knethen, Andreas ; Choubey, Divaker ; Mehta, Rajendra G

Experimental Cell Research, 15 November 2012, Vol.318(19), pp.2490-2497 [Peer Reviewed Journal]

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Discovery of new selective glucocorticoid receptor agonist leads

Berger, Markus ; Rehwinkel, Hartmut ; Schmees, Norbert ; Schäcke, Heike ; Edman, Karl ; Wissler, Lisa ; Reichel, Andreas ; Jaroch, Stefan

Bioorganic & Medicinal Chemistry Letters, 01 February 2017, Vol.27(3), pp.437-442 [Peer Reviewed Journal]

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Effects of representative glucocorticoids on TNFα- and CD40L-induced NF-κB activation in sensor cells

Cechin, Sirlene R ; Buchwald, Peter

Steroids, July 2014, Vol.85, pp.36-43 [Peer Reviewed Journal]

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Tetrahydroquinoline glucocorticoid receptor agonists: Discovery of a 3-hydroxyl for improving receptor selectivity

Roach, Steven L ; Higuchi, Robert I ; Hudson, Andrew R ; Adams, Mark E ; Syka, Peter M ; Mais, Dale E ; Miner, Jeffrey N ; Marschke, Keith B ; Zhi, Lin

Bioorganic & Medicinal Chemistry Letters, 01 January 2011, Vol.21(1), pp.168-171 [Peer Reviewed Journal]

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Selective modulation through the glucocorticoid receptor ameliorates muscle pathology in mdx mice

Huynh, Tony ; Uaesoontrachoon, Kitipong ; Quinn, James L ; Tatem, Kathleen S ; Heier, Christopher R ; Van Der Meulen, Jack H ; Yu, Qing ; Harris, Mark ; Nolan, Christopher J ; Haegeman, Guy ; Grounds, Miranda D ; Nagaraju, Kanneboyina

Journal of Pathology, October 2013, Vol.231(2), pp.223-235 [Peer Reviewed Journal]

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3,5-Diiodothyronine-mediated transrepression of the thyroid hormone receptor beta gene in tilapia. Insights on cross-talk between the thyroid hormone and cortisol signaling pathways

Hernández-Puga, Gabriela ; Navarrete-Ramírez, Pamela ; Mendoza, Arturo ; Olvera, Aurora ; Villalobos, Patricia ; Orozco, Aurea

Molecular and Cellular Endocrinology, 15 April 2016, Vol.425, pp.103-110 [Peer Reviewed Journal]

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Discovery of GW 870086: a potent anti‐inflammatory steroid with a unique pharmacological profile

Uings, I J ; Needham, D ; Matthews, J ; Haase, M ; Austin, R ; Angell, D ; Leavens, K ; Holt, J ; Biggadike, K ; Farrow, S N

British Journal of Pharmacology, July 2013, Vol.169(6), pp.1389-1403 [Peer Reviewed Journal]

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19
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Wild‐type but not mutant androgen receptor inhibits expression of the hTERT telomerase subunit: a novel role of AR mutation for prostate cancer development

Moehren, Udo ; Papaioannou, Maria ; Reeb, Christina A. ; Grasselli, Annalisa ; Nanni, Simona ; Asim, Mohammad ; Roell, Daniela ; Prade, Ina ; Farsetti, Antonella ; Baniahmad, Aria

FASEB Journal, April 2008, Vol.22(4), pp.1258-1267 [Peer Reviewed Journal]

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20
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The activated glucocorticoid receptor inhibits the transcription factor T‐bet by direct protein‐protein interaction

Liberman, Ana C. ; Refojo, Damian ; Druker, Jimena ; Toscano, Marta ; Rein, Theo ; Holsboer, Florian ; Arzt, Eduardo

FASEB Journal, April 2007, Vol.21(4), pp.1177-1188 [Peer Reviewed Journal]

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21
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The nuclear receptor superfamily: A structural perspective

Weikum, Emily R. ; Liu, Xu ; Ortlund, Eric A.

Protein Science, November 2018, Vol.27(11), pp.1876-1892 [Peer Reviewed Journal]

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22
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Protective Microglia and Their Regulation in Parkinson’s Disease

Le, Weidong ; Wu, Junjiao ; Tang, Yu

Frontiers in Molecular Neuroscience, Sep 21, 2016 [Peer Reviewed Journal]

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23
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Steroidal C-21 heteroaryl thioethers (Part 2): Discovery of orally bioavailable selective glucocorticoid receptor modulators (dissociated steroids)

Biju, Purakkattle ; Mccormick, Kevin ; Aslanian, Robert ; Berlin, Michael ; Solomon, Daniel ; Wang, Hongwu ; Lee, Yoon Joo ; Bitar, Rema ; Prelusky, Daniel ; Mcleod, Robbie ; Jia, Yanlin ; Fernandez, Xiomora ; Eckel, Stephen ; House, Aileen ; Lieber, Gissela ; Jimenez, Johanna ; Kelly, George ; Chapman, Richard ; Phillips, Jonathan ; Anthes, John

Bioorganic & Medicinal Chemistry Letters, 15 January 2012, Vol.22(2), pp.1086-1090 [Peer Reviewed Journal]

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24
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Transposons, p53 and Genome Security

Tiwari, Bhavana ; Jones, Amanda E ; Abrams, John M

Trends in Genetics, November 2018, Vol.34(11), pp.846-855 [Peer Reviewed Journal]

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25
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Steroidal C-21 heteroaryl thioethers. Part 3: Pregn-4-eno-[3,2-c]pyrazole fused A ring modified steroids as selective glucocorticoid receptor modulators (dissociated steroids)

Biju, Purakkattle ; Wang, Hongwu ; Anthes, John ; Mccormick, Kevin ; Aslanian, Robert ; Berlin, Michael ; Bitar, Rema ; Lim, Yeon-Hee ; Lee, Yoon Joo ; Prelusky, Daniel ; Mcleod, Robbie ; Jia, Yanlin ; Fernandez, Xiomora ; Lieber, Gissela ; Jimenez, Johanna ; Eckel, Steve ; House, Aileen ; Chapman, Richard ; Phillips, Jonathan

Bioorganic & Medicinal Chemistry Letters, 01 May 2012, Vol.22(9), pp.3291-3295 [Peer Reviewed Journal]

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26
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Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators

Nomura, Sayaka ; Endo-Umeda, Kaori ; Aoyama, Atsushi ; Makishima, Makoto ; Hashimoto, Yuichi ; Ishikawa, Minoru

ACS medicinal chemistry letters, 13 August 2015, Vol.6(8), pp.902-7 [Peer Reviewed Journal]

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27
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Selective Glucocorticoid Receptor modulators

De Bosscher, Karolien

Journal of Steroid Biochemistry and Molecular Biology, 31 May 2010, Vol.120(2-3), pp.96-104 [Peer Reviewed Journal]

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28
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AtMYBL2, a protein with a single MYB domain, acts as a negative regulator of anthocyanin biosynthesis in Arabidopsis

Matsui, Kyoko ; Umemura, Yoshimi ; Ohme‐Takagi, Masaru

Plant Journal, September 2008, Vol.55(6), pp.954-967 [Peer Reviewed Journal]

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29
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Crosstalk between the vitamin D receptor (VDR) and miR-214 in regulating SuFu, a hedgehog pathway inhibitor in breast cancer cells

Alimirah, Fatouma ; Peng, Xinjian ; Gupta, Akash ; Yuan, Liang ; Welsh, Joellen ; Cleary, Michele ; Mehta, Rajendra G

Experimental Cell Research, 15 November 2016, Vol.349(1), pp.15-22 [Peer Reviewed Journal]

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30
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Steroidal C-21 mercapto derivatives as dissociated steroids: Discovery of an inhaled dissociated steroid

Biju, Purakkattle ; Mccormick, Kevin ; Aslanian, Robert ; Berlin, Michael ; Solomon, Daniel ; Chapman, Richard ; Mcleod, Robbie ; Prelusky, Daniel ; Eckel, Stephen ; Kelly, George ; Natiello, Michelle ; House, Aileen ; Fernandez, Xiomara ; Bitar, Rema ; Phillips, Jonathan ; Anthes, John

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(21), pp.6343-6347 [Peer Reviewed Journal]

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31
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Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α

Zhang, Feng ; Lu, Shuai ; He, Jianlin ; Jin, Huanhuan ; Wang, Feixia ; Wu, Li ; Shao, Jiangjuan ; Chen, Anping ; Zheng, Shizhong

Theranostics, 2018, Vol.8(3), pp.610-626 [Peer Reviewed Journal]

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32
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The Role of Glucocorticoid Receptor Signaling in Bladder Cancer Progression

Hiroki Ide ; Satoshi Inoue ; Hiroshi Miyamoto

Cancers, 01 December 2018, Vol.10(12), p.484 [Peer Reviewed Journal]

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33
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Multiple Functions of Protein Inhibitor of Activated STAT1 in Regulating Endothelial Cell Proliferation and Inflammation

Abe, Jun-Ichi

Arteriosclerosis, thrombosis, and vascular biology, September 2016, Vol.36(9), pp.1717-9 [Peer Reviewed Journal]

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34
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Protective Microglia and Their Regulation in Parkinson's Disease

Le, Weidong ; Wu, Junjiao ; Tang, Yu

Frontiers in molecular neuroscience, 2016, Vol.9, pp.89 [Peer Reviewed Journal]

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35
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Gene Expression Control by Glucocorticoid Receptors during Innate Immune Responses

Xavier, Andre Machado ; Anunciato, Aparecida Kataryna Olimpio ; Rosenstock, Tatiana Rosado ; Glezer, Isaias

Frontiers in endocrinology, 2016, Vol.7, pp.31 [Peer Reviewed Journal]

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Heterocyclic glucocorticoid receptor modulators with a 2,2-dimethyl-3-phenyl-N-(thiazol or thiadiazol-2-yl)propanamide core

Xiao, Hai-Yun ; Wu, Dauh-Rurng ; Sheppeck, James E ; Habte, Sium F ; Cunningham, Mark D ; Somerville, John E ; Barrish, Joel C ; Nadler, Steven G ; Dhar, T.G. Murali

Bioorganic & Medicinal Chemistry Letters, 15 October 2013, Vol.23(20), pp.5571-5574 [Peer Reviewed Journal]

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LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux

Thomas, David G ; Doran, Amanda C ; Fotakis, Panagiotis ; Westerterp, Marit ; Antonson, Per ; Jiang, Hui ; Jiang, Xian-Cheng ; Gustafsson, Jan-Åke ; Tabas, Ira ; Tall, Alan R

Cell Reports, 26 December 2018, Vol.25(13), pp.3774-3785.e4 [Peer Reviewed Journal]

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