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27 Results  for Everything (Includes Articles)

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1
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Discovery of a novel glucagon receptor antagonist N-(4-{(1S)-1-3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-ylethyl}phenyl)carbonyl-β-alanine (MK-0893) for the treatment of type II diabetes

Xiong, Yusheng ; Guo, Jian ; Candelore, Mari R ; Liang, Rui ; Miller, Corey ; Dallas-Yang, Qing ; Jiang, Guoqiang ; Mccann, Peggy E ; Qureshi, Sajjad A ; Tong, Xinchun ; Xu, Shiyao Sherrie ; Shang, Jackie ; Vincent, Stella H ; Tota, Laurie M ; Wright, Michael J ; Yang, Xiaodong ; Zhang, Bei B ; Tata, James R ; Parmee, Emma R

Journal of medicinal chemistry, 12 July 2012, Vol.55(13), pp.6137-48 [Peer Reviewed Journal]

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A novel series of indazole-/indole-based glucagon receptor antagonists

Lin, Songnian ; Zhang, Fengqi ; Jiang, Guoqiang ; Qureshi, Sajjad A ; Yang, Xiaodong ; Chicchi, Gary G ; Tota, Laurie ; Bansal, Alka ; Brady, Edward ; Trujillo, Maria ; Salituro, Gino ; Miller, Corey ; Tata, James R ; Zhang, Bei B ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 01 October 2015, Vol.25(19), pp.4143-4147 [Peer Reviewed Journal]

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Discovery of N-Aryl-2-acylindole human glucagon receptor antagonists

Sinz, Christopher ; Bittner, Amy ; Brady, Ed ; Candelore, Mari ; Dallas-Yang, Qing ; Ding, Victor ; Jiang, Guoqiang ; Lin, Zhen ; Qureshi, Sajjad ; Salituro, Gino ; Saperstein, Richard ; Shang, Jackie ; Szalkowski, Deborah ; Tota, Laurie ; Vincent, Stella ; Wright, Michael ; Xu, Shiyao ; Yang, Xiaodong ; Zhang, Bei ; Tata, James

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(23), pp.7124-7130 [Peer Reviewed Journal]

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Discovery of cyclic guanidines as potent, orally active, human glucagon receptor antagonists

Sinz, Christopher ; Chang, Jiang ; Lins, Ashley Rouse ; Brady, Ed ; Candelore, Mari ; Dallas-Yang, Qing ; Ding, Victor ; Jiang, Guoqiang ; Lin, Zhen ; Mock, Steven ; Qureshi, Sajjad ; Salituro, Gino ; Saperstein, Richard ; Shang, Jackie ; Szalkowski, Deborah ; Tota, Laurie ; Vincent, Stella ; Wright, Michael ; Xu, Shiyao ; Yang, Xiaodong

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(23), pp.7131-7136 [Peer Reviewed Journal]

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Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core

Shen, Dong-Ming ; Brady, Edward J ; Candelore, Mari R ; Dallas-Yang, Qing ; Ding, Victor D.-H ; Feeney, William P ; Jiang, Guoquiang ; Mccann, Margaret E ; Mock, Steve ; Qureshi, Sajjad A ; Saperstein, Richard ; Shen, Xiaolan ; Tong, Xinchun ; Tota, Laurie M ; Wright, Michael J ; Yang, Xiaodong ; Zheng, Song ; Chapman, Kevin T ; Zhang, Bei B ; Tata, James R

Bioorganic & Medicinal Chemistry Letters, 01 January 2011, Vol.21(1), pp.76-81 [Peer Reviewed Journal]

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6
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Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice

Pocai, Alessandro ; Carrington, Paul E ; Adams, Jennifer R ; Wright, Michael ; Eiermann, George ; Zhu, Lan ; Du, Xiaobing ; Petrov, Aleksandr ; Lassman, Michael E ; Jiang, Guoqiang ; Liu, Franklin ; Miller, Corey ; Tota, Laurie M ; Zhou, Gaochao ; Zhang, Xiaoping ; Sountis, Michael M ; Santoprete, Alessia ; Capito', Elena ; Chicchi

Diabetes, October 2009, Vol.58(10), pp.2258-66 [Peer Reviewed Journal]

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Direct observation (NMR) of the efficacy of glucagon receptor antagonists in murine liver expressing the human glucagon receptor

Cohen, Sheila M ; Duffy, Joseph L ; Miller, Corin ; Kirk, Brian A ; Candelore, Mari Rios ; Ding, Victor D.H ; Kaczorowski, Gregory ; Tota, Laurie M ; Werrmann, Jeffrey G ; Wright, Michael ; Parmee, Emma R ; Tata, James R ; Zhang, Bei B

Bioorganic & Medicinal Chemistry, 2006, Vol.14(5), pp.1506-1517 [Peer Reviewed Journal]

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Desensitization of β 3-adrenergic receptor- stimulated adenylyl cyclase activity and lipolysis in rats

Vicario, Pasquale P ; Candelore, Mari R ; Schaeffer, Marie-Therese ; Kelly, Linda ; Thompson, G.Marie ; Brady, Edward J ; Saperstein, Richard ; Macintyre, D.Euan ; Tota, Laurie M ; Cascieri, Margaret A

Life Sciences, 1998, Vol.62(7), pp.627-638 [Peer Reviewed Journal]

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9
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A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects

Qureshi, Sajjad A ; Rios Candelore, Mari ; Xie, Dan ; Yang, Xiaodong ; Tota, Laurie M ; Ding, Victor D-H ; Li, Zhihua ; Bansal, Alka ; Miller, Corin ; Cohen, Sheila M ; Jiang, Guoqiang ; Brady, Ed ; Saperstein, Richard ; Duffy, Joseph L ; Tata, James R ; Chapman, Kevin T ; Moller, David E ; Zhang, Bei B

Diabetes, December 2004, Vol.53(12), pp.3267-73 [Peer Reviewed Journal]

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Phytosphingosine 1-phosphate: a high affinity ligand for the S1P 4/Edg-6 receptor

Rios Candelore, Mari ; Wright, Michael J ; Tota, Laurie M ; Milligan, James ; Shei, Gan-Ju ; Bergstrom, James D ; Mandala, Suzanne M

Biochemical and Biophysical Research Communications, 2002, Vol.297(3), pp.600-606 [Peer Reviewed Journal]

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11
Discovery of a Potent, Orally Bioavailable β 3 Adrenergic Receptor Agonist, ( R )- N -[4-[2-[[2-Hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide
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Discovery of a Potent, Orally Bioavailable β 3 Adrenergic Receptor Agonist, ( R )- N -[4-[2-[[2-Hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide

Mathvink, Robert J. ; Tolman, J. Samuel ; Chitty, Dawn ; Candelore, Mari R. ; Cascieri, Margaret A. ; Colwell, Lawrence F. ; Deng, Liping ; Feeney, William P. ; Forrest, Michael J. ; Hom, Gary J. ; Macintyre, D. Euan ; Miller, Randall R. ; Stearns, Ralph A. ; Tota, Laurie ; Wyvratt, Matthew J. ; Fisher, Michael H. ; Weber, Ann E.

Journal of Medicinal Chemistry, 10/2000, Vol.43(21), pp.3832-3836 [Peer Reviewed Journal]

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12
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L-750355, a human ß3-adrenoceptor agonist; in vitro pharmacology and profile of activity in vivo in the rhesus monkey

Forrest, Michael J ; Hom, Gary ; Bach, Tom ; Candelore, Mari Rios ; Cascieri, Margaret A ; Strader, Catherine ; Tota, Laurie ; Fisher, Michael H ; Szumiloski, John ; Ok, Hyun O ; Weber, Ann E ; Wyvratt, Matthew ; Vicario, Pasquale ; Marko, Olga ; Deng, Liping ; Cioffe, Christine ; Hegarty-Friscino, Bonnie ; Macintyre, Euan

European Journal of Pharmacology, 2000, Vol.407(1), pp.175-181 [Peer Reviewed Journal]

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13
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Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor

Liang, Rui ; Abrardo, Lauren ; Brady, Edward J ; Candelore, Mari Rios ; Ding, Victor ; Saperstein, Richard ; Tota, Laurie M ; Wright, Michael ; Mock, Steve ; Tamvakopolous, Constantin ; Tong, Sharon ; Zheng, Song ; Zhang, Bei B ; Tata, James R ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(3), pp.587-592 [Peer Reviewed Journal]

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14
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Human β3 adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties

Brockunier, Linda L ; Candelore, Mari R ; Cascieri, Margaret A ; Liu, Yong ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 02 February 2001, Vol.11(3), pp.379-382 [Peer Reviewed Journal]

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15
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Discovery of potent, orally active benzimidazole glucagon receptor antagonists

Kim, Ronald M ; Chang, Jiang ; Lins, Ashley R ; Brady, Ed ; Candelore, Mari R ; Dallas-Yang, Qing ; Ding, Victor ; Dragovic, Jasminka ; Iliff, Susan ; Jiang, Guoqiang ; Mock, Steven ; Qureshi, Sajjad ; Saperstein, Richard ; Szalkowski, Deborah ; Tamvakopoulos, Constantin ; Tota, Laurie ; Wright, Michael ; Yang, Xiaodong ; Tata, James R ; Chapman, Kevin ; Zhang, Bei B ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(13), pp.3701-3705 [Peer Reviewed Journal]

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16
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Potent, selective human β3 adrenergic receptor agonists containing a substituted indoline-5-sulfonamide pharmacophore

Mathvink, Robert J ; Barritta, Anna Maria ; Candelore, Mari R ; Cascieri, Margaret A ; Liping Deng ; Tota, Laurie ; Strader, Catherine D ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 1999, Vol.9(13), pp.1869-1874 [Peer Reviewed Journal]

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17
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Potent, selective benzenesulfonamide agonists of the human β 3 adrenergic receptor

Weber, Ann E ; Mathvink, Robert J ; Perkins, Leroy ; Hutchins, Jennifer E ; Candelore, Mari R ; Tota, Laurie ; Strader, Catherine D ; Wyvratt, Matthew J ; Fisher, Michael H

Bioorganic & Medicinal Chemistry Letters, 1998, Vol.8(9), pp.1101-1106 [Peer Reviewed Journal]

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18
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Discovery of L-755,507: A subnanomolar human β3 adrenergic receptor agonist

Parmee, Emma R ; Ok, Hyun O ; Candelore, Mari R ; Tota, Laurie ; Deng, Liping ; Strader, Catherine D ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 1998, Vol.8(9), pp.1107-1112 [Peer Reviewed Journal]

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19
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3-pyridylethanolamines: Potent and selective human β 3 adrenergic receptor agonists

Naylor, Elizabeth M ; Colandrea, Vincent J ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Euan Macintyre, D ; Strader, Catherine D ; Tota, Laurie ; Wang, Pei-Ran ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 1998, Vol.8(21), pp.3087-3092 [Peer Reviewed Journal]

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20
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Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human β 3 adrenergic receptor agonists

Parmee, Emma R ; Brockunier, Linda L ; He, Jiafang ; Singh, Suresh B ; Candelore, Mari R ; Cascieri, Margaret A ; Deng, Liping ; Liu, Yong ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2000, Vol.10(20), pp.2283-2286 [Peer Reviewed Journal]

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21
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Discovery of an orally bioavailable alkyl oxadiazole β 3 adrenergic receptor agonist

Feng, Danqing D ; Biftu, Tesfaye ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Miller, Randall R ; Stearns, Ralph A ; Strader, Catherine D ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2000, Vol.10(13), pp.1427-1429 [Peer Reviewed Journal]

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22
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Potent, selective 3-pyridylethanolamine β 3 adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore

Mathvink, Robert J ; Tolman, J.Samuel ; Chitty, Dawn ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2000, Vol.10(17), pp.1971-1973 [Peer Reviewed Journal]

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23
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Human β 3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides

Brockunier, Linda L ; Parmee, Emma R ; Ok, Hyun O ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2000, Vol.10(18), pp.2111-2114 [Peer Reviewed Journal]

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24
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Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists

Shen, Dong-Ming ; Zhang, Fengqi ; Brady, Edward J ; Candelore, Mari Rios ; Dallas-Yang, Qing ; Ding, Victor D.-H ; Dragovic, Jasminka ; Feeney, William P ; Jiang, Guoquiang ; Mccann, Peggy E ; Mock, Steve ; Qureshi, Sajjad A ; Saperstein, Richard ; Shen, Xiaolan ; Tamvakopoulos, Constantin ; Tong, Xinchun ; Tota, Laurie M ; Wright, Michael J ; Yang, Xiaodong ; Zheng, Song

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(20), pp.4564-4569 [Peer Reviewed Journal]

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25
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Human β3 adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides

Parmee, Emma R ; Naylor, Elizabeth M ; Perkins, Leroy ; Colandrea, Vincent J ; Ok, Hyun O ; Candelore, Mari R ; Cascieri, Margaret A ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Miller, Randall R ; Stearns, Ralph A ; Strader, Catherine D ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 1999, Vol.9(5), pp.749-754 [Peer Reviewed Journal]

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26
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L-770,644: A potent and selective human β3 adrenergic receptor agonist with improved oral bioavailability

Shih, Thomas L ; Candelore, Mari R ; Cascieri, Margaret A ; Chiu, Shuet-Hing L ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Miller, Randall R ; Stearns, Ralph A ; Strader, Catherine D ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 1999, Vol.9(9), pp.1251-1254 [Peer Reviewed Journal]

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27
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3-Pyridyloxypropanolamine agonists of the β3 adrenergic receptor with improved pharmacokinetic properties

Weber, Ann E ; Ok, Hyun O ; Alvaro, Raul F ; Candelore, Mari R ; Cascieri, Margaret A ; Chiu, Shuet-Hing L ; Deng, Liping ; Forrest, Michael J ; Hom, Gary J ; Hutchins, Jennifer E ; Kao, John ; Macintyre, D.Euan ; Mathvink, Robert J ; Mcloughlin, Debra ; Miller, Randall R ; Newbold, Ronald C ; Olah, Timothy V ; Parmee, Emma R ; Perkins, Leroy ; Stearns, Ralph A

Bioorganic & Medicinal Chemistry Letters, 1998, Vol.8(16), pp.2111-2116 [Peer Reviewed Journal]

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