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Discovery of N-Bis(4-methoxyphenyl)methyl-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia

Debenham, John S ; Madsen-Duggan, Christina ; Clements, Matthew J ; Walsh, Thomas F ; Kuethe, Jeffrey T ; Reibarkh, Mikhail ; Salowe, Scott P ; Sonatore, Lisa M ; Hajdu, Richard ; Milligan, James A ; Visco, Denise M ; Zhou, Dan ; Lingham, Russell B ; Stickens, Dominique ; Demartino, Julie A ; Tong, Xinchun ; Wolff, Michael ; Pang, Jianmei ; Miller, Randy R ; Sherer, Edward C ; Hale, Jeffrey J

Journal of medicinal chemistry, 22 December 2016, Vol.59(24), pp.11039-11049 [Peer Reviewed Journal]

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Discovery of a novel glucagon receptor antagonist N-(4-{(1S)-1-3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-ylethyl}phenyl)carbonyl-β-alanine (MK-0893) for the treatment of type II diabetes

Xiong, Yusheng ; Guo, Jian ; Candelore, Mari R ; Liang, Rui ; Miller, Corey ; Dallas-Yang, Qing ; Jiang, Guoqiang ; Mccann, Peggy E ; Qureshi, Sajjad A ; Tong, Xinchun ; Xu, Shiyao Sherrie ; Shang, Jackie ; Vincent, Stella H ; Tota, Laurie M ; Wright, Michael J ; Yang, Xiaodong ; Zhang, Bei B ; Tata, James R ; Parmee, Emma R

Journal of medicinal chemistry, 12 July 2012, Vol.55(13), pp.6137-48 [Peer Reviewed Journal]

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Measurement of catecholamines in rat and mini-pig plasma and urine by liquid chromatography–tandem mass spectrometry coupled with solid phase extraction

He, Huaibing ; Carballo-Jane, Ester ; Tong, Xinchun ; Cohen, Lucinda H

Journal of Chromatography B, 01 August 2015, Vol.997, pp.154-161 [Peer Reviewed Journal]

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Effect of signal interference from dosing excipients on pharmacokinetic screening of drug candidates by liquid chromatography/mass spectrometry

Tong, Xinchun S ; Wang, Junying ; Zheng, Song ; Pivnichny, James V ; Griffin, Patrick R ; Shen, Xiaolan ; Donnelly, Marcie ; Vakerich, Ken ; Nunes, Chris ; Fenyk-Melody, Judy

Analytical chemistry, 15 December 2002, Vol.74(24), pp.6305-13 [Peer Reviewed Journal]

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Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: modifications of the oxazolidinone ring leading to the discovery of anacetrapib

Smith, Cameron J ; Ali, Amjad ; Hammond, Milton L ; Li, Hong ; Lu, Zhijian ; Napolitano, Joann ; Taylor, Gayle E ; Thompson, Christopher F ; Anderson, Matt S ; Chen, Ying ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Sparrow, Carl P ; Wright, Samuel D ; Cumiskey, Anne-Marie ; Latham, Melanie ; Peterson, Laurence B ; Rosa, Ray ; Pivnichny, James V ; Tong, Xinchun ; Xu, Suoyu S ; Sinclair, Peter J

Journal of medicinal chemistry, 14 July 2011, Vol.54(13), pp.4880-95 [Peer Reviewed Journal]

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2-(3aR,4R,5S,7aS)-5-{(1S)-1-3,5-bis(trifluoromethyl)phenyl-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl-1,3-oxazol-4(5H)-one: a potent human NK1 receptor antagonist with multiple clearance pathways

Kassick, Andrew J ; Jiang, Jinlong ; Bunda, Jaime ; Wilson, David ; Bao, Jianming ; Lu, Huagang ; Lin, Peter ; Ball, Richard G ; Doss, George A ; Tong, Xinchun ; Tsao, Kwei-Lan C ; Wang, Hong ; Chicchi, Gary ; Karanam, Bindhu ; Tschirret-Guth, Richard ; Samuel, Koppara ; Hora, Donald F ; Kumar, Sanjeev ; Madeira, Maria ; Eng, Waisi ; Hargreaves, Richard ; Purcell, Mona ; Gantert, Liza ; Cook, Jacquelyn ; Devita, Robert J ; Mills, Sander G

Journal of medicinal chemistry, 25 July 2013, Vol.56(14), pp.5940-8 [Peer Reviewed Journal]

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Solid-phase method for the purification of DNA sequencing reactions

Tong, Xinchun ; Smith, Lloyd

Analytical Chemistry, Nov 15, 1992, Vol.64(22), p.2672 [Peer Reviewed Journal]

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Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release—Potential insight into mechanism of action

Liu, Jinqi ; Gorski, Judith N. ; Gold, Stephen J. ; Chen, Dunlu ; Chen, Shirley ; Forrest, Gail ; Itoh, Yoshiki ; Marsh, Donald J. ; Mclaren, David G. ; Shen, Zhu ; Sonatore, Lisa ; Carballo‐Jane, Ester ; Craw, Stephanie ; Guan, Xiaoming ; Karanam, Bindhu ; Sakaki, Junichi ; Szeto, Daphne ; Tong, Xinchun ; Xiao, Jianying ; Yoshimoto, Ryo ; Yu, Hong ; Roddy, Thomas P. ; Balkovec, James ; Pinto, Shirly

Obesity, July 2013, Vol.21(7), pp.1406-1415 [Peer Reviewed Journal]

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Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity

Zhou, Changyou ; Garcia-Calvo, Margareta ; Pinto, Shirly ; Lombardo, Matthew ; Feng, Zhe ; Bender, Kate ; Pryor, Kellyann D ; Bhatt, Urmi R ; Chabin, Renee M ; Geissler, Wayne M ; Shen, Zhu ; Tong, Xinchun ; Zhang, Zhoupeng ; Wong, Kenny K ; Roy, Ranabir Sinha ; Chapman, Kevin T ; Yang, Lihu ; Xiong, Yusheng

Journal of medicinal chemistry, 14 October 2010, Vol.53(19), pp.7251-63 [Peer Reviewed Journal]

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1,3,8-Triazaspiro4.5decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia

Vachal, Petr ; Miao, Shouwu ; Pierce, Joan M ; Guiadeen, Deodial ; Colandrea, Vincent J ; Wyvratt, Matthew J ; Salowe, Scott P ; Sonatore, Lisa M ; Milligan, James A ; Hajdu, Richard ; Gollapudi, Anantha ; Keohane, Carol A ; Lingham, Russell B ; Mandala, Suzanne M ; Demartino, Julie A ; Tong, Xinchun ; Wolff, Michael ; Steinhuebel, Dietrich ; Kieczykowski, Gerard R ; Fleitz, Fred J ; Chapman, Kevin ; Athanasopoulos, John ; Adam, Gregory ; Akyuz, Can D ; Jena, Dhirendra K ; Lusen, Jeffrey W ; Meng, Juncai ; Stein, Benjamin D ; Xia, Lei ; Sherer, Edward C ; Hale, Jeffrey J

Journal of medicinal chemistry, 12 April 2012, Vol.55(7), pp.2945-59 [Peer Reviewed Journal]

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11
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Rhesus monkey model for concurrent analyses of in vivo selectivity, pharmacokinetics and pharmacodynamics of aldosterone synthase inhibitors

Cai, Tian-Quan ; Stribling, Sloan ; Tong, Xinchun ; Xu, Ling ; Wisniewski, Thomas ; Fontenot, Jane A ; Struthers, Mary ; Akinsanya, Karen O

Journal of Pharmacological and Toxicological Methods, January 2015, Vol.71, pp.137-146 [Peer Reviewed Journal]

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12
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Discovery of N-(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano2,3-bpyridin-4-yl-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity

Yan, Lin ; Huo, Pei ; Debenham, John S ; Madsen-Duggan, Christina B ; Lao, Julie ; Chen, Richard Z ; Xiao, Jing Chen ; Shen, Chun-Pyn ; Stribling, D Sloan ; Shearman, Lauren P ; Strack, Alison M ; Tsou, Nancy ; Ball, Richard G ; Wang, Junying ; Tong, Xinchun ; Bateman, Thomas J ; Reddy, Vijay B G ; Fong, Tung M ; Hale, Jeffrey J

Journal of medicinal chemistry, 27 May 2010, Vol.53(10), pp.4028-37 [Peer Reviewed Journal]

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13
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Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate

Shen, Hong C ; Ding, Fa-Xiang ; Raghavan, Subharekha ; Deng, Qiaolin ; Luell, Silvi ; Forrest, Michael J ; Carballo-Jane, Ester ; Wilsie, Larissa C ; Krsmanovic, Mihajlo L ; Taggart, Andrew K ; Wu, Kenneth K ; Wu, Tsuei-Ju ; Cheng, Kang ; Ren, Ning ; Cai, Tian-Quan ; Chen, Qing ; Wang, Junying ; Wolff, Michael S ; Tong, Xinchun ; Holt, Tom G ; Waters, M Gerard ; Hammond, Milton L ; Tata, James R ; Colletti, Steven L

Journal of medicinal chemistry, 25 March 2010, Vol.53(6), pp.2666-70 [Peer Reviewed Journal]

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14
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Chiral separation and detection of terbutaline and ephedrine by capillary electrophoresis coupled with ion spray mass spectrometry

Sheppard, Robin ; Tong, Xinchun ; Cai, Jianyi ; Henion, Jack

Analytical Chemistry, Jul 1, 1995, Vol.67(13), p.2054 [Peer Reviewed Journal]

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15
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Pyrazoles as non-classical bioisosteres in prolylcarboxypeptidase (PrCP) inhibitors

Graham, Thomas H ; Shu, Min ; Verras, Andreas ; Chen, Qing ; Garcia-Calvo, Margarita ; Li, Xiaohua ; Lisnock, Jeanmarie ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 01 April 2014, Vol.24(7), pp.1657-1660 [Peer Reviewed Journal]

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Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors

Shen, Hong C ; Ding, Fa-Xiang ; Zhou, Changyou ; Xiong, Yusheng ; Verras, Andreas ; Chabin, Renee M ; Xu, Suoyu ; Tong, Xinchun ; Xie, Dan ; Lassman, Michael E ; Bhatt, Urmi R ; Garcia-Calvo, Margarita M ; Geissler, Wayne ; Shen, Zhu ; Chen, Dunlu ; Sinharoy, Ranabir ; Hale, Jeffery J ; Tata, James R ; Pinto, Shirly ; Shen, Dong-Ming ; Colletti, Steven L

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(5), pp.1299-1305 [Peer Reviewed Journal]

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17
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Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors

Shen, Hong C ; Ding, Fa-Xiang ; Jiang, Jinlong ; Verras, Andreas ; Chabin, Renee M ; Xu, Suoyu ; Tong, Xinchun ; Chen, Qing ; Xie, Dan ; Lassman, Mike E ; Bhatt, Urmi R ; Garcia-Calvo, Margarita M ; Geissler, Wayne ; Shen, Zhu ; Murphy, Beth Ann ; Gorski, Judith N ; Wiltsie, Judyann ; Sinharoy, Ranabir ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 February 2012, Vol.22(4), pp.1550-1556 [Peer Reviewed Journal]

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18
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Comparative analysis of the effects of antimuscarinic agents on bladder functions in both nonhuman primates and rodents

Nagabukuro, Hiroshi ; Villa, Katherine L ; Wickham, L Alexandra ; Kulick, Alison A ; Gichuru, Loise ; Donnelly, Marcie J ; Voronin, Gregory O ; Pereira, Tony ; Tong, Xinchun ; Nichols, Andrew ; Alves, Stephen E ; O'Neill, Gary P ; Johnson, Christopher V ; Hickey, Emily J

The Journal of pharmacology and experimental therapeutics, July 2011, Vol.338(1), pp.220-7 [Peer Reviewed Journal]

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19
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SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors

Lu, Zhijian ; Chen, Yi-Heng ; Napolitano, Joann B ; Taylor, Gayle ; Ali, Amjad ; Hammond, Milton L ; Deng, Qiaolin ; Tan, Eugene ; Tong, Xinchun ; Xu, Suoyu S ; Latham, Melanie J ; Peterson, Laurence B ; Anderson, Matt S ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Chen, Ying ; Sparrow, Carl P ; Wright, Samuel D ; Sinclair, Peter J

Bioorganic & Medicinal Chemistry Letters, 01 January 2012, Vol.22(1), pp.199-203 [Peer Reviewed Journal]

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20
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Discovery of aminoheterocycles as potent and brain penetrant prolylcarboxypeptidase inhibitors

Wu, Zhicai ; Yang, Cangming ; Graham, Thomas H ; Verras, Andreas ; Chabin, Renee M ; Xu, Suoyu ; Tong, Xinchun ; Xie, Dan ; Lassman, Mike E ; Bhatt, Urmi R ; Garcia-Calvo, Margarita M ; Shen, Zhu ; Chen, Qing ; Bleasby, Kelly ; Sinharoy, Ranabir ; Hale, Jeffrey J ; Tata, James R ; Pinto, Shirly ; Colletti, Steven L ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 February 2012, Vol.22(4), pp.1727-1730 [Peer Reviewed Journal]

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Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine

Wu, Zhicai ; Yang, Cangming ; Xiong, Yusheng ; Feng, Zhe ; Lombardo, Matthew ; Verras, Andreas ; Chabin, Renee M ; Xu, Suoyu ; Tong, Xinchun ; Xie, Dan ; Lassman, Mike E ; Bhatt, Urmi R ; Garcia-Calvo, Margarita M ; Geissler, Wayne ; Shen, Zhu ; Chen, Qing ; Sinharoy, Ranabir ; Hale, Jeffrey J ; Tata, James R ; Pinto, Shirly ; Shen, Dong-Ming ; Colletti, Steven L

Bioorganic & Medicinal Chemistry Letters, 15 February 2012, Vol.22(4), pp.1774-1778 [Peer Reviewed Journal]

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22
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Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core

Shen, Dong-Ming ; Brady, Edward J ; Candelore, Mari R ; Dallas-Yang, Qing ; Ding, Victor D.-H ; Feeney, William P ; Jiang, Guoquiang ; Mccann, Margaret E ; Mock, Steve ; Qureshi, Sajjad A ; Saperstein, Richard ; Shen, Xiaolan ; Tong, Xinchun ; Tota, Laurie M ; Wright, Michael J ; Yang, Xiaodong ; Zheng, Song ; Chapman, Kevin T ; Zhang, Bei B ; Tata, James R ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 01 January 2011, Vol.21(1), pp.76-81 [Peer Reviewed Journal]

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Mineralocorticoid receptor antagonists: Identification of heterocyclic amide replacements in the oxazolidinedione series

Cox, Jason M ; Chu, Hong D ; Yang, Christine ; Shen, Hong C ; Wu, Zhicai ; Balsells, Jaume ; Crespo, Alejandro ; Brown, Patricia ; Zamlynny, Beata ; Wiltsie, Judyann ; Clemas, Joseph ; Gibson, Jack ; Contino, Lisa ; Lisnock, Jeanmarie ; Zhou, Gaochao ; Garcia-Calvo, Margarita ; Bateman, Thomas ; Xu, Ling ; Tong, Xinchun ; Crook, Martin ; Sinclair, Peter

Bioorganic & Medicinal Chemistry Letters, 01 April 2014, Vol.24(7), pp.1681-1684 [Peer Reviewed Journal]

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A new class of prolylcarboxypeptidase inhibitors, Part 2: The aminocyclopentanes

Graham, Thomas H ; Liu, Wensheng ; Verras, Andreas ; Reibarkh, Mikhail ; Bleasby, Kelly ; Bhatt, Urmi R ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; Gorski, Judith N ; He, Huaibing ; Lassman, Michael E ; Lisnock, Jeanmarie ; Li, Xiaohua ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Xie, Dan ; Xu, Suoyu ; Xiao, Jianying ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 April 2012, Vol.22(8), pp.2818-2822 [Peer Reviewed Journal]

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25
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Discovery of novel non-steroidal reverse indole mineralocorticoid receptor antagonists

Ogawa, Anthony K ; Bunte, Ellen Vande ; Mal, Rudrajit ; Lan, Ping ; Sun, Zhongxiang ; Crespo, Alejandro ; Wiltsie, Judyann ; Clemas, Joseph ; Gibson, Jack ; Contino, Lisa ; Lisnock, Jeanmarie ; Zhou, Gaochao ; Garcia-Calvo, Margarita ; Jochnowitz, Nina ; Ma, Xiuying ; Pan, Yi ; Brown, Patricia ; Zamlynny, Beata ; Bateman, Thomas ; Leung, Dennis ; Xu, Ling ; Tong, Xinchun ; Liu, Kun ; Crook, Martin ; Sinclair, Peter

Bioorganic & Medicinal Chemistry Letters, 15 June 2016, Vol.26(12), pp.2866-2869 [Peer Reviewed Journal]

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Discovery of novel oxazolidinedione derivatives as potent and selective mineralocorticoid receptor antagonists

Yang, Christine ; Shen, Hong C ; Wu, Zhicai ; Chu, Hong D ; Cox, Jason M ; Balsells, Jaume ; Crespo, Alejandro ; Brown, Patricia ; Zamlynny, Beata ; Wiltsie, Judyann ; Clemas, Joseph ; Gibson, Jack ; Contino, Lisa ; Lisnock, Jeanmarie ; Zhou, Gaochao ; Garcia-Calvo, Margarita ; Bateman, Tom ; Xu, Ling ; Tong, Xinchun ; Crook, Martin ; Sinclair, Peter

Bioorganic & Medicinal Chemistry Letters, 01 August 2013, Vol.23(15), pp.4388-4392 [Peer Reviewed Journal]

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Fused tricyclic pyrrolizinones that exhibit pseudo-irreversible blockade of the NK 1 receptor

Morriello, Gregori J ; Chicchi, Gary ; Johnson, Tricia ; Mills, Sander G ; Demartino, Julie ; Kurtz, Marc ; Tsao, K.L.C ; Zheng, Song ; Tong, Xinchun ; Carlson, Emma ; Townson, Karen ; Wheeldon, Alan ; Boyce, Susan ; Collinson, Neil ; Rupniak, Nadia ; Devita, Robert J

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(19), pp.5925-5932 [Peer Reviewed Journal]

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Tetrahydroindolizinone NK 1 antagonists

Bao, Jianming ; Lu, Huagang ; Morriello, Gregori J ; Carlson, Emma J ; Wheeldon, Alan ; Chicchi, Gary G ; Kurtz, Marc M ; Tsao, Kwei-Lan C ; Zheng, Song ; Tong, Xinchun ; Mills, Sander G ; Devita, Robert J

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(7), pp.2354-2358 [Peer Reviewed Journal]

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Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor

Chen, Richard Z ; Frassetto, Andrea ; Lao, Julie Z ; Huang, Ruey-Ruey C ; Xiao, Jing C ; Clements, Matthew J ; Walsh, Thomas F ; Hale, Jeffrey J ; Wang, Junying ; Tong, Xinchun ; Fong, Tung M

European Journal of Pharmacology, 28 April 2008, Vol.584(2-3), pp.338-342 [Peer Reviewed Journal]

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30
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2-Arylbenzoxazoles as CETP inhibitors: Raising HDL-C in cynoCETP transgenic mice

Kallashi, Florida ; Kim, Dooseop ; Kowalchick, Jennifer ; Park, You Jung ; Hunt, Julianne A ; Ali, Amjad ; Smith, Cameron J ; Hammond, Milton L ; Pivnichny, James V ; Tong, Xinchun ; Xu, Suoyu S ; Anderson, Matt S ; Chen, Ying ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Cumiskey, Anne-Marie ; Latham, Melanie ; Peterson, Laurence B ; Rosa, Raymond ; Sparrow, Carl P ; Wright, Samuel D ; Sinclair, Peter J

Bioorganic & Medicinal Chemistry Letters, 01 January 2011, Vol.21(1), pp.558-561 [Peer Reviewed Journal]

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Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis

Strack, Alison M ; Carballo-Jane, Ester ; Wang, Sheng-Ping ; Xue, Jiyan ; Ping, Xiaoli ; Mcnamara, Lesley Ann ; Thankappan, Anil ; Price, Olga ; Wolff, Michael ; Wu, T J ; Kawka, Douglas ; Mariano, Michele ; Burton, Charlotte ; Chang, Ching H ; Chen, Jing ; Menke, John ; Luell, Silvi ; Zycband, Emanuel I ; Tong, Xinchun ; Raubertas, Richard ; Sparrow, Carl P ; Hubbard, Brian ; Woods, John ; O'Neill, Gary ; Waters, M Gerard ; Sitlani, Ayesha

Journal of lipid research, January 2013, Vol.54(1), pp.177-88 [Peer Reviewed Journal]

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Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors

Debenham, John S ; Graham, Thomas H ; Verras, Andreas ; Zhang, Yong ; Clements, Matthew J ; Kuethe, Jeffrey T ; Madsen-Duggan, Christina ; Liu, Wensheng ; Bhatt, Urmi R ; Chen, Dunlu ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; He, Huaibing ; Li, Xiaohua ; Lisnock, Jeanmarie ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Xu, Suoyu ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 01 December 2013, Vol.23(23), pp.6228-6233 [Peer Reviewed Journal]

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Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus

Xu, Jiayi ; Lin, Songnian ; Myers, Robert W ; Trujillo, Maria E ; Pachanski, Michele J ; Malkani, Sunita ; Chen, Hsuan-Shen ; Chen, Zhesheng ; Campbell, Brian ; Eiermann, George J ; Elowe, Nadine ; Farrer, Brian T ; Feng, Wen ; Fu, Qinghong ; Kats-Kagan, Roman ; Kavana, Michael ; Mcmasters, Daniel R ; Mitra, Kaushik ; Tong, Xinchun ; Xu, Libo ; Zhang, Fengqi ; Zhang, Rui ; Addona, George H ; Berger, Joel P ; Zhang, Bei ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 01 May 2017, Vol.27(9), pp.2063-2068 [Peer Reviewed Journal]

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A new class of prolylcarboxypeptidase inhibitors, Part 1: Discovery and evaluation

Graham, Thomas H ; Liu, Wensheng ; Verras, Andreas ; Sebhat, Iyassu K ; Xiong, Yusheng ; Bleasby, Kelly ; Bhatt, Urmi R ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; Gorski, Judith N ; He, Huaibing ; Lassman, Michael E ; Lisnock, Jeanmarie ; Li, Xiaohua ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Xiao, Jianying ; Xie, Dan ; Xu, Suoyu ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 April 2012, Vol.22(8), pp.2811-2817 [Peer Reviewed Journal]

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Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus

Xu, Jiayi ; Lin, Songnian ; Myers, Robert W ; Addona, George ; Berger, Joel P ; Campbell, Brian ; Chen, Hsuan-Shen ; Chen, Zhesheng ; Eiermann, George J ; Elowe, Nadine H ; Farrer, Brian T ; Feng, Wen ; Fu, Qinghong ; Kats-Kagan, Roman ; Kavana, Michael ; Malkani, Sunita ; Mcmasters, Daniel R ; Mitra, Kaushik ; Pachanski, Michele J ; Tong, Xinchun ; Trujillo, Maria E ; Xu, Libo ; Zhang, Bei ; Zhang, Fengqi ; Zhang, Rui ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 01 May 2017, Vol.27(9), pp.2069-2073 [Peer Reviewed Journal]

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