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25 Results  for Everything (Includes Articles)

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1
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Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes

Biftu, Tesfaye ; Sinha-Roy, Ranabir ; Chen, Ping ; Qian, Xiaoxia ; Feng, Dennis ; Kuethe, Jeffrey T ; Scapin, Giovanna ; Gao, Ying Duo ; Yan, Youwei ; Krueger, Davida ; Bak, Annette ; Eiermann, George ; He, Jiafang ; Cox, Jason ; Hicks, Jacqueline ; Lyons, Kathy ; He, Huaibing ; Salituro, Gino ; Tong, Sharon ; Patel

Journal of medicinal chemistry, 24 April 2014, Vol.57(8), pp.3205-12 [Peer Reviewed Journal]

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Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes

Wilson, Jonathan E ; Kurukulasuriya, Ravi ; Sinz, Christopher ; Lombardo, Matthew ; Bender, Kate ; Parker, Dann ; Sherer, Edward C ; Costa, Melissa ; Dingley, Karen ; Li, Xiaofang ; Mitelman, Stanley ; Tong, Sharon ; Bugianesi, Randal ; Ehrhardt, Anka ; Priest, Birgit ; Ratliff, Kevin ; Ujjainwalla, Feroze ; Nargund, Ravi ; Hagmann, William K ; Edmondson, Scott

Bioorganic & Medicinal Chemistry Letters, 15 June 2016, Vol.26(12), pp.2947-2951 [Peer Reviewed Journal]

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3
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Investigation of Cardiovascular Effects of Tetrahydro-β-carboline sstr3 antagonists

He, Shuwen ; Lai, Zhong ; Ye, Zhixiong ; Dobbelaar, Peter H ; Shah, Shrenik K ; Truong, Quang ; Du, Wu ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Qi, Hongbo ; Bakshi, Raman K ; Hong, Qingmei ; Dellureficio, James ; Reibarkh, Mikhail ; Samuel, Koppara ; Reddy, Vijay B ; Mitelman, Stan ; Tong, Sharon X ; Chicchi

ACS medicinal chemistry letters, 10 July 2014, Vol.5(7), pp.748-53 [Peer Reviewed Journal]

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4
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Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Wu, Zhicai ; Yu, Yang ; Kim, David W ; Ting, Pauline C ; Kuethe, Jeffrey T ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sperbeck, Donald M ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Murphy

ACS medicinal chemistry letters, 08 August 2013, Vol.4(8), pp.773-8 [Peer Reviewed Journal]

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5
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Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Yang, David X ; Ting, Pauline C ; Kuethe, Jeffrey T ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sonatore, Lisa M ; Wiltsie, Judyann ; Liu, Jinqi ; Gorski

ACS medicinal chemistry letters, 09 October 2014, Vol.5(10), pp.1082-7 [Peer Reviewed Journal]

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6
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SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists

He, Shuwen ; Dobbelaar, Peter H ; Guo, Liangqin ; Ye, Zhixiong ; Liu, Jian ; Jian, Tianying ; Truong, Quang ; Shah, Shrenik K ; Du, Wu ; Qi, Hongbo ; Bakshi, Raman K ; Hong, Qingmei ; Dellureficio, James D ; Sherer, Edward ; Pasternak, Alexander ; Feng, Zhe ; Reibarkh, Mikhail ; Lin, Melissa ; Samuel, Koppara ; Reddy

Bioorganic & medicinal chemistry letters, 15 March 2016, Vol.26(6), pp.1529-1535 [Peer Reviewed Journal]

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7
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Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow

Egger, Linda A ; Kidambi, Usha ; Cao, Jin ; Van Riper, Gail ; Mccauley, Ermengilda ; Mumford, Richard A ; Amo, Suzanne ; Lingham, Russell ; Lanza, Thomas ; Lin, Linus S ; De Laszlo, Stephen E ; Young, David N ; Kopka, Ihor E ; Tong, Sharon ; Pikounis, Bill ; Benson, Evelyn ; Warwood, Sarah ; Bargatze, Robert F ; Hagmann, William K ; Schmidt

The Journal of pharmacology and experimental therapeutics, July 2002, Vol.302(1), pp.153-62 [Peer Reviewed Journal]

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8
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Characterization of a novel and selective cannabinoid CB 1 receptor inverse agonist, Imidazole 24b, in rodents

Shearman, Lauren P ; Stribling, D. Sloan ; Camacho, Ramon E ; Rosko, Kimberly M ; Wang, Junying ; Tong, Sharon ; Feng, Yue ; Marsh, Donald J ; Yu, Hong ; Guan, Xiaoming ; Spann, Stephanie K ; Macneil, Douglas J ; Fong, Tung M ; Metzger, Joseph M ; Goulet, Mark T ; Hagmann, William K ; Plummer, Christopher W ; Finke, Paul E ; Mills, Sander G ; Shah, Shrenik K

European Journal of Pharmacology, 2008, Vol.579(1), pp.215-224 [Peer Reviewed Journal]

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9
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The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes

He, Shuwen ; Ye, Zhixiong ; Truong, Quang ; Shah, Shrenik ; Du, Wu ; Guo, Liangqin ; Dobbelaar, Peter H ; Lai, Zhong ; Liu, Jian ; Jian, Tianying ; Qi, Hongbo ; Bakshi, Raman K ; Hong, Qingmei ; Dellureficio, James ; Pasternak, Alexander ; Feng, Zhe ; Dejesus, Reynalda ; Yang, Lihu ; Reibarkh, Mikhail ; Bradley

ACS medicinal chemistry letters, 14 June 2012, Vol.3(6), pp.484-9 [Peer Reviewed Journal]

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10
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Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes

Shah, Shrenik K ; He, Shuwen ; Guo, Liangqin ; Truong, Quang ; Qi, Hongbo ; Du, Wu ; Lai, Zhong ; Liu, Jian ; Jian, Tianying ; Hong, Qingmei ; Dobbelaar, Peter ; Ye, Zhixiong ; Sherer, Edward ; Feng, Zhe ; Yu, Yang ; Wong, Frederick ; Samuel, Koppara ; Madiera, Maria ; Karanam, Bindhu V ; Reddy

ACS Medicinal Chemistry Letters, 2015, Vol.6(5), p.513-517 [Peer Reviewed Journal]

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11
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N-Aryl 2,6-Dimethoxybiphenylalanine Analogues as VLA-4 Antagonists

Doherty, George A ; Kamenecka, Theodore ; Mccauley, Ermenegilda ; Van Riper, Gail ; Mumford, Richard A ; Tong, Sharon ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(5), pp.729-731 [Peer Reviewed Journal]

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12
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Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor

Liang, Rui ; Abrardo, Lauren ; Brady, Edward J ; Candelore, Mari Rios ; Ding, Victor ; Saperstein, Richard ; Tota, Laurie M ; Wright, Michael ; Mock, Steve ; Tamvakopolous, Constantin ; Tong, Sharon ; Zheng, Song ; Zhang, Bei B ; Tata, James R ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(3), pp.587-592 [Peer Reviewed Journal]

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13
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N-(3-Phenylsulfonyl-3-piperidinoyl)-phenylalanine derivatives as potent, selective VLA-4 antagonists

Gutteridge, Clare E ; de Laszlo, Stephen E ; Kamenecka, Theodore M ; Mccauley, Ermengilda ; van Riper, Gail ; Mumford, Richard A ; Kidambi, Usha ; Egger, Linda A ; Tong, Sharon ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(5), pp.885-890 [Peer Reviewed Journal]

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14
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Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor

Duffy, Joseph L ; Kirk, Brian A ; Konteatis, Zenon ; Campbell, Elizabeth L ; Liang, Rui ; Brady, Edward J ; Candelore, Mari Rios ; Ding, Victor D.H ; Jiang, Guoqiang ; Liu, Frank ; Qureshi, Sajjad A ; Saperstein, Richard ; Szalkowski, Deborah ; Tong, Sharon ; Tota, Lauri M ; Xie, Dan ; Yang, Xiaodong ; Zafian, Peter ; Zheng, Song ; Chapman, Kevin T

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(5), pp.1401-1405 [Peer Reviewed Journal]

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15
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Amidines as amide bond replacements in VLA-4 antagonists

Kamenecka, Theodore M ; Park, You-Jung ; Lin, Linus S ; De Laszlo, Stephen ; Mccauley, Ermengilda D ; Van Riper, Gail ; Egger, Linda ; Kidambi, Usha ; Mumford, Richard A ; Tong, Sharon ; Tang, Wei ; Colletti, Adria ; Teffera, Yohannes ; Stearns, Ralph ; Maccoss, Malcolm ; Schmidt, John A ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 03 May 2004, Vol.14(9), pp.2323-6 [Peer Reviewed Journal]

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16
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Corrigendum to “ N-Isonicotinoyl-( l)-4-aminophenylalanine Derivatives as Tight Binding VLA-4 Antagonists”[Bioorg. Med. Chem. Lett. 13 (2003) 1891]

Doherty, George A ; Yang, Ginger X ; Borges, Edite ; Tong, Sharon ; Mccauley, Ermengilda D ; Treonz, Kelly M ; Van Riper, Gail ; Pacholok, Stephen ; Si, Qian ; Koo, Gloria C ; Shah, Kashmira ; Mumford, Richard A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(17), pp.2937-2938 [Peer Reviewed Journal]

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17
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N-(Arylacetyl)-biphenylalanines as Potent VLA-4 Antagonists

Li, Bing ; de Laszlo, Stephen E ; Kamenecka, Theodore M ; Kopka, Ihor E ; Durette, Philippe L ; Lanza, Jr, Thomas ; Maccoss, Malcolm ; Tong, Sharon ; Mumford, Richard A ; Mccauley, Ermengilda D ; Van Riper, Gail ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(16), pp.2141-2144 [Peer Reviewed Journal]

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18
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N-Aryl-prolyl-dipeptides as potent antagonists of VLA-4

Kamenecka, Theodore M ; Lanza, Jr, Thomas ; de Laszlo, Stephen E ; Li, Bing ; Mccauley, Ermengilda D ; Van Riper, Gail ; Egger, Linda A ; Kidambi, Usha ; Mumford, Richard A ; Tong, Sharon ; Maccoss, Malcolm ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(16), pp.2205-2208 [Peer Reviewed Journal]

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19
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N-Isonicotinoyl-( l)-4-aminophenylalanine derivatives as tight binding VLA-4 antagonists

Doherty, George A ; Yang, Ginger X ; Borges, Edite ; Tong, Sharon ; Mccauley, Ermengilda D ; Treonz, Kelly M ; Van Riper, Gail ; Pacholok, Stephen ; Si, Qian ; Koo, Gloria C ; Shah, Kashmira ; Mumford, Richard A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(11), pp.1891-1895 [Peer Reviewed Journal]

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20
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Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists

Kopka, Ihor E ; Lin, Linus S ; Mumford, Richard A ; Lanza, Thomas ; Magriotis, Plato A ; Young, David ; Delaszlo, Stephen E ; Maccoss, Malcolm ; Mills, Sander G ; Van Riper, Gail ; Mccauley, Ermengilda ; Lyons, Kathryn ; Vincent, Stella ; Egger, Linda A ; Kidambi, Usha ; Stearns, Ralph ; Colletti, Adria ; Teffera, Yohannes ; Tong, Sharon ; Owens, Karen

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(17), pp.2415-2418 [Peer Reviewed Journal]

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21
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Substituted tetrahydrofuroyl-1-phenylalanine derivatives as potent and specific VLA-4 antagonists

Doherty, George A ; Yang, Ginger X ; Borges, Edite ; Chang, Linda L ; Maccoss, Malcolm ; Tong, Sharon ; Kidambi, Usha ; Egger, Linda A ; Mccauley, Ermenegilda ; Van Riper, Gail ; Mumford, Richard A ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(11), pp.1501-1505 [Peer Reviewed Journal]

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22
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Substituted N-(3,5-Dichlorobenzenesulfonyl)- l-prolyl-phenylalanine analogues as potent VLA-4 antagonists

Kopka, Ihor E ; Young, David N ; Lin, Linus S ; Mumford, Richard A ; Magriotis, Plato A ; Maccoss, Malcolm ; Mills, Sander G ; Riper, Gail Van ; Mccauley, Ermengilda ; Egger, Linda E ; Kidambi, Usha ; Schmidt, John A ; Lyons, Kathryn ; Stearns, Ralph ; Vincent, Stella ; Colletti, Adria ; Wang, Zhen ; Tong, Sharon ; Wang, Junying ; Zheng, Song

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(4), pp.637-640 [Peer Reviewed Journal]

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23
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Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)

Yu, Yang ; Wu, Zhicai ; Shi, Zhi-Cai ; He, Shuwen ; Lai, Zhong ; Cernak, Timothy A ; Vachal, Petr ; Liu, Min ; Liu, Jian ; Hong, Qingmei ; Jian, Tianying ; Guiadeen, Deodial ; Krikorian, Arto ; Sperbeck, Donald M ; Verras, Andreas ; Sonatore, Lisa M ; Murphy, Beth A ; Wiltsie, Judyann ; Chung, Christine C ; Gorski

Bioorganic & medicinal chemistry letters, 01 June 2019, Vol.29(11), pp.1380-1385 [Peer Reviewed Journal]

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24
The discovery of sulfonylated dipeptides as Potent VLA-4 antagonists
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The discovery of sulfonylated dipeptides as Potent VLA-4 antagonists

Hagmann, William K ; Durette, Philippe L ; Lanza, Thomas ; Kevin, Nancy Jo ; de Laszlo, Stephen E ; Kopka, Ihor E ; Young, David ; Magriotis, Plato A ; Li, Bing ; Lin, Linus S ; Yang, Ginger ; Kamenecka, Theodore ; Chang, Linda L ; Wilson, Jonathan ; Maccoss, Malcolm ; Mills, Sander G ; Van Riper, Gail ; Mccauley, Ermengilda ; Egger, Linda A ; Kidambi, Usha ; Lyons, Kathryn ; Vincent, Stella ; Stearns, Ralph ; Colletti, Adria ; Teffera, Johannes ; Tong, Sharon ; Fenyk-Melody, Judy ; Owens, Karen ; Levorse, Dorothy ; Kim, Philip ; Schmidt, John A ; Mumford, Richard A

Bioorganic & Medicinal Chemistry Letters, 10/2001, Vol.11(20), pp.2709-2713 [Peer Reviewed Journal]

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25
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Benzimidazole-based DGAT1 inhibitors with a 3.1.0 bicyclohexane carboxylic acid moiety

He, Shuwen ; Lai, Zhong ; Hong, Qingmei ; Shang, Jackie ; Reibarkh, Mikhail ; Kuethe, Jeffrey T ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Verras, Andreas ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung

Bioorganic & medicinal chemistry letters, 15 May 2019, Vol.29(10), pp.1182-1186 [Peer Reviewed Journal]

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