skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Index

Results 1 - 50 of 67  for Everything (Includes Articles)

Results 1 2 next page
Result Number Material Type Add to My Shelf Action Record Details and Options
1
Material Type:
Article
Add to e-Shelf

Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion

Soni, Mufaddal S ; Rabaglia, Mary E ; Bhatnagar, Sushant ; Shang, Jin ; Ilkayeva, Olga ; Mynatt, Randall ; Zhou, Yun-Ping ; Schadt, Eric E ; Thornberry, Nancy A ; Muoio, Deborah M ; Keller, Mark P ; Attie, Alan D

Diabetes, November 2014, Vol.63(11), pp.3805-14 [Peer Reviewed Journal]

Full text available

View all versions
2
Material Type:
Article
Add to e-Shelf

Glucagon-like peptide 1-based drugs and pancreatic safety

Brodovicz, Kimberly G ; Engel, Samuel S ; Thornberry, Nancy A

JAMA internal medicine, 28 October 2013, Vol.173(19), pp.1842-3 [Peer Reviewed Journal]

Full text available

View all versions
3
Material Type:
Article
Add to e-Shelf

Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes

Biftu, Tesfaye ; Sinha-Roy, Ranabir ; Chen, Ping ; Qian, Xiaoxia ; Feng, Dennis ; Kuethe, Jeffrey T ; Scapin, Giovanna ; Gao, Ying Duo ; Yan, Youwei ; Krueger, Davida ; Bak, Annette ; Eiermann, George ; He, Jiafang ; Cox, Jason ; Hicks, Jacqueline ; Lyons, Kathy ; He, Huaibing ; Salituro, Gino ; Tong, Sharon ; Patel, Sangita ; Doss, George ; Petrov, Aleksandr ; Wu, Joseph ; Xu, Shiyao Sherrie ; Sewall, Charles ; Zhang, Xiaoping ; Zhang, Bei ; Thornberry, Nancy A ; Weber, Ann E

Journal of medicinal chemistry, 24 April 2014, Vol.57(8), pp.3205-12 [Peer Reviewed Journal]

Full text available

View all versions
4
Material Type:
Article
Add to e-Shelf

Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance

Conarello, Stacey L ; Li, Zhihua ; Ronan, John ; Roy, Ranabir Sinha ; Zhu, Lan ; Jiang, Guoqiang ; Liu, Franklin ; Woods, John ; Zycband, Emanuel ; Moller, David E ; Thornberry, Nancy A ; Zhang, Bei B

Proceedings of the National Academy of Sciences of the United States of America, 27 May 2003, Vol.100(11), pp.6825-30 [Peer Reviewed Journal]

Full text available

View all versions
5
Material Type:
Article
Add to e-Shelf

Synthesis and evaluation of [(1 R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1 R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors

Chen, Ping ; Caldwell, Charles G ; Ashton, Wallace ; Wu, Joseph K ; He, Huaibing ; Lyons, Kathryn A ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(6), pp.1880-1886 [Peer Reviewed Journal]

Full text available

View all versions
6
Material Type:
Article
Add to e-Shelf

Mechanism of action of inhibitors of dipeptidyl-peptidase-4 (DPP-4)

Thornberry, Nancy A ; Gallwitz, Baptist

Best Practice & Research Clinical Endocrinology & Metabolism, 2009, Vol.23(4), pp.479-486 [Peer Reviewed Journal]

Full text available

View all versions
7
Material Type:
Article
Add to e-Shelf

Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway

Casciola-Rosen, Livia ; Garcia-Calvo, Margarita ; Bull, Herbert G ; Becker, Joseph W ; Hines, Tonie ; Thornberry, Nancy A ; Rosen, Antony

The Journal of biological chemistry, 16 February 2007, Vol.282(7), pp.4545-52 [Peer Reviewed Journal]

Full text available

8
Material Type:
Article
Add to e-Shelf

The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites

Kisselev, Alexei F ; Garcia-Calvo, Margarita ; Overkleeft, Herman S ; Peterson, Erin ; Pennington, Michael W ; Ploegh, Hidde L ; Thornberry, Nancy A ; Goldberg, Alfred L

The Journal of biological chemistry, 19 September 2003, Vol.278(38), pp.35869-77 [Peer Reviewed Journal]

Full text available

9
Material Type:
Article
Add to e-Shelf

Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents

Day, Jonathan W ; Gelfanov, Vasily ; Smiley, David ; Carrington, Paul E ; Eiermann, George ; Chicchi, Gary ; Erion, Mark D ; Gidda, Jas ; Thornberry, Nancy A ; Tschöp, Matthias H ; Marsh, Donald J ; Sinharoy, Ranabir ; Dimarchi, Richard ; Pocai, Alessandro

Biopolymers, 2012, Vol.98(5), pp.443-50 [Peer Reviewed Journal]

Full text available

View all versions
10
Material Type:
Article
Add to e-Shelf

A model selection approach for expression quantitative trait loci (eQTL) mapping

Wang, Ping ; Dawson, John A ; Keller, Mark P ; Yandell, Brian S ; Thornberry, Nancy A ; Zhang, Bei B ; Wang, I-Ming ; Schadt, Eric E ; Attie, Alan D ; Kendziorski, C

Genetics, February 2011, Vol.187(2), pp.611-21 [Peer Reviewed Journal]

Full text available

11
Material Type:
Article
Add to e-Shelf

Caspase-mediated proteolysis during apoptosis: insights from apoptotic neutrophils

Sanghavi, Darshak M ; Thelen, Marcus ; Thornberry, Nancy A ; Casciola-Rosen, Livia ; Rosen, Antony

FEBS Letters, 1998, Vol.422(2), pp.179-184 [Peer Reviewed Journal]

Full text available

View all versions
12
Material Type:
Article
Add to e-Shelf

Kinetic Effects of ATP and Two Cellular Stimulatory Components on Human Leukocyte 5‐Lipoxygenasea

Rouzer, Carol A. ; Thornberry, Nancy A. ; Bull, Herbert G.

Annals of the New York Academy of Sciences, April 1988, Vol.524(1), pp.1-11 [Peer Reviewed Journal]

Full text available

View all versions
13
Material Type:
Article
Add to e-Shelf

Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells

Shang, Jin ; Li, Jing ; Keller, Mark P ; Hohmeier, Hans E ; Wang, Yong ; Feng, Yue ; Zhou, Heather H ; Shen, Xiaolan ; Rabaglia, Mary ; Soni, Mufaddal ; Attie, Alan D ; Newgard, Christopher B ; Thornberry, Nancy A ; Howard, Andrew D ; Zhou, Yun-Ping

Molecular endocrinology (Baltimore, Md.), September 2015, Vol.29(9), pp.1243-53 [Peer Reviewed Journal]

Full text available

14
Material Type:
Article
Add to e-Shelf

The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets

Li, Xiaoyan Nina ; Herrington, James ; Petrov, Aleksandr ; Ge, Lan ; Eiermann, George ; Xiong, Yusheng ; Jensen, Mette V ; Hohmeier, Hans E ; Newgard, Christopher B ; Garcia, Maria L ; Wagner, Michael ; Zhang, Bei B ; Thornberry, Nancy A ; Howard, Andrew D ; Kaczorowski, Gregory J ; Zhou, Yun-Ping

The Journal of pharmacology and experimental therapeutics, February 2013, Vol.344(2), pp.407-16 [Peer Reviewed Journal]

Full text available

15
Material Type:
Article
Add to e-Shelf

A comparative study of the binding properties, dipeptidyl peptidase‐4 (DPP‐4) inhibitory activity and glucose‐lowering efficacy of the DPP‐4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice

Berger, Joel P. ; Sinharoy, Ranabir ; Pocai, Alessandro ; Kelly, Theresa M. ; Scapin, Giovanna ; Gao, Ying‐Duo ; Pryor, Kelly Ann D. ; Wu, Joseph K. ; Eiermann, George J. ; Xu, Shiyao S. ; Zhang, Xiaoping ; Tatosian, Daniel A. ; Weber, Ann E. ; Thornberry, Nancy A. ; Carr, Richard D.

Endocrinology, Diabetes & Metabolism, January 2018, Vol.1(1), pp.n/a-n/a [Peer Reviewed Journal]

Full text available

View all versions
16
Material Type:
Article
Add to e-Shelf

Apoptosis. Life and death decisions

Nicholson, Donald W ; Thornberry, Nancy A

Science (New York, N.Y.), 10 January 2003, Vol.299(5604), pp.214-5 [Peer Reviewed Journal]

Full text available

17
Material Type:
Article
Add to e-Shelf

Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes

Mu, James ; Petrov, Aleksandr ; Eiermann, George J ; Woods, John ; Zhou, Yun-Ping ; Li, Zhihua ; Zycband, Emanuel ; Feng, Yue ; Zhu, Lan ; Roy, Ranabir Sinha ; Howard, Andrew D ; Li, Cai ; Thornberry, Nancy A ; Zhang, Bei B

European Journal of Pharmacology, 2009, Vol.623(1), pp.148-154 [Peer Reviewed Journal]

Full text available

View all versions
18
Material Type:
Article
Add to e-Shelf

The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides: in vivo metabolism of pituitary adenylate cyclase activating polypeptide-(1-38)

Zhu, Lan ; Tamvakopoulos, Constantin ; Xie, Dan ; Dragovic, Jasminka ; Shen, Xiaolan ; Fenyk-Melody, Judith E ; Schmidt, Keith ; Bagchi, Ansuman ; Griffin, Patrick R ; Thornberry, Nancy A ; Sinha Roy, Ranabir

The Journal of biological chemistry, 20 June 2003, Vol.278(25), pp.22418-23 [Peer Reviewed Journal]

Full text available

19
Material Type:
Article
Add to e-Shelf

The IL‐1β Converting Enzyme as a Therapeutic Target

Miller, Douglas K. ; Calaycay, Jimmy R. ; Chapman, Kevin T. ; Howard, Andrew D. ; Kostura, Matthew J. ; Molineaux, Susan M. ; Thornberry, Nancy A.

Annals of the New York Academy of Sciences, November 1993, Vol.696(1), pp.133-148 [Peer Reviewed Journal]

Full text available

View all versions
20
Material Type:
Article
Add to e-Shelf

Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII

Leiting, Barbara ; Pryor, Kellyann D ; Wu, Joseph K ; Marsilio, Frank ; Patel, Reshma A ; Craik, Charles S ; Ellman, Jonathan A ; Cummings, Richard T ; Thornberry, Nancy A

The Biochemical journal, 15 April 2003, Vol.371(Pt 2), pp.525-32 [Peer Reviewed Journal]

Full text available

21
Material Type:
Article
Add to e-Shelf

Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines

Kim, Dooseop ; Kowalchick, Jennifer E ; Brockunier, Linda L ; Parmee, Emma R ; Eiermann, George J ; Fisher, Michael H ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathryn ; Scapin, Giovanna ; Patel, Sangita B ; Petrov, Aleksandr ; Pryor, Kellyann D ; Roy, Ranabir Sinha ; Wu, Joseph K ; Zhang, Xiaoping ; Wyvratt, Matthew J ; Zhang, Bei B ; Zhu, Lan ; Thornberry, Nancy A ; Weber, Ann E

Journal of medicinal chemistry, 14 February 2008, Vol.51(3), pp.589-602 [Peer Reviewed Journal]

Full text available

View all versions
22
Material Type:
Article
Add to e-Shelf

Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice

Tan, Carina P ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George J ; Petrov, Aleksandr ; Zhou, Changyou ; Lin, Songnian ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro E ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel P ; Mills, Sander G ; Thornberry, Nancy A ; Yang, Lihu ; Howard, Andrew D

Diabetes, August 2008, Vol.57(8), pp.2211-9 [Peer Reviewed Journal]

Full text available

View all versions
23
Material Type:
Article
Add to e-Shelf

The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling

Mancini, Marie ; Nicholson, Donald W ; Roy, Sophie ; Thornberry, Nancy A ; Peterson, Erin P ; Casciola-Rosen, Livia A ; Rosen, Antony

The Journal of Cell Biology, 1998, Vol.140(6), p.1485-1495 [Peer Reviewed Journal]

Full text available

View all versions
24
Material Type:
Article
Add to e-Shelf

Caspase-2 Is Localized at the Golgi Complex and Cleaves Golgin-160 during Apoptosis

Mancini, Marie ; Machamer, Carolyn E ; Roy, Sophie ; Nicholson, Donald W ; Thornberry, Nancy A ; Casciola-Rosen, Livia A ; Rosen, Antony

The Journal of Cell Biology, 2000, Vol.149(3), p.603-612 [Peer Reviewed Journal]

Full text available

View all versions
25
Interleukin-1βconverting enzyme: A novel cysteine protease required for IL-1β production and implicated in programmed cell death
Material Type:
Article
Add to e-Shelf

Interleukin-1βconverting enzyme: A novel cysteine protease required for IL-1β production and implicated in programmed cell death

Thornberry, Nancy A. ; Molineaux, Susan M.

Protein Science, 01/1995, Vol.4(1), pp.3-12 [Peer Reviewed Journal]

Full text available

26
Material Type:
Article
Add to e-Shelf

Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes

Mu, James ; Woods, John ; Zhou, Yun-Ping ; Roy, Ranabir Sinha ; Li, Zhihua ; Zycband, Emanuel ; Feng, Yue ; Zhu, Lan ; Li, Cai ; Howard, Andrew D ; Moller, David E ; Thornberry, Nancy A ; Zhang, Bei B

Diabetes, June 2006, Vol.55(6), pp.1695-704 [Peer Reviewed Journal]

Full text available

27
Material Type:
Article
Add to e-Shelf

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

Garcia-Calvo, Margarita ; Lisnock, Jeanmarie ; Bull, Herbert G ; Hawes, Brian E ; Burnett, Duane A ; Braun, Matthew P ; Crona, James H ; Davis, Harry R ; Dean, Dennis C ; Detmers, Patricia A ; Graziano, Michael P ; Hughes, Meredith ; Macintyre, D Euan ; Ogawa, Anthony ; O'Neill, Kim A ; Iyer, Sai Prasad N ; Shevell, Diane E ; Smith, Marsha M ; Tang, Yui S ; Makarewicz, Amanda M ; Ujjainwalla, Feroze ; Altmann, Scott W ; Chapman, Kevin T ; Thornberry, Nancy A

Proceedings of the National Academy of Sciences of the United States of America, 07 June 2005, Vol.102(23), pp.8132-7 [Peer Reviewed Journal]

Full text available

View all versions
28
Material Type:
Article
Add to e-Shelf

Interleukin‐1 β converting enzyme: A novel cysteine protease required for IL‐1 β production and implicated in programmed cell death

Thornberry, Nancy A. ; Molineaux, Susan M.

Protein Science, January 1995, Vol.4(1), pp.3-12 [Peer Reviewed Journal]

Full text available

29
Material Type:
Article
Add to e-Shelf

(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-1,2,4triazolo1,5-a-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Edmondson, Scott D ; Mastracchio, Anthony ; Mathvink, Robert J ; He, Jiafang ; Harper, Bart ; Park, You-Jung ; Beconi, Maria ; Di Salvo, Jerry ; Eiermann, George J ; He, Huaibing ; Leiting, Barbara ; Leone, Joseph F ; Levorse, Dorothy A ; Lyons, Kathryn ; Patel, Reshma A ; Patel, Sangita B ; Petrov, Aleksandr ; Scapin, Giovanna ; Shang, Jackie ; Roy, Ranabir Sinha ; Smith, Aaron ; Wu, Joseph K ; Xu, Shiyao ; Zhu, Bing ; Thornberry, Nancy A ; Weber, Ann E

Journal of medicinal chemistry, 15 June 2006, Vol.49(12), pp.3614-27 [Peer Reviewed Journal]

Full text available

View all versions
30
Material Type:
Article
Add to e-Shelf

Dual Role of Caspase-11 in Mediating Activation of Caspase-1 and Caspase-3 under Pathological Conditions

Kang, Shin-Jung ; Wang, Suyue ; Hara, Hideaki ; Peterson, Erin P ; Namura, Shobu ; Amin-Hanjani, Sepideh ; Huang, Zhihong ; Srinivasan, Anu ; Tomaselli, Kevin J ; Thornberry, Nancy A ; Moskowitz, Michael A ; Yuan, Junying

The Journal of Cell Biology, 2000, Vol.149(3), p.613-622 [Peer Reviewed Journal]

Full text available

View all versions
31
Material Type:
Article
Add to e-Shelf

(2R)-4-oxo-4-3-(trifluoromethyl)-5,6-dihydro1,2,4triazolo4,3-apyrazin-7(8H)-yl-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Kim, Dooseop ; Wang, Liping ; Beconi, Maria ; Eiermann, George J ; Fisher, Michael H ; He, Huaibing ; Hickey, Gerard J ; Kowalchick, Jennifer E ; Leiting, Barbara ; Lyons, Kathryn ; Marsilio, Frank ; Mccann, Margaret E ; Patel, Reshma A ; Petrov, Aleksandr ; Scapin, Giovanna ; Patel, Sangita B ; Roy, Ranabir Sinha ; Wu, Joseph K ; Wyvratt, Matthew J ; Zhang, Bei B ; Zhu, Lan ; Thornberry, Nancy A ; Weber, Ann E

Journal of medicinal chemistry, 13 January 2005, Vol.48(1), pp.141-51 [Peer Reviewed Journal]

Full text available

View all versions
32
Material Type:
Article
Add to e-Shelf

Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9

Lankas, George R ; Leiting, Barbara ; Roy, Ranabir Sinha ; Eiermann, George J ; Beconi, Maria G ; Biftu, Tesfaye ; Chan, Chi-Chung ; Edmondson, Scott ; Feeney, William P ; He, Huaibing ; Ippolito, Dawn E ; Kim, Dooseop ; Lyons, Kathryn A ; Ok, Hyun O ; Patel, Reshma A ; Petrov, Aleksandr N ; Pryor, Kelly Ann ; Qian, Xiaoxia ; Reigle, Leah ; Woods, Andrea ; Wu, Joseph K ; Zaller, Dennis ; Zhang, Xiaoping ; Zhu, Lan ; Weber, Ann E ; Thornberry, Nancy A

Diabetes, October 2005, Vol.54(10), pp.2988-94 [Peer Reviewed Journal]

Full text available

33
Material Type:
Article
Add to e-Shelf

Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis

Willoughby, Christopher A ; Bull, Herbert G ; Garcia-Calvo, Margarita ; Jiang, Joanne ; Chapman, Kevin T ; Thornberry, Nancy A

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(16), pp.2197-2200 [Peer Reviewed Journal]

Full text available

View all versions
34
Material Type:
Article
Add to e-Shelf

Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors

Edmondson, Scott D ; Mastracchio, Anthony ; Cox, Jason M ; Eiermann, George J ; He, Huaibing ; Lyons, Kathryn A ; Patel, Reshma A ; Patel, Sangita B ; Petrov, Aleksandr ; Scapin, Giovanna ; Wu, Joseph K ; Xu, Shiyao ; Zhu, Bing ; Thornberry, Nancy A ; Roy, Ranabir Sinha ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 01 August 2009, Vol.19(15), pp.4097-4101 [Peer Reviewed Journal]

Full text available

View all versions
35
Material Type:
Article
Add to e-Shelf

Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design

Liang, Gui-Bai ; Qian, Xiaoxia ; Biftu, Tesfaye ; Singh, Suresh ; Gao, Ying-Duo ; Scapin, Giovanna ; Patel, Sangita ; Leiting, Barbara ; Patel, Reshma ; Wu, Joseph ; Zhang, Xiaoping ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(13), pp.3706-3710 [Peer Reviewed Journal]

Full text available

View all versions
36
Material Type:
Article
Add to e-Shelf

Identification of Glucose-Dependent Insulin Secretion Targets in Pancreatic β Cells by Combining Defined-Mechanism Compound Library Screening and siRNA Gene Silencing

Weizhen Wu ; Jin Shang ; Yue Feng ; Thompson, Chris M ; Horwitz, Sarah ; Thompson, John R ; Macintyre, Euan D ; Thornberry, Nancy A ; Chapman, Kevin ; Zhou, Yun-Ping ; Howard, Andrew D ; Jing Li

Journal of Biomolecular Screening, February 2008, Vol.13(2), pp.128-134 [Peer Reviewed Journal]

Full text available

View all versions
37
Material Type:
Article
Add to e-Shelf

Phenylalkyl ketones as potent reversible inhibitors of interleukin-1β converting enzyme

Mjalli, Adnan M.M ; Chapman, Kevin T ; Maccoss, Malcolm ; Thornberry, Nancy A

Bioorganic & Medicinal Chemistry Letters, 1993, Vol.3(12), pp.2689-2692 [Peer Reviewed Journal]

Full text available

View all versions