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22 Results  for Everything (Includes Articles)

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1
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In vitro characterization of MK-1439, a novel HIV-1 nonnucleoside reverse transcriptase inhibitor

Lai, Ming-Tain ; Feng, Meizhen ; Falgueyret, Jean-Pierre ; Tawa, Paul ; Witmer, Marc ; Distefano, Daniel ; Li, Yuan ; Burch, Jason ; Sachs, Nancy ; Lu, Meiqing ; Cauchon, Elizabeth ; Campeau, Louis-Charles ; Grobler, Jay ; Yan, Youwei ; Ducharme, Yves ; Côté, Bernard ; Asante-Appiah, Ernest ; Hazuda

Antimicrobial agents and chemotherapy, 2014, Vol.58(3), pp.1652-63 [Peer Reviewed Journal]

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Probing cathepsin S activity in whole blood by the activity-based probe BIL-DMK: Cellular distribution in human leukocyte populations and evidence of diurnal modulation

Veilleux, Alain ; Black, W. Cameron ; Gauthier, Jacques Yves ; Mellon, Christophe ; Percival, M. David ; Tawa, Paul ; Falgueyret, Jean-Pierre

Analytical Biochemistry, 2011, Vol.411(1), pp.43-49 [Peer Reviewed Journal]

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Identification of novel bifunctional HIV-1 reverse transcriptase inhibitors

Lai, Ming - Tain ; Tawa, Paul ; Auger, Anick ; Wang, Deping ; Su, Hua - Poo ; Yan, Youwei ; Hazuda, Daria J ; Miller, Michael D ; Asante - Appiah, Ernest ; Melnyk, Roman A

Journal of Antimicrobial Chemotherapy, 2018, Vol. 73(1), pp.109-117 [Peer Reviewed Journal]

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High-Throughput Scintillation Proximity Assay for Stearoyl-CoA Desaturase-1

Tawa, Paul ; Falgueyret, Jean-Pierre ; Guiral, Sebastien ; Isabel, Elise ; Powell, David A ; Zuck, Paul ; Skorey, Kathryn

Journal of Biomolecular Screening, June 2011, Vol.16(5), pp.506-517 [Peer Reviewed Journal]

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5
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Mutational activation of CheA, the protein kinase in the chemotaxis system of Escherichia coli

Tawa, Paul ; Stewart, Richard

Journal of Bacteriology, Jul 1994, Vol.176(14), p.4210 [Peer Reviewed Journal]

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6
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Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor

Mandal, Mihirbaran ; Tan, Zheng ; Madsen-Duggan, Christina ; Buevich, Alexei V ; Caldwell, John P ; Dejesus, Reynalda ; Flattery, Amy ; Garlisi, Charles G ; Gill, Charles ; Ha, Sookhee Nicole ; Ho, Ginny ; Koseoglu, Sandra ; Labroli, Marc ; Basu, Kallol ; Lee, Sang Ho ; Liang, Lianzhu ; Liu, Jenny ; Mayhood, Todd ; Mcguinness, Debra ; Mclaren

Journal of medicinal chemistry, 11 May 2017, Vol.60(9), pp.3851-3865 [Peer Reviewed Journal]

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2-Aryl benzimidazoles: Human SCD1-specific stearoyl coenzyme-A desaturase inhibitors

Powell, David A ; Ramtohul, Yeeman ; Lebrun, Marie-Eve ; Oballa, Renata ; Bhat, Sathesh ; Falgueyret, Jean-Pierre ; Guiral, Sebastien ; Huang, Zheng ; Skorey, Kathryn ; Tawa, Paul ; Zhang, Lei

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(22), pp.6366-6369 [Peer Reviewed Journal]

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8
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Correlating the fractional inhibition of caspase-3 in NT2 cells with apoptotic markers using an active-caspase-3 enzyme-linked immunosorbent assay

Tawa, Paul ; Giroux, Andre ; Grimm, Erich ; Han, Yongxin ; Nicholson, Donald W ; Xanthoudakis, Steven

Analytical Biochemistry, 2006, Vol.350(1), pp.32-40 [Peer Reviewed Journal]

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Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors

Leclerc, Jean-Philippe ; Falgueyret, Jean-Pierre ; Girardin, Mélina ; Guay, Jocelyne ; Guiral, Sébastien ; Huang, Zheng ; Li, Chun Sing ; Oballa, Renata ; Ramtohul, Yeeman K ; Skorey, Kathryn ; Tawa, Paul ; Wang, Hao ; Zhang, Lei

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(21), pp.6505-6509 [Peer Reviewed Journal]

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Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors

Isabel, Elise ; Powell, David A ; Black, W. Cameron ; Chan, Chi-Chung ; Crane, Sheldon ; Gordon, Robert ; Guay, Jocelyne ; Guiral, Sebastien ; Huang, Zheng ; Robichaud, Joël ; Skorey, Kathryn ; Tawa, Paul ; Xu, Lijing ; Zhang, Lei ; Oballa, Renata

Bioorganic & Medicinal Chemistry Letters, 01 January 2011, Vol.21(1), pp.479-483 [Peer Reviewed Journal]

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11
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pH dependence of CheA autophosphorylation in Escherichia coli

Conley, M ; Berg, Howard ; Tawa, Paul ; Stewart, Richard

Journal of Bacteriology, Jul 1994, Vol.176(13), p.3870 [Peer Reviewed Journal]

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12
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Concise syntheses and HCV NS5B polymerase inhibition of (2′R)-3 and (2′S)-2′-ethynyluridine-10 and related nucleosides

Bennett, Frank ; Buevich, Alexei V ; Huang, Hsueh-Cheng ; Girijavallabhan, Vinay ; Kerekes, Angela D ; Huang, Yuhua ; Malikzay, Asra ; Smith, Elizabeth ; Ferrari, Eric ; Senior, Mary ; Osterman, Rebecca ; Wang, Lingyan ; Wang, Jun ; Pu, Haiyan ; Truong, Quang T ; Tawa, Paul ; Bogen, Stephane L ; Davies, Ian W ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 01 December 2017, Vol.27(23), pp.5349-5352 [Peer Reviewed Journal]

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Hsp60 accelerates the maturation of pro‐caspase‐3 by upstream activator proteases during apoptosis

Xanthoudakis, Steven ; Roy, Sophie ; Rasper, Dita ; Hennessey, Trevor ; Aubin, Yves ; Cassady, Robin ; Tawa, Paul ; Ruel, Rejean ; Rosen, Antony ; Nicholson, Donald W.

EMBO Journal, 15 April 1999, Vol.18(8), pp.2049-2056 [Peer Reviewed Journal]

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14
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Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses

Côté, Bernard ; Burch, Jason D ; Asante-Appiah, Ernest ; Bayly, Chris ; Bédard, Leanne ; Blouin, Marc ; Campeau, Louis-Charles ; Cauchon, Elizabeth ; Chan, Manuel ; Chefson, Amandine ; Coulombe, Nathalie ; Cromlish, Wanda ; Debnath, Smita ; Deschênes, Denis ; Dupont-Gaudet, Kristina ; Falgueyret, Jean-Pierre

Bioorganic & Medicinal Chemistry Letters, 01 February 2014, Vol.24(3), pp.917-922 [Peer Reviewed Journal]

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15
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Erratum to “An activity-based probe for the determination of cysteine cathepsin protease activities in whole cells” [Anal. Biochem. 335 (2004) 218–227]

Falgueyret, Jean-Pierre ; Black, W. Cameron ; Cromlish, Wanda ; Desmarais, Sylvie ; Lamontagne, Sonia ; Mellon, Christophe ; Riendeau, Denis ; Rodan, Sevgi B ; Tawa, Paul ; Wesolowski, Gregg ; Bass, Kathryn E ; Venkatraman, Shankar ; Percival, M. David

Analytical Biochemistry, 2005, Vol.340(2), pp.380-380 [Peer Reviewed Journal]

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16
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Solid phase synthesis of selective caspase-3 peptide inhibitors

Grimm, Erich L ; Roy, Bruno ; Aspiotis, Renee ; Bayly, Christopher I ; Nicholson, Donald W ; Rasper, Dita M ; Renaud, Johanne ; Roy, Sophie ; Tam, John ; Tawa, Paul ; Vaillancourt, John P ; Xanthoudakis, Steven ; Zamboni, Robert J

Bioorganic & Medicinal Chemistry, 01 March 2004, Vol.12(5), pp.845-851 [Peer Reviewed Journal]

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17
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An activity-based probe for the determination of cysteine cathepsin protease activities in whole cells

Falgueyret, Jean-Pierre ; Black, W. Cameron ; Cromlish, Wanda ; Desmarais, Sylvie ; Lamontagne, Sonia ; Mellon, Christophe ; Riendeau, Denis ; Rodan, Sevgi ; Tawa, Paul ; Wesolowski, Gregg ; Bass, Kathryn E ; Venkatraman, Shankar ; Percival, M. David

Analytical Biochemistry, 15 December 2004, Vol.335(2), pp.218-227 [Peer Reviewed Journal]

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18
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Effect of cathepsin k inhibitor basicity on in vivo off-target activities

Desmarais, Sylvie ; Black, W Cameron ; Oballa, Renata ; Lamontagne, Sonia ; Riendeau, Denis ; Tawa, Paul ; Duong, Le Thi ; Pickarski, Maureen ; Percival, M David

Molecular pharmacology, January 2008, Vol.73(1), pp.147-56 [Peer Reviewed Journal]

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19
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Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors

Han, Yongxin ; Giroux, André ; Colucci, John ; Bayly, Christopher I ; Mckay, Daniel J ; Roy, Sophie ; Xanthoudakis, Steve ; Vaillancourt, John ; Rasper, Dita M ; Tam, John ; Tawa, Paul ; Nicholson, Donald W ; Zamboni, Robert J

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(4), pp.1173-1180 [Peer Reviewed Journal]

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20
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Adenovirus IL-13-Induced Airway Disease in Mice: A Corticosteroid-Resistant Model of Severe Asthma

Therien, Alex ; Bernier, Virginie ; Weicker, Sean ; Tawa, Paul ; Falgueyret, Jean-Pierre ; Mathieu, Marie-Claude ; Honsberger, Jeanne ; Pomerleau, Véronique ; Robichaud, Annette ; Stocco, Rino ; Dufresne, Lynn ; Houshyar, Hani ; Lafleur, Josiane ; Ramachandran, Chidambaram ; O'Neill, Gary ; Slipetz, Deborah ; Tan, Christopher

American Journal of Respiratory Cell and Molecular Biology, Jul 2008, Vol.39(1), pp.26-35 [Peer Reviewed Journal]

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21
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Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones

Isabel, Elise ; Aspiotis, Renee ; Black, W. Cameron ; Colucci, John ; Fortin, Réjean ; Giroux, André ; Grimm, Erich L ; Han, Yongxin ; Mellon, Christophe ; Nicholson, Donald W ; Rasper, Dita M ; Renaud, Johanne ; Roy, Sophie ; Tam, John ; Tawa, Paul ; Vaillancourt, John P ; Xanthoudakis, Steven ; Zamboni, Robert J

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(6), pp.1671-1674 [Peer Reviewed Journal]

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Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors

Han, Yongxin ; Giroux, André ; Grimm, Erich L ; Aspiotis, Renée ; Francoeur, Sébastien ; Bayly, Christopher I ; Mckay, Daniel J ; Roy, Sophie ; Xanthoudakis, Steve ; Vaillancourt, John P ; Rasper, Dita M ; Tam, John ; Tawa, Paul ; Thornberry, Nancy A ; Paterson, Erin P ; Garcia-Calvo, Margarita ; Becker, Joseph W

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(3), pp.805-808 [Peer Reviewed Journal]

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