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15 Results  for Everything (Includes Articles)

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Fasiglifam (TAK-875): Mechanistic Investigation and Retrospective Identification of Hazards for Drug Induced Liver Injury

Otieno, Monicah A ; Snoeys, Jan ; Lam, Wing ; Ghosh, Avi ; Player, Mark R ; Pocai, Alessandro ; Salter, Rhys ; Simic, Damir ; Skaggs, Hollie ; Singh, Bhanu ; Lim, Heng - Keang

Toxicological Sciences, 2018, Vol. 163(2), pp.374-384 [Peer Reviewed Journal]

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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Properties of the GPR40 Agonist TAK‐875: Results From a Double‐Blind, Placebo‐Controlled Single Oral Dose Rising Study in Healthy Volunteers

Naik, Himanshu ; Vakilynejad, Majid ; Wu, Jingtao ; Viswanathan, Prabhakar ; Dote, Nobuhito ; Higuchi, Tomoaki ; Leifke, Eckhard

Journal of Clinical Pharmacology, July 2012, Vol.52(7), pp.1007-1016 [Peer Reviewed Journal]

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GPR40‐induced insulin secretion by the novel agonist TAK‐875: first clinical findings in patients with type 2 diabetes

Araki, T. ; Hirayama, M. ; Hiroi, S. ; Kaku, K.

Diabetes, Obesity and Metabolism, March 2012, Vol.14(3), pp.271-278 [Peer Reviewed Journal]

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Efficacy and safety of fasiglifam (TAK‐875), a G protein‐coupled receptor 40 agonist, in Japanese patients with type 2 diabetes inadequately controlled by diet and exercise: a randomized, double‐blind, placebo‐controlled, phase III trial

Kaku, K. ; Enya, K. ; Nakaya, R. ; Ohira, T. ; Matsuno, R.

Diabetes, Obesity and Metabolism, July 2015, Vol.17(7), pp.675-681 [Peer Reviewed Journal]

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Long‐term safety and efficacy of fasiglifam (TAK‐875), a G‐protein‐coupled receptor 40 agonist, as monotherapy and combination therapy in Japanese patients with type 2 diabetes: a 52‐week open‐label phase III study

Kaku, K. ; Enya, K. ; Nakaya, R. ; Ohira, T. ; Matsuno, R.

Diabetes, Obesity and Metabolism, September 2016, Vol.18(9), pp.925-929 [Peer Reviewed Journal]

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Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist

Negoro, Nobuyuki ; Sasaki, Shinobu ; Mikami, Satoshi ; Ito, Masahiro ; Suzuki, Masami ; Tsujihata, Yoshiyuki ; Ito, Ryo ; Harada, Ayako ; Takeuchi, Koji ; Suzuki, Nobuhiro ; Miyazaki, Junichi ; Santou, Takashi ; Odani, Tomoyuki ; Kanzaki, Naoyuki ; Funami, Miyuki ; Tanaka, Toshimasa ; Kogame, Akifumi ; Matsunaga, Shinichiro ; Yasuma, Tsuneo ; Momose

ACS medicinal chemistry letters, 09 September 2010, Vol.1(6), pp.290-4 [Peer Reviewed Journal]

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Fasiglifam (TAK‐875) has dual potentiating mechanisms via Gαq‐GPR40/FFAR1 signaling branches on glucose‐dependent insulin secretion

Sakuma, Kensuke ; Yabuki, Chiori ; Maruyama, Minoru ; Abiru, Akiko ; Komatsu, Hidetoshi ; Negoro, Nobuyuki ; Tsujihata, Yoshiyuki ; Takeuchi, Koji ; Habata, Yugo ; Mori, Masaaki

Pharmacology Research & Perspectives, June 2016, Vol.4(3), pp.n/a-n/a [Peer Reviewed Journal]

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TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial

Burant, Charles ; Viswanathan, Prabhakar ; Marcinak, John ; Cao, Charlie ; Vakilynejad, Majid ; Xie, Benhuai ; Leifke, Eckhard

The Lancet, Apr 14-Apr 20, 2012, Vol.379(9824), pp.1403-11 [Peer Reviewed Journal]

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Comparative hepatic transcriptome analyses revealed possible pathogenic mechanisms of fasiglifam (TAK-875)-induced acute liver injury in mice

Urano, Yuya ; Oda, Shingo ; Tsuneyama, Koichi ; Yokoi, Tsuyoshi

Chemico-Biological Interactions, 25 December 2018, Vol.296, pp.185-197 [Peer Reviewed Journal]

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Toward molecular imaging of the free fatty acid receptor 1

Hellstrom-Lindahl, E. ; Aberg, O. ; Ericsson, C. ; O'Mahony, G. ; Johnstrom, P. ; Skrtic, Stanko ; Eriksson, O. ; Hellström-Lindahl, Ewa ; Åberg, Ola ; Johnström, Peter

Acta Diabetologica, 2017, Vol.54(7), pp.663-668 [Peer Reviewed Journal]

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TAK-875, a GPR40/FFAR1 agonist, in combination with metformin prevents progression of diabetes and β-cell dysfunction in Zucker diabetic fatty rats

Ito, R ; Tsujihata, Y ; Matsuda-Nagasumi, K ; Mori, I ; Negoro, N ; Takeuchi, K

British journal of pharmacology, October 2013, Vol.170(3), pp.568-80 [Peer Reviewed Journal]

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Pharmacokinetics of TAK‐875 and its toxic metabolite TAK‐875‐ acylglucuronide in rat plasma by liquid chromatography tandem mass spectrometry

Qiang, Yongzai ; Zhang, Xiaohui

Biomedical Chromatography, March 2019, Vol.33(3), pp.n/a-n/a [Peer Reviewed Journal]

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Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury

Longo, Diane M ; Woodhead, Jeffrey L ; Walker, Paul ; Herédi-Szabó, Krisztina ; Mogyorósi, Károly ; Wolenski, Francis S ; Dragan, Yvonne P ; Mosedale, Merrie ; Siler, Scott Q ; Watkins, Paul B ; Howell, Brett A

Toxicological Sciences, 2019, Vol.167(2), p.458-467 [Peer Reviewed Journal]

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Takeda suffers a big blow to its diabetes pipeline with PhIII failure of TAK-875

Carroll, John

FierceBiotech, Dec 27, 2013

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Takeda's R&D boss injects 'urgency' into Japan's No. 1 drugmaker

Mcbride, Ryan

FierceBiotech, Jan 16, 2013

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