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1
Material Type:
Review
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Molecular characterization of a common binding site for small molecules within the transmembrane domain of G-protein coupled receptors

Cascieri, Margaret A ; Fong, Tung Ming ; Strader, Catherine D

Journal of Pharmacological and Toxicological Methods, 1995, Vol.33(4), pp.179-185 [Peer Reviewed Journal]

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2
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Article
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An Updated Review of Iclaprim: A Potent and Rapidly Bactericidal Antibiotic for the Treatment of Skin and Skin Structure Infections and Nosocomial Pneumonia Caused by Gram-Positive Including Multidrug-Resistant Bacteria

Huang, David B ; Strader, Catherine D ; Macdonald, James S ; Vanarendonk, Mark ; Peck, Richard ; Holland, Thomas

Open Forum Infectious Diseases, 2018, Vol. 5(2)

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3
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Article
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Randomized controlled trials of the D1/D5 antagonist ecopipam for weight loss in obese subjects

Astrup, Arne ; Greenway, Frank L ; Ling, Walter ; Pedicone, Lisa ; Lachowicz, Jean ; Strader, Catherine D ; Kwan, Rudolf

Obesity (Silver Spring, Md.), July 2007, Vol.15(7), pp.1717-31 [Peer Reviewed Journal]

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4
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Article
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Association of sequestered beta-adrenergic receptors with the plasma membrane: A novel mechanism for receptor down regulation

Strader, Catherine D ; Sibley, David R ; Lefkowitz, Robert J

Life Sciences, 1984, Vol.35(15), pp.1601-1610 [Peer Reviewed Journal]

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5
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Article
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Specific activation of G s by synthetic peptides corresponding to an intracellular loop of the β-adrenergic receptor

Cheung, Anne H ; Huang, Ruey-Ruey C ; Graziano, Michael P ; Strader, Catherine D

FEBS Letters, 1991, Vol.279(2), pp.277-280 [Peer Reviewed Journal]

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6
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Article
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Cytoplasmic loop of β-adrenergic receptors: synaptic and intracellular localization and relation to catecholaminergic neurons in the nuclei of the solitary tracts

Aoki, Chiye ; Zemcik, Barbara A ; Strader, Catherine D ; Pickel, Virginia M

Brain Research, 1989, Vol.493(2), pp.331-347 [Peer Reviewed Journal]

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7
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Article
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Facilitation of acetylcholine release and improvement in cognition by a selective M 2 muscarinic antagonist, SCH 72788

Lachowicz, Jean E ; Duffy, Ruth A ; Ruperto, Vilma ; Kozlowski, Joseph ; Zhou, Guowei ; Clader, John ; Billard, William ; Binch, Herbert ; Crosby, Gordon ; Cohen-Williams, Mary ; Strader, Catherine D ; Coffin, Victoria

Life Sciences, 2001, Vol.68(22), pp.2585-2592 [Peer Reviewed Journal]

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8
Synthesis of Potent Cyclic Hexapeptide NK-1 Antagonists. Use of a Minilibrary in Transforming a Peptidal Somatostatin Receptor Ligand into an NK-1 Receptor Ligand via a Polyvalent Peptidomimetic
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Article
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Synthesis of Potent Cyclic Hexapeptide NK-1 Antagonists. Use of a Minilibrary in Transforming a Peptidal Somatostatin Receptor Ligand into an NK-1 Receptor Ligand via a Polyvalent Peptidomimetic

Hirschmann, Ralph ; Yao, Wenqing ; Cascieri, Margaret A. ; Strader, Catherine D. ; Maechler, Laurie ; Cichy-Knight, Maria A. ; Hynes,, John ; van Rijn, Rachel D. ; Sprengeler, Paul A. ; Smith, Amos B.

Journal of Medicinal Chemistry, 01/1996, Vol.39(13), pp.2441-2448 [Peer Reviewed Journal]

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9
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Article
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Genomic organization and functional characterization of the mouse GalR1 galanin receptor

Wang, Suke ; He, Chaogang ; Maguire, Maureen T ; Clemmons, Anthony L ; Burrier, Robert E ; Guzzi, Mario F ; Strader, Catherine D ; Parker, Eric M ; Bayne, Marvin L

FEBS Letters, 1997, Vol.411(2), pp.225-230 [Peer Reviewed Journal]

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10
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Article
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Women making strides in big pharma

Strader, Catherine D ; Narula, Satwant K ; Lachowicz, Jean E

Science (New York, N.Y.), 09 September 2005, Vol.309(5741), pp.1673 [Peer Reviewed Journal]

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11
2( S )-((3,5-Bis(trifluoromethyl)benzyl)oxy)-3( S )-phenyl-4-((3-oxo-1,2,4-triazol- 5-yl)methyl)morpholine ( 1 ):  A Potent, Orally Active, Morpholine-Based Human Neurokinin-1 Receptor Antagonist
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Article
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2( S )-((3,5-Bis(trifluoromethyl)benzyl)oxy)-3( S )-phenyl-4-((3-oxo-1,2,4-triazol- 5-yl)methyl)morpholine ( 1 ):  A Potent, Orally Active, Morpholine-Based Human Neurokinin-1 Receptor Antagonist

Hale, Jeffrey J. ; Mills, Sander G. ; Maccoss, Malcolm ; Shah, Shrenik K. ; Qi, Hongbo ; Mathre, David J. ; Cascieri, Margaret A. ; Sadowski, Sharon ; Strader, Catherine D. ; Macintyre, D. Euan ; Metzger, Joseph M.

Journal of Medicinal Chemistry, 01/1996, Vol.39(9), pp.1760-1762 [Peer Reviewed Journal]

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12
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Article
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SCH 57790: A novel M 2 receptor selective antagonist

Lachowicz, Jean E ; Lowe, Derek ; Duffy, Ruth A ; Ruperto, Vilma ; Taylor, Lisa A ; Guzik, Henry ; Brown, Joan ; Berger, Joel G ; Tice, Melissa ; Mcquade, Robert ; Kozlowski, Joseph ; Clader, John ; Strader, Catherine D ; Murgolo, Nicholas

Life Sciences, 1999, Vol.64(6), pp.535-539 [Peer Reviewed Journal]

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13
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Article
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Molecular modeling and site-specific mutagenesis of the histamine-binding site of the histamine H4 receptor

Shin, Niu ; Coates, Elizabeth ; Murgolo, Nicholas J ; Morse, Kelley L ; Bayne, Marvin ; Strader, Catherine D ; Monsma, Frederick J

Molecular pharmacology, July 2002, Vol.62(1), pp.38-47 [Peer Reviewed Journal]

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14
Material Type:
Article
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Novel molecular targets for the treatment of obesity

Strader, Catherine D ; Hwa, Joyce J ; Van Heek, Margaret ; Parker, Eric M

Drug Discovery Today, 1998, Vol.3(6), pp.250-256 [Peer Reviewed Journal]

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15
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Article
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Presenilin mutations in Alzheimer's disease: molecular models suggest a potential functional locus

Murgolo, Nicholas J ; Brown, Joan E ; Bayne, Marvin L ; Strader, Catherine D

Trends in Pharmacological Sciences, 1996, Vol.17(11), pp.389-393 [Peer Reviewed Journal]

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16
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Article
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Molecular approaches to the discovery of new treatments for obesity

Strader, Catherine D ; Macintyre, D Euan ; Candelore, Mari R ; Parker, Eric M

Current Opinion in Chemical Biology, 1997, Vol.1(2), pp.204-209 [Peer Reviewed Journal]

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17
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Article
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Biophysical and genetic analysis of the ligand-binding site of the β-adrenoceptor

Tota, Michael R ; Candelore, Marialuisa Rios ; Dixon, Richard A.F ; Strader, Catherine D

Trends in Pharmacological Sciences, 1991, Vol.12, pp.4-6 [Peer Reviewed Journal]

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18
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Article
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Mapping the ligand binding site of the NK-1 receptor

Fong, Tung Ming ; Huang, Ruey-Ruey C ; Yu, Hong ; Strader, Catherine D

Regulatory Peptides, 1993, Vol.46(1), pp.43-48 [Peer Reviewed Journal]

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19
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Article
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(Thr-59)-insulin-like growth factor I stimulates 2-deoxyglucose transport in BC3H1 myocytes through the insulin-like growth factor receptor, not the insulin receptor

Cascieri, Margaret A ; Chicchi, Gary G ; Hayes, Nancy S ; Strader, Catherine D

BBA - Molecular Cell Research, 1986, Vol.886(3), pp.491-499 [Peer Reviewed Journal]

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20
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Article
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Phosphorylation of the β-adrenergic receptor in intact cells: Relationship to heterologous and homologous mechanisms of adenylate cyclase desensitization

Sibley, David R ; Daniel, Kiefer ; Strader, Catherine D ; Lefkowitz, Robert J

Archives of Biochemistry and Biophysics, 1987, Vol.258(1), pp.24-32 [Peer Reviewed Journal]

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21
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Article
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Morphologic demonstration of clathrin-coated pits in frog and turkey erythrocytes

Willingham, Mark C ; Strader, Catherine D ; Lefkowitz, Robert J ; Pastan, Ira

Experimental Cell Research, 1984, Vol.151(2), pp.573-577 [Peer Reviewed Journal]

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22
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Article
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The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption

Altmann, Scott W ; Davis, Harry R ; Yao, Xiaorui ; Laverty, Maureen ; Compton, Douglas S ; Zhu, Li-Ji ; Crona, James H ; Caplen, Mary Ann ; Hoos, Lizbeth M ; Tetzloff, Glen ; Priestley, Tony ; Burnett, Duane A ; Strader, Catherine D ; Graziano, Michael P

BBA - Molecular and Cell Biology of Lipids, 2002, Vol.1580(1), pp.77-93 [Peer Reviewed Journal]

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23
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Article
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Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor

Hess, J. Fred ; Borkowski, Joseph A ; Young, Gretchen S ; Strader, Catherine D ; Ransom, Richard W

Biochemical and Biophysical Research Communications, 15 April 1992, Vol.184(1), pp.260-268 [Peer Reviewed Journal]

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24
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Article
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cDNA Sequence and heterologous expression of the human neurokinin-3 receptor

Huang, Ruey-Ruey C ; Cheung, Anne H ; Mazina, Kathryn E ; Strader, Catherine D ; Fong, Tung Ming

Biochemical and Biophysical Research Communications, 1992, Vol.184(2), pp.966-972 [Peer Reviewed Journal]

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25
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Article
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1,2,3-Trisubstituted cyclohexyl substance P antagonists: significance of the ring nitrogen in piperidine-based NK-1 receptor antagonists

Mills, Sander G ; Maccoss, Malcolm ; Underwood, Dennis ; Shah, Shrenik K ; Finke, Paul E ; Miller, Daniel J ; Budhu, Richard J ; Cascieri, Margaret A ; Sadowski, Sharon ; Strader, Catherine D

Bioorganic & Medicinal Chemistry Letters, 1995, Vol.5(13), pp.1345-1350 [Peer Reviewed Journal]

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26
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Article
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Potent, selective human β3 adrenergic receptor agonists containing a substituted indoline-5-sulfonamide pharmacophore

Mathvink, Robert J ; Barritta, Anna Maria ; Candelore, Mari R ; Cascieri, Margaret A ; Liping Deng ; Tota, Laurie ; Strader, Catherine D ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 1999, Vol.9(13), pp.1869-1874 [Peer Reviewed Journal]

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27
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Article
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Potent, selective benzenesulfonamide agonists of the human β 3 adrenergic receptor

Weber, Ann E ; Mathvink, Robert J ; Perkins, Leroy ; Hutchins, Jennifer E ; Candelore, Mari R ; Tota, Laurie ; Strader, Catherine D ; Wyvratt, Matthew J ; Fisher, Michael H

Bioorganic & Medicinal Chemistry Letters, 1998, Vol.8(9), pp.1101-1106 [Peer Reviewed Journal]

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28
Nociception and inflammatory hyperalgesia in B2 bradykinin receptor knockout mice
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Article
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Nociception and inflammatory hyperalgesia in B2 bradykinin receptor knockout mice

Boyce, Susan ; Rupniak, Nadia M.J. ; Carlson, Emma J. ; Webb, Janine ; Borkowski, Joseph A. ; Fred Hess, J. ; Strader, Catherine D. ; Hill, Raymond G.

Immunopharmacology, 6/1996, Vol.33(1-3), pp.333-335 [Peer Reviewed Journal]

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29
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Article
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Discovery of L-755,507: A subnanomolar human β3 adrenergic receptor agonist

Parmee, Emma R ; Ok, Hyun O ; Candelore, Mari R ; Tota, Laurie ; Deng, Liping ; Strader, Catherine D ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 1998, Vol.8(9), pp.1107-1112 [Peer Reviewed Journal]

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30
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Article
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Synthetic segments of the mammalian βAR are preferentially recognized by cAMP-dependent protein kinase and protein kinase C

Blake, Allan D ; Mumford, Richard A ; Vincent Strout, H ; Slater, Eve E ; Strader, Catherine D

Biochemical and Biophysical Research Communications, 1987, Vol.147(1), pp.168-173 [Peer Reviewed Journal]

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31
Effect of Chronic Central Administration of Glucagon-Like Peptide-1 (7-36) Amide on Food Consumption and Body Weight in Normal and Obese Rats
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Article
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Effect of Chronic Central Administration of Glucagon-Like Peptide-1 (7-36) Amide on Food Consumption and Body Weight in Normal and Obese Rats

Davis, Harry R. ; Mullins, Deborra E. ; Pines, Jesse M. ; Hoos, Lizbeth M. ; France, Constance F. ; Compton, Douglas S. ; Graziano, Michael P. ; Sybertz, Edmund J. ; Strader, Catherine D. ; Van Heek, Margaret

Obesity Research, 03/1998, Vol.6(2), pp.147-156

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32
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Article
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3-pyridylethanolamines: Potent and selective human β 3 adrenergic receptor agonists

Naylor, Elizabeth M ; Colandrea, Vincent J ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Euan Macintyre, D ; Strader, Catherine D ; Tota, Laurie ; Wang, Pei-Ran ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 1998, Vol.8(21), pp.3087-3092 [Peer Reviewed Journal]

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33
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Article
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Discovery of an orally bioavailable alkyl oxadiazole β 3 adrenergic receptor agonist

Feng, Danqing D ; Biftu, Tesfaye ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Miller, Randall R ; Stearns, Ralph A ; Strader, Catherine D ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2000, Vol.10(13), pp.1427-1429 [Peer Reviewed Journal]

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34
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Article
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1,4-Diacylpiperazine-2-(S)-[(N-aminoalkyl)carboxamides] as novel, potent substance P receptor antagonists

Mills, Sander G ; Wu, Mu Tsu ; Maccoss, Malcolm ; Budhu, Richard J ; Dorn, Conrad P ; Cascieri, Margaret A ; Sadowski, Sharon ; Strader, Catherine D ; Greenlee, William J

Bioorganic & Medicinal Chemistry Letters, 1993, Vol.3(12), pp.2707-2712 [Peer Reviewed Journal]

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35
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Article
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Human β3 adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides

Parmee, Emma R ; Naylor, Elizabeth M ; Perkins, Leroy ; Colandrea, Vincent J ; Ok, Hyun O ; Candelore, Mari R ; Cascieri, Margaret A ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Miller, Randall R ; Stearns, Ralph A ; Strader, Catherine D ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 1999, Vol.9(5), pp.749-754 [Peer Reviewed Journal]

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36