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29 Results  for Everything (Includes Articles)

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1
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Absorption and glucuronidation of the angiotensin II receptor antagonist losartan by the rat intestine

Krieter, P A ; Colletti, A E ; Miller, R R ; Stearns, R A

The Journal of pharmacology and experimental therapeutics, May 1995, Vol.273(2), pp.816-22 [Peer Reviewed Journal]

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Biotransformation of Finasteride (MK‐0906) by Selenastrum capricornutum (Green Algae

Venkataramani, E. S. ; Carlin, J. R. ; Dolling, U. ; Christofalo, P. ; Magliette, R. J. ; Arison, B. H. ; Stearns, R. A.

Annals of the New York Academy of Sciences, November 1994, Vol.745(1), pp.51-60 [Peer Reviewed Journal]

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Biotransformation of finasteride (MK-0906) by Selenastrum capricornutum (green algae)

Venkataramani, E S ; Carlin, J R ; Dolling, U ; Christofalo, P ; Magliette, R J ; Arison, B H ; Stearns, R A

Annals of the New York Academy of Sciences, 30 November 1994, Vol.745, pp.51-60 [Peer Reviewed Journal]

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4
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Interaction of diclofenac and quinidine in monkeys: stimulation of diclofenac metabolism

Tang, W ; Stearns, R A ; Kwei, G Y ; Iliff, S A ; Miller, R R ; Egan, M A ; Yu, N X ; Dean, D C ; Kumar, S ; Shou, M ; Lin, J H ; Baillie, T A

The Journal of pharmacology and experimental therapeutics, December 1999, Vol.291(3), pp.1068-74 [Peer Reviewed Journal]

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5
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In vitro stimulation of warfarin metabolism by quinidine: increases in the formation of 4'- and 10-hydroxywarfarin

Ngui, J S ; Chen, Q ; Shou, M ; Wang, R W ; Stearns, R A ; Baillie, T A ; Tang, W

Drug metabolism and disposition: the biological fate of chemicals, June 2001, Vol.29(6), pp.877-86 [Peer Reviewed Journal]

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Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-4-2-2-hydroxy-2-(3-pyridinyl)ethylaminoethylphenyl-4-4 -4-(trifluoromethyl)phenylthiazol-2-ylbenzenesulfonamide

Mathvink, R J ; Tolman, J S ; Chitty, D ; Candelore, M R ; Cascieri, M A ; Colwell, L F ; Deng, L ; Feeney, W P ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Miller, R R ; Stearns, R A ; Tota, L ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Journal of medicinal chemistry, 19 October 2000, Vol.43(21), pp.3832-6 [Peer Reviewed Journal]

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7
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Biotransformation of losartan to its active carboxylic acid metabolite in human liver microsomes. Role of cytochrome P4502C and 3A subfamily members

Stearns, R A ; Chakravarty, P K ; Chen, R ; Chiu, S H

Drug metabolism and disposition: the biological fate of chemicals, February 1995, Vol.23(2), pp.207-15 [Peer Reviewed Journal]

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8
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Evidence for a novel heme adduct generated by the in vitro reaction of 2,4,6-trinitrotoluene with human hemoglobin using electrospray ionization mass spectrometry

Bakhtiar, R ; Leung, K H ; Stearns, R A ; Hop, C E

Journal of inorganic biochemistry, December 1997, Vol.68(4), pp.273-8 [Peer Reviewed Journal]

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9
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Synthesis and identification of a novel tetrazole metabolite of the angiotensin II receptor antagonist DuP 753

Stearns, R A ; Doss, G A ; Miller, R R ; Chiu, S H

Drug metabolism and disposition: the biological fate of chemicals, 1991, Vol.19(6), pp.1160-2 [Peer Reviewed Journal]

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10
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In vivo covalent binding of 14Ctrinitrotoluene to proteins in the rat

Liu, Y Y ; Lu, A Y ; Stearns, R A ; Chiu, S H

Chemico-biological interactions, March 1992, Vol.82(1), pp.1-19 [Peer Reviewed Journal]

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11
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A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys

Fisher, M H ; Amend, A M ; Bach, T J ; Barker, J M ; Brady, E J ; Candelore, M R ; Carroll, D ; Cascieri, M A ; Chiu, S H ; Deng, L ; Forrest, M J ; Hegarty-Friscino, B ; Guan, X M ; Hom, G J ; Hutchins, J E ; Kelly, L J ; Mathvink, R J ; Metzger, J M ; Miller, R R ; Ok

The Journal of clinical investigation, 01 June 1998, Vol.101(11), pp.2387-93 [Peer Reviewed Journal]

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12
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Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac

Tang, W ; Stearns, R A ; Wang, R W ; Chiu, S H ; Baillie, T A

Chemical research in toxicology, February 1999, Vol.12(2), pp.192-9 [Peer Reviewed Journal]

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13
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The allylisopropylacetamide and novonal prosthetic heme adducts

Ortiz De Montellano, P R ; Stearns, R A ; Langry, K C

Molecular pharmacology, March 1984, Vol.25(2), pp.310-7 [Peer Reviewed Journal]

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14
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Bioactivation of diclofenac via benzoquinone imine intermediates-identification of urinary mercapturic acid derivatives in rats and humans

Poon, G K ; Chen, Q ; Teffera, Y ; Ngui, J S ; Griffin, P R ; Braun, M P ; Doss, G A ; Freeden, C ; Stearns, R A ; Evans, D C ; Baillie, T A ; Tang, W

Drug metabolism and disposition: the biological fate of chemicals, December 2001, Vol.29(12), pp.1608-13 [Peer Reviewed Journal]

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15
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Pharmacokinetics and disposition of L-692,429. A novel nonpeptidyl growth hormone secretagogue in preclinical species

Leung, K H ; Cohn, D A ; Miller, R R ; Doss, G A ; Stearns, R A ; Simpson, R E ; Feeney, W P ; Chiu, S H

Drug metabolism and disposition: the biological fate of chemicals, July 1996, Vol.24(7), pp.753-60 [Peer Reviewed Journal]

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16
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Cytochrome P450 3A4-mediated interaction of diclofenac and quinidine

Ngui, J S ; Tang, W ; Stearns, R A ; Shou, M ; Miller, R R ; Zhang, Y ; Lin, J H ; Baillie, T A

Drug metabolism and disposition: the biological fate of chemicals, September 2000, Vol.28(9), pp.1043-50 [Peer Reviewed Journal]

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17
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Orally active inhibitors of human leukocyte elastase. III. Identification and characterization of metabolites of L-694,458 by liquid chromatography-tandem mass spectrometry

Luffer-Atlas, D ; Vincent, S H ; Painter, S K ; Arison, B H ; Stearns, R A ; Chiu, S H

Drug metabolism and disposition: the biological fate of chemicals, August 1997, Vol.25(8), pp.940-52 [Peer Reviewed Journal]

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18
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Metabolites of L-735,524, a potent HIV-1 protease inhibitor, in human urine

Balani, S K ; Arison, B H ; Mathai, L ; Kauffman, L R ; Miller, R R ; Stearns, R A ; Chen, I W ; Lin, J H

Drug metabolism and disposition: the biological fate of chemicals, February 1995, Vol.23(2), pp.266-70 [Peer Reviewed Journal]

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19
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Metabolism of a nitrogen-containing steroid by rat hepatocytes and hepatic subcellular fractions

Kedderis, G L ; Argenbright, L S ; Walsh, J S ; Smith, J L ; Stearns, R A ; Arison, B A ; Miwa, G T

Drug metabolism and disposition: the biological fate of chemicals, 1989, Vol.17(6), pp.606-11 [Peer Reviewed Journal]

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20
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Evidence for a 1,2-hydride shift in the microsomal metabolism of the heterocycle L-158,338, a nonpeptide angiotensin II receptor antagonist

Stearns, R A ; Miller, R R ; Arison, B H ; Rosegay, A ; Smith, J L ; Mantlo, N B ; Chiu, S H

Drug metabolism and disposition: the biological fate of chemicals, 1993, Vol.21(4), pp.670-6 [Peer Reviewed Journal]

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21
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The metabolism of DuP 753, a nonpeptide angiotensin II receptor antagonist, by rat, monkey, and human liver slices

Stearns, R A ; Miller, R R ; Doss, G A ; Chakravarty, P K ; Rosegay, A ; Gatto, G J ; Chiu, S H

Drug metabolism and disposition: the biological fate of chemicals, 1992, Vol.20(2), pp.281-7 [Peer Reviewed Journal]

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22
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Determination of brain and plasma drug concentrations by liquid chromatography/tandem mass spectrometry

Tamvakopoulos, C. S. ; Colwell, L. F. ; Barakat, K. ; Fenyk‐Melody, J. ; Griffin, P. R. ; Nargund, R. ; Palucki, B. ; Sebhat, I. ; Shen, X. ; Stearns, R. A.

Rapid Communications in Mass Spectrometry, 15 October 2000, Vol.14(19), pp.1729-1735 [Peer Reviewed Journal]

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23
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Disposition of L-732,531, a potent immunosuppressant, in rats and baboons

Karanam, B V ; Miller, R R ; Colletti, A ; Montgomery, T ; Carey, K D ; Hawkins, T ; Tang, Y S ; Lavin, M ; Stearns, R A ; Chiu, S H ; Vincent, S H

Drug metabolism and disposition: the biological fate of chemicals, October 1998, Vol.26(10), pp.949-57 [Peer Reviewed Journal]

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24
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Human beta3 adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides

Parmee, E R ; Naylor, E M ; Perkins, L ; Colandrea, V J ; Ok, H O ; Candelore, M R ; Cascieri, M A ; Deng, L ; Feeney, W P ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Miller, R R ; Stearns, R A ; Strader, C D ; Tota, L ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 08 March 1999, Vol.9(5), pp.749-54 [Peer Reviewed Journal]

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25
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Discovery of an orally bioavailable alkyl oxadiazole beta3 adrenergic receptor agonist

Feng, D D ; Biftu, T ; Candelore, M R ; Cascieri, M A ; Colwell, L F ; Deng, L ; Feeney, W P ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Miller, R R ; Stearns, R A ; Strader, C D ; Tota, L ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 03 July 2000, Vol.10(13), pp.1427-9 [Peer Reviewed Journal]

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26
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Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective beta3 adrenergic receptor agonist antiobesity agents

Biftu, T ; Feng, D D ; Liang, G B ; Kuo, H ; Qian, X ; Naylor, E M ; Colandrea, V J ; Candelore, M R ; Cascieri, M A ; Colwell, L F ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Stearns, R A ; Strader, C D ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 03 July 2000, Vol.10(13), pp.1431-4 [Peer Reviewed Journal]

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27
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L-770,644: a potent and selective human beta3 adrenergic receptor agonist with improved oral bioavailability

Shih, T L ; Candelore, M R ; Cascieri, M A ; Chiu, S H ; Colwell, L F ; Deng, L ; Feeney, W P ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Miller, R R ; Stearns, R A ; Strader, C D ; Tota, L ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 03 May 1999, Vol.9(9), pp.1251-4 [Peer Reviewed Journal]

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28
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Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites

Tang, W ; Stearns, R A ; Bandiera, S M ; Zhang, Y ; Raab, C ; Braun, M P ; Dean, D C ; Pang, J ; Leung, K H ; Doss, G A ; Strauss, J R ; Kwei, G Y ; Rushmore, T H ; Chiu, S H ; Baillie, T A

Drug metabolism and disposition: the biological fate of chemicals, March 1999, Vol.27(3), pp.365-72 [Peer Reviewed Journal]

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29
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3-Pyridyloxypropanolamine agonists of the beta 3 adrenergic receptor with improved pharmacokinetic properties

Weber, A E ; Ok, H O ; Alvaro, R F ; Candelore, M R ; Cascieri, M A ; Chiu, S H ; Deng, L ; Forrest, M J ; Hom, G J ; Hutchins, J E ; Kao, J ; Macintyre, D E ; Mathvink, R J ; Mcloughlin, D ; Miller, R R ; Newbold, R C ; Olah, T V ; Parmee, E R ; Perkins, L ; Stearns

Bioorganic & medicinal chemistry letters, 18 August 1998, Vol.8(16), pp.2111-6 [Peer Reviewed Journal]

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