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11 Results  for Everything (Includes Articles)

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Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes

Biftu, Tesfaye ; Sinha-Roy, Ranabir ; Chen, Ping ; Qian, Xiaoxia ; Feng, Dennis ; Kuethe, Jeffrey T ; Scapin, Giovanna ; Gao, Ying Duo ; Yan, Youwei ; Krueger, Davida ; Bak, Annette ; Eiermann, George ; He, Jiafang ; Cox, Jason ; Hicks, Jacqueline ; Lyons, Kathy ; He, Huaibing ; Salituro, Gino ; Tong, Sharon ; Patel

Journal of medicinal chemistry, 24 April 2014, Vol.57(8), pp.3205-12 [Peer Reviewed Journal]

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Mutational Analysis of Posttranslational Heterocycle Biosynthesis in the Gyrase Inhibitor Microcin B17:  Distance Dependence from Propeptide and Tolerance for Substitution in a GSCG Cyclizable Sequence †
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Mutational Analysis of Posttranslational Heterocycle Biosynthesis in the Gyrase Inhibitor Microcin B17:  Distance Dependence from Propeptide and Tolerance for Substitution in a GSCG Cyclizable Sequence †

Sinha Roy, Ranabir ; Belshaw, Peter J. ; Walsh, Christopher T.

Biochemistry, 03/1998, Vol.37(12), pp.4125-4136 [Peer Reviewed Journal]

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The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors

Cox, Jason M ; Chu, Hong D ; Kuethe, Jeffrey T ; Gao, Ying-Duo ; Scapin, Giovanna ; Eiermann, George ; He, Huaibing ; Li, Xiaohua ; Lyons, Kathryn A ; Metzger, Joseph ; Petrov, Aleksandr ; Wu, Joseph K ; Xu, Shiyao ; Sinha-Roy, Ranabir ; Weber, Ann E ; Biftu, Tesfaye

Bioorganic & Medicinal Chemistry Letters, 01 June 2016, Vol.26(11), pp.2622-2626 [Peer Reviewed Journal]

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Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine (23)

Biftu, Tesfaye ; Qian, Xiaoxia ; Chen, Ping ; Feng, Dennis ; Scapin, Giovanna ; Gao, Ying-Duo ; Cox, Jason ; Sinha Roy, Ranabir ; Eiermann, George ; He, Huabing ; Lyons, Kathy ; Salituro, Gino ; Patel, Sangita ; Petrov, Alexander ; Xu, Feng ; Xu, Shiyao Sherrie ; Zhang, Bei ; Caldwell, Charles ; Wu, Joseph K ; Lyons, Kathy

Bioorganic & Medicinal Chemistry Letters, 01 October 2013, Vol.23(19), pp.5361-5366 [Peer Reviewed Journal]

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The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides: in vivo metabolism of pituitary adenylate cyclase activating polypeptide-(1-38)

Zhu, Lan ; Tamvakopoulos, Constantin ; Xie, Dan ; Dragovic, Jasminka ; Shen, Xiaolan ; Fenyk-Melody, Judith E ; Schmidt, Keith ; Bagchi, Ansuman ; Griffin, Patrick R ; Thornberry, Nancy A ; Sinha Roy, Ranabir

The Journal of biological chemistry, 20 June 2003, Vol.278(25), pp.22418-23 [Peer Reviewed Journal]

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Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes

Liang, Gui-Bai ; Qian, Xiaoxia ; Feng, Dennis ; Biftu, Tesfaye ; Eiermann, George ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathy ; Petrov, Aleksandr ; Sinha-Roy, Ranabir ; Zhang, Bei ; Wu, Joseph ; Zhang, Xiaoping ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(7), pp.1903-1907 [Peer Reviewed Journal]

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Identification of peptidase substrates in human plasma by FTMS based differential mass spectrometry

Yates, Nathan A ; Deyanova, Ekaterina G ; Geissler, Wayne ; Wiener, Matthew C ; Sachs, Jeffrey R ; Wong, Kenny K ; Thornberry, Nancy A ; Sinha Roy, Ranabir ; Settlage, Robert E ; Hendrickson, Ronald C

International Journal of Mass Spectrometry, 2007, Vol.259(1), pp.174-183 [Peer Reviewed Journal]

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Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors

Cox, Jason M ; Harper, Bart ; Mastracchio, Anthony ; Leiting, Barbara ; Sinha Roy, Ranabir ; Patel, Reshma A ; Wu, Joseph K ; Lyons, Kathryn A ; He, Huaibing ; Xu, Shiyao ; Zhu, Bing ; Thornberry, Nancy A ; Weber, Ann E ; Edmondson, Scott D

Bioorganic & Medicinal Chemistry Letters, 15 August 2007, Vol.17(16), pp.4579-4583 [Peer Reviewed Journal]

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Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors

Gao, Ying-Duo ; Feng, Dennis ; Sheridan, Robert P ; Scapin, Giovanna ; Patel, Sangita B ; Wu, Joseph K ; Zhang, Xiaoping ; Sinha-Roy, Ranabir ; Thornberry, Nancy A ; Weber, Ann E ; Biftu, Tesfaye

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(14), pp.3877-3879 [Peer Reviewed Journal]

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(3 R)-4-[(3 R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Biftu, Tesfaye ; Feng, Dennis ; Qian, Xiaoxia ; Liang, Gui-Bai ; Kieczykowski, Gerard ; Eiermann, George ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathy ; Petrov, Aleksandr ; Sinha-Roy, Ranabir ; Zhang, Bei ; Scapin, Giovanna ; Patel, Sangita ; Gao, Ying-Duo ; Singh, Suresh ; Wu, Joseph ; Zhang, Xiaoping ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(1), pp.49-52 [Peer Reviewed Journal]

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Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin

Biftu, Tesfaye ; Scapin, Giovanna ; Singh, Suresh ; Feng, Dennis ; Becker, Joe W ; Eiermann, George ; He, Huaibing ; Lyons, Kathy ; Patel, Sangita ; Petrov, Aleksandr ; Sinha-Roy, Ranabir ; Zhang, Bei ; Wu, Joseph ; Zhang, Xiaoping ; Doss, George A ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(12), pp.3384-3387 [Peer Reviewed Journal]

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