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A method for the reductive scission of heterocyclic thioethers

Graham, Thomas H ; Liu, Wensheng ; Shen, Dong-Ming

Organic letters, 02 December 2011, Vol.13(23), pp.6232-5 [Peer Reviewed Journal]

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Identification and Characterization of Sebaceous Gland Atrophy-Sparing DGAT1 Inhibitors

Muise, Eric S ; Zhu, Yonghua ; Verras, Andreas ; Karanam, Bindhu V ; Gorski, Judith ; Weingarth, Drew ; Lin, Hua V ; Hwa, Joyce ; Thompson, John R ; Hu, Guanghui ; Liu, Jian ; He, Shuwen ; Devita, Robert J ; Shen, Dong-Ming ; Pinto, Shirly Slominski, Andrzej T. (editor)

PLoS ONE, 2014, Vol.9(2) [Peer Reviewed Journal]

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Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors

Cernak, Tim ; Gesmundo, Nathan J ; Dykstra, Kevin ; Yu, Yang ; Wu, Zhicai ; Shi, Zhi-Cai ; Vachal, Petr ; Sperbeck, Donald ; He, Shuwen ; Murphy, Beth Ann ; Sonatore, Lisa ; Williams, Steven ; Madeira, Maria ; Verras, Andreas ; Reiter, Maud ; Lee, Claire Heechoon ; Cuff, James ; Sherer, Edward C ; Kuethe, Jeffrey ; Goble, Stephen ; Perrotto, Nicholas ; Pinto, Shirly ; Shen, Dong-Ming ; Nargund, Ravi ; Balkovec, James ; Devita, Robert J ; Dreher, Spencer D

Journal of medicinal chemistry, 11 May 2017, Vol.60(9), pp.3594-3605 [Peer Reviewed Journal]

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Design, synthesis, and evaluation of conformationally restricted acetanilides as potent and selective β3 adrenergic receptor agonists for the treatment of overactive bladder

Moyes, Christopher R ; Berger, Richard ; Goble, Stephen D ; Harper, Bart ; Shen, Dong-Ming ; Wang, Liping ; Bansal, Alka ; Brown, Patricia N ; Chen, Airu S ; Dingley, Karen H ; Di Salvo, Jerry ; Fitzmaurice, Aileen ; Gichuru, Loise N ; Hurley, Amanda L ; Jochnowitz, Nina ; Miller, Randall R ; Mistry, Shruty ; Nagabukuro, Hiroshi ; Salituro, Gino M ; Sanfiz, Anthony ; Stevenson, Andra S ; Villa, Katherine ; Zamlynny, Beata ; Struthers, Mary ; Weber, Ann E ; Edmondson, Scott D

Journal of medicinal chemistry, 27 February 2014, Vol.57(4), pp.1437-53 [Peer Reviewed Journal]

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Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors

Imbriglio, Jason E ; Shen, Dong-Ming ; Liang, Rui ; Marby, Ken ; You, Ming ; Youm, Hye Won ; Feng, Zhe ; London, Clare ; Xiong, Yusheng ; Tata, Jim ; Verras, Andreas ; Garcia-Calvo, Margarita ; Song, Xuelei ; Addona, George H ; Mclaren, Dave G ; He, Timothy ; Murphy, Beth ; Metzger, Dan E ; Salituro, Gino ; Deckman, Diana ; Chen, Qing ; Jin, Xiaoling ; Stout, Steven J ; Wang, Sheng-Ping ; Wilsie, Larissa ; Palyha, Oksana ; Han, Seongah ; Hubbard, Brian K ; Previs, Stephen F ; Pinto, Shirly ; Taggart, Andrew

Journal of medicinal chemistry, 10 December 2015, Vol.58(23), pp.9345-53 [Peer Reviewed Journal]

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Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder

Edmondson, Scott D ; Zhu, Cheng ; Kar, Nam Fung ; Di Salvo, Jerry ; Nagabukuro, Hiroshi ; Sacre-Salem, Beatrice ; Dingley, Karen ; Berger, Richard ; Goble, Stephen D ; Morriello, Gregori ; Harper, Bart ; Moyes, Christopher R ; Shen, Dong-Ming ; Wang, Liping ; Ball, Richard ; Fitzmaurice, Aileen ; Frenkl, Tara ; Gichuru, Loise N ; Ha, Sookhee ; Hurley, Amanda L ; Jochnowitz, Nina ; Levorse, Dorothy ; Mistry, Shruty ; Miller, Randy R ; Ormes, James ; Salituro, Gino M ; Sanfiz, Anthony ; Stevenson, Andra S ; Villa, Katherine ; Zamlynny, Beata ; Green, Stuart ; Struthers, Mary ; Weber, Ann E

Journal of medicinal chemistry, 28 January 2016, Vol.59(2), pp.609-23 [Peer Reviewed Journal]

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Versatile and Efficient Solid-Phase Syntheses of Pyrazoles and Isoxazoles
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Versatile and Efficient Solid-Phase Syntheses of Pyrazoles and Isoxazoles

Shen, Dong-Ming ; Shu, Min ; Chapman, Kevin T.

Organic Letters, 09/2000, Vol.2(18), pp.2789-2792 [Peer Reviewed Journal]

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Pyrazoles as non-classical bioisosteres in prolylcarboxypeptidase (PrCP) inhibitors

Graham, Thomas H ; Shu, Min ; Verras, Andreas ; Chen, Qing ; Garcia-Calvo, Margarita ; Li, Xiaohua ; Lisnock, Jeanmarie ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 01 April 2014, Vol.24(7), pp.1657-1660 [Peer Reviewed Journal]

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Mass Spectrometry Screening of Combinatorial Mixtures, Correlation of Measured and Predicted Electrospray Ionization Spectra
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Mass Spectrometry Screening of Combinatorial Mixtures, Correlation of Measured and Predicted Electrospray Ionization Spectra

Yates, Nathan ; Wislocki, Daniel ; Roberts, Andrew ; Berk, Scott ; Klatt, Tracey ; Shen, Dong-Ming ; Willoughby, Chris ; Rosauer, Keith ; Chapman, Kevin ; Griffin, Patrick

Analytical Chemistry, 07/2001, Vol.73(13), pp.2941-2951 [Peer Reviewed Journal]

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Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors

Shen, Hong C ; Ding, Fa-Xiang ; Zhou, Changyou ; Xiong, Yusheng ; Verras, Andreas ; Chabin, Renee M ; Xu, Suoyu ; Tong, Xinchun ; Xie, Dan ; Lassman, Michael E ; Bhatt, Urmi R ; Garcia-Calvo, Margarita M ; Geissler, Wayne ; Shen, Zhu ; Chen, Dunlu ; Sinharoy, Ranabir ; Hale, Jeffery J ; Tata, James R ; Pinto, Shirly ; Shen, Dong-Ming ; Colletti, Steven L

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(5), pp.1299-1305 [Peer Reviewed Journal]

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11
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Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors

Shen, Hong C ; Ding, Fa-Xiang ; Jiang, Jinlong ; Verras, Andreas ; Chabin, Renee M ; Xu, Suoyu ; Tong, Xinchun ; Chen, Qing ; Xie, Dan ; Lassman, Mike E ; Bhatt, Urmi R ; Garcia-Calvo, Margarita M ; Geissler, Wayne ; Shen, Zhu ; Murphy, Beth Ann ; Gorski, Judith N ; Wiltsie, Judyann ; Sinharoy, Ranabir ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 February 2012, Vol.22(4), pp.1550-1556 [Peer Reviewed Journal]

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12
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Discovery of aminoheterocycles as potent and brain penetrant prolylcarboxypeptidase inhibitors

Wu, Zhicai ; Yang, Cangming ; Graham, Thomas H ; Verras, Andreas ; Chabin, Renee M ; Xu, Suoyu ; Tong, Xinchun ; Xie, Dan ; Lassman, Mike E ; Bhatt, Urmi R ; Garcia-Calvo, Margarita M ; Shen, Zhu ; Chen, Qing ; Bleasby, Kelly ; Sinharoy, Ranabir ; Hale, Jeffrey J ; Tata, James R ; Pinto, Shirly ; Colletti, Steven L ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 February 2012, Vol.22(4), pp.1727-1730 [Peer Reviewed Journal]

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Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine

Wu, Zhicai ; Yang, Cangming ; Xiong, Yusheng ; Feng, Zhe ; Lombardo, Matthew ; Verras, Andreas ; Chabin, Renee M ; Xu, Suoyu ; Tong, Xinchun ; Xie, Dan ; Lassman, Mike E ; Bhatt, Urmi R ; Garcia-Calvo, Margarita M ; Geissler, Wayne ; Shen, Zhu ; Chen, Qing ; Sinharoy, Ranabir ; Hale, Jeffrey J ; Tata, James R ; Pinto, Shirly ; Shen, Dong-Ming ; Colletti, Steven L

Bioorganic & Medicinal Chemistry Letters, 15 February 2012, Vol.22(4), pp.1774-1778 [Peer Reviewed Journal]

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14
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Selective, direct activation of high-conductance, calcium-activated potassium channels causes smooth muscle relaxation

Ponte, Cristiano G ; Mcmanus, Owen B ; Schmalhofer, William A ; Shen, Dong-Ming ; Dai, Ge ; Stevenson, Andra ; Sur, Sylvie ; Shah, Tarak ; Kiss, Laszlo ; Shu, Min ; Doherty, James B ; Nargund, Ravi ; Kaczorowski, Gregory J ; Suarez-Kurtz, Guilherme ; Garcia, Maria L

Molecular pharmacology, April 2012, Vol.81(4), pp.567-77 [Peer Reviewed Journal]

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15
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Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core

Shen, Dong-Ming ; Brady, Edward J ; Candelore, Mari R ; Dallas-Yang, Qing ; Ding, Victor D.-H ; Feeney, William P ; Jiang, Guoquiang ; Mccann, Margaret E ; Mock, Steve ; Qureshi, Sajjad A ; Saperstein, Richard ; Shen, Xiaolan ; Tong, Xinchun ; Tota, Laurie M ; Wright, Michael J ; Yang, Xiaodong ; Zheng, Song ; Chapman, Kevin T ; Zhang, Bei B ; Tata, James R ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 01 January 2011, Vol.21(1), pp.76-81 [Peer Reviewed Journal]

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A new class of prolylcarboxypeptidase inhibitors, Part 2: The aminocyclopentanes

Graham, Thomas H ; Liu, Wensheng ; Verras, Andreas ; Reibarkh, Mikhail ; Bleasby, Kelly ; Bhatt, Urmi R ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; Gorski, Judith N ; He, Huaibing ; Lassman, Michael E ; Lisnock, Jeanmarie ; Li, Xiaohua ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Xie, Dan ; Xu, Suoyu ; Xiao, Jianying ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 April 2012, Vol.22(8), pp.2818-2822 [Peer Reviewed Journal]

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17
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Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors

Debenham, John S ; Graham, Thomas H ; Verras, Andreas ; Zhang, Yong ; Clements, Matthew J ; Kuethe, Jeffrey T ; Madsen-Duggan, Christina ; Liu, Wensheng ; Bhatt, Urmi R ; Chen, Dunlu ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; He, Huaibing ; Li, Xiaohua ; Lisnock, Jeanmarie ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Xu, Suoyu ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 01 December 2013, Vol.23(23), pp.6228-6233 [Peer Reviewed Journal]

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18
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A new class of prolylcarboxypeptidase inhibitors, Part 1: Discovery and evaluation

Graham, Thomas H ; Liu, Wensheng ; Verras, Andreas ; Sebhat, Iyassu K ; Xiong, Yusheng ; Bleasby, Kelly ; Bhatt, Urmi R ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; Gorski, Judith N ; He, Huaibing ; Lassman, Michael E ; Lisnock, Jeanmarie ; Li, Xiaohua ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Xiao, Jianying ; Xie, Dan ; Xu, Suoyu ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 April 2012, Vol.22(8), pp.2811-2817 [Peer Reviewed Journal]

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19
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The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors

Graham, Thomas H ; Shen, Hong C ; Liu, Wensheng ; Xiong, Yusheng ; Verras, Andreas ; Bleasby, Kelly ; Bhatt, Urmi R ; Chabin, Renee M ; Chen, Dunlu ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; He, Huaibing ; Lassman, Michael E ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Xie, Dan ; Xu, Suoyu ; Colletti, Steven L ; Tata, James R ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 01 January 2012, Vol.22(1), pp.658-665 [Peer Reviewed Journal]

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20
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Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase

Zhao, Xuemei ; Southwick, Katie ; Cardasis, Helene L. ; Du, Yi ; Lassman, Michael E. ; Xie, Dan ; El‐Sherbeini, Mohamed ; Geissler, Wayne M. ; Pryor, Kellyann D. ; Verras, Andreas ; Garcia‐Calvo, Margarita ; Shen, DongMing ; Yates, Nathan A. ; Pinto, Shirly ; Hendrickon, Ronald C.

PROTEOMICS, August 2010, Vol.10(15), pp.2882-2886 [Peer Reviewed Journal]

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21
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Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase

Zhao, Xuemei ; Southwick, Katie ; Cardasis, Helene L. ; Du, Yi ; Lassman, Michael E. ; Xie, Dan ; El‐Sherbeini, Mohamed ; Geissler, Wayne M. ; Pryor, Kellyann D. ; Verras, Andreas ; Garcia‐Calvo, Margarita ; Shen, DongMing ; Yates, Nathan A. ; Pinto, Shirly ; Hendrickon, Ronald C.

PROTEOMICS – Clinical Applications, November 2010, Vol.4(10‐11), pp.865-865 [Peer Reviewed Journal]

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22
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Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Wu, Zhicai ; Yu, Yang ; Kim, David W ; Ting, Pauline C ; Kuethe, Jeffrey T ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sperbeck, Donald M ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Murphy, Beth A ; Gorski, Judith N ; Liu, Jinqi ; Chen, Dunlu ; Chen, Xiaoli ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

ACS medicinal chemistry letters, 08 August 2013, Vol.4(8), pp.773-8 [Peer Reviewed Journal]

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23
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Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Yang, David X ; Ting, Pauline C ; Kuethe, Jeffrey T ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sonatore, Lisa M ; Wiltsie, Judyann ; Liu, Jinqi ; Gorski, Judith N ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

ACS medicinal chemistry letters, 09 October 2014, Vol.5(10), pp.1082-7 [Peer Reviewed Journal]

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24
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CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity

Lynch, Christopher L ; Hale, Jeffrey J ; Budhu, Richard J ; Gentry, Amy L ; Finke, Paul E ; Caldwell, Charles G ; Mills, Sander G ; Maccoss, Malcolm ; Shen, Dong-Ming ; Chapman, Kevin T ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Emini, Emilio

Organic letters, 10 July 2003, Vol.5(14), pp.2473-5 [Peer Reviewed Journal]

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25
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Triptolide binds covalently to a 90 kDa nuclear protein. Role of epoxides in binding and activity

Mccallum, Christine ; Kwon, Suzy ; Leavitt, Penny ; Shen, Dong-Ming ; Liu, Wensheng ; Gurnett, Anne

Immunobiology, 2007, Vol.212(7), pp.549-556 [Peer Reviewed Journal]

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26
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CCDC 1421635: Experimental Crystal Structure Determination

Edmondson, Scott D. ; Zhu, Cheng ; Kar, Nam Fung ; Di Salvo, Jerry ; Nagabukuro, Hiroshi ; Sacre-Salem, Beatrice ; Dingley, Karen ; Berger, Richard ; Goble, Stephen D. ; Morriello, Gregori ; Harper, Bart ; Moyes, Christopher R. ; Shen, Dong-Ming ; Wang, Liping ; Ball, Richard ; Fitzmaurice, Aileen ; Frenkl, Tara ; Gichuru, Loise N. ; Ha, Sookhee ; Hurley, Amanda L. ; Jochnowitz, Nina ; Levorse, Dorothy ; Mistry, Shruty ; Miller, Randy R. ; Ormes, James ; Salituro, Gino M. ; Sanfiz, Anthony ; Stevenson, Andra S. ; Villa, Katherine ; Zamlynny, Beata ; Green, Stuart ; Struthers, Mary ; Weber, Ann E.

2016

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27
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Development of indazole mineralocorticoid receptor antagonists and investigation into their selective late-stage functionalization

Liu, Kun ; Kurukulasuriya, Ravi ; Dykstra, Kevin ; Dimichelle, Lisa ; Liu, Jinchu ; Vachal, Petr ; Ogawa, Anthony ; Devita, Robert J ; Shen, Dong-Ming ; Tan, Qiang ; Chen, Yili ; Gauthier, Don ; Verras, Andreas ; Crespo, Alejandro ; Zamlynny, Beata ; Madwed, Jeffrey ; Hoek, Maarten ; Bateman, Thomas ; Yang, Yun-Fang ; Houk, K.N ; Krska, Shane ; Cernak, Tim

Bioorganic & Medicinal Chemistry Letters, 15 July 2019, Vol.29(14), pp.1854-1858 [Peer Reviewed Journal]

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28
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Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists

Shen, Dong-Ming ; Zhang, Fengqi ; Brady, Edward J ; Candelore, Mari Rios ; Dallas-Yang, Qing ; Ding, Victor D.-H ; Dragovic, Jasminka ; Feeney, William P ; Jiang, Guoquiang ; Mccann, Peggy E ; Mock, Steve ; Qureshi, Sajjad A ; Saperstein, Richard ; Shen, Xiaolan ; Tamvakopoulos, Constantin ; Tong, Xinchun ; Tota, Laurie M ; Wright, Michael J ; Yang, Xiaodong ; Zheng, Song ; Chapman, Kevin T ; Zhang, Bei B ; Tata, James R ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(20), pp.4564-4569 [Peer Reviewed Journal]

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29
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Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains

Shen, Dong-Ming ; Shu, Min ; Mills, Sander G ; Chapman, Kevin T ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Kwei, Gloria Y ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael D ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 23 February 2004, Vol.14(4), pp.935-939 [Peer Reviewed Journal]

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30
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Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment

Shu, Min ; Loebach, Jennifer L ; Parker, Kerry A ; Mills, Sander G ; Chapman, Kevin T ; Shen, Dong-Ming ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Salvo, Jerry Di ; Lyons, Kathy ; Pivnichny, James V ; Kwei, Gloria Y ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael D ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 23 February 2004, Vol.14(4), pp.947-952 [Peer Reviewed Journal]

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31
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Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds

Shen, Dong-Ming ; Shu, Min ; Willoughby, Christopher A ; Shah, Shrenik ; Lynch, Christopher L ; Hale, Jeffrey J ; Mills, Sander G ; Chapman, Kevin T ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Lyons, Kathy ; Pivnichny, James V ; Kwei, Gloria Y ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael D ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 23 February 2004, Vol.14(4), pp.941-945 [Peer Reviewed Journal]

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32
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Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)

Yu, Yang ; Wu, Zhicai ; Shi, Zhi-Cai ; He, Shuwen ; Lai, Zhong ; Cernak, Timothy A ; Vachal, Petr ; Liu, Min ; Liu, Jian ; Hong, Qingmei ; Jian, Tianying ; Guiadeen, Deodial ; Krikorian, Arto ; Sperbeck, Donald M ; Verras, Andreas ; Sonatore, Lisa M ; Murphy, Beth A ; Wiltsie, Judyann ; Chung, Christine C ; Gorski, Judith N ; Liu, Jinqi ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; De Vita, Robert J ; Pinto, Shirly ; Nargund, Ravi P

Bioorganic & Medicinal Chemistry Letters, 01 June 2019, Vol.29(11), pp.1380-1385 [Peer Reviewed Journal]

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Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety

He, Shuwen ; Lai, Zhong ; Hong, Qingmei ; Shang, Jackie ; Reibarkh, Mikhail ; Kuethe, Jeffrey T ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Verras, Andreas ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Murphy, Beth A ; Gorski, Judith N ; Liu, Jinqi ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

Bioorganic & Medicinal Chemistry Letters, 15 May 2019, Vol.29(10), pp.1182-1186 [Peer Reviewed Journal]

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