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11 Results  for Everything (Includes Articles)

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Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program

Zhang, Ting ; Liu, Yong ; Yang, Xianshu ; Martin, Gary E ; Yao, Huifang ; Shang, Jackie ; Bugianesi, Randal M ; Ellsworth, Kenneth P ; Sonatore, Lisa M ; Nizner, Peter ; Sherer, Edward C ; Hill, Susan E ; Knemeyer, Ian W ; Geissler, Wayne M ; Dandliker, Peter J ; Helmy, Roy ; Wood, Harold B

Journal of medicinal chemistry, 10 March 2016, Vol.59(5), pp.1818-29 [Peer Reviewed Journal]

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Discovery of a novel glucagon receptor antagonist N-(4-{(1S)-1-3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-ylethyl}phenyl)carbonyl-β-alanine (MK-0893) for the treatment of type II diabetes

Xiong, Yusheng ; Guo, Jian ; Candelore, Mari R ; Liang, Rui ; Miller, Corey ; Dallas-Yang, Qing ; Jiang, Guoqiang ; Mccann, Peggy E ; Qureshi, Sajjad A ; Tong, Xinchun ; Xu, Shiyao Sherrie ; Shang, Jackie ; Vincent, Stella H ; Tota, Laurie M ; Wright, Michael J ; Yang, Xiaodong ; Zhang, Bei B ; Tata, James R ; Parmee, Emma R

Journal of medicinal chemistry, 12 July 2012, Vol.55(13), pp.6137-48 [Peer Reviewed Journal]

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Rat liver microsomal enzyme catalyzed oxidation of 4-phenyl- trans-1-(2-phenylcyclopropyl)-1,2,3,6-tetrahydropyridine

Kuttab, Simon ; Shang, Jackie ; Castagnoli, Neal

Bioorganic & Medicinal Chemistry, 2001, Vol.9(7), pp.1685-1689 [Peer Reviewed Journal]

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Metabolic activation and major protein target of a 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonist

Aloysius, Herve ; Tong, Vincent W ; Yabut, Jocelyn ; Bradley, Scott A ; Shang, Jackie ; Zou, Yan ; Tschirret-Guth, Richard A

Chemical research in toxicology, 16 July 2012, Vol.25(7), pp.1412-22 [Peer Reviewed Journal]

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Discovery of N-Aryl-2-acylindole human glucagon receptor antagonists

Sinz, Christopher ; Bittner, Amy ; Brady, Ed ; Candelore, Mari ; Dallas-Yang, Qing ; Ding, Victor ; Jiang, Guoqiang ; Lin, Zhen ; Qureshi, Sajjad ; Salituro, Gino ; Saperstein, Richard ; Shang, Jackie ; Szalkowski, Deborah ; Tota, Laurie ; Vincent, Stella ; Wright, Michael ; Xu, Shiyao ; Yang, Xiaodong ; Zhang, Bei ; Tata, James ; Kim, Ronald ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(23), pp.7124-7130 [Peer Reviewed Journal]

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Discovery of cyclic guanidines as potent, orally active, human glucagon receptor antagonists

Sinz, Christopher ; Chang, Jiang ; Lins, Ashley Rouse ; Brady, Ed ; Candelore, Mari ; Dallas-Yang, Qing ; Ding, Victor ; Jiang, Guoqiang ; Lin, Zhen ; Mock, Steven ; Qureshi, Sajjad ; Salituro, Gino ; Saperstein, Richard ; Shang, Jackie ; Szalkowski, Deborah ; Tota, Laurie ; Vincent, Stella ; Wright, Michael ; Xu, Shiyao ; Yang, Xiaodong ; Zhang, Bei ; Tata, James ; Kim, Ronald ; Parmee, Emma

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(23), pp.7131-7136 [Peer Reviewed Journal]

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(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-1,2,4triazolo1,5-a-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Edmondson, Scott D ; Mastracchio, Anthony ; Mathvink, Robert J ; He, Jiafang ; Harper, Bart ; Park, You-Jung ; Beconi, Maria ; Di Salvo, Jerry ; Eiermann, George J ; He, Huaibing ; Leiting, Barbara ; Leone, Joseph F ; Levorse, Dorothy A ; Lyons, Kathryn ; Patel, Reshma A ; Patel, Sangita B ; Petrov, Aleksandr ; Scapin, Giovanna ; Shang, Jackie ; Roy, Ranabir Sinha ; Smith, Aaron ; Wu, Joseph K ; Xu, Shiyao ; Zhu, Bing ; Thornberry, Nancy A ; Weber, Ann E

Journal of medicinal chemistry, 15 June 2006, Vol.49(12), pp.3614-27 [Peer Reviewed Journal]

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Bioactivation of GPR40 Agonist MK-8666: Formation of Protein Adducts in Vitro from Reactive Acyl Glucuronide and Acyl CoA Thioester

Shang, Jackie ; Tschirret-Guth, Richard ; Cancilla, Mark ; Samuel, Koppara ; Chen, Qing ; Chobanian, Harry R ; Thomas, Ann ; Tong, Wei ; Josien, Hubert ; Buevich, Alexei V ; Mitra, Kaushik

Chemical research in toxicology, 30 September 2019 [Peer Reviewed Journal]

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Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors

Edmondson, Scott D ; Wei, Lan ; Xu, Jinyou ; Shang, Jackie ; Xu, Shiyao ; Pang, Jianmei ; Chaudhary, Ashok ; Dean, Dennis C ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathryn A ; Patel, Reshma A ; Patel, Sangita B ; Scapin, Giovanna ; Wu, Joseph K ; Beconi, Maria G ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(7), pp.2409-2413 [Peer Reviewed Journal]

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Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs

Pio, Barbara ; Chobanian, Harry R ; Guo, Yan ; Josien, Hubert ; Hagmann, William K ; Miller, Michael ; Trujillo, Maria E ; Kirkland, Melissa ; Kosinski, Daniel ; Mane, Joel ; Pachanski, Michele ; Cheewatrakoolpong, Boonlert ; Ashley, Eric ; Orr, Robert ; Wright, Michael J ; Bugianesi, Randal ; Souza, Sarah ; Zhang, Xiaoping ; Di Salvo, Jerry ; Weinglass, Adam B ; Tschirret-Guth, Richard ; Samuel, Koppara ; Chen, Qing ; Shang, Jackie ; Lamca, James ; Ehrhart, Juliann ; Nargund, Ravi ; Howard, Andrew D ; Colletti, Steven L

Bioorganic & Medicinal Chemistry Letters, 15 July 2019, Vol.29(14), pp.1842-1848 [Peer Reviewed Journal]

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Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety

He, Shuwen ; Lai, Zhong ; Hong, Qingmei ; Shang, Jackie ; Reibarkh, Mikhail ; Kuethe, Jeffrey T ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Verras, Andreas ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Murphy, Beth A ; Gorski, Judith N ; Liu, Jinqi ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

Bioorganic & Medicinal Chemistry Letters, 15 May 2019, Vol.29(10), pp.1182-1186 [Peer Reviewed Journal]

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