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Linkage disequilibrium of evolutionarily conserved regions in the human genome

Johnson Todd A ; Ohnishi Yozo ; Sekine Akihiro ; Kato Mamoru ; Tanaka Toshihiro ; Nakamura Yusuke ; Tsunoda Tatsuhiko

BMC Genomics, 01 December 2006, Vol.7(1), p.326 [Peer Reviewed Journal]

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Increased aortic wave reflection and smaller pulse pressure amplification in smokers and passive smokers confirmed by urinary cotinine levels: The Nagahama Study

Tabara, Yasuharu ; Takahashi, Yoshimitsu ; Setoh, Kazuya ; Muro, Shigeo ; Kawaguchi, Takahisa ; Terao, Chikashi ; Kosugi, Shinji ; Sekine, Akihiro ; Yamada, Ryo ; Mishima, Michiaki ; Nakayama, Takeo ; Matsuda, Fumihiko

International Journal of Cardiology, 03 October 2013, Vol.168(3), pp.2673-2677 [Peer Reviewed Journal]

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Knee Pain and Low Back Pain Additively Disturb Sleep in the General Population: A Cross-Sectional Analysis of the Nagahama Study

Murase, Kimihiko ; Tabara, Yasuharu ; Ito, Hiromu ; Kobayashi, Masahiko ; Takahashi, Yoshimitsu ; Setoh, Kazuya ; Kawaguchi, Takahisa ; Muro, Shigeo ; Kadotani, Hiroshi ; Kosugi, Shinji ; Sekine, Akihiro ; Yamada, Ryo ; Nakayama, Takeo ; Mishima, Michiaki ; Matsuda, Shuichi ; Matsuda, Fumihiko ; Chin, Kazuo

PLoS One, Oct 2015, Vol.10(10), p.e0140058 [Peer Reviewed Journal]

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Combined association of clinical and lifestyle factors with non-restorative sleep: The Nagahama Study

Matsumoto, Takeshi ; Tabara, Yasuharu ; Murase, Kimihiko ; Takahashi, Yoshimitsu ; Setoh, Kazuya ; Kawaguchi, Takahisa ; Muro, Shigeo ; Kadotani, Hiroshi ; Kosugi, Shinji ; Sekine, Akihiro ; Yamada, Ryo ; Nakayama, Takeo ; Mishima, Michiaki ; Matsuda, Fumihiko ; Chin, Kazuo

PLoS One, Mar 2017, Vol.12(3), p.e0171849 [Peer Reviewed Journal]

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Mastication and Risk for Diabetes in a Japanese Population: A Cross-Sectional Study

Yamazaki, Toru ; Yamori, Masashi ; Asai, Keita ; Nakano-Araki, Ikuko ; Yamaguchi, Akihiko ; Takahashi, Katsu ; Sekine, Akihiro ; Matsuda, Fumihiko ; Kosugi, Shinji ; Nakayama, Takeo ; Inagaki, Nobuya ; Bessho, Kazuhisa

PLoS One, Jun 2013, Vol.8(6), p.e64113 [Peer Reviewed Journal]

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An enantioselective formal synthesis of 4-demethoxydaunomycin using the catalytic asymmetric ring opening reaction of meso-epoxide with p-anisidine

Sekine, Akihiro ; Ohshima, Takashi ; Shibasaki, Masakatsu

Tetrahedron, 2002, Vol.58(1), pp.75-82 [Peer Reviewed Journal]

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Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease

Hotta, Kikuko ; Yoneda, Masato ; Hyogo, Hideyuki ; Ochi, Hidenori ; Mizusawa, Seiho ; Ueno, Takato ; Chayama, Kazuaki ; Nakajima, Atsushi ; Nakao, Kazuwa ; Sekine, Akihiro

BMC Medical Genetics, 2010, Vol.11(1), p.172 [Peer Reviewed Journal]

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IKZF1, a new susceptibility gene for cold medicine–related Stevens-Johnson syndrome/toxic epidermal necrolysis with severe mucosal involvement

Ueta, Mayumi ; Sawai, Hiromi ; Sotozono, Chie ; Hitomi, Yuki ; Kaniwa, Nahoko ; Kim, Mee Kum ; Seo, Kyoung Yul ; Yoon, Kyung-Chul ; Joo, Choun-Ki ; Kannabiran, Chitra ; Wakamatsu, Tais Hitomi ; Sangwan, Virender ; Rathi, Varsha ; Basu, Sayan ; Ozeki, Takeshi ; Mushiroda, Taisei ; Sugiyama, Emiko ; Maekawa, Keiko ; Nakamura, Ryosuke ; Aihara, Michiko

The Journal of Allergy and Clinical Immunology, June 2015, Vol.135(6), pp.1538-1545.e17 [Peer Reviewed Journal]

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Prevalence of postmicturition urinary incontinence in J apanese men: Comparison with other types of incontinence

Yoshimura, Koji ; Nakayama, Takeo ; Sekine, Akihiro ; Matsuda, Fumihiko ; Kosugi, Shinji ; Sugino, Yoshio ; Yoshimura, Kenichi ; Ogawa, Osamu

International Journal of Urology, September 2013, Vol.20(9), pp.911-916 [Peer Reviewed Journal]

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Development of new asymmetric two-center catalysts in phase-transfer reactions

Shibuguchi, Tomoyuki ; Fukuta, Yuhei ; Akachi, Yoko ; Sekine, Akihiro ; Ohshima, Takashi ; Shibasaki, Masakatsu

Tetrahedron Letters, 2002, Vol.43(52), pp.9539-9543 [Peer Reviewed Journal]

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Stable, Storable, and Reusable Asymmetric Catalyst:  A Novel La-linked-BINOL Complex for the Catalytic Asymmetric Michael Reaction
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Stable, Storable, and Reusable Asymmetric Catalyst:  A Novel La-linked-BINOL Complex for the Catalytic Asymmetric Michael Reaction

Kim, Yun Sik ; Matsunaga, Shigeki ; Das, Jagattaran ; Sekine, Akihiro ; Ohshima, Takashi ; Shibasaki, Masakatsu

Journal of the American Chemical Society, 07/2000, Vol.122(27), pp.6506-6507 [Peer Reviewed Journal]

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B‐type natriuretic peptide as an independent correlate of nocturnal voiding in Japanese women

Yoshimura, Koji ; Nakayama, Takeo ; Sekine, Akihiro ; Matsuda, Fumihiko ; Kosugi, Shinji ; Yamada, Ryo ; Shimizu, Yosuke ; Kanematsu, Akihiro ; Yoshimura, Kenichi ; Ogawa, Osamu

Neurourology and Urodynamics, November 2012, Vol.31(8), pp.1266-1271 [Peer Reviewed Journal]

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Synergistic association of elevated serum free fatty acid and glucose levels with large arterial stiffness in a general population: The Nagahama Study

Tabara, Yasuharu ; Takahashi, Yoshimitsu ; Setoh, Kazuya ; Kawaguchi, Takahisa ; Gotoh, Norimoto ; Terao, Chikashi ; Yamada, Ryo ; Kosugi, Shinji ; Sekine, Akihiro ; Nakayama, Takeo ; Matsuda, Fumihiko

Metabolism, January 2016, Vol.65(1), pp.66-72 [Peer Reviewed Journal]

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14
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Association of Serum–Free Fatty Acid Level With Reduced Reflection Pressure Wave Magnitude and Central Blood Pressure: The Nagahama Study

Tabara, Yasuharu ; Takahashi, Yoshimitsu ; Kawaguchi, Takahisa ; Setoh, Kazuya ; Terao, Chikashi ; Yamada, Ryo ; Kosugi, Shinji ; Sekine, Akihiro ; Nakayama, Takeo ; Matsuda, Fumihiko

Hypertension, 2014, Vol.64(6), pp.1212-1218 [Peer Reviewed Journal]

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Evolution of multi-drug resistant HCV clones from pre-existing resistant-associated variants during direct-acting antiviral therapy determined by third-generation sequencing

Takeda, Haruhiko ; Ueda, Yoshihide ; Inuzuka, Tadashi ; Yamashita, Yukitaka ; Osaki, Yukio ; Nasu, Akihiro ; Umeda, Makoto ; Takemura, Ryo ; Seno, Hiroshi ; Sekine, Akihiro ; Marusawa, Hiroyuki

Scientific Reports (Nature Publisher Group), Mar 2017, Vol.7, p.45605 [Peer Reviewed Journal]

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16
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Genetic variations in the gene encoding ELMO1 are associated with susceptibility to diabetic nephropathy

Shimazaki, Atsuyuki ; Kawamura, Yoshihiro ; Kanazawa, Akio ; Sekine, Akihiro ; Saito, Susumu ; Tsunoda, Tatsuhiko ; Koya, Daisuke ; Babazono, Tetsuya ; Tanaka, Yasushi ; Matsuda, Masafumi ; Kawai, Koichi ; Iiizumi, Tomohiro ; Imanishi, Masahito ; Shinosaki, Toshihiro ; Yanagimoto, Toru ; Ikeda, Minoru ; Omachi, Shigeki ; Kashiwagi, Atsunori ; Kaku, Kohei ; Iwamoto

Diabetes, April 2005, Vol.54(4), pp.1171-8 [Peer Reviewed Journal]

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17
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Association of solute carrier family 12 (sodium/chloride) member 3 with diabetic nephropathy, identified by genome-wide analyses of single nucleotide polymorphisms

Tanaka, Nobue ; Babazono, Tetsuya ; Saito, Susumu ; Sekine, Akihiro ; Tsunoda, Tatsuhiko ; Haneda, Masakazu ; Tanaka, Yasushi ; Fujioka, Tomoaki ; Kaku, Kohei ; Kawamori, Ryuzou ; Kikkawa, Ryuichi ; Iwamoto, Yasuhiko ; Nakamura, Yusuke ; Maeda, Shiro

Diabetes, November 2003, Vol.52(11), pp.2848-53 [Peer Reviewed Journal]

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18
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An efficient method for the synthesis of versatile intermediates leading to 13-deoxy- and 9,13-dideoxyphorbols

Sekine, Akihiro ; Kumagai, Naoya ; Uotsu, Koichiro ; Ohshima, Takashi ; Shibasaki, Masakatsu

Tetrahedron Letters, 2000, Vol.41(4), pp.509-513 [Peer Reviewed Journal]

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19
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Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease

Hotta, Kikuko ; Yoneda, Masato ; Hyogo, Hideyuki ; Ochi, Hidenori ; Mizusawa, Seiho ; Ueno, Takato ; Chayama, Kazuaki ; Nakajima, Atsushi ; Nakao, Kazuwa ; Sekine, Akihiro

BMC Medical Genetics, 2010, Vol.11, p.172 [Peer Reviewed Journal]

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20
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Genome-wide scan revealed that polymorphisms in the PNPLA3 , SAMM50 , and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan

Kitamoto, Takuya ; Kitamoto, Aya ; Yoneda, Masato ; Hyogo, Hideyuki ; Ochi, Hidenori ; Nakamura, Takahiro ; Teranishi, Hajime ; Mizusawa, Seiho ; Ueno, Takato ; Chayama, Kazuaki ; Nakajima, Atsushi ; Nakao, Kazuwa ; Sekine, Akihiro ; Hotta, Kikuko

Human Genetics, 2013, Vol.132(7), pp.783-792 [Peer Reviewed Journal]

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21
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Dietary habits associated with reduced insulin resistance: The Nagahama study

Ikeda, Kaori ; Sato, Tosiya ; Nakayama, Takeo ; Tanaka, Daisuke ; Nagashima, Kazuaki ; Mano, Fumika ; Joo, Erina ; Fujimoto, Shimpei ; Takahashi, Yoshimitsu ; Kosugi, Shinji ; Sekine, Akihiro ; Tabara, Yasuharu ; Matsuda, Fumihiko ; Inagaki, Nobuya

Diabetes Research and Clinical Practice, July 2018, Vol.141, pp.26-34 [Peer Reviewed Journal]

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22
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Gastroesophageal reflux disease symptoms and dietary behaviors are significant correlates of short sleep duration in the general population: the Nagahama Study

Murase, Kimihiko ; Tabara, Yasuharu ; Takahashi, Yoshimitsu ; Muro, Shigeo ; Yamada, Ryo ; Setoh, Kazuya ; Kawaguchi, Takahisa ; Kadotani, Hiroshi ; Kosugi, Shinji ; Sekine, Akihiro ; Nakayama, Takeo ; Mishima, Michiaki ; Chiba, Tsutomu ; Chin, Kazuo ; Matsuda, Fumihiko

Sleep, 01 November 2014, Vol.37(11), pp.1809-15 [Peer Reviewed Journal]

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23
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Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels

Setoh, Kazuya ; Terao, Chikashi ; Muro, Shigeo ; Kawaguchi, Takahisa ; Tabara, Yasuharu ; Takahashi, Meiko ; Nakayama, Takeo ; Kosugi, Shinji ; Sekine, Akihiro ; Yamada, Ryo ; Mishima, Michiaki ; Matsuda, Fumihiko

Nature Communications, Jul 2015, Vol.6, p.7754 [Peer Reviewed Journal]

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24
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Association Between Antinuclear Antibodies and the HLA Class II Locus and Heterogeneous Characteristics of Staining Patterns: The Nagahama Study

Terao, Chikashi ; Ohmura, Koichiro ; Yamada, Ryo ; Kawaguchi, Takahisa ; Shimizu, Masakazu ; Tabara, Yasuharu ; Takahashi, Meiko ; Setoh, Kazuya ; Nakayama, Takeo ; Kosugi, Shinji ; Sekine, Akihiro ; Matsuda, Fumihiko ; Mimori, Tsuneyo

Arthritis & Rheumatology, Dec 2014, Vol.66(12), pp.3395-3403 [Peer Reviewed Journal]

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25
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Association Between Antinuclear Antibodies and the HLA Class II Locus and Heterogeneous Characteristics of Staining Patterns: The Nagahama Study

Terao, Chikashi ; Ohmura, Koichiro ; Yamada, Ryo ; Kawaguchi, Takahisa ; Shimizu, Masakazu ; Tabara, Yasuharu ; Takahashi, Meiko ; Setoh, Kazuya ; Nakayama, Takeo ; Kosugi, Shinji ; Sekine, Akihiro ; Matsuda, Fumihiko ; Mimori, Tsuneyo

Arthritis & Rheumatology, December 2014, Vol.66(12), pp.3395-3403 [Peer Reviewed Journal]

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26
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Effects of Smoking and Shared Epitope on the Production of Anti–Citrullinated Peptide Antibody in a Japanese Adult Population

Terao, Chikashi ; Ohmura, Koichiro ; Ikari, Katsunori ; Kawaguchi, Takahisa ; Takahashi, Meiko ; Setoh, Kazuya ; Nakayama, Takeo ; Kosugi, Shinji ; Sekine, Akihiro ; Tabara, Yasuharu ; Taniguchi, Atsuo ; Momohara, Shigeki ; Yamanaka, Hisashi ; Yamada, Ryo ; Matsuda, Fumihiko ; Mimori, Tsuneyo

Arthritis Care & Research, December 2014, Vol.66(12), pp.1818-1827 [Peer Reviewed Journal]

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27
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Relationship Among Chlamydia and Mycoplasma Pneumoniae Seropositivity, IKZF1 Genotype and Chronic Obstructive Pulmonary Disease in A General Japanese Population: The Nagahama Study

Muro, Shigeo ; Tabara, Yasuharu ; Matsumoto, Hisako ; Setoh, Kazuya ; Kawaguchi, Takahisa ; Takahashi, Meiko ; Ito, Isao ; Ito, Yutaka ; Murase, Kimihiko ; Terao, Chikashi ; Kosugi, Shinji ; Yamada, Ryo ; Sekine, Akihiro ; Nakayama, Takeo ; Chin, Kazuo ; Mishima, Michiaki ; Matsuda, Fumihiko

Medicine, 2016, Vol.95(15), pp.e3371-e3371 [Peer Reviewed Journal]

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28
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Risks and Cough-Aggravating Factors in Prolonged Cough: Epidemiological Observations from the Nagahama Cohort Study

Matsumoto, Hisako ; Izuhara, Yumi ; Niimi, Akio ; Tabara, Yasuharu ; Nagasaki, Tadao ; Kanemitsu, Yoshihiro ; Murase, Kimihiko ; Oguma, Tsuyoshi ; Ito, Isao ; Muro, Shigeo ; Sekine, Akihiro ; Matsuda, Fumihiko ; Kosugi, Shinji ; Nakayama, Takeo ; Chin, Kazuo ; Mishima, Michiaki

Annals of the American Thoracic Society, May 2017, Vol.14(5), pp.698-705 [Peer Reviewed Journal]

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29
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Complete Genome Sequences of Eight Helicobacter pylori Strains with Different Virulence Factor Genotypes and Methylation Profiles, Isolated from Patients with Diverse Gastrointestinal Diseases on Okinawa Island, Japan, Determined Using PacBio Single-Molecule Real-Time Technology

Satou, Kazuhito ; Shiroma, Akino ; Teruya, Kuniko ; Shimoji, Makiko ; Nakano, Kazuma ; Juan, Ayaka ; Tamotsu, Hinako ; Terabayashi, Yasunobu ; Aoyama, Misako ; Teruya, Morimi ; Suzuki, Rumiko ; Matsuda, Miyuki ; Sekine, Akihiro ; Kinjo, Nagisa ; Kinjo, Fukunori ; Yamaoka, Yoshio ; Hirano, Takashi

Genome announcements, 17 April 2014, Vol.2(2) [Peer Reviewed Journal]

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30
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Airflow limitation in smokers is associated with arterial stiffness: The Nagahama Study

Tabara, Yasuharu ; Muro, Shigeo ; Takahashi, Yoshimitsu ; Setoh, Kazuya ; Kawaguchi, Takahisa ; Terao, Chikashi ; Kosugi, Shinji ; Sekine, Akihiro ; Yamada, Ryo ; Nakayama, Takeo ; Mishima, Michiaki ; Matsuda, Fumihiko

Atherosclerosis, January 2014, Vol.232(1), pp.59-64 [Peer Reviewed Journal]

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31
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Analysis of single‐nucleotide polymorphisms in Japanese rheumatoid arthritis patients shows additional susceptibility markers besides the classic shared epitope susceptibility sequences

Kochi, Yuta ; Yamada, Ryo ; Kobayashi, Kyoko ; Takahashi, Atsushi ; Suzuki, Akari ; Sekine, Akihiro ; Mabuchi, Akihiko ; Akiyama, Fumihiro ; Tsunoda, Tatsuhiko ; Nakamura, Yusuke ; Yamamoto, Kazuhiko

Arthritis & Rheumatism, January 2004, Vol.50(1), pp.63-71 [Peer Reviewed Journal]

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32
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Significant association of periodontal disease with anti-citrullinated peptide antibody in a Japanese healthy population – The Nagahama study

Terao, Chikashi ; Asai, Keita ; Hashimoto, Motomu ; Yamazaki, Toru ; Ohmura, Koichiro ; Yamaguchi, Akihiko ; Takahashi, Katsu ; Takei, Noriko ; Ishii, Takanori ; Kawaguchi, Takahisa ; Tabara, Yasuharu ; Takahashi, Meiko ; Nakayama, Takeo ; Kosugi, Shinji ; Sekine, Akihiro ; Fujii, Takao ; Yamada, Ryo ; Mimori, Tsuneyo ; Matsuda, Fumihiko ; Bessho, Kazuhisa

Journal of Autoimmunity, May 2015, Vol.59, pp.85-90 [Peer Reviewed Journal]

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33
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Tooth Loss and Atherosclerosis: The Nagahama Study

Asai, K ; Yamori, M ; Yamazaki, T ; Yamaguchi, A ; Takahashi, K ; Sekine, A ; Kosugi, S ; Matsuda, F ; Nakayama, T ; Bessho, K ; Asai, Keita ; Yamazaki, Toru ; Yamori, Masashi ; Sakata-Goto, Tomoko ; Kiso, Honoka ; Takahashi, Katsu ; Bessho, Kazuhisa ; Mizusawa, Seiho ; Sekine, Akihiro ; Kawaguchi, Takahisa

Journal of Dental Research, March 2015, Vol.94(3_suppl), pp.52S-58S [Peer Reviewed Journal]

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34
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Hypothalamic AMP-Activated Protein Kinase Regulates Biphasic Insulin Secretion from Pancreatic β Cells during Fasting and in Type 2 Diabetes

Kume, Shinji ; Kondo, Motoyuki ; Maeda, Shiro ; Nishio, Yoshihiko ; Yanagimachi, Tsuyoshi ; Fujita, Yukihiro ; Haneda, Masakazu ; Kondo, Keiko ; Sekine, Akihiro ; Araki, Shin-Ich ; Araki, Hisazumi ; Chin-Kanasaki, Masami ; Ugi, Satoshi ; Koya, Daisuke ; Kitahara, Sawako ; Maeda, Kiyosumi ; Kashiwagi, Atsunori ; Uzu, Takashi ; Maegawa, Hiroshi

EBioMedicine, November 2016, Vol.13, pp.168-180 [Peer Reviewed Journal]

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35
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Large-Scale Single-Nucleotide Polymorphism (SNP) and Haplotype Analyses, Using Dense SNP Maps, of 199 Drug-Related Genes in 752 Subjects: the Analysis of the Association between Uncommon SNPs within Haplotype Blocks and the Haplotypes Constructed with Haplotype-Tagging SNPs

Kamatani, Naoyuki ; Sekine, Akihiro ; Kitamoto, Takuya ; Iida, Aritoshi ; Saito, Susumu ; Kogame, Akifumi ; Inoue, Eisuke ; Kawamoto, Manabu ; Harigai, Masayoshi ; Nakamura, Yusuke

The American Journal of Human Genetics, 2004, Vol.75(2), pp.190-203 [Peer Reviewed Journal]

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