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Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis

Scapin, Giovanna ; Dandey, Venkata P ; Zhang, Zhening ; Prosise, Winifred ; Hruza, Alan ; Kelly, Theresa ; Mayhood, Todd ; Strickland, Corey ; Potter, Clinton S ; Carragher, Bridget

Nature, 05 April 2018, Vol.556(7699), pp.122-125 [Peer Reviewed Journal]

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Molecular replacement then and now

Scapin, Giovanna

Acta Crystallographica Section D, 01 November 2013, Vol.69(11), pp.2266-2275 [Peer Reviewed Journal]

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Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes

Biftu, Tesfaye ; Sinha-Roy, Ranabir ; Chen, Ping ; Qian, Xiaoxia ; Feng, Dennis ; Kuethe, Jeffrey T ; Scapin, Giovanna ; Gao, Ying Duo ; Yan, Youwei ; Krueger, Davida ; Bak, Annette ; Eiermann, George ; He, Jiafang ; Cox, Jason ; Hicks, Jacqueline ; Lyons, Kathy ; He, Huaibing ; Salituro, Gino ; Tong, Sharon ; Patel

Journal of medicinal chemistry, 24 April 2014, Vol.57(8), pp.3205-12 [Peer Reviewed Journal]

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Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors

Pissarnitski, Dmitri A ; Zhao, Zhiqiang ; Cole, David ; Wu, Wen-Lian ; Domalski, Martin ; Clader, John W ; Scapin, Giovanna ; Voigt, Johannes ; Soriano, Aileen ; Kelly, Theresa ; Powles, Mary Ann ; Yao, Zuliang ; Burnett, Duane A

Bioorganic & Medicinal Chemistry, 01 November 2016, Vol.24(21), pp.5534-5545 [Peer Reviewed Journal]

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A novel storage system for cryoEM samples

Scapin, Giovanna ; Prosise, Winifred W ; Wismer, Michael K ; Strickland, Corey

Journal of Structural Biology, July 2017, Vol.199(1), pp.84-86 [Peer Reviewed Journal]

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Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase

Walker, Scott ; Labroli, Marc ; Painter, Ronald ; Wiltsie, Judyann ; Sherborne, Brad ; Murgolo, Nicholas ; Sher, Xinwei ; Mann, Paul ; Zuck, Paul ; Garlisi, Charles ; Su, Jing ; Kargman, Stacia ; Li, Xiao ; Scapin, Giovanna ; Salowe, Scott ; Devito, Kristine ; Sheth, Payal ; Buist, Nichole ; Tan, Christopher ; Black

PLoS One, Jul 2017, Vol.12(7), p.e0180965 [Peer Reviewed Journal]

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Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab

Scapin, Giovanna ; Yang, Xiaoyu ; Prosise, Winifred W ; Mccoy, Mark ; Reichert, Paul ; Johnston, Jennifer M ; Kashi, Ramesh S ; Strickland, Corey

Nature structural & molecular biology, December 2015, Vol.22(12), pp.953-8 [Peer Reviewed Journal]

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The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity

Cirilli, Maurizio ; Zheng, Renjian ; Scapin, Giovanna ; Blanchard, John S

Biochemistry, 16 September 2003, Vol.42(36), pp.10644-50 [Peer Reviewed Journal]

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Residues distant from the active site influence protein-tyrosine phosphatase 1B inhibitor binding

Montalibet, Jacqueline ; Skorey, Kathryn ; Mckay, Dan ; Scapin, Giovanna ; Asante-Appiah, Ernest ; Kennedy, Brian P

The Journal of biological chemistry, 24 February 2006, Vol.281(8), pp.5258-66 [Peer Reviewed Journal]

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Interaction of Pyridine Nucleotide Substrates with Escherichia coli Dihydrodipicolinate Reductase:  Thermodynamic and Structural Analysis of Binary Complexes † , ‡
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Interaction of Pyridine Nucleotide Substrates with Escherichia coli Dihydrodipicolinate Reductase:  Thermodynamic and Structural Analysis of Binary Complexes † , ‡

Reddy, Sreelatha G. ; Scapin, Giovanna ; Blanchard, John S.

Biochemistry, 01/1996, Vol.35(41), pp.13294-13302 [Peer Reviewed Journal]

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Three-Dimensional Structure of Escherichia coli Dihydrodipicolinate Reductase in Complex with NADH and the Inhibitor 2,6-Pyridinedicarboxylate † , ‡
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Three-Dimensional Structure of Escherichia coli Dihydrodipicolinate Reductase in Complex with NADH and the Inhibitor 2,6-Pyridinedicarboxylate † , ‡

Scapin, Giovanna ; Reddy, Sreelatha G. ; Zheng, Renjian ; Blanchard, John S.

Biochemistry, 12/1997, Vol.36(49), pp.15081-15088 [Peer Reviewed Journal]

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12
Three-Dimensional Structure of meso -Diaminopimelic Acid Dehydrogenase from Corynebacterium glutamicum † , ‡
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Three-Dimensional Structure of meso -Diaminopimelic Acid Dehydrogenase from Corynebacterium glutamicum † , ‡

Scapin, Giovanna ; Reddy, Sreelatha G. ; Blanchard, John S.

Biochemistry, 01/1996, Vol.35(42), pp.13540-13551 [Peer Reviewed Journal]

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13
Structural Symmetry:  The Three-Dimensional Structure of Haemophilus Influenzae Diaminopimelate Epimerase † , ‡
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Structural Symmetry:  The Three-Dimensional Structure of Haemophilus Influenzae Diaminopimelate Epimerase † , ‡

Cirilli, Maurizio ; Zheng, Renjian ; Scapin, Giovanna ; Blanchard, John S.

Biochemistry, 11/1998, Vol.37(47), pp.16452-16458 [Peer Reviewed Journal]

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14
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Functional characterization and crystal structure of the C215D mutant of protein-tyrosine phosphatase-1B

Romsicki, Yolanda ; Scapin, Giovanna ; Beaulieu-Audy, Veronique ; Patel, Sangita ; Becker, Joseph W ; Kennedy, Brian P ; Asante-Appiah, Ernest

The Journal of biological chemistry, 01 August 2003, Vol.278(31), pp.29009-15 [Peer Reviewed Journal]

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A comparative study of the binding properties, dipeptidyl peptidase‐4 (DPP‐4) inhibitory activity and glucose‐lowering efficacy of the DPP‐4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice

Berger, Joel P. ; Sinharoy, Ranabir ; Pocai, Alessandro ; Kelly, Theresa M. ; Scapin, Giovanna ; Gao, Ying‐Duo ; Pryor, Kelly Ann D. ; Wu, Joseph K. ; Eiermann, George J. ; Xu, Shiyao S. ; Zhang, Xiaoping ; Tatosian, Daniel A. ; Weber, Ann E. ; Thornberry, Nancy A. ; Carr, Richard D.

Endocrinology, Diabetes & Metabolism, January 2018, Vol.1(1), pp.n/a-n/a [Peer Reviewed Journal]

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16
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Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®

Blizzard, Timothy A ; Chen, Helen ; Kim, Seongkon ; Wu, Jane ; Bodner, Rena ; Gude, Candido ; Imbriglio, Jason ; Young, Katherine ; Park, Young-Whan ; Ogawa, Aimie ; Raghoobar, Susan ; Hairston, Nichelle ; Painter, Ronald E ; Wisniewski, Doug ; Scapin, Giovanna ; Fitzgerald, Paula ; Sharma, Nandini ; Lu, Jun ; Ha, Sookhee ; Hermes, Jeff

Bioorganic & Medicinal Chemistry Letters, 01 February 2014, Vol.24(3), pp.780-785 [Peer Reviewed Journal]

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17
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The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors

Cox, Jason M ; Chu, Hong D ; Kuethe, Jeffrey T ; Gao, Ying-Duo ; Scapin, Giovanna ; Eiermann, George ; He, Huaibing ; Li, Xiaohua ; Lyons, Kathryn A ; Metzger, Joseph ; Petrov, Aleksandr ; Wu, Joseph K ; Xu, Shiyao ; Sinha-Roy, Ranabir ; Weber, Ann E ; Biftu, Tesfaye

Bioorganic & Medicinal Chemistry Letters, 01 June 2016, Vol.26(11), pp.2622-2626 [Peer Reviewed Journal]

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18
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Corrigendum to “Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(4,6-dihydropyrrolo[3,4-c]pyrazol-5-(1H)-yl)tetrahydro-2H-pyran-3-amine (23)” [Bioorg. Med. Chem. Lett. 23 (2013) 5361–5366]

Biftu, Tesfaye ; Qian, Xiaoxia ; Chen, Ping ; Feng, Dennis ; Scapin, Giovanna ; Gao, Ying-Duo ; Cox, Jason ; Roy, Ranabir Sinha ; Eiermann, George ; He, Huabing ; Lyons, Kathy ; Salituro, Gino ; Patel, Sangita ; Petrov, Alexander ; Xu, Feng ; Xu, Shiyao Sherrie ; Zhang, Bei ; Caldwell, Charles ; Wu, Joseph K ; Lyons, Kathy

Bioorganic & Medicinal Chemistry Letters, 01 June 2014, Vol.24(11), pp.2590-2590 [Peer Reviewed Journal]

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19
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Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine (23)

Biftu, Tesfaye ; Qian, Xiaoxia ; Chen, Ping ; Feng, Dennis ; Scapin, Giovanna ; Gao, Ying-Duo ; Cox, Jason ; Sinha Roy, Ranabir ; Eiermann, George ; He, Huabing ; Lyons, Kathy ; Salituro, Gino ; Patel, Sangita ; Petrov, Alexander ; Xu, Feng ; Xu, Shiyao Sherrie ; Zhang, Bei ; Caldwell, Charles ; Wu, Joseph K ; Lyons, Kathy

Bioorganic & Medicinal Chemistry Letters, 01 October 2013, Vol.23(19), pp.5361-5366 [Peer Reviewed Journal]

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20
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Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712

Chen, Helen ; Blizzard, Timothy A ; Kim, Seongkon ; Wu, Jane ; Young, Katherine ; Park, Young-Whan ; Ogawa, Aimie M ; Raghoobar, Susan ; Painter, Ronald E ; Wisniewski, Doug ; Hairston, Nichelle ; Fitzgerald, Paula ; Sharma, Nandini ; Scapin, Giovanna ; Lu, Jun ; Hermes, Jeff ; Hammond, Milton L

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(14), pp.4267-4270 [Peer Reviewed Journal]

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21
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Primary Structure and Crystallization of Orotate Phosphoribosyltransferase from Salmonella typhimurium

Scapin, Giovanna ; Sacchettini, James C ; Dessen, Andrea ; Bhatia, Mohit ; Grubmeyer, Charles

Journal of Molecular Biology, 20 April 1993, Vol.230(4), pp.1304-1308 [Peer Reviewed Journal]

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22
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Best practices for managing large CryoEM facilities

Alewijnse, Bart ; Ashton, Alun W ; Chambers, Melissa G ; Chen, Songye ; Cheng, Anchi ; Ebrahim, Mark ; Eng, Edward T ; Hagen, Wim J.H ; Koster, Abraham J ; López, Claudia S ; Lukoyanova, Natalya ; Ortega, Joaquin ; Renault, Ludovic ; Reyntjens, Steve ; Rice, William J ; Scapin, Giovanna ; Schrijver, Raymond ; Siebert, Alistair ; Stagg, Scott M

Journal of Structural Biology, September 2017, Vol.199(3), pp.225-236 [Peer Reviewed Journal]

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23
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Structure–activity-relationship of amide and sulfonamide analogs of omarigliptin

Chen, Ping ; Feng, Dennis ; Qian, Xiaoxia ; Apgar, James ; Wilkening, Robert ; Kuethe, Jeffrey T ; Gao, Ying-Duo ; Scapin, Giovanna ; Cox, Jason ; Doss, George ; Eiermann, George ; He, Huaibing ; Li, Xiaohua ; Lyons, Kathryn A ; Metzger, Joseph ; Petrov, Aleksandr ; Wu, Joseph K ; Xu, Shiyao ; Weber, Ann E ; Yan, Youwei

Bioorganic & Medicinal Chemistry Letters, 15 December 2015, Vol.25(24), pp.5767-5771 [Peer Reviewed Journal]

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24
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Routine Single Particle CryoEM Sample and Grid Characterization by Tomography

Noble, Alex ; Dandey, Venkata ; Wei, Hui ; Brasch, Julia ; Chase, Jillian ; Acharya, Priyamvada ; Zhang, Zhening ; Kim, Laura ; Scapin, Giovanna ; Rapp, Micah ; Eng, Edward ; Rice, William ; Cheng, Anchi ; Negro, Carl ; Shapiro, Lawrence ; Kwong, Peter ; Jeruzalmi, David ; Potter, Clinton ; Carragher, Bridget Carragher, Bridget (pacrepositoryorg)

BioRxiv, Dec 11, 2017

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25
Three-Dimensional Structure of the Inosine−Uridine Nucleoside N -Ribohydrolase from Crithidia fasciculata † , ‡
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Three-Dimensional Structure of the Inosine−Uridine Nucleoside N -Ribohydrolase from Crithidia fasciculata † , ‡

Degano, Massimo ; Gopaul, Deshmukh N. ; Scapin, Giovanna ; Schramm, Vern L. ; Sacchettini, James C.

Biochemistry, 01/1996, Vol.35(19), pp.5971-5981 [Peer Reviewed Journal]

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26
Crystal Structure of 3-Amino-5-hydroxybenzoic Acid (AHBA) Synthase † , ‡
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Crystal Structure of 3-Amino-5-hydroxybenzoic Acid (AHBA) Synthase † , ‡

Eads, Janina C. ; Beeby, Morgan ; Scapin, Giovanna ; Yu, Tin-Wein ; Floss, Heinz G.

Biochemistry, 08/1999, Vol.38(31), pp.9840-9849 [Peer Reviewed Journal]

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27
Substrate and Inhibitor Binding Sites in Corynebacterium glutamicum Diaminopimelate Dehydrogenase † , ‡
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Substrate and Inhibitor Binding Sites in Corynebacterium glutamicum Diaminopimelate Dehydrogenase † , ‡

Scapin, Giovanna ; Cirilli, Maurizio ; Reddy, Sreelatha G. ; Gao, Yong ; Vederas, John C. ; Blanchard, John S.

Biochemistry, 03/1998, Vol.37(10), pp.3278-3285 [Peer Reviewed Journal]

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28
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Crystallization of κ-bungarotoxin: Preliminary X-ray data obtained from the venom-derived protein

Sachettini, James C ; Patel, Sangita ; Scapin, Giovanna ; Fiordalisi, James J ; Grant, Gregory A

Journal of Molecular Biology, 1992, Vol.226(2), pp.559-562 [Peer Reviewed Journal]

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29
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Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase

Asante-Appiah, Ernest ; Patel, Sangita ; Desponts, Caroline ; Taylor, Jillian M ; Lau, Cheuk ; Dufresne, Claude ; Therien, Michel ; Friesen, Rick ; Becker, Joseph W ; Leblanc, Yves ; Kennedy, Brian P ; Scapin, Giovanna

The Journal of biological chemistry, 24 March 2006, Vol.281(12), pp.8010-5 [Peer Reviewed Journal]

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30
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Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity

Scapin, Giovanna ; Patel, Sangita B ; Chung, Christine ; Varnerin, Jeffrey P ; Edmondson, Scott D ; Mastracchio, Anthony ; Parmee, Emma R ; Singh, Suresh B ; Becker, Joseph W ; Van Der Ploeg, Lex H T ; Tota, Michael R

Biochemistry, 25 May 2004, Vol.43(20), pp.6091-100 [Peer Reviewed Journal]

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31
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The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates

Asante-Appiah, Ernest ; Patel, Sangita ; Dufresne, Claude ; Roy, Patrick ; Wang, Qingping ; Patel, Vira ; Friesen, Richard W ; Ramachandran, Chidambaram ; Becker, Joseph W ; Leblanc, Yves ; Kennedy, Brian P ; Scapin, Giovanna

Biochemistry, 23 July 2002, Vol.41(29), pp.9043-51 [Peer Reviewed Journal]

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32
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Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors

Bogen, Stéphane L ; Pan, Weidong ; Gibeau, Craig R ; Lahue, Brian R ; Ma, Yao ; Nair, Latha G ; Seigel, Elise ; Shipps, Gerald W ; Tian, Yuan ; Wang, Yaolin ; Lin, Yinghui ; Liu, Ming ; Liu, Suxing ; Mirza, Asra ; Wang, Xiaoying ; Lipari, Philip ; Seidel-Dugan, Cynthia ; Hicklin, Daniel J ; Bishop, W. Robert ; Rindgen, Diane ; Nomeir, Amin ; Prosise, Winifred ; Reichert, Paul ; Scapin, Giovanna ; Strickland, Corey ; Doll, Ronald J Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

ACS Medicinal Chemistry Letters, 10 March 2016, Vol.7(3) [Peer Reviewed Journal]

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33
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Routine single particle CryoEM sample and grid characterization by tomography

Noble, Alex J ; Dandey, Venkata P ; Wei, Hui ; Brasch, Julia ; Chase, Jillian ; Acharya, Priyamvada ; Tan, Yong Zi ; Zhang, Zhening ; Kim, Laura Y ; Scapin, Giovanna ; Rapp, Micah ; Eng, Edward T ; Rice, William J ; Cheng, Anchi ; Negro, Carl J ; Shapiro, Lawrence ; Kwong, Peter D ; Jeruzalmi, David ; Des Georges, Amedee ; Potter

eLife, 29 May 2018, Vol.7 [Peer Reviewed Journal]

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34
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Chicken liver basic fatty acid-binding protein (p I = 9.0) Purification, crystallization and preliminary X-ray data

Scapin, Giovanna ; Spadon, Paola ; Pengo, Licia ; Mammi, Mario ; Zanotti, Giuseppe ; Monaco, Hugo L

FEBS Letters, 1988, Vol.240(1), pp.196-200 [Peer Reviewed Journal]

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35
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The three‐dimensional structure of MAP kinase p38β: different features of the ATP‐binding site in p38β compared with p38α

Patel, Sangita B. ; Cameron, Patricia M. ; O' Keefe, Stephen J. ; Frantz‐Wattley, Betsy ; Thompson, Jed ; O' Neill, Edward A. ; Tennis, Trevor ; Liu, Luping ; Becker, Joseph W. ; Scapin, Giovanna

Acta Crystallographica Section D, 01 August 2009, Vol.65(8), pp.777-785 [Peer Reviewed Journal]

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36
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Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines

Kim, Dooseop ; Kowalchick, Jennifer E ; Brockunier, Linda L ; Parmee, Emma R ; Eiermann, George J ; Fisher, Michael H ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathryn ; Scapin, Giovanna ; Patel, Sangita B ; Petrov, Aleksandr ; Pryor, Kellyann D ; Roy, Ranabir Sinha ; Wu, Joseph K ; Zhang, Xiaoping ; Wyvratt, Matthew J ; Zhang, Bei B ; Zhu, Lan ; Thornberry

Journal of medicinal chemistry, 14 February 2008, Vol.51(3), pp.589-602 [Peer Reviewed Journal]

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