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Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

Wu, Margaret ; Singh, Sheo B ; Wang, Jun ; Chung, Christine C ; Salituro, Gino ; Karanam, Bindhu V ; Lee, Sang Ho ; Powles, Maryann ; Ellsworth, Kenneth P ; Lassman, Michael E ; Miller, Corey ; Myers, Robert W ; Tota, Michael R ; Zhang, Bei B ; Li, Cai

Proceedings of the National Academy of Sciences of the United States of America, 29 March 2011, Vol.108(13), pp.5378-83 [Peer Reviewed Journal]

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Discovery of a small molecule insulin mimetic with antidiabetic activity in mice

Zhang, Bei ; Salituro, Gino ; Szalkowski, Deborah ; Li, Zhihua

Science, May 7, 1999, Vol.284(5416), pp.974-7 [Peer Reviewed Journal]

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Design, synthesis, and evaluation of conformationally restricted acetanilides as potent and selective β3 adrenergic receptor agonists for the treatment of overactive bladder

Moyes, Christopher R ; Berger, Richard ; Goble, Stephen D ; Harper, Bart ; Shen, Dong-Ming ; Wang, Liping ; Bansal, Alka ; Brown, Patricia N ; Chen, Airu S ; Dingley, Karen H ; Di Salvo, Jerry ; Fitzmaurice, Aileen ; Gichuru, Loise N ; Hurley, Amanda L ; Jochnowitz, Nina ; Miller, Randall R ; Mistry, Shruty ; Nagabukuro, Hiroshi ; Salituro, Gino M ; Sanfiz, Anthony ; Stevenson, Andra S ; Villa, Katherine ; Zamlynny, Beata ; Struthers, Mary ; Weber, Ann E ; Edmondson, Scott D

Journal of medicinal chemistry, 27 February 2014, Vol.57(4), pp.1437-53 [Peer Reviewed Journal]

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Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes

Biftu, Tesfaye ; Sinha-Roy, Ranabir ; Chen, Ping ; Qian, Xiaoxia ; Feng, Dennis ; Kuethe, Jeffrey T ; Scapin, Giovanna ; Gao, Ying Duo ; Yan, Youwei ; Krueger, Davida ; Bak, Annette ; Eiermann, George ; He, Jiafang ; Cox, Jason ; Hicks, Jacqueline ; Lyons, Kathy ; He, Huaibing ; Salituro, Gino ; Tong, Sharon ; Patel, Sangita ; Doss, George ; Petrov, Aleksandr ; Wu, Joseph ; Xu, Shiyao Sherrie ; Sewall, Charles ; Zhang, Xiaoping ; Zhang, Bei ; Thornberry, Nancy A ; Weber, Ann E

Journal of medicinal chemistry, 24 April 2014, Vol.57(8), pp.3205-12 [Peer Reviewed Journal]

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Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors

Imbriglio, Jason E ; Shen, Dong-Ming ; Liang, Rui ; Marby, Ken ; You, Ming ; Youm, Hye Won ; Feng, Zhe ; London, Clare ; Xiong, Yusheng ; Tata, Jim ; Verras, Andreas ; Garcia-Calvo, Margarita ; Song, Xuelei ; Addona, George H ; Mclaren, Dave G ; He, Timothy ; Murphy, Beth ; Metzger, Dan E ; Salituro, Gino ; Deckman, Diana ; Chen, Qing ; Jin, Xiaoling ; Stout, Steven J ; Wang, Sheng-Ping ; Wilsie, Larissa ; Palyha, Oksana ; Han, Seongah ; Hubbard, Brian K ; Previs, Stephen F ; Pinto, Shirly ; Taggart, Andrew

Journal of medicinal chemistry, 10 December 2015, Vol.58(23), pp.9345-53 [Peer Reviewed Journal]

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Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder

Edmondson, Scott D ; Zhu, Cheng ; Kar, Nam Fung ; Di Salvo, Jerry ; Nagabukuro, Hiroshi ; Sacre-Salem, Beatrice ; Dingley, Karen ; Berger, Richard ; Goble, Stephen D ; Morriello, Gregori ; Harper, Bart ; Moyes, Christopher R ; Shen, Dong-Ming ; Wang, Liping ; Ball, Richard ; Fitzmaurice, Aileen ; Frenkl, Tara ; Gichuru, Loise N ; Ha, Sookhee ; Hurley, Amanda L ; Jochnowitz, Nina ; Levorse, Dorothy ; Mistry, Shruty ; Miller, Randy R ; Ormes, James ; Salituro, Gino M ; Sanfiz, Anthony ; Stevenson, Andra S ; Villa, Katherine ; Zamlynny, Beata ; Green, Stuart ; Struthers, Mary ; Weber, Ann E

Journal of medicinal chemistry, 28 January 2016, Vol.59(2), pp.609-23 [Peer Reviewed Journal]

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Modulating Drug Release and Enhancing the Oral Bioavailability of Torcetrapib with Solid Lipid Dispersion Formulations

Liu, Yajun ; Salituro, Gino ; Lee, Keun-joong ; Bak, Annette ; Leung, Dennis H.

AAPS PharmSciTech, 2015, Vol.16(5), pp.1091-1100 [Peer Reviewed Journal]

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A novel series of indazole-/indole-based glucagon receptor antagonists

Lin, Songnian ; Zhang, Fengqi ; Jiang, Guoqiang ; Qureshi, Sajjad A ; Yang, Xiaodong ; Chicchi, Gary G ; Tota, Laurie ; Bansal, Alka ; Brady, Edward ; Trujillo, Maria ; Salituro, Gino ; Miller, Corey ; Tata, James R ; Zhang, Bei B ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 01 October 2015, Vol.25(19), pp.4143-4147 [Peer Reviewed Journal]

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Discovery of benzamides as potent human β3 adrenergic receptor agonists

Zhu, Cheng ; Kar, Nam F ; Li, Bing ; Costa, Melissa ; Dingley, Karen H ; Di Salvo, Jerry ; Ha, Sookhee N ; Hurley, Amanda L ; Li, Xiaofang ; Miller, Randy R ; Salituro, Gino M ; Struthers, Mary ; Weber, Ann E ; Hale, Jeffrey J ; Edmondson, Scott D

Bioorganic & Medicinal Chemistry Letters, 01 January 2016, Vol.26(1), pp.55-59 [Peer Reviewed Journal]

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3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists

Walsh, Shawn P ; Severino, Alexandra ; Zhou, Changyou ; He, Jiafang ; Liang, Gui-Bai ; Tan, Carina P ; Cao, Jin ; Eiermann, George J ; Xu, Ling ; Salituro, Gino ; Howard, Andrew D ; Mills, Sander G ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(11), pp.3390-3394 [Peer Reviewed Journal]

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Novel sesquiterpenoids from the fermentation of Xylaria persicaria are selective ligands for the NPY Y5 receptor

Smith, Cameron J ; Morin, Nancy R ; Bills, Gerald F ; Dombrowski, Anne W ; Salituro, Gino M ; Smith, Scott K ; Zhao, Annie ; Macneil, Douglas J

The Journal of organic chemistry, 12 July 2002, Vol.67(14), pp.5001-4 [Peer Reviewed Journal]

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12
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Biogenetically-modelled total syntheses (−)-nocardicin A and (−)-nocardicin G

Townsend, Craig A ; Salituro, Gino M ; Nguyen, Loan T ; Dinovi, Michael J

Tetrahedron Letters, 1986, Vol.27(33), pp.3819-3822 [Peer Reviewed Journal]

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Meridamycin: A novel nonimmunosuppressive FKBP12 ligand from streptomyces hygroscopicus

Salituro, Gino M ; Zink, Deborah L ; Dahl, Arlene ; Nielsen, Jennifer ; Wu, Elizabeth ; Huang, Leeyuan ; Kastner, Carolyn ; Dumont, Francis J

Tetrahedron Letters, 1995, Vol.36(7), pp.997-1000 [Peer Reviewed Journal]

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14
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Discovery of N-Aryl-2-acylindole human glucagon receptor antagonists

Sinz, Christopher ; Bittner, Amy ; Brady, Ed ; Candelore, Mari ; Dallas-Yang, Qing ; Ding, Victor ; Jiang, Guoqiang ; Lin, Zhen ; Qureshi, Sajjad ; Salituro, Gino ; Saperstein, Richard ; Shang, Jackie ; Szalkowski, Deborah ; Tota, Laurie ; Vincent, Stella ; Wright, Michael ; Xu, Shiyao ; Yang, Xiaodong ; Zhang, Bei ; Tata, James ; Kim, Ronald ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(23), pp.7124-7130 [Peer Reviewed Journal]

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15
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Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists

Liu, Weiguo ; Hussain, Zahid ; Zang, Yi ; Sweis, Ramzi F ; Romero, F Anthony ; Finke, Paul E ; Moningka, Remond ; Bao, Jianming ; Plotkin, Michael A ; Shang, Jin ; Dingley, Karen H ; Salituro, Gino ; Murphy, Beth Ann ; Howard, Andrew D ; Ujjainwalla, Feroze ; Wood, Harold B ; Duffy, Joseph L

ACS medicinal chemistry letters, 08 November 2018, Vol.9(11), pp.1088-1093 [Peer Reviewed Journal]

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Discovery of cyclic guanidines as potent, orally active, human glucagon receptor antagonists

Sinz, Christopher ; Chang, Jiang ; Lins, Ashley Rouse ; Brady, Ed ; Candelore, Mari ; Dallas-Yang, Qing ; Ding, Victor ; Jiang, Guoqiang ; Lin, Zhen ; Mock, Steven ; Qureshi, Sajjad ; Salituro, Gino ; Saperstein, Richard ; Shang, Jackie ; Szalkowski, Deborah ; Tota, Laurie ; Vincent, Stella ; Wright, Michael ; Xu, Shiyao ; Yang, Xiaodong ; Zhang, Bei ; Tata, James ; Kim, Ronald ; Parmee, Emma

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(23), pp.7131-7136 [Peer Reviewed Journal]

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17
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Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension

Hoyt, Scott B ; Taylor, Jerry ; London, Clare ; Ali, Amjad ; Ujjainwalla, Feroze ; Tata, Jim ; Struthers, Mary ; Cully, Doris ; Wisniewski, Tom ; Ren, Ning ; Bopp, Charlene ; Sok, Andrea ; Verras, Andreas ; Mcmasters, Daniel ; Chen, Qing ; Tung, Elaine ; Tang, Wei ; Salituro, Gino ; Clemas, Joe ; Zhou, Gaochao ; Macneil, Douglas ; Duffy, Ruth ; Xiong, Yusheng

Bioorganic & Medicinal Chemistry Letters, 01 June 2017, Vol.27(11), pp.2384-2388 [Peer Reviewed Journal]

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18
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Improved Stability of Proline-Derived Direct Thrombin Inhibitors through Hydroxyl to Heterocycle Replacement

Chobanian, Harry R ; Pio, Barbara ; Guo, Yan ; Shen, Hong ; Huffman, Mark A ; Madeira, Maria ; Salituro, Gino ; Terebetski, Jenna L ; Ormes, James ; Jochnowitz, Nina ; Hoos, Lizbeth ; Zhou, Yuchen ; Lewis, Dale ; Hawes, Brian ; Mitnaul, Lyndon ; O'Neill, Kim ; Ellsworth, Kenneth ; Wang, Liangsu ; Biftu, Tesfaye ; Duffy, Joseph L

ACS medicinal chemistry letters, 14 May 2015, Vol.6(5), pp.553-7 [Peer Reviewed Journal]

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19
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Investigation of piperazine benzamides as human β3 adrenergic receptor agonists for the treatment of overactive bladder

Harper, Bart H ; Wang, Liping ; Zhu, Cheng ; Kar, Nam F ; Li, Bing ; Moyes, Christopher R ; Goble, Stephen D ; Costa, Melissa ; Dingley, Karen ; Di Salvo, Jerry ; Ha, Sookhee N ; Hurley, Amanda ; Li, Xiaofang ; Miller, Randy R ; Nagabukuro, Hiroshi ; Salituro, Gino M ; Smith, Sean ; Struthers, Mary ; Hale, Jeffrey J ; Edmondson, Scott D ; Berger, Richard

Bioorganic & Medicinal Chemistry Letters, 15 February 2017, Vol.27(4), pp.1094-1098 [Peer Reviewed Journal]

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20
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Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine (23)

Biftu, Tesfaye ; Qian, Xiaoxia ; Chen, Ping ; Feng, Dennis ; Scapin, Giovanna ; Gao, Ying-Duo ; Cox, Jason ; Sinha Roy, Ranabir ; Eiermann, George ; He, Huabing ; Lyons, Kathy ; Salituro, Gino ; Patel, Sangita ; Petrov, Alexander ; Xu, Feng ; Xu, Shiyao Sherrie ; Zhang, Bei ; Caldwell, Charles ; Wu, Joseph K ; Lyons, Kathy ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 01 October 2013, Vol.23(19), pp.5361-5366 [Peer Reviewed Journal]

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21
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Evaluation of CETP activity in vivo under non-steady-state conditions: influence of anacetrapib on HDL-TG flux

Mclaren, David G ; Previs, Stephen F ; Phair, Robert D ; Stout, Steven J ; Xie, Dan ; Chen, Ying ; Salituro, Gino M ; Xu, Suoyu S ; Castro-Perez, Jose M ; Opiteck, Gregory J ; Akinsanya, Karen O ; Cleary, Michele A ; Dansky, Hayes M ; Johns, Douglas G ; Roddy, Thomas P

Journal of lipid research, March 2016, Vol.57(3), pp.398-409 [Peer Reviewed Journal]

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22
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Corrigendum to “Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(4,6-dihydropyrrolo[3,4-c]pyrazol-5-(1H)-yl)tetrahydro-2H-pyran-3-amine (23)” [Bioorg. Med. Chem. Lett. 23 (2013) 5361–5366]

Biftu, Tesfaye ; Qian, Xiaoxia ; Chen, Ping ; Feng, Dennis ; Scapin, Giovanna ; Gao, Ying-Duo ; Cox, Jason ; Roy, Ranabir Sinha ; Eiermann, George ; He, Huabing ; Lyons, Kathy ; Salituro, Gino ; Patel, Sangita ; Petrov, Alexander ; Xu, Feng ; Xu, Shiyao Sherrie ; Zhang, Bei ; Caldwell, Charles ; Wu, Joseph K ; Lyons, Kathy ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 01 June 2014, Vol.24(11), pp.2590-2590 [Peer Reviewed Journal]

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23
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Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity

Air, Ellen L ; Strowski, Mathias Z ; Benoit, Stephen C ; Conarello, Stacey L ; Salituro, Gino M ; Guan, Xiao-Ming ; Liu, Kun ; Woods, Stephen C ; Zhang, Bei B

Nature medicine, February 2002, Vol.8(2), pp.179-83 [Peer Reviewed Journal]

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24
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Complestatin to chloropeptin I via a quantitative acid catalyzed rearrangement. Absolute stereochemical determination of complestatin

Jayasuriya, Hiranthi ; Salituro, Gino M ; Smith, Scott K ; Heck, James V ; Gould, Steven J ; Singh, Sheo B ; Homnick, Carl F ; Holloway, M.Katharine ; Pitzenberger, Steven M ; Patane, Michael A

Tetrahedron Letters, 1998, Vol.39(16), pp.2247-2248 [Peer Reviewed Journal]

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25
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Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition

Liu, Weiguo ; Shao, Pengcheng P ; Liang, Gui-Bai ; Bawiec, John ; He, Jiafang ; Aster, Susan D ; Wu, Margaret ; Chicchi, Garry ; Wang, John ; Tsao, Kwei-Lan ; Shang, Jin ; Salituro, Gino ; Zhou, Yun-Ping ; Li, Cai ; Akiyama, Taro E ; Metzger, Daniel E ; Murphy, Beth Ann ; Howard, Andrew D ; Weber, Ann E ; Duffy, Joseph L

ACS medicinal chemistry letters, 08 November 2018, Vol.9(11), pp.1082-1087 [Peer Reviewed Journal]

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26
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Discovery of phenyl acetamides as potent and selective GPR119 agonists

Zhu, Cheng ; Wang, Liping ; Zhu, Yuping ; Guo, Zack Zhiqiang ; Liu, Ping ; Hu, Zhiyong ; Szewczyk, Jason W ; Kang, Ling ; Chicchi, Gary ; Ehrhardt, Anka ; Woods, Andrea ; Seo, Toru ; Woods, Morgan ; van Heek, Margaret ; Dingley, Karen H ; Pang, Jianmei ; Salituro, Gino M ; Powell, Joyce ; Terebetski, Jenna L ; Hornak, Viktor ; Campeau, Louis-Charles ; Orr, Robert K ; Ujjainwalla, Feroze ; Miller, Michael ; Stamford, Andrew ; Wood, Harold B ; Kowalski, Timothy ; Nargund, Ravi P ; Edmondson, Scott D

Bioorganic & Medicinal Chemistry Letters, 01 March 2017, Vol.27(5), pp.1124-1128 [Peer Reviewed Journal]

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27
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Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension

Petrilli, Whitney L ; Hoyt, Scott B ; London, Clare ; Mcmasters, Daniel ; Verras, Andreas ; Struthers, Mary ; Cully, Doris ; Wisniewski, Thomas ; Ren, Ning ; Bopp, Charlene ; Sok, Andrea ; Chen, Qing ; Li, Ying ; Tung, Elaine ; Tang, Wei ; Salituro, Gino ; Knemeyer, Ian ; Karanam, Bindhu ; Clemas, Joseph ; Zhou, Gaochao ; Gibson, Jack ; Shipley, Carrie Ann ; Macneil, Douglas J ; Duffy, Ruth ; Tata, James R ; Ujjainwalla, Feroze ; Ali, Amjad ; Xiong, Yusheng

ACS medicinal chemistry letters, 12 January 2017, Vol.8(1), pp.128-132 [Peer Reviewed Journal]

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28
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Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β 3 adrenergic receptor agonists

Morriello, Gregori J ; Wendt, Harvey R ; Bansal, Alka ; Salvo, Jerry Di ; Feighner, Scott ; He, Jiafang ; Hurley, Amanda L ; Hreniuk, Donna L ; Salituro, Gino M ; Reddy, Marat Vijay ; Galloway, Sheila M ; Mcgettigan, Katherine K ; Laws, George ; Mcknight, Crystal ; Doss, George A ; Tsou, Nancy N ; Black, Regina M ; Morris, Judy ; Ball, Richard G ; Sanfiz, Anthony T ; Streckfuss, Eric ; Struthers, Mary ; Edmondson, Scott D

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(6), pp.1865-1870 [Peer Reviewed Journal]

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29
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Heterocyclic acetamide and benzamide derivatives as potent and selective β 3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles

Goble, Stephen D ; Wang, Liping ; Howell, K. Lulu ; Bansal, Alka ; Berger, Richard ; Brockunier, Linda ; Disalvo, Jerry ; Feighner, Scott ; Harper, Bart ; He, Jiafang ; Hurley, Amanda ; Hreniuk, Donna ; Parmee, Emma ; Robbins, Michael ; Salituro, Gino ; Sanfiz, Anthony ; Streckfuss, Eric ; Watkins, Eloisa ; Weber, Ann E ; Struthers, Mary ; Edmondson, Scott D

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(6), pp.1895-1899 [Peer Reviewed Journal]

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30
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Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists

Zhou, Changyou ; Tang, Cheng ; Chang, Eric ; Ge, Min ; Lin, Songnian ; Cline, Eric ; Tan, Carina P ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George J ; Petrov, Aleksandr ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro E ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel ; Howard, Andrew D ; Thornberry, Nancy ; Mills, Sander G ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(3), pp.1298-1301 [Peer Reviewed Journal]

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31
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Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice

Tan, Carina P ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George J ; Petrov, Aleksandr ; Zhou, Changyou ; Lin, Songnian ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro E ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel P ; Mills, Sander G ; Thornberry, Nancy A ; Yang, Lihu ; Howard, Andrew D

Diabetes, August 2008, Vol.57(8), pp.2211-9 [Peer Reviewed Journal]

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32
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Using similarity searches over databases of estimated 13C NMR spectra for structure identification of natural product compounds

Tsipouras, Athanasios ; Ondeyka, John ; Dufresne, Claude ; Lee, Seok ; Salituro, Gino ; Tsou, Nancy ; Goetz, Michael ; Singh, Sheo Bux ; Kearsley, Simon K

Analytica Chimica Acta, 30 November 1995, Vol.316(2), pp.161-171 [Peer Reviewed Journal]

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33
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Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes

Guo, Liangqin ; Parker, Dann L ; Zang, Yi ; Sweis, Ramzi F ; Liu, Weiguo ; Sherer, Edward C ; Buist, Nicole ; Terebetski, Jenna ; Kelly, Terri ; Bugianesi, Randal ; Priest, Birgit T ; Dingley, Karen H ; Li, Xiaofang ; Mitelman, Stan ; Salituro, Gino ; Trujillo, Maria E ; Pachanski, Michele ; Kirkland, Melissa ; Powles, Mary Ann ; Eiermann, George J ; Feng, Yue ; Shang, Jin ; Howard, Andrew D ; Ujjainwalla, Feroze ; Sinz, Christopher J ; Debenham, John S ; Edmondson, Scott D ; Nargund, Ravi P ; Hagmann, William K ; Li, Derun

ACS medicinal chemistry letters, 08 December 2016, Vol.7(12), pp.1107-1111 [Peer Reviewed Journal]

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Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes

Liu, Ping ; Hu, Zhiyong ; Dubois, Byron G ; Moyes, Christopher R ; Hunter, David N ; Zhu, Cheng ; Kar, Nam Fung ; Zhu, Yuping ; Garfunkle, Joie ; Kang, Ling ; Chicchi, Gary ; Ehrhardt, Anka ; Woods, Andrea ; Seo, Toru ; Woods, Morgan ; Van Heek, Margaret ; Dingley, Karen H ; Pang, Jianmei ; Salituro, Gino M ; Powell, Joyce ; Terebetski, Jenna L ; Hornak, Viktor ; Campeau, Louis-Charles ; Lamberson, Joe ; Ujjainwalla, Fez ; Miller, Michael ; Stamford, Andrew ; Wood, Harold B ; Kowalski, Timothy ; Nargund, Ravi P ; Edmondson, Scott D

ACS medicinal chemistry letters, 13 August 2015, Vol.6(8), pp.936-41 [Peer Reviewed Journal]

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Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain

Chobanian, Harry R ; Guo, Yan ; Liu, Ping ; Chioda, Marc D ; Fung, Selena ; Lanza, Thomas J ; Chang, Linda ; Bakshi, Raman K ; Dellureficio, James P ; Hong, Qingmei ; Mclaughlin, Mark ; Belyk, Kevin M ; Krska, Shane W ; Makarewicz, Amanda K ; Martel, Elliot J ; Leone, Joseph F ; Frey, Lisa ; Karanam, Bindhu ; Madeira, Maria ; Alvaro, Raul ; Shuman, Joyce ; Salituro, Gino ; Terebetski, Jenna L ; Jochnowitz, Nina ; Mistry, Shruti ; Mcgowan, Erin ; Hajdu, Richard ; Rosenbach, Mark ; Abbadie, Catherine ; Alexander, Jessica P ; Shiao, Lin-Lin ; Sullivan, Kathleen M ; Nargund, Ravi P ; Wyvratt, Matthew J ; Lin, Linus S ; Devita, Robert J

ACS medicinal chemistry letters, 12 June 2014, Vol.5(6), pp.717-21 [Peer Reviewed Journal]

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Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys

Hoyt, Scott B ; Petrilli, Whitney ; London, Clare ; Liang, Gui-Bai ; Tata, Jim ; Hu, Qingzhong ; Yin, Lina ; Van Koppen, Chris J ; Hartmann, Rolf W ; Struthers, Mary ; Wisniewski, Tom ; Ren, Ning ; Bopp, Charlene ; Sok, Andrea ; Cai, Tian-Quan ; Stribling, Sloan ; Pai, Lee-Yuh ; Ma, Xiuying ; Metzger, Joe ; Verras, Andreas ; Mcmasters, Daniel ; Chen, Qing ; Tung, Elaine ; Tang, Wei ; Salituro, Gino ; Buist, Nicole ; Clemas, Joe ; Zhou, Gaochao ; Gibson, Jack ; Maxwell, Carrie Ann ; Lassman, Mike ; Mclaughlin, Theresa ; Castro-Perez, Jose ; Szeto, Daphne ; Forrest, Gail ; Hajdu, Richard ; Rosenbach, Mark ; Xiong, Yusheng

ACS medicinal chemistry letters, 13 August 2015, Vol.6(8), pp.861-5 [Peer Reviewed Journal]

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