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21 Results  for Everything (Includes Articles)

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1
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Development of a high capacity microassay for measurement of neutrophil adhesion

Miller, Douglas K ; Sadowski, Sharon

Journal of Immunological Methods, 21 January 1988, Vol.106(1), pp.37-47 [Peer Reviewed Journal]

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2
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Identification and isolation of a membrane protein necessary for leukotriene production

Miller, Douglas ; Gillard, John ; Vickers, Philip ; Sadowski, Sharon ; Léveillé, Claire ; Mancini, Joseph ; Charleson, Peter ; Dixon, Richard ; Ford-Hutchinson, Anthony ; Fortin, Réjean ; Gauthier, Jacques ; Rodkey, John ; Rosen, Ronda ; Rouzer, Carol ; Sigal, Irving ; Strader, Catherine ; Evans, Jilly

Nature, Jan 18, 1990, Vol.343(6255), pp.278-281 [Peer Reviewed Journal]

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Short Segment of Human Melanin-Concentrating Hormone That Is Sufficient for Full Activation of Human Melanin-Concentrating Hormone Receptors 1 and 2
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Short Segment of Human Melanin-Concentrating Hormone That Is Sufficient for Full Activation of Human Melanin-Concentrating Hormone Receptors 1 and 2

Bednarek, Maria A. ; Feighner, Scott D. ; Hreniuk, Donna L. ; Palyha, Oksana C. ; Morin, Nancy R. ; Sadowski, Sharon J. ; Macneil, Douglas J. ; Howard, Andrew D. ; Van Der Ploeg, Lex H. Y.

Biochemistry, 08/2001, Vol.40(31), pp.9379-9386 [Peer Reviewed Journal]

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4
An Orally Active, Water-Soluble Neurokinin-1 Receptor Antagonist Suitable for Both Intravenous and Oral Clinical Administration
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An Orally Active, Water-Soluble Neurokinin-1 Receptor Antagonist Suitable for Both Intravenous and Oral Clinical Administration

Harrison, Timothy ; Owens, Andrew P. ; Williams, Brian J. ; Swain, Christopher J. ; Williams, Angela ; Carlson, Emma J. ; Rycroft, Wayne ; Tattersall, F. David ; Cascieri, Margaret A. ; Chicchi, Gary G. ; Sadowski, Sharon ; Rupniak, Nadia M. J. ; Hargreaves, Richard J.

Journal of Medicinal Chemistry, 11/2001, Vol.44(24), pp.4296-4299 [Peer Reviewed Journal]

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4,4-Disubstituted Piperidine High-Affinity NK 1 Antagonists:  Structure−Activity Relationships and in Vivo Activity
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4,4-Disubstituted Piperidine High-Affinity NK 1 Antagonists:  Structure−Activity Relationships and in Vivo Activity

Stevenson, Graeme I. ; Huscroft, Ian ; Macleod, Angus M. ; Swain, Christopher J. ; Cascieri, Margaret A. ; Chicchi, Gary G. ; Graham, Michael I. ; Harrison, Timothy ; Kelleher, Fintan J. ; Kurtz, Marc ; Ladduwahetty, Tamara ; Merchant, Kevin J. ; Metzger, Joseph M. ; Macintyre, D. E. ; Sadowski, Sharon ; Sohal, Balbinder ; Owens, Andrew P.

Journal of Medicinal Chemistry, 11/1998, Vol.41(23), pp.4623-4635 [Peer Reviewed Journal]

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6
2( S )-((3,5-Bis(trifluoromethyl)benzyl)oxy)-3( S )-phenyl-4-((3-oxo-1,2,4-triazol- 5-yl)methyl)morpholine ( 1 ):  A Potent, Orally Active, Morpholine-Based Human Neurokinin-1 Receptor Antagonist
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2( S )-((3,5-Bis(trifluoromethyl)benzyl)oxy)-3( S )-phenyl-4-((3-oxo-1,2,4-triazol- 5-yl)methyl)morpholine ( 1 ):  A Potent, Orally Active, Morpholine-Based Human Neurokinin-1 Receptor Antagonist

Hale, Jeffrey J. ; Mills, Sander G. ; Maccoss, Malcolm ; Shah, Shrenik K. ; Qi, Hongbo ; Mathre, David J. ; Cascieri, Margaret A. ; Sadowski, Sharon ; Strader, Catherine D. ; Macintyre, D. Euan ; Metzger, Joseph M.

Journal of Medicinal Chemistry, 01/1996, Vol.39(9), pp.1760-1762 [Peer Reviewed Journal]

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7
Structural Optimization Affording 2-( R )-(1-( R )-3,5-Bis(trifluoromethyl)phenylethoxy)-3-( S )-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist
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Structural Optimization Affording 2-( R )-(1-( R )-3,5-Bis(trifluoromethyl)phenylethoxy)-3-( S )-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

Hale, Jeffrey J. ; Mills, Sander G. ; Maccoss, Malcolm ; Finke, Paul E. ; Cascieri, Margaret A. ; Sadowski, Sharon ; Ber, Elzbieta ; Chicchi, Gary G. ; Kurtz, Marc ; Metzger, Joseph ; Eiermann, George ; Tsou, Nancy N. ; Tattersall, F. David ; Rupniak, Nadia M. J. ; Williams, Angela R. ; Rycroft, Wayne ; Hargreaves, Richard ; Macintyre, D. Euan

Journal of Medicinal Chemistry, 11/1998, Vol.41(23), pp.4607-4614 [Peer Reviewed Journal]

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8
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L-tryptophan urea amides as [formula omitted] dual antagonists

Qi, Hongbo ; Shah, Shrenik K ; Cascieri, Margaret A ; Sadowski, Sharon J ; Maccoss, Malcolm

Bioorganic & Medicinal Chemistry Letters, 1998, Vol.8(16), pp.2259-2262 [Peer Reviewed Journal]

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9
Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs
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Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs

Hale, Jeffrey J. ; Mills, Sander G. ; Maccoss, Malcolm ; Dorn, Conrad P. ; Finke, Paul E. ; Budhu, Richard J. ; Reamer, Robert A. ; Huskey, Su-Er W. ; Luffer-Atlas, Debra ; Dean, Brian J. ; Mcgowan, Erin M. ; Feeney, William P. ; Chiu, Shuet-Hing Lee ; Cascieri, Margaret A. ; Chicchi, Gary G. ; Kurtz, Marc M. ; Sadowski, Sharon ; Ber, Elzbieta ; Tattersall, F. David ; Rupniak, Nadia M. J. ; Williams, Angela R. ; Rycroft, Wayne ; Hargreaves, Richard ; Metzger, Joseph M. ; Macintyre, D. Euan

Journal of Medicinal Chemistry, 03/2000, Vol.43(6), pp.1234-1241 [Peer Reviewed Journal]

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10
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1,2,4-Triacylpiperidine substance p antagonists: Separation of affinities for the NK-1 receptor and the L-type calcium channel

Mills, Sander G ; Maccoss, Malcolm ; Cascieri, Margaret A ; Sadowski, Sharon ; Patel, Smita ; Chapman, Kerry L ; Hutson, Peter H

Bioorganic & Medicinal Chemistry Letters, 1995, Vol.5(6), pp.599-604 [Peer Reviewed Journal]

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11
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Cyclopentane-based human NK1 antagonists. Part 1: Discovery and initial SAR

Finke, Paul E ; Meurer, Laura C ; Levorse, Dorothy A ; Mills, Sander G ; Maccoss, Malcolm ; Sadowski, Sharon ; Cascieri, Margaret A ; Tsao, Kwei-Lan ; Chicchi, Gary G ; Metzger, Joseph M ; Macintyre, D. Euan

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(17), pp.4497-4503 [Peer Reviewed Journal]

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12
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1,2,3-Trisubstituted cyclohexyl substance P antagonists: significance of the ring nitrogen in piperidine-based NK-1 receptor antagonists

Mills, Sander G ; Maccoss, Malcolm ; Underwood, Dennis ; Shah, Shrenik K ; Finke, Paul E ; Miller, Daniel J ; Budhu, Richard J ; Cascieri, Margaret A ; Sadowski, Sharon ; Strader, Catherine D

Bioorganic & Medicinal Chemistry Letters, 1995, Vol.5(13), pp.1345-1350 [Peer Reviewed Journal]

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13
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Combinatorial synthesis of 3-(Amidoalkyl) and 3-(Aminoalkyl)-2-arylindole derivatives: discovery of potent ligands for a variety of G-protein coupled receptors

Willoughby, Christopher A ; Hutchins, Steven M ; Rosauer, Keith G ; Dhar, Madhumeeta J ; Chapman, Kevin T ; Chicchi, Gary G ; Sadowski, Sharon ; Weinberg, David H ; Patel, Smita ; Malkowitz, Lorraine ; Di Salvo, Jerry ; Pacholok, Stephen G ; Cheng, Kang

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(1), pp.93-96 [Peer Reviewed Journal]

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14
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Spirocyclic NK 1 antagonists I: [4.5] and [5.5]-Spiroketals

Seward, Eileen M ; Carlson, Emma ; Harrison, Timothy ; Haworth, Karen E ; Herbert, Richard ; Kelleher, Fintan J ; Kurtz, Marc M ; Moseley, Jonathan ; Owen, Simon N ; Owens, Andrew P ; Sadowski, Sharon J ; Swain, Christopher J ; Williams, Brian J

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(18), pp.2515-2518 [Peer Reviewed Journal]

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Inhibition of the release of prostaglandins, leukotrienes and lysosomal acid hydrolases from macrophages by selective inhibitors of lecithin biosynthesis

Bonney, Robert J ; Wightman, Paul D ; Dahlgren, Mary Ellen ; Sadowski, Sharon J ; Davies, Philip ; Jensen, Norman ; Lanza, Thomas ; Humes, John L

Biochemical Pharmacology, 1983, Vol.32(2), pp.361-366 [Peer Reviewed Journal]

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16
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Development of enzyme-linked immunosorbent assays for measurement of leukotrienes and prostaglandins

Miller, Douglas K ; Sadowski, Sharon ; Desousa, Donna ; Maycock, Alan L ; Lombardo, Donna L ; Young, Robert N ; Hayes, Edward C

Journal of Immunological Methods, 1985, Vol.81(2), pp.169-185 [Peer Reviewed Journal]

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17
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Pharmacological effects of non-steroidal antiinflammatory agents on prostaglandin and leukotriene synthesis in mouse peritoneal macrophages

Humes, John L ; Sadowski, Sharon ; Galavage, Mary ; Goldenberg, Marvin ; Subers, Emily ; Kuehl, Frederick A ; Bonney, Robert J

Biochemical Pharmacology, 1983, Vol.32(15), pp.2319-2322 [Peer Reviewed Journal]

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18
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Acyclic NK-1 antagonists: 2-benzhydryl-2-aminoethyl ethers

Williams, Brian J ; Teall, Martin ; Mc Kenna, Jeffrey ; Harrison, Timothy ; Swain, Christopher J ; Cascieri, Margaret A ; Sadowski, Sharon ; Strader, Catherine ; Baker, Raymond

Bioorganic & Medicinal Chemistry Letters, 1994, Vol.4(16), pp.1903-1908 [Peer Reviewed Journal]

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19
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Quinuclidine-based NK-1 antagonists I: 3-benzyloxy-1-azabicyclo[2.2.2]octanes

Seward, Eileen M ; Swain, Christopher J ; Merchant, Kevin J ; Owen, Simon N ; Sabin, Verity ; Cascieri, Margaret A ; Sadowski, Sharon ; Strader, Catherine ; Baker, Raymond

Bioorganic & Medicinal Chemistry Letters, 1993, Vol.3(6), pp.1361-1366 [Peer Reviewed Journal]

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20
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Cyclopentane-based human NK1 antagonists. Part 2: Development of potent, orally active, water-soluble derivatives

Meurer, Laura C ; Finke, Paul E ; Owens, Karen A ; Tsou, Nancy N ; Ball, Richard G ; Mills, Sander G ; Maccoss, Malcolm ; Sadowski, Sharon ; Cascieri, Margaret A ; Tsao, Kwei-Lan ; Chicchi, Gary G ; Egger, Linda A ; Luell, Silvi ; Metzger, Joseph M ; Macintyre, D. Euan ; Rupniak, Nadia M.J ; Williams, Angela R ; Hargreaves, Richard J

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(17), pp.4504-4511 [Peer Reviewed Journal]

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21
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1,4-Diacylpiperazine-2-(S)-[(N-aminoalkyl)carboxamides] as novel, potent substance P receptor antagonists

Mills, Sander G ; Wu, Mu Tsu ; Maccoss, Malcolm ; Budhu, Richard J ; Dorn, Conrad P ; Cascieri, Margaret A ; Sadowski, Sharon ; Strader, Catherine D ; Greenlee, William J

Bioorganic & Medicinal Chemistry Letters, 1993, Vol.3(12), pp.2707-2712 [Peer Reviewed Journal]

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